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Protein

Myosin regulatory light polypeptide 9

Gene

MYL9

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion.By similarity

Miscellaneous

This chain binds calcium.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi42 – 531PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • ATPase activity Source: UniProtKB
  • calcium ion binding Source: InterPro
  • glutamate receptor binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionMotor protein, Muscle protein, Myosin
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-3928664 Ephrin signaling
R-BTA-445355 Smooth Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin regulatory light polypeptide 9
Alternative name(s):
Myosin regulatory light chain 2, smooth muscle isoform
Myosin regulatory light chain 9
Gene namesi
Name:MYL9
Synonyms:MYRL2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002476002 – 172Myosin regulatory light polypeptide 9Add BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei19Phosphothreonine; by MLCK, CIT and ROCK2By similarity1
Modified residuei20Phosphoserine; by CDC42BP, CIT, MLCK, PAK1, ROCK1, ROCK2, DAPK1, DAPK2 and ZIPK/DAPK3By similarity1

Post-translational modificationi

Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5E9E2
PRIDEiQ5E9E2

PTM databases

iPTMnetiQ5E9E2

Expressioni

Gene expression databases

BgeeiENSBTAG00000016024 Expressed in 9 organ(s), highest expression level in lung

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains: interacts with myosin heavy chain MYO19.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021328

Structurei

3D structure databases

ProteinModelPortaliQ5E9E2
SMRiQ5E9E2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 64EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini98 – 133EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini134 – 169EF-hand 3PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0031 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000119196
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiQ5E9E2
KOiK12757
OMAiGFVDHED
OrthoDBiEOG091G0QF6
TreeFamiTF314218

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR015070 EF_hand_DJBP
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF08976 EF-hand_11, 1 hit
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5E9E2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSKRAKTKT TKKRPQRATS NVFAMFDQSQ IQEFKEAFNM IDQNRDGFID
60 70 80 90 100
KEDLHDMLAS LGKNPTDEYL DAMMNEAPGP INFTMFLTMF GEKLNGTDPE
110 120 130 140 150
DVIRNAFACF DEEATGTIQE DYLRELLTTM GDRFTDEEVD ELYREAPIDK
160 170
KGNFNYIEFT RILKHGAKDK DD
Length:172
Mass (Da):19,865
Last modified:January 23, 2007 - v3
Checksum:i27DB2A9FC9BC086B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020978 mRNA Translation: AAX08995.1
BC118244 mRNA Translation: AAI18245.1
RefSeqiNP_001015640.1, NM_001015640.2
XP_005224259.1, XM_005224202.3
UniGeneiBt.2832

Genome annotation databases

EnsembliENSBTAT00000021328; ENSBTAP00000021328; ENSBTAG00000016024
GeneIDi531505
KEGGibta:531505

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020978 mRNA Translation: AAX08995.1
BC118244 mRNA Translation: AAI18245.1
RefSeqiNP_001015640.1, NM_001015640.2
XP_005224259.1, XM_005224202.3
UniGeneiBt.2832

3D structure databases

ProteinModelPortaliQ5E9E2
SMRiQ5E9E2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021328

PTM databases

iPTMnetiQ5E9E2

Proteomic databases

PaxDbiQ5E9E2
PRIDEiQ5E9E2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000021328; ENSBTAP00000021328; ENSBTAG00000016024
GeneIDi531505
KEGGibta:531505

Organism-specific databases

CTDi10627

Phylogenomic databases

eggNOGiKOG0031 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000119196
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiQ5E9E2
KOiK12757
OMAiGFVDHED
OrthoDBiEOG091G0QF6
TreeFamiTF314218

Enzyme and pathway databases

ReactomeiR-BTA-3928664 Ephrin signaling
R-BTA-445355 Smooth Muscle Contraction

Gene expression databases

BgeeiENSBTAG00000016024 Expressed in 9 organ(s), highest expression level in lung

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR015070 EF_hand_DJBP
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF08976 EF-hand_11, 1 hit
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMYL9_BOVIN
AccessioniPrimary (citable) accession number: Q5E9E2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 94 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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