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Protein

Immunoglobulin superfamily member 11

Gene

IGSF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth.2 Publications

Miscellaneous

The last 20 cytoplasmic amino acids are not required for the cell adhesion function.

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processCell adhesion, Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily member 11
Short name:
IgSF11
Alternative name(s):
Brain and testis-specific immunoglobulin superfamily protein
Short name:
Bt-IGSF
V-set and immunoglobulin domain-containing protein 3
Gene namesi
Name:IGSF11
Synonyms:BTIGSF, CXADRL1, VSIG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144847.12
HGNCiHGNC:16669 IGSF11
MIMi608351 gene
neXtProtiNX_Q5DX21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 241ExtracellularSequence analysisAdd BLAST219
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 431CytoplasmicSequence analysisAdd BLAST169

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi152404
OpenTargetsiENSG00000144847
PharmGKBiPA134939253

Polymorphism and mutation databases

BioMutaiIGSF11
DMDMi311033430

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000031737023 – 431Immunoglobulin superfamily member 11Add BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 120PROSITE-ProRule annotation
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi165 ↔ 215PROSITE-ProRule annotation
Modified residuei378Omega-N-methylarginineBy similarity1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation

Proteomic databases

PaxDbiQ5DX21
PeptideAtlasiQ5DX21
PRIDEiQ5DX21
ProteomicsDBi62754
62755 [Q5DX21-2]
62756 [Q5DX21-3]
TopDownProteomicsiQ5DX21-1 [Q5DX21-1]

PTM databases

iPTMnetiQ5DX21
PhosphoSitePlusiQ5DX21

Expressioni

Tissue specificityi

Abundantly expressed in testis and ovary and to a lower extent in brain, kidney and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000144847
CleanExiHS_IGSF11
ExpressionAtlasiQ5DX21 baseline and differential
GenevisibleiQ5DX21 HS

Organism-specific databases

HPAiHPA046377

Interactioni

Protein-protein interaction databases

BioGridi127445, 1 interactor
IntActiQ5DX21, 1 interactor
STRINGi9606.ENSP00000377370

Structurei

3D structure databases

ProteinModelPortaliQ5DX21
SMRiQ5DX21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 136Ig-like V-typeAdd BLAST114
Domaini144 – 234Ig-like C2-typeAdd BLAST91

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJM9 Eukaryota
ENOG410Y8CN LUCA
GeneTreeiENSGT00760000119145
HOGENOMiHOG000111222
HOVERGENiHBG107996
InParanoidiQ5DX21
KOiK06791
OMAiQHTHSYT
OrthoDBiEOG091G05PI
PhylomeDBiQ5DX21
TreeFamiTF330875

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5DX21-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSQRSPLAP LLLLSLHGVA ASLEVSESPG SIQVARGQPA VLPCTFTTSA
60 70 80 90 100
ALINLNVIWM VTPLSNANQP EQVILYQGGQ MFDGAPRFHG RVGFTGTMPA
110 120 130 140 150
TNVSIFINNT QLSDTGTYQC LVNNLPDIGG RNIGVTGLTV LVPPSAPHCQ
160 170 180 190 200
IQGSQDIGSD VILLCSSEEG IPRPTYLWEK LDNTLKLPPT ATQDQVQGTV
210 220 230 240 250
TIRNISALSS GLYQCVASNA IGTSTCLLDL QVISPQPRNI GLIAGAIGTG
260 270 280 290 300
AVIIIFCIAL ILGAFFYWRS KNKEEEEEEI PNEIREDDLP PKCSSAKAFH
310 320 330 340 350
TEISSSDNNT LTSSNAYNSR YWSNNPKVHR NTESVSHFSD LGQSFSFHSG
360 370 380 390 400
NANIPSIYAN GTHLVPGQHK TLVVTANRGS SPQVMSRSNG SVSRKPRPPH
410 420 430
THSYTISHAT LERIGAVPVM VPAQSRAGSL V
Length:431
Mass (Da):46,120
Last modified:November 2, 2010 - v3
Checksum:i724985A1F8DEA8FC
GO
Isoform 2 (identifier: Q5DX21-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MTSQRSPLAPLLLLSLH → MSLVELLLWWNCFSRT

Show »
Length:430
Mass (Da):46,241
Checksum:i3B6A2BA2005943B0
GO
Isoform 3 (identifier: Q5DX21-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MTSQRSPLAPLLLLSLH → MSLVELLLWWNCFSRT
     211-235: GLYQCVASNAIGTSTCLLDLQVISP → A

Note: No experimental confirmation available.
Show »
Length:406
Mass (Da):43,763
Checksum:iC3CF882B958AFCF3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti267Y → H in BAC05139 (PubMed:14702039).Curated1
Sequence conflicti374V → A in BAC05139 (PubMed:14702039).Curated1
Sequence conflicti395K → E in BAD90695 (PubMed:16108831).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03851639P → T2 PublicationsCorresponds to variant dbSNP:rs2903250Ensembl.1
Natural variantiVAR_038517333E → D2 PublicationsCorresponds to variant dbSNP:rs36052974Ensembl.1
Natural variantiVAR_056048388S → N. Corresponds to variant dbSNP:rs34908332Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0309361 – 17MTSQR…LLSLH → MSLVELLLWWNCFSRT in isoform 2 and isoform 3. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_030937211 – 235GLYQC…QVISP → A in isoform 3. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB071618 mRNA Translation: BAD90695.1
AK097667 mRNA Translation: BAC05139.1
AC007023 Genomic DNA No translation available.
AC012032 Genomic DNA No translation available.
AC068984 Genomic DNA No translation available.
AC083800 Genomic DNA No translation available.
BC034411 mRNA Translation: AAH34411.1
AL834256 mRNA Translation: CAD38931.1
CCDSiCCDS2983.1 [Q5DX21-2]
CCDS46891.1 [Q5DX21-1]
RefSeqiNP_001015887.1, NM_001015887.1 [Q5DX21-1]
NP_689751.2, NM_152538.2 [Q5DX21-2]
XP_011510771.1, XM_011512469.1 [Q5DX21-2]
XP_011510772.1, XM_011512470.1 [Q5DX21-2]
XP_011510774.1, XM_011512472.1 [Q5DX21-3]
UniGeneiHs.112873

Genome annotation databases

EnsembliENST00000354673; ENSP00000346700; ENSG00000144847 [Q5DX21-2]
ENST00000393775; ENSP00000377370; ENSG00000144847 [Q5DX21-1]
ENST00000425327; ENSP00000406092; ENSG00000144847 [Q5DX21-2]
ENST00000441144; ENSP00000401240; ENSG00000144847 [Q5DX21-3]
GeneIDi152404
KEGGihsa:152404
UCSCiuc003ebw.5 human [Q5DX21-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIGS11_HUMAN
AccessioniPrimary (citable) accession number: Q5DX21
Secondary accession number(s): C9JZN0
, Q8N4F1, Q8N7T8, Q8NDD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 2, 2010
Last modified: June 20, 2018
This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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