Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 59 (11 Dec 2019)
Sequence version 1 (15 Mar 2005)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Major vault protein

Gene

MVP

Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport (By similarity).By similarity

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Major vault proteinImported
Short name:
MVP1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MVPImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStrongylocentrotus purpuratus (Purple sea urchin)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7668 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007110 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003947561 – 857Major vault proteinAdd BLAST857

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q5EAJ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in embryos, tube feet and coelomocytes (at protein level). Not expressed in sperm cells (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly and constitutively expressed throughout development. However, the ratio of soluble to insoluble protein changes during embryogenesis. Additionally, the distribution changes from a largely cytoplasmic distribution in the cleavage stage embryo to a predominantly nuclear and/or perinuclear location at blastula and gastrula stages.2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs).

By similarity1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7668.SPU_000881-tr

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati18 – 60MVP 1Sequence analysisAdd BLAST43
Repeati62 – 122MVP 2Sequence analysisAdd BLAST61
Repeati123 – 174MVP 3Sequence analysisAdd BLAST52
Repeati175 – 227MVP 4Sequence analysisAdd BLAST53
Repeati228 – 282MVP 5Sequence analysisAdd BLAST55
Repeati284 – 332MVP 6Sequence analysisAdd BLAST49
Repeati333 – 387MVP 7Sequence analysisAdd BLAST55
Repeati388 – 441MVP 8Sequence analysisAdd BLAST54
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini665 – 694IQPROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF6T Eukaryota
ENOG410ZCU8 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000255109

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5EAJ7

KEGG Orthology (KO)

More...
KOi
K17266

Identification of Orthologs from Complete Genome Data

More...
OMAi
MVMVPPR

Database of Orthologous Groups

More...
OrthoDBi
256008at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08825 MVP_shoulder, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.550, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR039059 MVP
IPR041139 MVP_rep_dom
IPR043023 MVP_rep_sf
IPR021870 MVP_shoulder
IPR041134 Vault_2
IPR040989 Vault_3
IPR041136 Vault_4
IPR002499 Vault_N

The PANTHER Classification System

More...
PANTHERi
PTHR14165 PTHR14165, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11978 MVP_shoulder, 1 hit
PF01505 Vault, 4 hits
PF17794 Vault_2, 2 hits
PF17795 Vault_3, 1 hit
PF17796 Vault_4, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit
PS51224 MVP, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5EAJ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASKRGSNQD ESIFRIPPYY YIHVLDHNDN VTKVVVGPKT YIRQDHERVI
60 70 80 90 100
FGPEKMITIP PRHYCIIENP VVRNDTDQVV YDNLGQVKLF HADQEIRLAR
110 120 130 140 150
EPFPLYPGEV LKQAVTALKV VQANAALRLR AILDFEDGTQ KRVAGDEWLF
160 170 180 190 200
EGPGTYIPRK EVVVDETIRA TIIRPNQAIK LRARKETNDR EGTARVTGEE
210 220 230 240 250
WQVKKVGAYL PGAYEEVVDT VNAYVLTEKN ALHLRATRTF VDMKGKTRKN
260 270 280 290 300
GEEWLINMAD TDAHIPDVYE EVVGVVDINT LTNRQYCVIV DPVGPDGKPQ
310 320 330 340 350
LGQKKLVKGE VSFFLQPGET LEQGIQSVFI LGEDEGLILR AQESFKDANA
360 370 380 390 400
AGAVRQPGDR WMIRGPCEYV PTVELEVVTR RKAIPLDENE GVYIRDTKTG
410 420 430 440 450
KVRAVTGETY MLSQDEELWA KELSPAVEEL LQSAKDPVAE RSDRRGDRAA
460 470 480 490 500
PRAREKTRVI SFRVPHNAAV QIYDYKEKKA RVVFGPELVM LGPDEQFTQL
510 520 530 540 550
SLSGGKPKRP NVIKALCLLL GPDFCTDIIT IETADHARLQ LQLSYNWHFD
560 570 580 590 600
VPDKTDVAAS AKLFSVPDFI GDACKAIASR IRGAVAGVQF DDFHKNSAKI
610 620 630 640 650
IRASVFGFDE KNKVRERFLF PQNSLVITSI DIQSVEPVDQ RTRDALQKSV
660 670 680 690 700
QLAIEITTNS QEATARHEAE RLEQEARGRL ERQKIMDEAE AEKSRKELLE
710 720 730 740 750
LQANSAAVES TGQAKAEAQS RAEAARIEGE AAVDQARLKA EAAKIESESE
760 770 780 790 800
LQRLTNAREA ETKYVREQNA LEVNKTKQMS DIETERFRNM VQSIGADTIK
810 820 830 840 850
AMAMAGPEMQ VKLLSSLGLK STLITDGSTP INLFNTAQGL LGGFSAKRGI

