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UniProtKB - Q5E9B4 (EI2BB_BOVIN)
Protein
Translation initiation factor eIF-2B subunit beta
Gene
EIF2B2
Organism
Bos taurus (Bovine)
Status
Functioni
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
By similarityGO - Molecular functioni
- ATP binding Source: UniProtKB
- GTP binding Source: UniProtKB
- guanyl-nucleotide exchange factor activity Source: Ensembl
- translation initiation factor activity Source: GO_Central
GO - Biological processi
- central nervous system development Source: UniProtKB
- myelination Source: UniProtKB
- oligodendrocyte development Source: UniProtKB
- ovarian follicle development Source: UniProtKB
- T cell receptor signaling pathway Source: UniProtKB
- translational initiation Source: UniProtKB
Keywordsi
Molecular function | Initiation factor |
Biological process | Protein biosynthesis |
Names & Taxonomyi
Protein namesi | Recommended name: Translation initiation factor eIF-2B subunit betaAlternative name(s): eIF-2B GDP-GTP exchange factor subunit beta |
Gene namesi | Name:EIF2B2 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000008664 |
VGNCi | VGNC:28385, EIF2B2 |
Subcellular locationi
Other locations
- cytoplasm Source: UniProtKB
- eukaryotic translation initiation factor 2B complex Source: UniProtKB
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000223470 | 1 – 351 | Translation initiation factor eIF-2B subunit betaAdd BLAST | 351 |
Proteomic databases
PaxDbi | Q5E9B4 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000008664, Expressed in prostate gland and 96 other tissues |
Interactioni
Subunit structurei
Complex of five different subunits; alpha, beta, gamma, delta and epsilon.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000011424 |
Family & Domainsi
Sequence similaritiesi
Belongs to the eIF-2B alpha/beta/delta subunits family.Curated
Phylogenomic databases
eggNOGi | KOG1465, Eukaryota |
GeneTreei | ENSGT00550000074908 |
HOGENOMi | CLU_016218_4_3_1 |
InParanoidi | Q5E9B4 |
OMAi | TSHTSYA |
OrthoDBi | 918011at2759 |
TreeFami | TF101506 |
Family and domain databases
Gene3Di | 3.40.50.10470, 1 hit |
InterProi | View protein in InterPro IPR000649, IF-2B-related IPR042529, IF_2B-like_C IPR037171, NagB/RpiA_transferase-like |
Pfami | View protein in Pfam PF01008, IF-2B, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5E9B4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGAAAKGSE LSERIESFVE ALKRGGGRRS SEDMARETLG LLRRIITDHR
60 70 80 90 100
WSNAGELMEL IRREGRRMTA AQPSETTVGN MVRRVLRIIR EEYGRLHGRS
110 120 130 140 150
DESDQQESLH KLLTSGGLSE DFRSHYAQLQ SNIIEAINEL LVELEGTTEN
160 170 180 190 200
IAAQALEHIH SNEVIMTIGF SRTVEAFLRE AARKRKFHVI VAECAPFCQG
210 220 230 240 250
HEMAVNLSKA GIETTVMTDA AIFAVMSRVN KVIIGTKTIL ANGALRAVAG
260 270 280 290 300
THTLALAAKH HSTPLIVCAP MFKLSPQFPN EEDSFHKFVA PEEVLPFTEG
310 320 330 340 350
DILEKVSVHC PVFDYVPPEL ITLFISNIGG NAPSYIYRLM SELYHPDDHV
L
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT021006 mRNA Translation: AAX09023.1 BC123823 mRNA Translation: AAI23824.1 |
RefSeqi | NP_001015593.1, NM_001015593.1 |
Genome annotation databases
Ensembli | ENSBTAT00000011424; ENSBTAP00000011424; ENSBTAG00000008664 |
GeneIDi | 513958 |
KEGGi | bta:513958 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT021006 mRNA Translation: AAX09023.1 BC123823 mRNA Translation: AAI23824.1 |
RefSeqi | NP_001015593.1, NM_001015593.1 |
3D structure databases
AlphaFoldDBi | Q5E9B4 |
SMRi | Q5E9B4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000011424 |
Proteomic databases
PaxDbi | Q5E9B4 |
Genome annotation databases
Ensembli | ENSBTAT00000011424; ENSBTAP00000011424; ENSBTAG00000008664 |
GeneIDi | 513958 |
KEGGi | bta:513958 |
Organism-specific databases
CTDi | 8892 |
VEuPathDBi | HostDB:ENSBTAG00000008664 |
VGNCi | VGNC:28385, EIF2B2 |
Phylogenomic databases
eggNOGi | KOG1465, Eukaryota |
GeneTreei | ENSGT00550000074908 |
HOGENOMi | CLU_016218_4_3_1 |
InParanoidi | Q5E9B4 |
OMAi | TSHTSYA |
OrthoDBi | 918011at2759 |
TreeFami | TF101506 |
Gene expression databases
Bgeei | ENSBTAG00000008664, Expressed in prostate gland and 96 other tissues |
Family and domain databases
Gene3Di | 3.40.50.10470, 1 hit |
InterProi | View protein in InterPro IPR000649, IF-2B-related IPR042529, IF_2B-like_C IPR037171, NagB/RpiA_transferase-like |
Pfami | View protein in Pfam PF01008, IF-2B, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | EI2BB_BOVIN | |
Accessioni | Q5E9B4Primary (citable) accession number: Q5E9B4 Secondary accession number(s): A4FV73 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2006 |
Last sequence update: | March 15, 2005 | |
Last modified: | May 25, 2022 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families