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Entry version 129 (17 Jun 2020)
Sequence version 1 (15 Mar 2005)
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Protein

Serine/threonine-protein kinase ATM

Gene

tefu

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase which recognizes the substrate consensus sequence [ST]-Q. Required to suppress spontaneous apoptosis of proliferating cells during development, and for their proper differentiation. Required for female fertility. Protects telomeres from fusion, maybe by recruiting or maintaining chromatin-modifying complexes such as Su(var)205/HP1. May activate checkpoint signaling in response to DNA double-stranded breaks induced by low-dose ionizing radiation. May phosphorylate histone H2AV.6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, DNA damage
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-2559586 DNA Damage/Telomere Stress Induced Senescence
R-DME-5693548 Sensing of DNA Double Strand Breaks
R-DME-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-DME-5693607 Processing of DNA double-strand break ends
R-DME-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-DME-6804756 Regulation of TP53 Activity through Phosphorylation
R-DME-6804757 Regulation of TP53 Degradation
R-DME-69473 G2/M DNA damage checkpoint
R-DME-69541 Stabilization of p53

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q5EAK6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase ATM (EC:2.7.11.1)
Alternative name(s):
Telomere fusion protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tefu
Synonyms:atm
ORF Names:CG6535
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0045035 tefu

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Flies die shortly before or after eclosion with a rough eye phenotype, misshapen wings, and missing or abnormal bristles.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002256271 – 2767Serine/threonine-protein kinase ATMAdd BLAST2767

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5EAK6

PRoteomics IDEntifications database

More...
PRIDEi
Q5EAK6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at low levels throughout development and at much higher levels in adult females compared to males.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0045035 Expressed in eye disc (Drosophila) and 25 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5EAK6 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5EAK6 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
66903, 24 interactors

Protein interaction database and analysis system

More...
IntActi
Q5EAK6, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0110174

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1713 – 2317FATPROSITE-ProRule annotationAdd BLAST605
Domaini2443 – 2696PI3K/PI4KPROSITE-ProRule annotationAdd BLAST254
Domaini2735 – 2767FATCPROSITE-ProRule annotationAdd BLAST33

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. ATM subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0892 Eukaryota
ENOG410XNPY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000174195

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_227091_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5EAK6

KEGG Orthology (KO)

More...
KOi
K04728

Identification of Orthologs from Complete Genome Data

More...
OMAi
AYCRLDS

Database of Orthologous Groups

More...
OrthoDBi
80538at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5EAK6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015519 ATM/Tel1
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR014009 PIK_FAT

