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Protein

RNA/RNP complex-1-interacting phosphatase

Gene

DUSP11

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei152Phosphocysteine intermediatePROSITE-ProRule annotation1
Active sitei158Proton donor/acceptorSequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA/RNP complex-1-interacting phosphatase (EC:3.1.3.-)
Alternative name(s):
Dual specificity protein phosphatase 11
Phosphatase that interacts with RNA/RNP complex 1
Gene namesi
Name:DUSP11
Synonyms:PIR1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948151 – 331RNA/RNP complex-1-interacting phosphataseAdd BLAST331

Proteomic databases

PaxDbiQ5E999
PRIDEiQ5E999

Interactioni

Subunit structurei

Monomer. May interact with SFRS7 and SFRS9/SRP30C.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000044476

Structurei

3D structure databases

ProteinModelPortaliQ5E999
SMRiQ5E999
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 197Tyrosine-protein phosphataseAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni153 – 158Substrate bindingBy similarity6

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2386 Eukaryota
COG5226 LUCA
HOGENOMiHOG000112295
HOVERGENiHBG051420
InParanoidiQ5E999
KOiK14165

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5E999-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQWHHVGGH WGQDRVFSGY SSAKKKGGNH IPERWKDYLP VGQRMPGTRF
60 70 80 90 100
IAFKVPLKKS FEKHLAPEEC FSPLDLFNKI QEQNEELGLI IDLTYTRRYY
110 120 130 140 150
KPEELPENFP YLKIYTVGHQ VPDDDTIFKF KNAVNGFLRE NKDNDRLIGV
160 170 180 190 200
HCTHGVNRTG YLICRYLIDV EGMRPDDAIE LFSRCRGHCL ERQNYIDDLR
210 220 230 240 250
NGPIRKNWDS SVSRTRGFED STHMMEPVFT ATKPVNRRPK HNIHQTQGYP
260 270 280 290 300
EPRHFHTWTQ DLQQSERKFS QNWNIYQRCH VPPPGPPGED YFQRRYSWNV
310 320 330
KPSAGQGGPN KRFSPGSYYR VPYSAYYRWT K
Length:331
Mass (Da):39,060
Last modified:March 15, 2005 - v1
Checksum:i8417A5DD3F6C943F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021021 mRNA Translation: AAX09038.1
BC105553 mRNA Translation: AAI05554.1
RefSeqiNP_001014875.1, NM_001014875.1
UniGeneiBt.13589

Genome annotation databases

GeneIDi508944
KEGGibta:508944

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021021 mRNA Translation: AAX09038.1
BC105553 mRNA Translation: AAI05554.1
RefSeqiNP_001014875.1, NM_001014875.1
UniGeneiBt.13589

3D structure databases

ProteinModelPortaliQ5E999
SMRiQ5E999
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000044476

Proteomic databases

PaxDbiQ5E999
PRIDEiQ5E999

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi508944
KEGGibta:508944

Organism-specific databases

CTDi8446

Phylogenomic databases

eggNOGiKOG2386 Eukaryota
COG5226 LUCA
HOGENOMiHOG000112295
HOVERGENiHBG051420
InParanoidiQ5E999
KOiK14165

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDUS11_BOVIN
AccessioniPrimary (citable) accession number: Q5E999
Secondary accession number(s): Q2KJ27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 15, 2005
Last modified: November 7, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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