Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 35A

Gene

TMEM35A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 35A
Gene namesi
Name:TMEM35A
Synonyms:TMEM35
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Organism-specific databases

VGNCiVGNC:36077 TMEM35A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Transmembranei115 – 132HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716061 – 177Transmembrane protein 35AAdd BLAST177

Proteomic databases

PaxDbiQ5E9T5

Expressioni

Gene expression databases

BgeeiENSBTAG00000021252 Expressed in 8 organ(s), highest expression level in brain

Interactioni

Subunit structurei

May interact with NGFR.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028319

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni43 – 54Interaction with NGFRBy similarityAdd BLAST12

Sequence similaritiesi

Belongs to the DoxX family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGYA Eukaryota
ENOG4111K2N LUCA
GeneTreeiENSGT00390000014255
HOGENOMiHOG000046204
HOVERGENiHBG054829
InParanoidiQ5E9T5
OMAiSKWYRRV
OrthoDBiEOG091G0TZU
TreeFamiTF300206

Family and domain databases

InterProiView protein in InterPro
IPR032808 DoxX
IPR029693 TMEM35A
PANTHERiPTHR13163:SF0 PTHR13163:SF0, 1 hit
PfamiView protein in Pfam
PF13564 DoxX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5E9T5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPRTVTVV ALSVALGLFF VFMGTIKLTP RLSKDAYSEM KRAYKSYVRA
60 70 80 90 100
LPLLKKMGIN SILLRKSIGA LEVACGIVMT LVPGRPKDVA NFFLLLLVLA
110 120 130 140 150
VLFFHQLVGD PLKRYAHALV FGILLTCRLL IARKPEDRSS EKKSSPPGNA
160 170
GSDGNAGNTE EQPSLYEKAP QGKMKLS
Length:177
Mass (Da):19,307
Last modified:March 15, 2005 - v1
Checksum:i539355781EB9D52F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5R → I in AAX08677 (PubMed:16305752).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020660 mRNA Translation: AAX08677.1
BT020835 mRNA Translation: AAX08852.1
BC122649 mRNA Translation: AAI22650.1
RefSeqiNP_001014940.1, NM_001014940.1
UniGeneiBt.22696

Genome annotation databases

EnsembliENSBTAT00000028319; ENSBTAP00000028319; ENSBTAG00000021252
GeneIDi533337
KEGGibta:533337

Similar proteinsi

Entry informationi

Entry nameiTM35A_BOVIN
AccessioniPrimary (citable) accession number: Q5E9T5
Secondary accession number(s): Q5EAA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 15, 2005
Last modified: September 12, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again