The PANTHER Classification System

More...
PANTHERi
PTHR11139:SF72 PTHR11139:SF72, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02260 FATC, 1 hit
PF00454 PI3_PI4_kinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5EAK6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSALLNEIQR ILGDLQSGKA ASRNKGIQQL DEKLSSCRED LDKLFLSKTS
60 70 80 90 100
DISWTTIFEA SKEALFKQAG NLEDVNEKVF KTLAGKNYLY DNVLEKITQF
110 120 130 140 150
NLEAGSQTSG NGHFLAKTSI FSAFEDGIKM RVVVKYFGDR ILSLLEKGIY
160 170 180 190 200
SSVSYVRDLK INEYSRILSY LFELNVDMDE VLRTRILKCI TRTVSLAKDR
210 220 230 240 250
VQLHVDLVEY LPELSSFALS AFGARKTEIV RVYLIFASEL AVNYNHQLNV
260 270 280 290 300
HMQEILPKLC EYHDEDAFRD DTRNLFFQCV SKSLHSMYLK MDMCDFNTLG
310 320 330 340 350
VPVHEKWPQT LLRLKTIVNV EIRKNSWARC KNALLSNNKF SDPFIKMSAL
360 370 380 390 400
AMYIVLWHLE TKKADENGEG DAPKKIPKPA DKMETIFSLI DKKENTFNDV
410 420 430 440 450
WLAIFTEILQ LSSVILNVAN YQMALTTVAE IMQMYGNAKN LRNLRLCLAH
460 470 480 490 500
LLTKEQELLH SKSIREDFLG ELWSQMANQL ISETTTNSEE IKEKQLVLQM
510 520 530 540 550
LIRHNKLNQK LSSTLLNNII SNEMLKRNEC LATIREIFIH ADKCGQDKAS
560 570 580 590 600
ADLEPIIAWA YGSADRFIAA QMIHNIDSID AQLQADTFAI SIINFLDVQQ
610 620 630 640 650
LRQISQSEHI VPSTERNLLA YKYNEQLICF DKDYATPFES ITHIQSETKN
660 670 680 690 700
CLIQSNYDCL MRGLNFEIAK ENKPAAIIKN LNSLLKLICT MERLLHYKVF
710 720 730 740 750
DADTYTGCPL IKRIGLYLSH IEFQLKANGA EILDKSDLPE ILRLEIYVLD
760 770 780 790 800
VFRTNLVLLD YLERQPIEML VEFVGAALKL HSMQRERSVD ADHGTITRLC
810 820 830 840 850
LNILAGLCAY NSHRDEAFEH IVKVTMRWHP QDVLIVTKML CSCQTISEAS
860 870 880 890 900
SSWLVSKLKT LFQQHHQDAE LMDKVVQHMP TIFYFVRHKE NHLDDMLMAL
910 920 930 940 950
NSLLRIAIKK SYTSNLTAKI VRCVGLIAQR CPDIYLLENF AVICKSTAKF
960 970 980 990 1000
ITMPTLEVRF ATLFTFTILL ESNCVTSDAI GHSRTHWDFC QELYESIEFK
1010 1020 1030 1040 1050
KLTYNNEDAI QNSNALIVQM LIAIFLRSSF HQEIALKELL HHCALRRLTE
1060 1070 1080 1090 1100
REFISLQSMS SCHRQTVRDL IRPFAAILLH HWSSKRWPIS KFPYFLCYST
1110 1120 1130 1140 1150
KSEFRKTHAS EIMAYTFLYG KTEDIERCSK SISEELALPI LASFLLIKNS
1160 1170 1180 1190 1200
SCSESEGQNF KEHLQLLSEN LSYSQLNATD VDLDLDILCY VISMLHDPQE
1210 1220 1230 1240 1250
MMRLFGSLAI CNRTASWYSL SGESLFKCLN FHIDPEMRPS MDSRIQSMTT
1260 1270 1280 1290 1300
LQTKHSRVLV DIFGRLKTNC YSASFSSQAL HDFFLYCEVA DAVYDAARKN
1310 1320 1330 1340 1350
ETIVTQCSFF VRDIWFFVVR LLIHTKFIRV QMAALTFLEL LLNKHNFRLD
1360 1370 1380 1390 1400
DYQNHFGDIA KLLSNFQLCC EAKEVREKTM SIVMYILESK KGHINLNSFL
1410 1420 1430 1440 1450
EETTDCEFLK PLREDCKSSQ PNIDRADVAN YLRSFLLSPT PERLRDLRTY
1460 1470 1480 1490 1500
IAEHKDKVQE HEKLLFGVIN KLIQMTRDAH NKTTSIDSLK CLAQIGPLKI
1510 1520 1530 1540 1550
STVSYYFQTD FEAFEKSNGE PMEAFLGVVC HSLDTSLFQF DPKTHEGLVS
1560 1570 1580 1590 1600
VAIQVVNSKP GSNIMERYKN LRIFADKSTA STFLHSNKQI RRIDWLSILK
1610 1620 1630 1640 1650
ATKSLSYEPW MCAFVSKVFQ MCGWLGFDKL AATSFAFAKT CLLPFIKLLL
1660 1670 1680 1690 1700
ENSLEHVESL SQMLDYFFEG FTSSTAPNSQ EIFRNKRAIK KFLHICEYIR
1710 1720 1730 1740 1750
IFNNWTIPIN LSNVVMASNH CQAYFLSIMY LELWACSESP KSKADFLDNE
1760 1770 1780 1790 1800
CFQDGAKKAY ESIGCLDAIP GFVNPMRSRL DFLGHGSNLS TILLESDHLD
1810 1820 1830 1840 1850
RASGQLCIDI MKGNGLWSFA KLQQHQNIEP DYEIFWRLGQ WDSLTDPKHQ
1860 1870 1880 1890 1900
QNQTVVRTSL DLEQEFKRHH FVALRSIGQR EEENSLSAIE QAYSCVRDIL
1910 1920 1930 1940 1950
MEISVECLQS VYKYLTWLCS LQQAEDFCQI QFGTQLDPAS TTKIFRKWQT
1960 1970 1980 1990 2000
ELELKYGNFS CKEYVIAHQI ALLKLAGTRA SRRMSEFYQK DPISTYLMKG
2010 2020 2030 2040 2050
IEECKSAGKL NLAAKYTATL RELPNIRESI KISVLLEDAE INLKMGNQQI
2060 2070 2080 2090 2100
AKAILDYVTN NNEFVYCVQR VPALRMQGEF LLDCNAETLS WVQSHKFNNS
2110 2120 2130 2140 2150
LKLIDDFVQH RQTLSEKYRD IFDWHQLDAY ASKQRTAAYA TIAKYADREY
2160 2170 2180 2190 2200
QQLHDYRHSQ EYQTLKDIIE QNRQTAEKVT QRENQDRRVI SVQMKRYASL
2210 2220 2230 2240 2250
DEQQLNQIEE KLTEYLRLAL TNYMAYCRLD SGFSSAAIYR IISLWFTNAT
2260 2270 2280 2290 2300
SKQCQECIKD EILTVPSYKF ICAANQLTAR LNSKNTSLLK GLTDLLVQCG
2310 2320 2330 2340 2350
KDHPYHTFYQ LYPLVFAHLD GENSNTERSG IARKIIAMIC EKNGTAGECS
2360 2370 2380 2390 2400
KQLESLLPAL ITFANEGKTN DNRPVSDSVR NKQFDKVRRW RNLNAVHCPT
2410 2420 2430 2440 2450
LELPVMPSKE YSIISVVKWT NETTQCGGLN APVKIMCVCS DGKIRAQLVK
2460 2470 2480 2490 2500
GKDDLRQDAV MQQVFGIVNE LLNQDSEFIE RKLKLRTYKV TPLSMRSGIL
2510 2520 2530 2540 2550
EWCTNSVPVG HYLVVEGKGG AHARYRPNDW NNNKCRKLSS DHLKSPKETR
2560 2570 2580 2590 2600
YAIYKKICEN IKPVFHYFLL EKFPIPGVWF ERRLAYTNSV ATTSMVGYVL
2610 2620 2630 2640 2650
GLGDRHTQNI LVDQQTAEVI HIDFGIAFEQ GKIQTTPETV PFRLTRDFVA
2660 2670 2680 2690 2700
PMGICGTKGV FAKSCEATMH ILRRYKSVFT TILEVLLYDP LFIWGVLKKK
2710 2720 2730 2740 2750
QSPQQSGEES VNLVAQRALL LVQNKLDGRE AGTMGDSNVE AQVERLINEA
2760
TLPSNLCMLF PGWDPHL
Length:2,767
Mass (Da):317,991
Last modified:March 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF354E55FA1B35570
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM29197 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2733T → P in AAM29197 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: ABI31168.1
AY395750 mRNA Translation: AAR89513.1
AY113192 mRNA Translation: AAM29197.1 Different initiation.
BK004084 mRNA Translation: DAA04940.1

