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Entry version 93 (18 Sep 2019)
Sequence version 2 (24 Jul 2013)
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Protein

X-linked retinitis pigmentosa GTPase regulator homolog

Gene

glo-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Could be a guanine-nucleotide releasing factor for glo-1 (PubMed:15843430). May play a role in gut granule biogenesis (PubMed:15843430). Regulates axon termination in PLM and ALM neurons (PubMed:21968191).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
X-linked retinitis pigmentosa GTPase regulator homolog
Alternative name(s):
Gut granule loss protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:glo-4
ORF Names:F07C3.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
F07C3.4 ; CE47730 ; WBGene00017195 ; glo-4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Worms exhibit lack of intestinal gut granules.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002066401 – 1386X-linked retinitis pigmentosa GTPase regulator homologAdd BLAST1386

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5DX34

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5DX34

PeptideAtlas

More...
PeptideAtlasi
Q5DX34

PRoteomics IDEntifications database

More...
PRIDEi
Q5DX34

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00017195 Expressed in 5 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.F07C3.4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati737 – 787RCC1 1Add BLAST51
Repeati788 – 838RCC1 2Add BLAST51
Repeati839 – 891RCC1 3Add BLAST53
Repeati893 – 943RCC1 4Add BLAST51
Repeati1034 – 1085RCC1 5Add BLAST52
Repeati1087 – 1139RCC1 6Add BLAST53

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1426 Eukaryota
COG5184 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000021586

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5DX34

Identification of Orthologs from Complete Genome Data

More...
OMAi
MANHEDV

Database of Orthologous Groups

More...
OrthoDBi
1062377at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00415 RCC1, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00633 RCCNDNSATION

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50985 SSF50985, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00626 RCC1_2, 3 hits
PS50012 RCC1_3, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5DX34-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFFKRSTNSR KTSANSSSDT STSSESLLLP LLNNTKAGAR SQKGSVHRQS
60 70 80 90 100
GKKARRKMME NPYVCSLELD ELSADDSIID YSVFSDDSFL LILLLTSKGD
110 120 130 140 150
VQAYLETSRD TKPRKNVVNI KTACSLNVSP VTVCIGSQAA FAIFGLADGN
160 170 180 190 200
LLVTPIRLLI DVTWGGSSWA TTTVIDLSLP TVDPCLATPT CTKCFVSNFP
210 220 230 240 250
PCTMAVVANK AGNILLVDLH LRKCVSELKA PQSLHQIDIL LDENSIELLV
260 270 280 290 300
TGFTGAQWII PIERSGKGFR EVLTTCVPSD LTVLEPATMQ FFAADSCGVV
310 320 330 340 350
ALDTTESIVE VYNTFHSLAH SSKRTFKVPP ETWMVHAGDN MLFTVSNDNE
360 370 380 390 400
IRSALHFGFM SSRLEYTLVR TSTNWRPLGI VAMPSRPHKL AGIFVVNERG
410 420 430 440 450
LVRVEQSTAL NLTKIASEFF FRLSPLQLNS KSVAQVANAC RIDTAEFQSA
460 470 480 490 500
LIPNLLSTRK NRQLTNKELS QIYSIAKAIN LSMSDLLKAF ENESIGEQLL
510 520 530 540 550
PEVLNTIQTN PAKHDNLMQR VVEMFVKRSL SAEGNMDKIR EYDAELSNFL
560 570 580 590 600
ARHEHLHKGS VDCAKAGMWK CTQTLVRRDV HETKSIDTST EVLLYIIKNR
610 620 630 640 650
LQIWNEANST DRLQIMSLVC HLDWSKLADA DGARVCAILS AWQRDISLPS
660 670 680 690 700
YHEMCLRIAI TNSDRFPRPC QILSLVSSIH ILSEKKISNH ANLPNFLPLA
710 720 730 740 750
GGNNCGATIT EDDRLMIWGN FTNAQQRMEM PQMNAKSKRS DSVTNGAPTL
760 770 780 790 800
PPPAPKPEQH LPRVLEYPGG RPRAIACGAE HILVLSSSGQ LSAWGGNRFG
810 820 830 840 850
QCGVGHSFRI ANLHQVDGDW PAIEKIACGQ FHSAFICSDG SLWTFGWGVW
860 870 880 890 900
GQLGHGGRNN SNQLVPTRVN GLICKVTQIA CGRAHTVVLT DTGRVLVCGS
910 920 930 940 950
GSYGQMGVDD DIKKVFAFTP LPLGPLRVRD IATHYYHSIC ITEDNRVFEW
960 970 980 990 1000
GRNPQELKMR MFVMKKIRSA QLKNTEDPSS PSPSTNGSTP RVNLNLPAEI
1010 1020 1030 1040 1050
PREDLGLREV KHFLDGNIVS VACGLSHSAL ITSEGTLYTW GKGLDYQLGH
1060 1070 1080 1090 1100
GNKNERMEPH QVFEPNGAKW VNVSLGNNHT IASTDDGSVF AWGKNDFGQC
1110 1120 1130 1140 1150
GVLTKKNGNS ADVTKKFFFQ ARDGRRFMPN VDESQFVQKP GLIPDVRVRN
1160 1170 1180 1190 1200
LNEDGNEGVD KEEIVDRLKA SDVNVVQAVS KHLYSPIEGK CNGSIIEDEP
1210 1220 1230 1240 1250
RNGKIQKQNK YDGEDGPLCT TTALVHLIAG DVKRAIRMIE WLKTDSSTCE
1260 1270 1280 1290 1300
KSLMVLSSLV WEVMANHEDV QSREALSAAF RHVPMSDSMR KGKQIAQLWP
1310 1320 1330 1340 1350
AVWNDERVQS SLSIDEKIAM LDGFTSASKP VSCPTIPSSS LEVSSKIRVY
1360 1370 1380
AQCAHAEPAA VGSPPECSTC LDEWTEKVRH TLGTQL
Length:1,386
Mass (Da):152,893
Last modified:July 24, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16C87EDC2151E89B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO081074 Genomic DNA Translation: CCD68933.2

