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Entry version 71 (08 May 2019)
Sequence version 1 (15 Mar 2005)
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Protein
Submitted name:

Hyaluronate lyase

Gene

VF_A0994

Organism
Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyaseImported

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
VFIS312309:G1G40-3748-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
PL8 Polysaccharide Lyase Family 8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Hyaluronate lyaseImported (EC:4.2.2.1Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:VF_A0994Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri312309 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000537 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500425576027 – 802Sequence analysisAdd BLAST776

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
312309.VF_A0994

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini47 – 382Lyase_8_NInterPro annotationAdd BLAST336
Domaini425 – 674Lyase_8InterPro annotationAdd BLAST250
Domaini689 – 756Lyase_8_CInterPro annotationAdd BLAST68

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4106AM8 Bacteria
ENOG410XTFC LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000073296

KEGG Orthology (KO)

More...
KOi
K01727

Identification of Orthologs from Complete Genome Data

More...
OMAi
RYYQDET

Database of Orthologous Groups

More...
OrthoDBi
941406at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.50.10.100, 1 hit
2.60.220.10, 1 hit
2.70.98.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008929 Chondroitin_lyas
IPR011013 Gal_mutarotase_sf_dom
IPR014718 GH-type_carb-bd
IPR038970 Lyase_8
IPR011071 Lyase_8-like_C
IPR012970 Lyase_8_alpha_N
IPR004103 Lyase_8_C
IPR003159 Lyase_8_central_dom

The PANTHER Classification System

More...
PANTHERi
PTHR38481 PTHR38481, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02278 Lyase_8, 1 hit
PF02884 Lyase_8_C, 1 hit
PF08124 Lyase_8_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48230 SSF48230, 1 hit
SSF49863 SSF49863, 1 hit
SSF74650 SSF74650, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5DYT2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYMIKKHRLN TIALSMLFLF TGNAYAAKNT QTPQYLPSDF EQVRENWAEN
60 70 80 90 100
YLGDPAITFD QTLKNMVTST NSSAQKHWDS MTPQPNASGI WDDLPLIDKD
110 120 130 140 150
TTLGPNIRNS YQRLFTMAKA YRLRDGNLEN NQLMLNDIMT AMNYINQNFY
160 170 180 190 200
FVNQLEYGNW WQWELAIPKD IHNILVLLFD DIKDNYQTII TNHLNATRYF
210 220 230 240 250
TPDPTHLGVS PGAAESTNPN YRESTGGNRT DNAQVVLIRG MLENNSEEIS
260 270 280 290 300
QAIAALPAVI EYVSEGDGYY TDGSFLQHSD IAYNGTYGNV LLGGLGIQMN
310 320 330 340 350
AVAGSPWSMD NQTISNVYNI INQSYEPLLY KGAMMDMVNG RSISRSAEQN
360 370 380 390 400
HDVGLNIVNS MLFYTNGPDS DKNKQLSSLI KTQITDDTYQ NFFDKIYYVS
410 420 430 440 450
TYQAAQHIVN DPTVSLKDPL IGNFSYPSMD RIVHRRTDWA FALAMHSYRI
460 470 480 490 500
GNYECMNGEN LKGWFTGDGM IYLYNDQLDH YTGYWPTVNA SRMPGTTVDS
510 520 530 540 550
QIMADCSGER VGGNVNTNMQ WVGSTSLNNY GIAGMQFYNW SDTLSAYKSW
560 570 580 590 600
FMFDNEVVML GSNIKDQSNA NNITTIENRK RLAETKLFID GTEQAALPYQ
610 620 630 640 650
GAPATFSIRN KTLANSDLSY VMLTPKTISI SQNDVDGNWS DIGNSKGDVS
660 670 680 690 700
DSYLQATLTQ VDQADYQYAL LPNQNNDTVQ NYAQHPDVTV LRQDEQAHAV
710 720 730 740 750
QENTLNIIAA NNWKNNPVNI TDTITLNSMM GFMIKEESSN TFTVAVSEPI
760 770 780 790 800
QTIDSVNFTF DKQGIVIKED IENRVVLNGT TLTINTSGLQ GQSYSFQVTI

QD
Length:802
Mass (Da):90,247
Last modified:March 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3B106E95DD227131
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CP000021 Genomic DNA Translation: AAW88064.1

NCBI Reference Sequences

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RefSeqi
WP_011263809.1, NC_006841.2
YP_206952.1, NC_006841.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAW88064; AAW88064; VF_A0994

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3280720

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vfi:VF_A0994

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|312309.11.peg.3594

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000021 Genomic DNA Translation: AAW88064.1
RefSeqiWP_011263809.1, NC_006841.2
YP_206952.1, NC_006841.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi312309.VF_A0994

Protein family/group databases

CAZyiPL8 Polysaccharide Lyase Family 8

Genome annotation databases

EnsemblBacteriaiAAW88064; AAW88064; VF_A0994
GeneIDi3280720
KEGGivfi:VF_A0994
PATRICifig|312309.11.peg.3594

Phylogenomic databases

eggNOGiENOG4106AM8 Bacteria
ENOG410XTFC LUCA
HOGENOMiHOG000073296
KOiK01727
OMAiRYYQDET
OrthoDBi941406at2

Enzyme and pathway databases

BioCyciVFIS312309:G1G40-3748-MONOMER

Family and domain databases

Gene3Di1.50.10.100, 1 hit
2.60.220.10, 1 hit
2.70.98.10, 1 hit
InterProiView protein in InterPro
IPR008929 Chondroitin_lyas
IPR011013 Gal_mutarotase_sf_dom
IPR014718 GH-type_carb-bd
IPR038970 Lyase_8
IPR011071 Lyase_8-like_C
IPR012970 Lyase_8_alpha_N
IPR004103 Lyase_8_C
IPR003159 Lyase_8_central_dom
PANTHERiPTHR38481 PTHR38481, 1 hit
PfamiView protein in Pfam
PF02278 Lyase_8, 1 hit
PF02884 Lyase_8_C, 1 hit
PF08124 Lyase_8_N, 1 hit
SUPFAMiSSF48230 SSF48230, 1 hit
SSF49863 SSF49863, 1 hit
SSF74650 SSF74650, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5DYT2_ALIF1
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5DYT2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 8, 2019
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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