Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Eukaryotic translation initiation factor 2 subunit 2

Gene

EIF2S2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri281 – 305C4-typeSequence analysisAdd BLAST25

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 2 subunit 2
Alternative name(s):
Eukaryotic translation initiation factor 2 subunit beta
Short name:
eIF-2-beta
Gene namesi
Name:EIF2S2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002471932 – 333Eukaryotic translation initiation factor 2 subunit 2Add BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Modified residuei36PhosphothreonineBy similarity1
Modified residuei67PhosphoserineBy similarity1
Cross-linki102Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei105PhosphoserineBy similarity1
Modified residuei158PhosphoserineBy similarity1
Modified residuei218PhosphoserineBy similarity1
Modified residuei265N6-acetyllysineBy similarity1
Modified residuei293N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5E9D0
PeptideAtlasiQ5E9D0
PRIDEiQ5E9D0

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007832

Structurei

3D structure databases

ProteinModelPortaliQ5E9D0
SMRiQ5E9D0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 21Poly-Lys8
Compositional biasi79 – 87Poly-Lys9
Compositional biasi124 – 129Poly-Lys6

Sequence similaritiesi

Belongs to the eIF-2-beta/eIF-5 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri281 – 305C4-typeSequence analysisAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2768 Eukaryota
COG1601 LUCA
HOGENOMiHOG000107198
HOVERGENiHBG000927
InParanoidiQ5E9D0
KOiK03238
TreeFamiTF101503

Family and domain databases

InterProiView protein in InterPro
IPR002735 Transl_init_fac_IF2/IF5
IPR016189 Transl_init_fac_IF2/IF5_N
IPR016190 Transl_init_fac_IF2/IF5_Zn-bd
PfamiView protein in Pfam
PF01873 eIF-5_eIF-2B, 1 hit
SMARTiView protein in SMART
SM00653 eIF2B_5, 1 hit
SUPFAMiSSF100966 SSF100966, 1 hit
SSF75689 SSF75689, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q5E9D0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGDEMIFDP TMSKKKKKKK KPFMLDEEGD AQTEETQPSE TKEVEPEPTE
60 70 80 90 100
DKDVEADEED SRKKDASDDL DDLNFFNQKK KKKKSKKIFD IDEAEEGIKD
110 120 130 140 150
LKIESDVQEP AEPEEDLDIM LGNKKKKKKV VKFPDEDEVL EKDEALEDED
160 170 180 190 200
SKKDDGISFS NQTGPAWAGS ERDYTYEELL NRVFNIMREK NPDMVAGEKR
210 220 230 240 250
KFVMKPPQVV RVGTKKTSFV NFTDICKLLH RQPKHLLAFL LAELGTSGSI
260 270 280 290 300
DGNNQLVIKG RFQQKQIENV LRRYIKEYVT CHTCRSPDTI LQKDTRLYFL
310 320 330
QCETCHSRCS VASIKTGFQA VTGRRAQLRA KAN
Length:333
Mass (Da):38,286
Last modified:March 15, 2005 - v1
Checksum:i96DD5CD2D50FC0B7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140T862A0A140T862_BOVIN
Eukaryotic translation initiation f...
EIF2S2
333Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti324R → K in AAI22610 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020990 mRNA Translation: AAX09007.1
BC122609 mRNA Translation: AAI22610.1
RefSeqiNP_001015621.1, NM_001015621.1
UniGeneiBt.3458

Genome annotation databases

GeneIDi520094
KEGGibta:520094

Similar proteinsi

Entry informationi

Entry nameiIF2B_BOVIN
AccessioniPrimary (citable) accession number: Q5E9D0
Secondary accession number(s): Q0IIJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 15, 2005
Last modified: February 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again