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Protein

PRA1 family protein 3

Gene

ARL6IP5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. May be involved in membrane traffic.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-210500 Glutamate Neurotransmitter Release Cycle

Names & Taxonomyi

Protein namesi
Recommended name:
PRA1 family protein 3
Alternative name(s):
ADP-ribosylation factor-like protein 6-interacting protein 5
Short name:
ARL-6-interacting protein 5
Short name:
Aip-5
Gene namesi
Name:ARL6IP5
Synonyms:PRAF3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Organism-specific databases

VGNCiVGNC:26151 ARL6IP5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicBy similarityAdd BLAST35
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Topological domaini78 – 93CytoplasmicBy similarityAdd BLAST16
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Topological domaini136 – 188CytoplasmicBy similarityAdd BLAST53

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002568471 – 188PRA1 family protein 3Add BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5E9M1
PeptideAtlasiQ5E9M1
PRIDEiQ5E9M1

Expressioni

Gene expression databases

BgeeiENSBTAG00000021506

Interactioni

Subunit structurei

Homodimer. Heterodimer with ARL6IP1. Forms multimers. Interacts with prenylated RAB1A, RAB3A and SLC1A1/EAAC1. Does not interact with VAMP1, VAMP2 or VAMP3. Interacts with ARL6. Interacts with SLC1A1/EAAC1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028661

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni103 – 117Required for homodimer formation and heterodimer formation with ARL6IP1By similarityAdd BLAST15
Regioni136 – 188Targeting to endoplasmic reticulum membraneBy similarityAdd BLAST53

Sequence similaritiesi

Belongs to the PRA1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4050 Eukaryota
ENOG4111MUC LUCA
GeneTreeiENSGT00390000008631
HOGENOMiHOG000231363
HOVERGENiHBG053661
InParanoidiQ5E9M1
KOiK20393
OMAiAHNKDIL
OrthoDBiEOG091G0QS5
TreeFamiTF105479

Family and domain databases

InterProiView protein in InterPro
IPR004895 Prenylated_rab_accept_PRA1
PfamiView protein in Pfam
PF03208 PRA1, 1 hit

Sequencei

Sequence statusi: Complete.

Q5E9M1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVNIAPLRA WDDFFPGSDR FARPDFRDIS KWNNRVVSNL LYYQTNYLVV
60 70 80 90 100
AAMMISVVGF LSPFNMILGG IVVVLVFTGF VWAAHNKDIL RRMKKQYPTA
110 120 130 140 150
FVMVVMLASY FLISLFGGVM VFVFGITFPL LLMFIHASLR LRNLKNKLEN
160 170 180
KMEEIGLKRT PMGIVLDALE QQEETITKFS DYISKMKE
Length:188
Mass (Da):21,666
Last modified:March 15, 2005 - v1
Checksum:iDDCB3D3CC815AF4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020899 mRNA Translation: AAX08916.1
BC102757 mRNA Translation: AAI02758.1
RefSeqiNP_001014891.1, NM_001014891.1
UniGeneiBt.13574

Genome annotation databases

EnsembliENSBTAT00000028661; ENSBTAP00000028661; ENSBTAG00000021506
GeneIDi509977
KEGGibta:509977

Similar proteinsi

Entry informationi

Entry nameiPRAF3_BOVIN
AccessioniPrimary (citable) accession number: Q5E9M1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 15, 2005
Last modified: April 25, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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