EHVEEED
Length:857
Mass (Da):95,925
Last modified:March 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAEACAE46FEC9DDFA
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CD295616 differs from that shown. Reason: Frameshift.Curated
The sequence CD295832 differs from that shown. Reason: Frameshift.Curated
The sequence CD304000 differs from that shown. Reason: Frameshift.Curated
The sequence CD305511 differs from that shown. Reason: Frameshift.Curated
The sequence CD333690 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti51F → S in CD333690 (PubMed:14656975).Curated1
Sequence conflicti58T → P in CD333690 (PubMed:14656975).Curated1
Sequence conflicti59I → T in CD305511 (PubMed:14656975).Curated1
Sequence conflicti74 – 76NDT → ERY in CD333690 (PubMed:14656975).Curated3
Sequence conflicti109E → K in CD333690 (PubMed:14656975).Curated1
Sequence conflicti124N → T in CD333690 (PubMed:14656975).Curated1
Sequence conflicti137D → T in CD333690 (PubMed:14656975).Curated1
Sequence conflicti296D → N in CD305646 (PubMed:14656975).Curated1
Sequence conflicti356Q → H in CD295616 (PubMed:14656975).Curated1
Sequence conflicti367C → R in CD295616 (PubMed:14656975).Curated1
Sequence conflicti388E → K in CD305646 (PubMed:14656975).Curated1
Sequence conflicti391G → E in CD305646 (PubMed:14656975).Curated1
Sequence conflicti475 – 476YK → LQ in CD295616 (PubMed:14656975).Curated2
Sequence conflicti489 – 491VML → CHA in CD295616 (PubMed:14656975).Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CD292179 mRNA No translation available.
CD292477 mRNA No translation available.
CD295616 mRNA No translation available.
CD295832 mRNA No translation available.
CD304000 mRNA No translation available.
CD305382 mRNA No translation available.
CD305511 mRNA No translation available.
CD305646 mRNA No translation available.
CD307400 mRNA No translation available.
CD310423 mRNA No translation available.
CD333690 mRNA No translation available.
BG784394 mRNA No translation available.
BG784484 mRNA No translation available.
BK005641 mRNA Translation: DAA05661.1

NCBI Reference Sequences

More...
RefSeqi
NP_001116989.1, NM_001123517.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
SPU_000881-tr; SPU_000881-tr; SPU_000881

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
575735

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spu:575735

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CD292179 mRNA No translation available.
CD292477 mRNA No translation available.
CD295616 mRNA No translation available.
CD295832 mRNA No translation available.
CD304000 mRNA No translation available.
CD305382 mRNA No translation available.
CD305511 mRNA No translation available.
CD305646 mRNA No translation available.
CD307400 mRNA No translation available.
CD310423 mRNA No translation available.
CD333690 mRNA No translation available.
BG784394 mRNA No translation available.
BG784484 mRNA No translation available.
BK005641 mRNA Translation: DAA05661.1
RefSeqiNP_001116989.1, NM_001123517.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7668.SPU_000881-tr

Proteomic databases

PRIDEiQ5EAJ7

Genome annotation databases

EnsemblMetazoaiSPU_000881-tr; SPU_000881-tr; SPU_000881
GeneIDi575735
KEGGispu:575735

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9961

Phylogenomic databases

eggNOGiENOG410IF6T Eukaryota
ENOG410ZCU8 LUCA
HOGENOMiHOG000255109
InParanoidiQ5EAJ7
KOiK17266
OMAiMVMVPPR
OrthoDBi256008at2759

Family and domain databases

CDDicd08825 MVP_shoulder, 1 hit
Gene3Di2.30.30.550, 4 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR039059 MVP
IPR041139 MVP_rep_dom
IPR043023 MVP_rep_sf
IPR021870 MVP_shoulder
IPR041134 Vault_2
IPR040989 Vault_3
IPR041136 Vault_4
IPR002499 Vault_N
PANTHERiPTHR14165 PTHR14165, 1 hit
PfamiView protein in Pfam
PF11978 MVP_shoulder, 1 hit
PF01505 Vault, 4 hits
PF17794 Vault_2, 2 hits
PF17795 Vault_3, 1 hit
PF17796 Vault_4, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51224 MVP, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMVP_STRPU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5EAJ7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 15, 2005
Last modified: December 11, 2019
This is version 59 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again