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Entry version 137 (16 Oct 2019)
Sequence version 2 (08 Mar 2011)
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Protein

Histone-lysine N-methyltransferase EHMT1

Gene

Ehmt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Methyltransferase activity is inhibited by BIX-01294. Efficiently inhibited by compound E72, a BIX-01294 derivative in which the diazepane ring and the benzyl are replaced with a 3-dimethylaminopropyl and a 5-aminopentyl group at sites B and C, respectively (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1060Zinc 1By similarity1
Metal bindingi1060Zinc 2By similarity1
Metal bindingi1062Zinc 1By similarity1
Metal bindingi1066Zinc 1By similarity1
Metal bindingi1066Zinc 3By similarity1
Metal bindingi1071Zinc 1By similarity1
Metal bindingi1073Zinc 2By similarity1
Metal bindingi1103Zinc 2By similarity1
Metal bindingi1103Zinc 3By similarity1
Metal bindingi1107Zinc 2By similarity1
Metal bindingi1109Zinc 3By similarity1
Metal bindingi1113Zinc 3By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1153Histone H3K9meBy similarity1
Binding sitei1171S-adenosyl-L-methioninePROSITE-ProRule annotation1
Metal bindingi1201Zinc 4By similarity1
Metal bindingi1254Zinc 4By similarity1
Binding sitei1255S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Metal bindingi1256Zinc 4By similarity1
Metal bindingi1261Zinc 4By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Transferase
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-3214841 PKMTs methylate histone lysines
R-MMU-6804760 Regulation of TP53 Activity through Methylation
R-MMU-8953750 Transcriptional Regulation by E2F6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase EHMT1 (EC:2.1.1.-, EC:2.1.1.43)
Alternative name(s):
Euchromatic histone-lysine N-methyltransferase 1
Short name:
Eu-HMTase1
G9a-like protein 1
Short name:
GLP
Short name:
GLP1
Lysine N-methyltransferase 1D
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ehmt1
Synonyms:Euhmtase1, Glp, Kmt1d
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1924933 Ehmt1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryos die around E9.5. Levels of H3K9me1 and H3K9me2 are drastically reduced.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1153Y → V in LM7; does not prevent methyltransferase activity; when associated with F-1240. 1 Publication1
Mutagenesisi1198 – 1201Missing in LM3; does not form heterodimer with EHMT2 and is defective in mediating both H3K9me and DNA methylation. 1 Publication4
Mutagenesisi1201C → A in LM4; does not prevent methyltransferase activity. 1 Publication1
Mutagenesisi1240Y → F in LM7; does not prevent methyltransferase activity; when associated with V-1153. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004058442 – 1296Histone-lysine N-methyltransferase EHMT1Add BLAST1295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki23Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki23Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki229Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki232Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki315Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki325Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki430Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei433PhosphoserineBy similarity1
Modified residuei481PhosphoserineBy similarity1
Cross-linki559Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki644Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki659Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki729Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1046PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5DW34

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q5DW34

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q5DW34

PeptideAtlas

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PeptideAtlasi
Q5DW34

PRoteomics IDEntifications database

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PRIDEi
Q5DW34

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5DW34

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5DW34

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q5DW34

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000036893 Expressed in 242 organ(s), highest expression level in pes

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q5DW34 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5DW34 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with WIZ. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EHMT1, RING1, RNF2, MBLR, L3MBTL2 and YAF2.

Interacts with MPHOSPH8 (By similarity).

Interacts with CDYL.

Interacts with REST only in the presence of CDYL.

Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2 (By similarity). Heterodimer; heterodimerizes with EHMT2.

Interacts (via ANK repeats) with RELA (when monomethylated at 'Lys-310').

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Prdm16A2A935-32EBI-16080518,EBI-16080455

