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Protein

Mitochondrial glycine transporter

Gene

SLC25A38

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glycine transporterUniRule annotation
Alternative name(s):
Solute carrier family 25 member 38UniRule annotation
Gene namesi
Name:SLC25A38UniRule annotation
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Organism-specific databases

VGNCiVGNC:34763 SLC25A38

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei31 – 56Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei89 – 115Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei127 – 152Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei180 – 203Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei221 – 247Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei276 – 294Helical; Name=6UniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002918011 – 306Mitochondrial glycine transporterAdd BLAST306

Proteomic databases

PaxDbiQ5EAC0
PRIDEiQ5EAC0

Expressioni

Gene expression databases

BgeeiENSBTAG00000022721
ExpressionAtlasiQ5EAC0 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045521

Structurei

3D structure databases

ProteinModelPortaliQ5EAC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati25 – 114Solcar 1UniRule annotationAdd BLAST90
Repeati121 – 205Solcar 2UniRule annotationAdd BLAST85
Repeati217 – 301Solcar 3UniRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0766 Eukaryota
ENOG410XRMK LUCA
GeneTreeiENSGT00550000075117
HOGENOMiHOG000006978
HOVERGENiHBG054682
InParanoidiQ5EAC0
KOiK15118

Family and domain databases

Gene3Di1.50.40.10, 2 hits
HAMAPiMF_03064 SLC25A38, 1 hit
InterProiView protein in InterPro
IPR030847 Hem25/SLC25A38
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q5EAC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQKSRPALL QHQDVGDRVE TLMLQPVIKA FLCGSISGTC STLLFQPLDL
60 70 80 90 100
LKTRLQTLQP SAHGSRRVGM LALLLNVVRT ESPLGLWKGM SPSIVRCVPG
110 120 130 140 150
VGIYFGTLYS LKQYFLRGHP PTALESIILG AGSRSVAGVC MSPITVIKTR
160 170 180 190 200
YESGRYGYES VYAALRSICH SEGFRGLFSG LTATLLRDAP FSGIYLMFYS
210 220 230 240 250
QTKNVVLHRT DQLDAVLVPV VNFSCGIFAG ILASLVTQPA DVIKTHMQLF
260 270 280 290 300
PMKFRWIGQS VTLIFKDYGL RGFFQGSVPR ALRRTLMAAM AWTVYEEMMA

KMGLKS
Length:306
Mass (Da):33,798
Last modified:July 7, 2009 - v2
Checksum:i604E4B6090B5B1EA
GO

Sequence cautioni

The sequence AAX46648 differs from that shown. Reason: Frameshift at position 275.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63H → R in AAX08897 (PubMed:16305752).Curated1
Sequence conflicti65 – 66Missing in AAX08897 (PubMed:16305752).Curated2
Sequence conflicti144 – 145IT → SA in AAX08830 (PubMed:16305752).Curated2
Sequence conflicti159E → K in AAX08669 (PubMed:16305752).Curated1
Sequence conflicti220V → L in AAX46648 (PubMed:16305752).Curated1
Sequence conflicti220V → L in AAX08669 (PubMed:16305752).Curated1
Sequence conflicti220V → L in AAX08666 (PubMed:16305752).Curated1
Sequence conflicti220V → L in ABG66996 (PubMed:16305752).Curated1
Sequence conflicti220V → L in AAX08897 (PubMed:16305752).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020649 mRNA Translation: AAX08666.1
BT020652 mRNA Translation: AAX08669.1
BT020813 mRNA Translation: AAX08830.1
BT020880 mRNA Translation: AAX08897.1
BT021801 mRNA Translation: AAX46648.1 Frameshift.
BT026157 mRNA Translation: ABG66996.1
BC148053 mRNA Translation: AAI48054.1
RefSeqiNP_001014905.2, NM_001014905.2
UniGeneiBt.6425

Genome annotation databases

EnsembliENSBTAT00000020606; ENSBTAP00000020606; ENSBTAG00000022721
GeneIDi512325
KEGGibta:512325

Similar proteinsi

Entry informationi

Entry nameiS2538_BOVIN
AccessioniPrimary (citable) accession number: Q5EAC0
Secondary accession number(s): A6QLQ9
, Q58CZ6, Q5E9P0, Q5E9V7, Q5EAB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 7, 2009
Last modified: May 23, 2018
This is version 83 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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