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Protein

Caseinolytic peptidase B protein homolog

Gene

CLPB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as a regulatory ATPase and be related to secretion/protein trafficking process.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi351 – 358ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Caseinolytic peptidase B protein homolog (EC:3.6.1.3By similarity)
Alternative name(s):
Suppressor of potassium transport defect 3
Gene namesi
Name:CLPB
Synonyms:SKD3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

Organism-specific databases

VGNCiVGNC:27458 CLPB

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28MitochondrionSequence analysisAdd BLAST28
ChainiPRO_000028634929 – 677Caseinolytic peptidase B protein homologAdd BLAST649

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei559N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5E9N5
PRIDEiQ5E9N5

Expressioni

Gene expression databases

BgeeiENSBTAG00000001280 Expressed in 10 organ(s), highest expression level in testis

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001687

Structurei

3D structure databases

ProteinModelPortaliQ5E9N5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati133 – 162ANK 1Add BLAST30
Repeati166 – 195ANK 2Add BLAST30
Repeati235 – 265ANK 3Add BLAST31
Repeati268 – 297ANK 4Add BLAST30

Sequence similaritiesi

Belongs to the ClpA/ClpB family.Curated

Keywords - Domaini

ANK repeat, Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG1051 Eukaryota
COG0542 LUCA
GeneTreeiENSGT00390000012961
HOGENOMiHOG000006543
HOVERGENiHBG025978
InParanoidiQ5E9N5
KOiK03695
OMAiVVHCYSK
OrthoDBiEOG091G05FP
TreeFamiTF328654

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR003959 ATPase_AAA_core
IPR019489 Clp_ATPase_C
IPR001270 ClpA/B
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF07724 AAA_2, 1 hit
PF12796 Ank_2, 2 hits
PF10431 ClpB_D2-small, 1 hit
PRINTSiPR00300 CLPPROTEASEA
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00248 ANK, 3 hits
SM01086 ClpB_D2-small, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5E9N5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGSLVSKRT APAPRLLLQL LRSPSLRSHE SATGQSVTTG GRGEPQWLRA
60 70 80 90 100
AVGGRHGTSP ALLTGGGAAT GGRQRGRTET PCLAAATWGR LPSPEDTLPG
110 120 130 140 150
QDSWNGVLSR AGLGVWALAT ALVVHCYSKS PSSKDAALME AARANNVQEV
160 170 180 190 200
SRLLSEGADV NARHRLGWTA LMVAAINRND SVVQVLLAAG ADPNLGDDFS
210 220 230 240 250
SVYKTAKDQG IHSLEVLVTR EDDFNNRLNN RASFKGCTAL HYAVLADDYR
260 270 280 290 300
TVKELLDGGA NPLQRNEMGH TPLDYAREGE VMKLLRTSET KYQEKQRKRE
310 320 330 340 350
AEERRRFPLE QRLKEHIIGQ ESAIATVGAA IRRKENGWYD EEHPLVFLFL
360 370 380 390 400
GSSGIGKTEL AKQTAKYMHK DAKKGFIRLD MSEFQERHEV AKFIGSPPGY
410 420 430 440 450
IGHEEGGQLT KKLKQCPNAV VLFDEVDKAH PDVLTIMLQL FDEGRLTDGK
460 470 480 490 500
GKTIDCKDAI FIMTSNVASD EIAQHALQLR QEALEMSRNR IAENLGDVQI
510 520 530 540 550
SDKITISKNF KENVIRPILK AHFRRDEFLG RINEIVYFLP FCHSELIQLV
560 570 580 590 600
NKELNFWAKR AKQRHNITLL WDREVADVLV EGYNVHYGAR SIKHEVERRV
610 620 630 640 650
VNQLAAAYEQ DLLPGGCTLR ITVEDSDKQL LRSPELSSSQ AERRPPKLRL
660 670
EIIDKDSKTH KLDIQAPLHP EKVCHTL
Length:677
Mass (Da):75,440
Last modified:March 15, 2005 - v1
Checksum:iEBFE78C4376E0A80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020885 mRNA Translation: AAX08902.1
BC103469 mRNA Translation: AAI03470.1
RefSeqiNP_001015625.1, NM_001015625.1
UniGeneiBt.49163

Genome annotation databases

EnsembliENSBTAT00000001687; ENSBTAP00000001687; ENSBTAG00000001280
GeneIDi520639
KEGGibta:520639

Similar proteinsi

Entry informationi

Entry nameiCLPB_BOVIN
AccessioniPrimary (citable) accession number: Q5E9N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 15, 2005
Last modified: September 12, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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