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UniProtKB - Q5EA20 (HPPD_BOVIN)
Protein
4-hydroxyphenylpyruvate dioxygenase
Gene
HPD
Organism
Bos taurus (Bovine)
Status
Functioni
Key enzyme in the degradation of tyrosine.
By similarityCatalytic activityi
- EC:1.13.11.27
Cofactori
Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity
: L-phenylalanine degradation Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine. This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 183 | IronBy similarity | 1 | |
Metal bindingi | 266 | IronBy similarity | 1 | |
Metal bindingi | 349 | IronBy similarity | 1 |
GO - Molecular functioni
- 4-hydroxyphenylpyruvate dioxygenase activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- L-phenylalanine catabolic process Source: UniProtKB-UniPathway
- tyrosine catabolic process Source: UniProtKB
Keywordsi
Molecular function | Dioxygenase, Oxidoreductase |
Biological process | Phenylalanine catabolism, Tyrosine catabolism |
Ligand | Iron, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00139;UER00362 |
Names & Taxonomyi
Protein namesi | Recommended name: 4-hydroxyphenylpyruvate dioxygenase (EC:1.13.11.27)Alternative name(s): 4-hydroxyphenylpyruvic acid oxidase Short name: 4HPPD Short name: HPD Short name: HPPDase |
Gene namesi | Name:HPD |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000004175 |
VGNCi | VGNC:29939, HPD |
Subcellular locationi
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: GO_Central
Golgi apparatus
- Golgi membrane Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000088387 | 2 – 393 | 4-hydroxyphenylpyruvate dioxygenaseAdd BLAST | 392 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylthreonineBy similarity | 1 | |
Modified residuei | 132 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 211 | PhosphoserineBy similarity | 1 | |
Modified residuei | 226 | PhosphoserineBy similarity | 1 | |
Modified residuei | 250 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | Q5EA20 |
PeptideAtlasi | Q5EA20 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000004175, Expressed in liver and 58 other tissues |
ExpressionAtlasi | Q5EA20, baseline and differential |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000005469 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 149 | VOC 1PROSITE-ProRule annotationAdd BLAST | 132 | |
Domaini | 180 – 338 | VOC 2PROSITE-ProRule annotationAdd BLAST | 159 |
Sequence similaritiesi
Belongs to the 4HPPD family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0638, Eukaryota |
GeneTreei | ENSGT00530000063474 |
HOGENOMi | CLU_034004_3_1_1 |
InParanoidi | Q5EA20 |
OrthoDBi | 1087836at2759 |
TreeFami | TF300622 |
Family and domain databases
CDDi | cd07250, HPPD_C_like, 1 hit cd08342, HPPD_N_like, 1 hit |
Gene3Di | 3.10.180.10, 2 hits |
InterProi | View protein in InterPro IPR005956, 4OHPhenylPyrv_dOase IPR041735, 4OHPhenylPyrv_dOase_C IPR041736, 4OHPhenylPyrv_dOase_N IPR029068, Glyas_Bleomycin-R_OHBP_Dase IPR004360, Glyas_Fos-R_dOase_dom IPR037523, VOC |
PANTHERi | PTHR11959, PTHR11959, 1 hit |
Pfami | View protein in Pfam PF00903, Glyoxalase, 1 hit |
PIRSFi | PIRSF009283, HPP_dOase, 1 hit |
SUPFAMi | SSF54593, SSF54593, 1 hit |
