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Protein

Thiamin pyrophosphokinase 1

Gene

TPK1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate (By similarity).By similarity

Catalytic activityi

ATP + thiamine = AMP + thiamine diphosphate.

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes thiamine diphosphate from thiamine.
Proteins known to be involved in this subpathway in this organism are:
  1. Thiamin pyrophosphokinase 1 (TPK1)
This subpathway is part of the pathway thiamine diphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes thiamine diphosphate from thiamine, the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-196819 Vitamin B1 (thiamin) metabolism
UniPathwayiUPA00060; UER00597

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamin pyrophosphokinase 1 (EC:2.7.6.2)
Alternative name(s):
Thiamine pyrophosphokinase 1
Gene namesi
Name:TPK1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Organism-specific databases

VGNCiVGNC:36251 TPK1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002391171 – 243Thiamin pyrophosphokinase 1Add BLAST243

Proteomic databases

PaxDbiQ5E9T4

Expressioni

Gene expression databases

BgeeiENSBTAG00000017676

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023510

Structurei

3D structure databases

ProteinModelPortaliQ5E9T4
SMRiQ5E9T4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiamine pyrophosphokinase family.Curated

Phylogenomic databases

eggNOGiKOG3153 Eukaryota
COG1564 LUCA
GeneTreeiENSGT00390000016016
HOGENOMiHOG000180834
HOVERGENiHBG003568
InParanoidiQ5E9T4
KOiK00949
OMAiTGNLKYC
OrthoDBiEOG091G0FS8
TreeFamiTF313224

Family and domain databases

CDDicd07995 TPK, 1 hit
Gene3Di3.40.50.10240, 1 hit
InterProiView protein in InterPro
IPR006282 Thi_PPkinase
IPR016966 Thiamin_pyrophosphokinase_euk
IPR007373 Thiamin_PyroPKinase_B1-bd
IPR036371 TPK_B1-bd_sf
IPR007371 TPK_catalytic
IPR036759 TPK_catalytic_sf
PfamiView protein in Pfam
PF04265 TPK_B1_binding, 1 hit
PF04263 TPK_catalytic, 1 hit
PIRSFiPIRSF031057 Thiamin_pyrophosphokinase, 1 hit
SMARTiView protein in SMART
SM00983 TPK_B1_binding, 1 hit
SUPFAMiSSF63862 SSF63862, 1 hit
SSF63999 SSF63999, 1 hit
TIGRFAMsiTIGR01378 thi_PPkinase, 1 hit

Sequencei

Sequence statusi: Complete.

Q5E9T4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHAITPLDP LLPSGSLKYC LVILNQPLDK CFRHLWHKAL LRACADGGAN
60 70 80 90 100
HLYDVTEGER ESFLPEFISG DFDSIRPEVR EHYAIKGCEI ISTPDQDHTD
110 120 130 140 150
FTKCLEVLQK KIEEKDLQVD MIVTLGGLAG RFDQIMASVS TLFQAPQITS
160 170 180 190 200
LPVIIIQEES LIYLLQPGKH KLHVDTGMEG DWCGLIPVGQ PCNQVTTTGL
210 220 230 240
KWNLTHQMLG FGTLVSTSNT YDGSGVVTVE TDHPLLWTMA IKN
Length:243
Mass (Da):27,028
Last modified:March 15, 2005 - v1
Checksum:i00471681ACC6FB47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020836 mRNA Translation: AAX08853.1
BC119895 mRNA Translation: AAI19896.1
RefSeqiNP_001073839.1, NM_001080370.1
XP_005205956.1, XM_005205899.1
UniGeneiBt.6512

Genome annotation databases

EnsembliENSBTAT00000023510; ENSBTAP00000023510; ENSBTAG00000017676
ENSBTAT00000044036; ENSBTAP00000041553; ENSBTAG00000017676
GeneIDi788066
KEGGibta:788066

Similar proteinsi

Entry informationi

Entry nameiTPK1_BOVIN
AccessioniPrimary (citable) accession number: Q5E9T4
Secondary accession number(s): Q0P5L2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 15, 2005
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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