Protein sequence database of the Protein Information Resource

More...
PIRi
T28816
T28817

NCBI Reference Sequences

More...
RefSeqi
NP_505392.3, NM_072991.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F07C3.4.1; F07C3.4.1; WBGene00017195

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
179306

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F07C3.4

UCSC genome browser

More...
UCSCi
F07C3.4 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081074 Genomic DNA Translation: CCD68933.2
PIRiT28816
T28817
RefSeqiNP_505392.3, NM_072991.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.F07C3.4

Proteomic databases

EPDiQ5DX34
PaxDbiQ5DX34
PeptideAtlasiQ5DX34
PRIDEiQ5DX34

Genome annotation databases

EnsemblMetazoaiF07C3.4.1; F07C3.4.1; WBGene00017195
GeneIDi179306
KEGGicel:CELE_F07C3.4
UCSCiF07C3.4 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
179306
WormBaseiF07C3.4 ; CE47730 ; WBGene00017195 ; glo-4

Phylogenomic databases

eggNOGiKOG1426 Eukaryota
COG5184 LUCA
HOGENOMiHOG000021586
InParanoidiQ5DX34
OMAiMANHEDV
OrthoDBi1062377at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q5DX34

Gene expression databases

BgeeiWBGene00017195 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

Gene3Di2.130.10.30, 2 hits
InterProiView protein in InterPro
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
PfamiView protein in Pfam
PF00415 RCC1, 3 hits
PRINTSiPR00633 RCCNDNSATION
SUPFAMiSSF50985 SSF50985, 1 hit
PROSITEiView protein in PROSITE
PS00626 RCC1_2, 3 hits
PS50012 RCC1_3, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPGRH_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5DX34
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: July 24, 2013
Last modified: September 18, 2019
This is version 93 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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