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Protein

SPRY domain-containing SOCS box protein 1

Gene

SPSB1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
SPRY domain-containing SOCS box protein 1
Short name:
SSB-1
Gene namesi
Name:SPSB1
Synonyms:SSB1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002384711 – 273SPRY domain-containing SOCS box protein 1Add BLAST273

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5E9X6
PRIDEiQ5E9X6

Interactioni

Subunit structurei

Component of the probable ECS(SPSB1) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB1. Interacts with CUL5, RNF7, ELOB and ELOC. Directly interacts with MET tyrosine kinase domain in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. When phosphorylated, interacts with RASA1 without affecting its stability. Interacts (via B30.2/SPRY domain) with PAWR; this interaction is direct and occurs in association with the Elongin BC complex.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000034027

Structurei

3D structure databases

ProteinModelPortaliQ5E9X6
SMRiQ5E9X6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 231B30.2/SPRYPROSITE-ProRule annotationAdd BLAST199
Domaini232 – 273SOCS boxPROSITE-ProRule annotationAdd BLAST42

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. The B30.2/SPRY domain is involved in MET binding (By similarity).By similarity
The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. The B30.2/SPRY domain is involved in MET and PAWR binding.By similarity

Sequence similaritiesi

Belongs to the SPSB family.Curated

Phylogenomic databases

eggNOGiKOG3953 Eukaryota
ENOG410XQC1 LUCA
HOGENOMiHOG000230524
HOVERGENiHBG055793
InParanoidiQ5E9X6
KOiK10343

Family and domain databases

InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR001496 SOCS_box
IPR003877 SPRY_dom
PfamiView protein in Pfam
PF07525 SOCS_box, 1 hit
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00969 SOCS_box, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50225 SOCS, 1 hit

Sequencei

Sequence statusi: Complete.

Q5E9X6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQKVTGGIK TVDMRDPTYR PLKQELQGLD YCKPTRLDLL LDMPPVSYDV
60 70 80 90 100
QLLHSWNNND RSLNVFVKED DKLIFHRHPV AQSTDAIRGK VGYTRGLHVW
110 120 130 140 150
QITWAMRQRG THAVVGVATA DAPLHSVGYT TLVGNNHESW GWDLGRNRLY
160 170 180 190 200
HDGKNQPSKT YPAFLEPDET FIVPDSFLVA LDMDDGTLSF IVDGQYMGVA
210 220 230 240 250
FRGLKGKKLY PVVSAVWGHC EIRMRYLNGL DPEPLPLMDL CRRSVRLALG
260 270
KGRLGEIHAL PLPASLKAYL LYQ
Length:273
Mass (Da):30,811
Last modified:March 15, 2005 - v1
Checksum:i603D5690A327B789
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020794 mRNA Translation: AAX08811.1
RefSeqiNP_001029381.1, NM_001034209.1
UniGeneiBt.111164
Bt.24841

Genome annotation databases

GeneIDi504407
KEGGibta:504407

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020794 mRNA Translation: AAX08811.1
RefSeqiNP_001029381.1, NM_001034209.1
UniGeneiBt.111164
Bt.24841

3D structure databases

ProteinModelPortaliQ5E9X6
SMRiQ5E9X6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000034027

Proteomic databases

PaxDbiQ5E9X6
PRIDEiQ5E9X6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi504407
KEGGibta:504407

Organism-specific databases

CTDi80176

Phylogenomic databases

eggNOGiKOG3953 Eukaryota
ENOG410XQC1 LUCA
HOGENOMiHOG000230524
HOVERGENiHBG055793
InParanoidiQ5E9X6
KOiK10343

Enzyme and pathway databases

UniPathwayi
UPA00143

Family and domain databases

InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR001496 SOCS_box
IPR003877 SPRY_dom
PfamiView protein in Pfam
PF07525 SOCS_box, 1 hit
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00969 SOCS_box, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50225 SOCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPSB1_BOVIN
AccessioniPrimary (citable) accession number: Q5E9X6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 15, 2005
Last modified: October 10, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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