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Protein

PDZ and LIM domain protein 1

Gene

PDLIM1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (By similarity). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi259Zinc 1By similarity1
Metal bindingi262Zinc 1By similarity1
Metal bindingi279Zinc 1By similarity1
Metal bindingi282Zinc 1By similarity1
Metal bindingi285Zinc 2By similarity1
Metal bindingi288Zinc 2By similarity1
Metal bindingi306Zinc 2By similarity1
Metal bindingi309Zinc 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ and LIM domain protein 1
Alternative name(s):
Elfin
Gene namesi
Name:PDLIM1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000758582 – 328PDZ and LIM domain protein 1Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1
Modified residuei90PhosphoserineBy similarity1
Modified residuei130PhosphoserineBy similarity1
Modified residuei144PhosphotyrosineBy similarity1
Modified residuei315PhosphothreonineBy similarity1
Modified residuei320PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5E9E1
PeptideAtlasiQ5E9E1
PRIDEiQ5E9E1

Interactioni

Subunit structurei

Interacts with ACTN1, ACTN2 and ACTN4 (By similarity). Interacts with PDLIM4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014850

Structurei

3D structure databases

ProteinModelPortaliQ5E9E1
SMRiQ5E9E1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 85PDZPROSITE-ProRule annotationAdd BLAST83
Domaini257 – 316LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiKOG1703 Eukaryota
ENOG410XRD4 LUCA
HOGENOMiHOG000290704
HOVERGENiHBG061371
InParanoidiQ5E9E1

Family and domain databases

InterProiView protein in InterPro
IPR031847 DUF4749
IPR028537 PDLIM1
IPR001478 PDZ
IPR036034 PDZ_sf
IPR006643 Zasp-like_motif
IPR001781 Znf_LIM
PANTHERiPTHR24214:SF5 PTHR24214:SF5, 1 hit
PfamiView protein in Pfam
PF15936 DUF4749, 1 hit
PF00412 LIM, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 1 hit
SM00228 PDZ, 1 hit
SM00735 ZM, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS50106 PDZ, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5E9E1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTLQIVLQG PGPWGFRLVG GKDFEQPLAI SRVTPGSKAA IGNLCVGDVI
60 70 80 90 100
TAIDGENTSN MTHLEAQNKI KGCTDNMTLT VARSEQKIWS PLVTEEGKRH
110 120 130 140 150
PYKMNLASEP QEALHIGSAH NRSAVPFTAS PAFSSAPRVI TNQYNNPAGL
160 170 180 190 200
YSSENISSFN NALESKTAAS GQENGRALDH SQLPSGLVID KESEVYKMLQ
210 220 230 240 250
EKQELNEPPK QSTSFLVLQE ILESEEKGDP NKPSGFRSVK APVTKVAASI
260 270 280 290 300
GNAQKLPMCD KCGTGIVGVF VKLRERHRHP ECYVCTDCGT NLKQKGHFFV
310 320
EDQIYCEKHA RERVTPPEGY DVITVFPK
Length:328
Mass (Da):35,881
Last modified:January 23, 2007 - v3
Checksum:i945F8C801E63D15E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020979 mRNA Translation: AAX08996.1
RefSeqiNP_001030532.1, NM_001035455.1
UniGeneiBt.32810

Genome annotation databases

GeneIDi614675
KEGGibta:614675

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020979 mRNA Translation: AAX08996.1
RefSeqiNP_001030532.1, NM_001035455.1
UniGeneiBt.32810

3D structure databases

ProteinModelPortaliQ5E9E1
SMRiQ5E9E1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014850

Proteomic databases

PaxDbiQ5E9E1
PeptideAtlasiQ5E9E1
PRIDEiQ5E9E1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi614675
KEGGibta:614675

Organism-specific databases

CTDi9124

Phylogenomic databases

eggNOGiKOG1703 Eukaryota
ENOG410XRD4 LUCA
HOGENOMiHOG000290704
HOVERGENiHBG061371
InParanoidiQ5E9E1

Family and domain databases

InterProiView protein in InterPro
IPR031847 DUF4749
IPR028537 PDLIM1
IPR001478 PDZ
IPR036034 PDZ_sf
IPR006643 Zasp-like_motif
IPR001781 Znf_LIM
PANTHERiPTHR24214:SF5 PTHR24214:SF5, 1 hit
PfamiView protein in Pfam
PF15936 DUF4749, 1 hit
PF00412 LIM, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 1 hit
SM00228 PDZ, 1 hit
SM00735 ZM, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS50106 PDZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDLI1_BOVIN
AccessioniPrimary (citable) accession number: Q5E9E1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: January 23, 2007
Last modified: December 20, 2017
This is version 88 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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