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Protein

Cochlin

Gene

COCH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in the control of cell shape and motility in the trabecular meshwork.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cochlin
Gene namesi
Name:COCH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000026601925 – 550CochlinAdd BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 50PROSITE-ProRule annotation
Disulfide bondi54 ↔ 74PROSITE-ProRule annotation
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi221N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi436N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5EA64
PRIDEiQ5EA64

Interactioni

Subunit structurei

Monomer. May form homodimer. Interacts with type II collagen. Interacts with SLC44A2. Interacts with ANXA2.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000049747

Structurei

3D structure databases

ProteinModelPortaliQ5EA64
SMRiQ5EA64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 121LCCLPROSITE-ProRule annotationAdd BLAST94
Domaini165 – 350VWFA 1PROSITE-ProRule annotationAdd BLAST186
Domaini367 – 537VWFA 2PROSITE-ProRule annotationAdd BLAST171

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KDA8 Eukaryota
ENOG410XRIU LUCA
HOGENOMiHOG000013195
HOVERGENiHBG005372
InParanoidiQ5EA64

Family and domain databases

Gene3Di2.170.130.20, 1 hit
3.40.50.410, 2 hits
InterProiView protein in InterPro
IPR030743 Cochlin
IPR004043 LCCL
IPR036609 LCCL_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR44729 PTHR44729, 1 hit
PfamiView protein in Pfam
PF03815 LCCL, 1 hit
PF00092 VWA, 2 hits
SMARTiView protein in SMART
SM00603 LCCL, 1 hit
SM00327 VWA, 2 hits
SUPFAMiSSF53300 SSF53300, 2 hits
SSF69848 SSF69848, 1 hit
PROSITEiView protein in PROSITE
PS50820 LCCL, 1 hit
PS50234 VWFA, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5EA64-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWASWIPVLC LGVCLLLPPE PVGSEGAVPI PITCSTRGLD IRKEKADVLC
60 70 80 90 100
PGGCPLEEFS VFGHIVYASV SSICGAAVHR GVIGHSGGPV RIYSLPGREN
110 120 130 140 150
YSSVVANGIQ SQMLSRWSAS FTVTKGKSGT QEATGQAVST AHPATGKRLK
160 170 180 190 200
KTPEKKTGNK DCKADIAFLI DGSFNIGQRR FNLQKNFVGK VALMLGIGTE
210 220 230 240 250
GPHVGLVQAS EHPKIEFYLK NFTSAKDVLF AIKEVAFRGG NSNTGKALKH
260 270 280 290 300
TAQKFFTADT GARKGIPKVV VVFIDGWPSD DIEEAGIVAR EFGVNVFIVS
310 320 330 340 350
VAKPIPEELG MVQDVAFVDK AVCRNNGFFS YHMPNWFGTT KYVKPLVQKL
360 370 380 390 400
CTHEQMMCSK TCYNSVNIAF LIDGSSSVGE SNFRLMLKFV SNIAKTFEIS
410 420 430 440 450
DIGAKIAAVQ FTYDQRTEFS FTDYSTKENV LAVIRNISYM SGGTATGDAI
460 470 480 490 500
SFTVRNVFGP VRDSPNKNFL VIVTDGQSYD DVRGPAAAAH DAGITIFSVG
510 520 530 540 550
VAWAPLDDLK DMASKPKESH AFFTREFTGL EPIVSDVIRG ICRDFLESQQ
Length:550
Mass (Da):59,594
Last modified:March 15, 2005 - v1
Checksum:iDB3B21839C68D209
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020705 mRNA Translation: AAX08722.1
RefSeqiNP_001071310.1, NM_001077842.1
UniGeneiBt.27005

Genome annotation databases

GeneIDi504316
KEGGibta:504316

Similar proteinsi

Cross-referencesi

Web resourcesi

Protein Spotlight

The Japanese Horseshoe Crab and Deafness - Issue 4 of November 2000

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020705 mRNA Translation: AAX08722.1
RefSeqiNP_001071310.1, NM_001077842.1
UniGeneiBt.27005

3D structure databases

ProteinModelPortaliQ5EA64
SMRiQ5EA64
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000049747

Proteomic databases

PaxDbiQ5EA64
PRIDEiQ5EA64

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi504316
KEGGibta:504316

Organism-specific databases

CTDi1690

Phylogenomic databases

eggNOGiENOG410KDA8 Eukaryota
ENOG410XRIU LUCA
HOGENOMiHOG000013195
HOVERGENiHBG005372
InParanoidiQ5EA64

Family and domain databases

Gene3Di2.170.130.20, 1 hit
3.40.50.410, 2 hits
InterProiView protein in InterPro
IPR030743 Cochlin
IPR004043 LCCL
IPR036609 LCCL_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR44729 PTHR44729, 1 hit
PfamiView protein in Pfam
PF03815 LCCL, 1 hit
PF00092 VWA, 2 hits
SMARTiView protein in SMART
SM00603 LCCL, 1 hit
SM00327 VWA, 2 hits
SUPFAMiSSF53300 SSF53300, 2 hits
SSF69848 SSF69848, 1 hit
PROSITEiView protein in PROSITE
PS50820 LCCL, 1 hit
PS50234 VWFA, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCOCH_BOVIN
AccessioniPrimary (citable) accession number: Q5EA64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 15, 2005
Last modified: November 7, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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