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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Vibrio fischeri (strain ATCC 700601 / ES114)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi: ppGpp biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes ppGpp from GTP.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (gppA)
This subpathway is part of the pathway ppGpp biosynthesis, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ppGpp from GTP, the pathway ppGpp biosynthesis and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciVFIS312309:G1G40-55-MONOMER
UniPathwayiUPA00908; UER00885

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:VF_0054
OrganismiVibrio fischeri (strain ATCC 700601 / ES114)
Taxonomic identifieri312309 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
Proteomesi
  • UP000000537 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001942931 – 497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseAdd BLAST497

Proteomic databases

PRIDEiQ5E8U7

Interactioni

Protein-protein interaction databases

STRINGi312309.VF_0054

Structurei

3D structure databases

ProteinModelPortaliQ5E8U7
SMRiQ5E8U7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9X Bacteria
COG0248 LUCA
HOGENOMiHOG000258672
KOiK01524
OMAiWQICVGA
OrthoDBiPOG091H00D6

Family and domain databases

HAMAPiMF_01550 GppA, 1 hit
InterProiView protein in InterPro
IPR023709 Guo-5TP_3DP_PyrP
IPR003695 Ppx_GppA
IPR030673 PyroPPase_GppA_Ppx
PfamiView protein in Pfam
PF02541 Ppx-GppA, 1 hit
PIRSFiPIRSF001267 Pyrophosphatase_GppA_Ppx, 1 hit

Sequencei

Sequence statusi: Complete.

Q5E8U7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSSTMSPMY AAIDLGSNSF HMLVVRHING SVQTMAKIKR KVRLAAGLNE
60 70 80 90 100
NNTLSHEAMQ RGWDCLSLFA ERLQDIPVEN IRIVGTATLR VASNVDIFLE
110 120 130 140 150
KANQILGHNI NVIEGEEEAR MIYQGVAHTS GGNGRRLVVD IGGASTELII
160 170 180 190 200
GEGFEAQALT SLKMGCVTWL EGYFKDRALT QKNFNAAIAG AKETLAPILQ
210 220 230 240 250
QYTDLGWQTC VGASGTVQAL QEIMLAQGMD EVITLAKLKR LQKQAMQYEH
260 270 280 290 300
LEELDIDGLT LERALVFPSG LSILIAIFEL LNIDSMTLAG GALREGLCYG
310 320 330 340 350
MIDELQHDEV CQRTIKSTQQ RYQLDVDYAQ QVTDLSIQLV QQCGNDWLIE
360 370 380 390 400
PQALPLLTAA TQLHEIGMCI DYKKGGEHSA YLINALDLPG FTRAQKHLLG
410 420 430 440 450
ELLRRYREYF SAMPTQHAVS DISAQRMLRI LRLAIILTHR RDVNLAPTVT
460 470 480 490
LSEKNDVLSL SIDGAWLAAN PLTRSELEIE ADKQTNIGWE LVIDARD
Length:497
Mass (Da):55,115
Last modified:March 15, 2005 - v1
Checksum:i07F0B3258F73AB1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000020 Genomic DNA Translation: AAW84549.1
RefSeqiWP_011260931.1, NC_006840.2
YP_203437.1, NC_006840.2

Genome annotation databases

EnsemblBacteriaiAAW84549; AAW84549; VF_0054
GeneIDi3277951
KEGGivfi:VF_0054
PATRICifig|312309.11.peg.55

Similar proteinsi

Entry informationi

Entry nameiGPPA_VIBF1
AccessioniPrimary (citable) accession number: Q5E8U7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 15, 2005
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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