UniProtKB - Q5E9T7 (JADE1_BOVIN)
Protein Jade-1
JADE1
Functioni
Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation. May also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 203 – 253 | PHD-type 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 255 – 289 | C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST | 35 | |
Zinc fingeri | 313 – 369 | PHD-type 2PROSITE-ProRule annotationAdd BLAST | 57 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- histone H3 acetylation Source: UniProtKB
- histone H4-K12 acetylation Source: UniProtKB
- histone H4-K5 acetylation Source: UniProtKB
- histone H4-K8 acetylation Source: UniProtKB
Keywordsi
Molecular function | Activator |
Biological process | Apoptosis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Jade-1Alternative name(s): Jade family PHD finger protein 1 PHD finger protein 17 |
Gene namesi | Name:JADE1 Synonyms:PHF17 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytoskeleton
- cilium basal body By similarity
Nucleus
- Nucleus By similarity
Other locations
- Chromosome By similarity
Note: Localizes to the ciliary transition zone.By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-KW
Nucleus
- histone acetyltransferase complex Source: UniProtKB
Other locations
- cell projection Source: UniProtKB-KW
- chromosome Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell projection, Chromosome, Cytoplasm, Cytoskeleton, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000253528 | 1 – 509 | Protein Jade-1Add BLAST | 509 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 89 | PhosphoserineBy similarity | 1 | |
Modified residuei | 92 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 114 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q5E9T7 |
PRIDEi | Q5E9T7 |
Interactioni
Subunit structurei
Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3.
Interacts with NPHP4.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000032057 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 45 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 60 – 80 | Interaction with KAT7/HBO1 and histonesBy similarityAdd BLAST | 21 | |
Regioni | 80 – 188 | Interaction with histonesBy similarityAdd BLAST | 109 | |
Regioni | 373 – 399 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 11 – 32 | Polar residuesSequence analysisAdd BLAST | 22 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 203 – 253 | PHD-type 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 255 – 289 | C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST | 35 | |
Zinc fingeri | 313 – 369 | PHD-type 2PROSITE-ProRule annotationAdd BLAST | 57 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0954, Eukaryota |
InParanoidi | Q5E9T7 |
OrthoDBi | 1235709at2759 |
Family and domain databases
Gene3Di | 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR019542, Enhancer_polycomb-like_N IPR034732, EPHD IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF10513, EPL1, 1 hit |
SMARTi | View protein in SMART SM00249, PHD, 2 hits |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS51805, EPHD, 1 hit PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MKRGRLPSSS EDSDDNGSLS TTWSQNSRSQ HRRSSCSRPE DRKPSEVFRT
60 70 80 90 100
DLITAMKLHD SYQLNPDEYY VLADPWRQEW EKGVQVPVSP GTIPQPVARV
110 120 130 140 150
VSEEKSLMFI RPKKYIVSSG SEPPELGYVD IRTLADSVCR YDLNDMDAAW
160 170 180 190 200
LELTNEEFKE MGMPELDEYT MERVLEEFEQ RCYDNMNHAI ETEEGLGIEY
210 220 230 240 250
DEYVVCDVCQ SPDGEDGNEM VFCDKCNICV HQACYGILKV PEGSWLCRTC
260 270 280 290 300
ALGVQPKCLL CPKKGGAMKP TRSGTKWVHV SCALWIPEVS IGSPEKMEPI
310 320 330 340 350
TKVSHIPSSR WALVCSLCNE KFGASIQCSV KNCRTAFHVT CAFDRGLEMK
360 370 380 390 400
TILAENDEVK FKSYCPKHSS HRKAEEGLGE GTAQENGAPE CSPRDPLEPF
410 420 430 440 450
AGLEQNREEA HRVSVRKQKL QQLEDEFYTF VNLLDVARAL RLPEEVVDFL
460 470 480 490 500
YQYWKLKRKV NFNKPLITPK KDEEDNLAKR EQDVLFRRLQ LFTHLRQDLE
RVMTDTDTL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT020833 mRNA Translation: AAX08850.1 |
RefSeqi | NP_001015559.1, NM_001015559.1 |
Genome annotation databases
GeneIDi | 509264 |
KEGGi | bta:509264 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT020833 mRNA Translation: AAX08850.1 |
RefSeqi | NP_001015559.1, NM_001015559.1 |
3D structure databases
SMRi | Q5E9T7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000032057 |
Proteomic databases
PaxDbi | Q5E9T7 |
PRIDEi | Q5E9T7 |
Genome annotation databases
GeneIDi | 509264 |
KEGGi | bta:509264 |
Organism-specific databases
CTDi | 79960 |
Phylogenomic databases
eggNOGi | KOG0954, Eukaryota |
InParanoidi | Q5E9T7 |
OrthoDBi | 1235709at2759 |
Family and domain databases
Gene3Di | 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR019542, Enhancer_polycomb-like_N IPR034732, EPHD IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF10513, EPL1, 1 hit |
SMARTi | View protein in SMART SM00249, PHD, 2 hits |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS51805, EPHD, 1 hit PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | JADE1_BOVIN | |
Accessioni | Q5E9T7Primary (citable) accession number: Q5E9T7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | March 15, 2005 | |
Last modified: | September 29, 2021 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families