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Protein

Gap junction beta-6 protein

Gene

GJB6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Biological processi

Keywordsi

Biological processHearing

Enzyme and pathway databases

ReactomeiR-BTA-190861 Gap junction assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-6 protein
Gene namesi
Name:GJB6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 12

Organism-specific databases

VGNCiVGNC:29381 GJB6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 45HelicalSequence analysisAdd BLAST23
Topological domaini46 – 75ExtracellularSequence analysisAdd BLAST30
Transmembranei76 – 98HelicalSequence analysisAdd BLAST23
Topological domaini99 – 131CytoplasmicSequence analysisAdd BLAST33
Transmembranei132 – 154HelicalSequence analysisAdd BLAST23
Topological domaini155 – 192ExtracellularSequence analysisAdd BLAST38
Transmembranei193 – 215HelicalSequence analysisAdd BLAST23
Topological domaini216 – 261CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002448781 – 261Gap junction beta-6 proteinAdd BLAST261

Proteomic databases

PaxDbiQ5E9Z5
PRIDEiQ5E9Z5

Expressioni

Gene expression databases

BgeeiENSBTAG00000038662

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000052852

Structurei

3D structure databases

SMRiQ5E9Z5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFM8 Eukaryota
ENOG410Y7VN LUCA
GeneTreeiENSGT00910000144026
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiQ5E9Z5
KOiK07625
OMAiQTQRNHP
OrthoDBiEOG091G0FKH
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5E9Z5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWGTLHTFV GGVNKHSTSI GKVWVTVLFV FRVMILVVAA QEVWGDEQED
60 70 80 90 100
FVCNTLQPGC RNVCYDHFFP VSHIRLWALQ LIFVSTPALL VAMHVAYYRH
110 120 130 140 150
EAARRFRRGE TRSEFKDLED IKRQKVRIEG SLWWTYTSSI FFRIVFEAAF
160 170 180 190 200
MYVFYFLYNG YHLPWVLKCG IQPCPNLVDC FISRPTEKTV FTIFMISASV
210 220 230 240 250
ICMLLNVAEL CYLLLKVCFR RSKRAQTQKA PPNHALKESK QNEMNELISE
260
GGQNAITGFP S
Length:261
Mass (Da):30,229
Last modified:March 15, 2005 - v1
Checksum:i3FAC8D34508348AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020774 mRNA Translation: AAX08791.1
BC123433 mRNA Translation: AAI23434.1
RefSeqiNP_001015546.1, NM_001015546.1
NP_001153649.1, NM_001160177.1
XP_005213824.1, XM_005213767.3
XP_005213825.1, XM_005213768.3
XP_005213826.1, XM_005213769.3
UniGeneiBt.35935

Genome annotation databases

EnsembliENSBTAT00000052057; ENSBTAP00000052852; ENSBTAG00000038662
GeneIDi508454
KEGGibta:508454

Similar proteinsi

Entry informationi

Entry nameiCXB6_BOVIN
AccessioniPrimary (citable) accession number: Q5E9Z5
Secondary accession number(s): Q08E41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 15, 2005
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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