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Entry version 95 (13 Nov 2019)
Sequence version 1 (15 Mar 2005)
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Protein
Submitted name:

Necdin

Gene

NDN

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
NecdinImported
Submitted name:
Necdin homolog (Mouse)Imported
Submitted name:
Necdin, MAGE family memberImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NDNImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:31936 NDN

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000002186 Expressed in 10 organ(s), highest expression level in brain

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000002832

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini102 – 301MAGEInterPro annotationAdd BLAST200

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 99DisorderedSequence analysisAdd BLAST99

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 48PolarSequence analysisAdd BLAST48
Compositional biasi82 – 97PolarSequence analysisAdd BLAST16

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4562 Eukaryota
ENOG4111S70 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163084

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231161

KEGG Orthology (KO)

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KOi
K19482

Identification of Orthologs from Complete Genome Data

More...
OMAi
RMIIWFP

Database of Orthologous Groups

More...
OrthoDBi
1195799at2759

TreeFam database of animal gene trees

More...
TreeFami
TF328505

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1200, 1 hit
1.10.10.1210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037445 MAGE
IPR041898 MAGE_WH1
IPR041899 MAGE_WH2
IPR002190 MHD_dom
IPR030086 Necdin

The PANTHER Classification System

More...
PANTHERi
PTHR11736 PTHR11736, 1 hit
PTHR11736:SF10 PTHR11736:SF10, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01454 MAGE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01373 MAGE, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50838 MAGE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5E9S5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEQSKDVCN PNFAAEASNS EVHSSPGIPG EPSSPGSQAA TLTESESPPL
60 70 80 90 100
SPPDAPLVSL PPQAPGEEGD PKALQQAAEE GRPHQAPSTT QLSPAPPAPA
110 120 130 140 150
QLVQKAHELM WYVLVKDQKR MIIWFPDMVK DVIGSYKKWC RSILRRTSLI
160 170 180 190 200
LARVFGLHLR LTSLHTMEFS LVKALEPEEL DRVALSNRMP MTGLLLMILS
210 220 230 240 250
LIYVKGRGAR ESAVWNVLRI LGLRPWKKHS TFGDVRKLIT EEFVQQNYLK
260 270 280 290 300
YQRVPHVEPP EYEFFWGSRA SREITKMQIM EFLARVFKKT PQAWPSRYRE
310 320
ALEEARALRA AHPTAHCPRN SVSED
Length:325
Mass (Da):36,590
Last modified:March 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i698B067A68A93EE4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC146188 mRNA Translation: AAI46189.1
BT020838 mRNA Translation: AAX08855.1
BT020845 mRNA Translation: AAX08862.1
BT029863 mRNA Translation: ABM06116.1
JX196877 Genomic DNA Translation: AFQ37846.1
JX196878 Genomic DNA Translation: AFQ37847.1
JX196879 Genomic DNA Translation: AFQ37848.1
JX196880 Genomic DNA Translation: AFQ37849.1
JX196881 Genomic DNA Translation: AFQ37850.1
JX196882 Genomic DNA Translation: AFQ37851.1
JX196883 Genomic DNA Translation: AFQ37852.1
JX196884 Genomic DNA Translation: AFQ37853.1
JX196885 Genomic DNA Translation: AFQ37854.1
JX196886 Genomic DNA Translation: AFQ37855.1
JX196887 Genomic DNA Translation: AFQ37856.1
JX196888 Genomic DNA Translation: AFQ37857.1
JX196890 Genomic DNA Translation: AFQ37859.1
JX196892 Genomic DNA Translation: AFQ37861.1
JX196893 Genomic DNA Translation: AFQ37862.1
JX196894 Genomic DNA Translation: AFQ37863.1
JX196895 Genomic DNA Translation: AFQ37864.1
JX196896 Genomic DNA Translation: AFQ37865.1
JX196897 Genomic DNA Translation: AFQ37866.1
JX196898 Genomic DNA Translation: AFQ37867.1
JX196899 Genomic DNA Translation: AFQ37868.1
JX196900 Genomic DNA Translation: AFQ37869.1
JX196901 Genomic DNA Translation: AFQ37870.1
JX196902 Genomic DNA Translation: AFQ37871.1
JX196905 Genomic DNA Translation: AFQ37874.1
JX196906 Genomic DNA Translation: AFQ37875.1
JX196907 Genomic DNA Translation: AFQ37876.1
JX196910 Genomic DNA Translation: AFQ37879.1
JX196911 Genomic DNA Translation: AFQ37880.1
JX196912 Genomic DNA Translation: AFQ37881.1
JX196913 Genomic DNA Translation: AFQ37882.1
JX196916 Genomic DNA Translation: AFQ37885.1
JX196917 Genomic DNA Translation: AFQ37886.1
JX196921 Genomic DNA Translation: AFQ37890.1
JX196922 Genomic DNA Translation: AFQ37891.1
JX196923 Genomic DNA Translation: AFQ37892.1
JX196924 Genomic DNA Translation: AFQ37893.1
JX196925 Genomic DNA Translation: AFQ37894.1

