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Protein

Thioredoxin domain-containing protein 12

Gene

TXNDC12

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Possesses significant protein thiol-disulfide oxidase activity.By similarity

Catalytic activityi

2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 12 (EC:1.8.4.2)
Gene namesi
Name:TXNDC12
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:36535 TXNDC12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000023397427 – 172Thioredoxin domain-containing protein 12Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi66 ↔ 69Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ5E936
PeptideAtlasiQ5E936
PRIDEiQ5E936

Expressioni

Gene expression databases

BgeeiENSBTAG00000011024

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014645

Structurei

3D structure databases

ProteinModelPortaliQ5E936
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi169 – 172Prevents secretion from ERSequence analysis4

Keywords - Domaini

Redox-active center, Signal

Phylogenomic databases

eggNOGiENOG410IWGE Eukaryota
ENOG4111X7E LUCA
GeneTreeiENSGT00530000063273
HOGENOMiHOG000231100
HOVERGENiHBG107174
InParanoidiQ5E936
KOiK05360
OMAiGNPNYKY
OrthoDBiEOG091G0RHV
TreeFamiTF321449

Family and domain databases

CDDicd02959 ERp19, 1 hit
InterProiView protein in InterPro
IPR037462 ERp19
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5E936-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELRPRLGAT CLLGFSFLLL VTSSHGPNGL GKGFGDHIHW RTLEDGKKEA
60 70 80 90 100
AASGLPLMVI IHKSWCGACK ALKPKFAEST EISELSHNFV MVNLEDEEEP
110 120 130 140 150
KDEDFSPDGG YIPRILFLDP SGKVRPEIIN ENGNPSYKYF YISAEQVVQG
160 170
MKEAQERLTG DAFREKHLED EL
Length:172
Mass (Da):19,222
Last modified:March 15, 2005 - v1
Checksum:iBE0614789E51D437
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021084 mRNA Translation: AAX09101.1
BC102314 mRNA Translation: AAI02315.1
RefSeqiNP_001015536.1, NM_001015536.1
XP_015320857.1, XM_015465371.1
UniGeneiBt.102137

Genome annotation databases

EnsembliENSBTAT00000014645; ENSBTAP00000014645; ENSBTAG00000011024
GeneIDi506991
KEGGibta:506991

Similar proteinsi

Entry informationi

Entry nameiTXD12_BOVIN
AccessioniPrimary (citable) accession number: Q5E936
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 15, 2005
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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