TIGRFAMsi | TIGR01263, 4HPPD, 1 hit |
PROSITEi | View protein in PROSITE PS51819, VOC, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q5EA20-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTYSDKGEK PERGRFLHFH SVTFWVGNAK QAASYYCSKL GFEPLAYKGL
60 70 80 90 100
ETGSREVVSH VVKQGQIVFV FSSALNPWNK EMGDHLVKHG DGVKDIAFEV
110 120 130 140 150
EDCDYIVQKA RERGAKIVRE PWVEQDKLGK VKFAVLQTYG DTTHTLVEKM
160 170 180 190 200
NYTGRFLPGF EAPPFMDPQL SKLPSCSLEI IDHIVGNQPD QEMVSASEWY
210 220 230 240 250
LKNLQFHRFW SVDDTQVHTE YSSLRSVVVA NYEESIKMPI NEPAPGKKKS
260 270 280 290 300
QIQEYVDYNG GAGVQHIALK TKDIITAIRH LRERGVEFLA VPSTYYKQLR
310 320 330 340 350
EKLKMAKIRV KENIDILEEL KILVDYDEKG YLLQIFTKPM QDRPTLFLEV
360 370 380 390
IQRHNHQGFG AGNFNSLFKA FEEEQDLRGN LTDMEPNGVV SGM
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1N2P4 | A0A3Q1N2P4_BOVIN | 4-hydroxyphenylpyruvate dioxygenase | HPD | 397 | Annotation score: | ||
A0A3Q1LG51 | A0A3Q1LG51_BOVIN | 4-hydroxyphenylpyruvate dioxygenase | HPD | 396 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT020749 mRNA Translation: AAX08766.1 BC105225 mRNA Translation: AAI05226.1 |
RefSeqi | NP_001015611.1, NM_001015611.1 |
Genome annotation databases
Ensembli | ENSBTAT00000005469; ENSBTAP00000005469; ENSBTAG00000004175 |
GeneIDi | 516058 |
KEGGi | bta:516058 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT020749 mRNA Translation: AAX08766.1 BC105225 mRNA Translation: AAI05226.1 |
RefSeqi | NP_001015611.1, NM_001015611.1 |
3D structure databases
SMRi | Q5EA20 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000005469 |
Proteomic databases
PaxDbi | Q5EA20 |
PeptideAtlasi | Q5EA20 |
Genome annotation databases
Ensembli | ENSBTAT00000005469; ENSBTAP00000005469; ENSBTAG00000004175 |
GeneIDi | 516058 |
KEGGi | bta:516058 |
Organism-specific databases
CTDi | 3242 |
VEuPathDBi | HostDB:ENSBTAG00000004175 |
VGNCi | VGNC:29939, HPD |
Phylogenomic databases
eggNOGi | KOG0638, Eukaryota |
GeneTreei | ENSGT00530000063474 |
HOGENOMi | CLU_034004_3_1_1 |
InParanoidi | Q5EA20 |
OrthoDBi | 1087836at2759 |
TreeFami | TF300622 |
Enzyme and pathway databases
UniPathwayi | UPA00139;UER00362 |
Gene expression databases
Bgeei | ENSBTAG00000004175, Expressed in liver and 58 other tissues |
ExpressionAtlasi | Q5EA20, baseline and differential |
Family and domain databases
CDDi | cd07250, HPPD_C_like, 1 hit cd08342, HPPD_N_like, 1 hit |
Gene3Di | 3.10.180.10, 2 hits |
InterProi | View protein in InterPro IPR005956, 4OHPhenylPyrv_dOase IPR041735, 4OHPhenylPyrv_dOase_C IPR041736, 4OHPhenylPyrv_dOase_N IPR029068, Glyas_Bleomycin-R_OHBP_Dase IPR004360, Glyas_Fos-R_dOase_dom IPR037523, VOC |
PANTHERi | PTHR11959, PTHR11959, 1 hit |
Pfami | View protein in Pfam PF00903, Glyoxalase, 1 hit |
PIRSFi | PIRSF009283, HPP_dOase, 1 hit |
SUPFAMi | SSF54593, SSF54593, 1 hit |
TIGRFAMsi | TIGR01263, 4HPPD, 1 hit |
PROSITEi | View protein in PROSITE PS51819, VOC, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | HPPD_BOVIN | |
Accessioni | Q5EA20Primary (citable) accession number: Q5EA20 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | January 23, 2007 | |
Last modified: | September 29, 2021 | |
This is version 113 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families