NCBI Reference Sequences

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RefSeqi
NP_001014982.1, NM_001014982.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSBTAT00000002832; ENSBTAP00000002832; ENSBTAG00000002186

Database of genes from NCBI RefSeq genomes

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GeneIDi
386664

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:386664

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC146188 mRNA Translation: AAI46189.1
BT020838 mRNA Translation: AAX08855.1
BT020845 mRNA Translation: AAX08862.1
BT029863 mRNA Translation: ABM06116.1
JX196877 Genomic DNA Translation: AFQ37846.1
JX196878 Genomic DNA Translation: AFQ37847.1
JX196879 Genomic DNA Translation: AFQ37848.1
JX196880 Genomic DNA Translation: AFQ37849.1
JX196881 Genomic DNA Translation: AFQ37850.1
JX196882 Genomic DNA Translation: AFQ37851.1
JX196883 Genomic DNA Translation: AFQ37852.1
JX196884 Genomic DNA Translation: AFQ37853.1
JX196885 Genomic DNA Translation: AFQ37854.1
JX196886 Genomic DNA Translation: AFQ37855.1
JX196887 Genomic DNA Translation: AFQ37856.1
JX196888 Genomic DNA Translation: AFQ37857.1
JX196890 Genomic DNA Translation: AFQ37859.1
JX196892 Genomic DNA Translation: AFQ37861.1
JX196893 Genomic DNA Translation: AFQ37862.1
JX196894 Genomic DNA Translation: AFQ37863.1
JX196895 Genomic DNA Translation: AFQ37864.1
JX196896 Genomic DNA Translation: AFQ37865.1
JX196897 Genomic DNA Translation: AFQ37866.1
JX196898 Genomic DNA Translation: AFQ37867.1
JX196899 Genomic DNA Translation: AFQ37868.1
JX196900 Genomic DNA Translation: AFQ37869.1
JX196901 Genomic DNA Translation: AFQ37870.1
JX196902 Genomic DNA Translation: AFQ37871.1
JX196905 Genomic DNA Translation: AFQ37874.1
JX196906 Genomic DNA Translation: AFQ37875.1
JX196907 Genomic DNA Translation: AFQ37876.1
JX196910 Genomic DNA Translation: AFQ37879.1
JX196911 Genomic DNA Translation: AFQ37880.1
JX196912 Genomic DNA Translation: AFQ37881.1
JX196913 Genomic DNA Translation: AFQ37882.1
JX196916 Genomic DNA Translation: AFQ37885.1
JX196917 Genomic DNA Translation: AFQ37886.1
JX196921 Genomic DNA Translation: AFQ37890.1
JX196922 Genomic DNA Translation: AFQ37891.1
JX196923 Genomic DNA Translation: AFQ37892.1
JX196924 Genomic DNA Translation: AFQ37893.1
JX196925 Genomic DNA Translation: AFQ37894.1
RefSeqiNP_001014982.1, NM_001014982.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002832

Genome annotation databases

EnsembliENSBTAT00000002832; ENSBTAP00000002832; ENSBTAG00000002186
GeneIDi386664
KEGGibta:386664

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4692
VGNCiVGNC:31936 NDN

Phylogenomic databases

eggNOGiKOG4562 Eukaryota
ENOG4111S70 LUCA
GeneTreeiENSGT00940000163084
HOGENOMiHOG000231161
KOiK19482
OMAiRMIIWFP
OrthoDBi1195799at2759
TreeFamiTF328505

Gene expression databases

BgeeiENSBTAG00000002186 Expressed in 10 organ(s), highest expression level in brain

Family and domain databases

Gene3Di1.10.10.1200, 1 hit
1.10.10.1210, 1 hit
InterProiView protein in InterPro
IPR037445 MAGE
IPR041898 MAGE_WH1
IPR041899 MAGE_WH2
IPR002190 MHD_dom
IPR030086 Necdin
PANTHERiPTHR11736 PTHR11736, 1 hit
PTHR11736:SF10 PTHR11736:SF10, 1 hit
PfamiView protein in Pfam
PF01454 MAGE, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5E9S5_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5E9S5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 13, 2019
This is version 95 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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