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
218847, 13 interactors

Database of interacting proteins

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DIPi
DIP-49000N
DIP-59572N

Protein interaction database and analysis system

More...
IntActi
Q5DW34, 10 interactors

Molecular INTeraction database

More...
MINTi
Q5DW34

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000100002

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5DW34

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati735 – 764ANK 1Add BLAST30
Repeati770 – 799ANK 2Add BLAST30
Repeati803 – 832ANK 3Add BLAST30
Repeati836 – 866ANK 4Add BLAST31
Repeati870 – 899ANK 5Add BLAST30
Repeati903 – 932ANK 6Add BLAST30
Repeati936 – 965ANK 7Add BLAST30
Repeati969 – 1002ANK 8Add BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1058 – 1121Pre-SETPROSITE-ProRule annotationAdd BLAST64
Domaini1124 – 1241SETPROSITE-ProRule annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni903 – 905Histone H3K9me bindingBy similarity3
Regioni1134 – 1136S-adenosyl-L-methionine bindingBy similarity3
Regioni1160 – 1179Interaction with histone H3By similarityAdd BLAST20
Regioni1198 – 1199S-adenosyl-L-methionine bindingBy similarity2
Regioni1240 – 1243Interaction with histone H3By similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi440 – 447Poly-Arg8
Compositional biasi1290 – 1293Poly-Ala4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ANK repeats specifically recognize and bind H3K9me1 and H3K9me2 (By similarity). They also specifically recognize and bind RELA subunit of NF-kappa-B, when RELA is monomethylated at 'Lys-310'.By similarity1 Publication
The SET domain mediates interaction with WIZ.By similarity
In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1082 Eukaryota
COG0666 LUCA
COG2940 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156002

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231216

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q5DW34

KEGG Orthology (KO)

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KOi
K11420

Identification of Orthologs from Complete Genome Data

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OMAi
TNGSCEH

Database of Orthologous Groups

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OrthoDBi
753093at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q5DW34

TreeFam database of animal gene trees

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TreeFami
TF106443

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR038035 EHMT1
IPR007728 Pre-SET_dom
IPR001214 SET_dom

The PANTHER Classification System

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PANTHERi
PTHR46307:SF2 PTHR46307:SF2, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF05033 Pre-SET, 1 hit
PF00856 SET, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00248 ANK, 7 hits
SM00468 PreSET, 1 hit
SM00317 SET, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS50867 PRE_SET, 1 hit
PS50280 SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5DW34-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAADAEQAV LAKQETKQDC CMKTELLRED TPMAADEGST EKQEGETPMA
60 70 80 90 100
ADGETNGSCE KSGDPSHLNA PKHTQENTRA SPQEGTNRVS RVAENGVSER
110 120 130 140 150
DTEVGKQNHV TADDFMQTSV IGSNGYFLNK PALQGQPLRT PNILTSSLPG
160 170 180 190 200
HAAKTLPGGA SKCRTLSALP QTPTTAPTVP GEGSADTEDR KPTASGTDVR
210 220 230 240 250
VHRARKTMPK SILGLHAASK DHREVQDHKE PKEDINRNIS ECGRQQLLPT
260 270 280 290 300
FPALHQSLPQ NQCYMATTKS QTACLPFVLA AAVSRKKKRR MGTYSLVPKK
310 320 330 340 350
KTKVLKQRTV IEMFKSITHS TVGAKGEKAL DDSALHVNGE SLEMDSEDED
360 370 380 390 400
SDELEDDEDH GAEQAAAFPT EDSRTSKESM SETDRAAKMD GDSEEEQESP
410 420 430 440 450
DTGEDEDGGD ESDLSSESSI KKKFLKRRGK TDSPWIKPAR KRRRRSRKKP
460 470 480 490 500
SSMLGSEACK SSPGSMEQAA LGDSAGYMEV SLDSLDLRVR GILSSQTENE
510 520 530 540 550
GLASGPDVLG TDGLQEVPLC SCRMETPKSR EISTLANNQC MATESVDHEL
560 570 580 590 600
GRCTNSVVKY ELMRPSNKAP LLVLCEDHRG RMVKHQCCPG CGYFCTAGNF
610 620 630 640 650
MECQPESSIS HRFHKDCASR VNNASYCPHC GEEASKAKEV TIAKADTTST
660 670 680 690 700
VTLAPGQEKS LAAEGRADTT TGSIAGAPED ERSQSTAPQA PECFDPAGPA
710 720 730 740 750
GLVRPTSGLS QGPGKETLES ALIALDSEKP KKLRFHPKQL YFSARQGELQ
760 770 780 790 800
KVLLMLVDGI DPNFKMEHQS KRSPLHAAAE AGHVDICHML VQAGANIDTC
810 820 830 840 850
SEDQRTPLME AAENNHLDAV KYLIKAGAQV DPKDAEGSTC LHLAAKKGHY
860 870 880 890 900
DVVQYLLSNG QMDVNCQDDG GWTPMIWATE YKHVELVKLL LSKGSDINIR
910 920 930 940 950
DNEENICLHW AAFSGCVDIA EILLAAKCDL HAVNIHGDSP LHIAARENRY
960 970 980 990 1000
DCVVLFLSRD SDVTLKNKEG ETPLQCASLS SQVWSALQMS KALRDSAPDK
1010 1020 1030 1040 1050
PVAVEKTVSR DIARGYERIP IPCVNAVDSE LCPTNYKYVS QNCVTSPMNI
1060 1070 1080 1090 1100
DRNITHLQYC VCVDDCSSST CMCGQLSMRC WYDKDGRLLP EFNMAEPPLI
1110 1120 1130 1140 1150
FECNHACSCW RNCRNRVVQN GLRARLQLYR TQDMGWGVRS LQDIPLGTFV
1160 1170 1180 1190 1200
CEYVGELISD SEADVREEDS YLFDLDNKDG EVYCIDARFY GNVSRFINHH
1210 1220 1230 1240 1250
CEPNLVPVRV FMSHQDLRFP RIAFFSTRLI QAGEQLGFDY GERFWDVKGK
1260 1270 1280 1290
LFSCRCGSSK CRHSSAALAQ RQASAAQEPQ ENGLPDTSSA AAADPL
Length:1,296
Mass (Da):141,999
Last modified:March 8, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB7783B6F38D3C7CB
GO
Isoform 2 (identifier: Q5DW34-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     273-279: Missing.
     455-500: Missing.

