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Protein

Triosephosphate isomerase

Gene

TPI1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (TPI1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96ElectrophileBy similarity1
Active sitei166Proton acceptorBy similarity1

GO - Molecular functioni

  • triose-phosphate isomerase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

ReactomeiR-BTA-70171 Glycolysis
R-BTA-70263 Gluconeogenesis
UniPathwayi
UPA00109;UER00189

UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomerase (EC:5.3.1.1)
Short name:
TIM
Alternative name(s):
Triose-phosphate isomerase
Gene namesi
Name:TPI1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:36250 TPI1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Protein family/group databases

Allergomei11905 Bos d TPI

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002362711 – 249Triosephosphate isomeraseAdd BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14N6-acetyllysineBy similarity1
Modified residuei68Nitrated tyrosineBy similarity1
Modified residuei80PhosphoserineBy similarity1
Modified residuei106PhosphoserineBy similarity1
Cross-linki142Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei149N6-succinyllysineBy similarity1
Modified residuei156N6-acetyllysine; alternateBy similarity1
Modified residuei156N6-succinyllysine; alternateBy similarity1
Modified residuei159PhosphoserineBy similarity1
Modified residuei173PhosphothreonineBy similarity1
Modified residuei194N6-acetyllysine; alternateBy similarity1
Modified residuei194N6-methyllysine; alternateBy similarity1
Modified residuei194N6-succinyllysine; alternateBy similarity1
Modified residuei198PhosphoserineBy similarity1
Modified residuei209Nitrated tyrosineBy similarity1
Modified residuei212PhosphoserineBy similarity1
Modified residuei214PhosphothreonineBy similarity1
Modified residuei223PhosphoserineBy similarity1
Modified residuei238N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Nitration, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5E956
PeptideAtlasiQ5E956
PRIDEiQ5E956

Expressioni

Gene expression databases

BgeeiENSBTAG00000019782 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ5E956, 1 interactor
STRINGi9913.ENSBTAP00000026358

Structurei

3D structure databases

ProteinModelPortaliQ5E956
SMRiQ5E956
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.Curated

Phylogenomic databases

eggNOGiKOG1643 Eukaryota
COG0149 LUCA
GeneTreeiENSGT00390000013354
HOGENOMiHOG000226413
HOVERGENiHBG002599
InParanoidiQ5E956
KOiK01803
OMAiLCVGEGL
OrthoDBiEOG091G0LEZ
TreeFamiTF300829

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_B TIM_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR022896 TrioseP_Isoase_bac/euk
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
TIGRFAMsiTIGR00419 tim, 1 hit
PROSITEiView protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5E956-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPSRKFFVG GNWKMNGRKN NLGELINTLN AAKVPADTEV VCAPPTAYID
60 70 80 90 100
FARQKLDPKI AVAAQNCYKV ANGAFTGEIS PGMIKDLGAT WVVLGHSERR
110 120 130 140 150
HVFGESDELI GQKVAHALAE GLGVIACIGE KLDEREAGIT EKVVFEQTKV
160 170 180 190 200
IADNVKDWSK VVLAYEPVWA IGTGKTATPQ QAQEVHEKLR GWLKSNVSDA
210 220 230 240
VAQSARIIYG GSVTGATCKE LASQPDVDGF LVGGASLKPE FVDIINAKQ
Length:249
Mass (Da):26,690
Last modified:January 23, 2007 - v3
Checksum:i8349A3A2AAC92D30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021064 mRNA Translation: AAX09081.1
BC102903 mRNA Translation: AAI02904.1
RefSeqiNP_001013607.1, NM_001013589.3
UniGeneiBt.3487

Genome annotation databases

EnsembliENSBTAT00000026358; ENSBTAP00000026358; ENSBTAG00000019782
GeneIDi281543
KEGGibta:281543

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021064 mRNA Translation: AAX09081.1
BC102903 mRNA Translation: AAI02904.1
RefSeqiNP_001013607.1, NM_001013589.3
UniGeneiBt.3487

3D structure databases

ProteinModelPortaliQ5E956
SMRiQ5E956
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5E956, 1 interactor
STRINGi9913.ENSBTAP00000026358

Protein family/group databases

Allergomei11905 Bos d TPI

Proteomic databases

PaxDbiQ5E956
PeptideAtlasiQ5E956
PRIDEiQ5E956

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000026358; ENSBTAP00000026358; ENSBTAG00000019782
GeneIDi281543
KEGGibta:281543

Organism-specific databases

CTDi7167
VGNCiVGNC:36250 TPI1

Phylogenomic databases

eggNOGiKOG1643 Eukaryota
COG0149 LUCA
GeneTreeiENSGT00390000013354
HOGENOMiHOG000226413
HOVERGENiHBG002599
InParanoidiQ5E956
KOiK01803
OMAiLCVGEGL
OrthoDBiEOG091G0LEZ
TreeFamiTF300829

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00189

UPA00138

ReactomeiR-BTA-70171 Glycolysis
R-BTA-70263 Gluconeogenesis

Gene expression databases

BgeeiENSBTAG00000019782 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_B TIM_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR022896 TrioseP_Isoase_bac/euk
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
TIGRFAMsiTIGR00419 tim, 1 hit
PROSITEiView protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPIS_BOVIN
AccessioniPrimary (citable) accession number: Q5E956
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 109 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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