NCBI Reference Sequences

More...
RefSeqi
NP_001036712.1, NM_001043247.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0110874; FBpp0110174; FBgn0045035

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41839

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6535

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: ABI31168.1
AY395750 mRNA Translation: AAR89513.1
AY113192 mRNA Translation: AAM29197.1 Different initiation.
BK004084 mRNA Translation: DAA04940.1
RefSeqiNP_001036712.1, NM_001043247.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi66903, 24 interactors
IntActiQ5EAK6, 2 interactors
STRINGi7227.FBpp0110174

Proteomic databases

PaxDbiQ5EAK6
PRIDEiQ5EAK6

Genome annotation databases

EnsemblMetazoaiFBtr0110874; FBpp0110174; FBgn0045035
GeneIDi41839
KEGGidme:Dmel_CG6535

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
41839
FlyBaseiFBgn0045035 tefu

Phylogenomic databases

eggNOGiKOG0892 Eukaryota
ENOG410XNPY LUCA
GeneTreeiENSGT00940000174195
HOGENOMiCLU_227091_0_0_1
InParanoidiQ5EAK6
KOiK04728
OMAiAYCRLDS
OrthoDBi80538at2759
PhylomeDBiQ5EAK6

Enzyme and pathway databases

ReactomeiR-DME-2559586 DNA Damage/Telomere Stress Induced Senescence
R-DME-5693548 Sensing of DNA Double Strand Breaks
R-DME-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-DME-5693607 Processing of DNA double-strand break ends
R-DME-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-DME-6804756 Regulation of TP53 Activity through Phosphorylation
R-DME-6804757 Regulation of TP53 Degradation
R-DME-69473 G2/M DNA damage checkpoint
R-DME-69541 Stabilization of p53
SignaLinkiQ5EAK6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
41839 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
41839

Protein Ontology

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PROi
PR:Q5EAK6

Gene expression databases

BgeeiFBgn0045035 Expressed in eye disc (Drosophila) and 25 other tissues
ExpressionAtlasiQ5EAK6 differential
GenevisibleiQ5EAK6 DM

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR015519 ATM/Tel1
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR014009 PIK_FAT
PANTHERiPTHR11139:SF72 PTHR11139:SF72, 1 hit
PfamiView protein in Pfam
PF02260 FATC, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
SMARTiView protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATM_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5EAK6
Secondary accession number(s): Q0KI71
, Q6TKQ1, Q8MZG4, Q9VFB1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 15, 2005
Last modified: June 17, 2020
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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