Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Proteasome activator complex subunit 2

Gene

PSME2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-1169091 Activation of NF-kappaB in B cells
R-BTA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-BTA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-BTA-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-BTA-174113 SCF-beta-TrCP mediated degradation of Emi1
R-BTA-174154 APC/C:Cdc20 mediated degradation of Securin
R-BTA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-BTA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-BTA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-BTA-195253 Degradation of beta-catenin by the destruction complex
R-BTA-202424 Downstream TCR signaling
R-BTA-2467813 Separation of Sister Chromatids
R-BTA-2871837 FCERI mediated NF-kB activation
R-BTA-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-BTA-350562 Regulation of ornithine decarboxylase (ODC)
R-BTA-382556 ABC-family proteins mediated transport
R-BTA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-BTA-4608870 Asymmetric localization of PCP proteins
R-BTA-4641257 Degradation of AXIN
R-BTA-4641258 Degradation of DVL
R-BTA-5358346 Hedgehog ligand biogenesis
R-BTA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-BTA-5607764 CLEC7A (Dectin-1) signaling
R-BTA-5610780 Degradation of GLI1 by the proteasome
R-BTA-5610785 GLI3 is processed to GLI3R by the proteasome
R-BTA-5632684 Hedgehog 'on' state
R-BTA-5658442 Regulation of RAS by GAPs
R-BTA-5668541 TNFR2 non-canonical NF-kB pathway
R-BTA-5676590 NIK-->noncanonical NF-kB signaling
R-BTA-5687128 MAPK6/MAPK4 signaling
R-BTA-5689603 UCH proteinases
R-BTA-5689880 Ub-specific processing proteases
R-BTA-68827 CDT1 association with the CDC6:ORC:origin complex
R-BTA-68949 Orc1 removal from chromatin
R-BTA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-BTA-69229 Ubiquitin-dependent degradation of Cyclin D1
R-BTA-69481 G2/M Checkpoints
R-BTA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-BTA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-BTA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-BTA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-BTA-8939902 Regulation of RUNX2 expression and activity
R-BTA-8941858 Regulation of RUNX3 expression and activity
R-BTA-8948751 Regulation of PTEN stability and activity
R-BTA-9020702 Interleukin-1 signaling
R-BTA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome activator complex subunit 2
Alternative name(s):
Proteasome activator 28 subunit beta
Short name:
PA28b
Short name:
PA28beta
Gene namesi
Name:PSME2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Organism-specific databases

VGNCiVGNC:33474 PSME2

Subcellular locationi

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001617842 – 239Proteasome activator complex subunit 2Add BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei10PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PeptideAtlasiQ5E9G3
PRIDEiQ5E9G3

Expressioni

Gene expression databases

BgeeiENSBTAG00000005814
ExpressionAtlasiQ5E9G3 baseline and differential

Interactioni

Subunit structurei

Heterodimer of PSME1 and PSME2, which forms a hexameric ring.

Protein-protein interaction databases

CORUMiQ5E9G3

Structurei

3D structure databases

ProteinModelPortaliQ5E9G3
SMRiQ5E9G3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PA28 family.Curated

Phylogenomic databases

GeneTreeiENSGT00510000046374
HOGENOMiHOG000282822
HOVERGENiHBG053745
InParanoidiQ5E9G3
KOiK06697

Family and domain databases

Gene3Di1.20.120.180, 1 hit
1.20.5.120, 1 hit
InterProiView protein in InterPro
IPR003186 PA28_C
IPR036997 PA28_C_sf
IPR036996 PA28_N_sf
IPR009077 Proteasome_activ_PA28
IPR003185 Proteasome_activ_PA28_N
IPR036252 Proteasome_activ_sf
PANTHERiPTHR10660 PTHR10660, 1 hit
PfamiView protein in Pfam
PF02251 PA28_alpha, 1 hit
PF02252 PA28_beta, 1 hit
SUPFAMiSSF47216 SSF47216, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5E9G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKPCGVRLS GEALKQVDVF RQNLFQEAEE FLYRFLPQKI IYLNQLLQED
60 70 80 90 100
SFNVTDLNSL RAPLDIPIPD PPPKDDEMET DKQEKKEVPK CGFLPGNEKV
110 120 130 140 150
LALLALVKPE VWTLKEKCIL VITWIQHLIP KIEDGNDFGV AIQEKVLERV
160 170 180 190 200
NAVKTKVEAF QTTISKYFSE RGDAVAKASK ETHVMDYRAL VHERDEAVYG
210 220 230
DLRAMVLDLR AFYAELYHII SSNLEKIVNP KGEEKPSMY
Length:239
Mass (Da):27,380
Last modified:January 23, 2007 - v3
Checksum:i83CD95CF899C0818
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020957 mRNA Translation: AAX08974.1
BC102583 mRNA Translation: AAI02584.1
RefSeqiNP_001014889.1, NM_001014889.1
UniGeneiBt.48996

Genome annotation databases

EnsembliENSBTAT00000007642; ENSBTAP00000007642; ENSBTAG00000005814
GeneIDi509857
KEGGibta:509857

Similar proteinsi

Entry informationi

Entry nameiPSME2_BOVIN
AccessioniPrimary (citable) accession number: Q5E9G3
Secondary accession number(s): Q3T038
, Q9TR87, Q9TR88, Q9TR89, Q9TR90
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 85 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health