Note: No experimental confirmation available.
Show »
Length:1,243
Mass (Da):136,496
Checksum:iAB666EE7F3CE9EC3
GO
Isoform 3 (identifier: Q5DW34-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     550-597: Missing.

Note: No experimental confirmation available.
Show »
Length:1,248
Mass (Da):136,631
Checksum:i6D881B82F181F36E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0H2UH19A0A0H2UH19_MOUSE
Histone-lysine N-methyltransferase ...
Ehmt1
1,289Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q5A3E9Q5A3_MOUSE
Histone-lysine N-methyltransferase ...
Ehmt1
1,248Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Z4YJZ7Z4YJZ7_MOUSE
Histone-lysine N-methyltransferase ...
Ehmt1
1,288Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YWA0A0A0A6YWA0_MOUSE
Histone-lysine N-methyltransferase ...
Ehmt1
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AIS5A2AIS5_MOUSE
Histone-lysine N-methyltransferase ...
Ehmt1
362Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6WWY8F6WWY8_MOUSE
Histone-lysine N-methyltransferase ...
Ehmt1
224Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JFI9A0A0G2JFI9_MOUSE
Histone-lysine N-methyltransferase ...
Ehmt1
254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LII4A0A140LII4_MOUSE
Histone-lysine N-methyltransferase ...
Ehmt1
232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GXE2A0A1B0GXE2_MOUSE
Histone-lysine N-methyltransferase ...
Ehmt1
286Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YXD1A0A0A6YXD1_MOUSE
Histone-lysine N-methyltransferase ...
Ehmt1
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAM22112 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti411E → D in BAD90007 (PubMed:15774718).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040724273 – 279Missing in isoform 2. 1 Publication7
Alternative sequenceiVSP_040725455 – 500Missing in isoform 2. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_040726550 – 597Missing in isoform 3. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB205007 mRNA Translation: BAD90007.1
AL732525 Genomic DNA Translation: CAM22112.1 Different initiation.
AL732525 Genomic DNA Translation: CAM22113.1
AL732525 Genomic DNA Translation: CAM22114.1
BC056938 mRNA Translation: AAH56938.1
BC089302 mRNA Translation: AAH89302.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS15740.1 [Q5DW34-1]
CCDS59634.1 [Q5DW34-2]
CCDS59636.1 [Q5DW34-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001012536.2, NM_001012518.3 [Q5DW34-1]
NP_001103156.1, NM_001109686.2 [Q5DW34-2]
NP_001103157.1, NM_001109687.2 [Q5DW34-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000046227; ENSMUSP00000046077; ENSMUSG00000036893 [Q5DW34-3]
ENSMUST00000114432; ENSMUSP00000110075; ENSMUSG00000036893 [Q5DW34-2]
ENSMUST00000147147; ENSMUSP00000119057; ENSMUSG00000036893 [Q5DW34-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
77683

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:77683

UCSC genome browser

More...
UCSCi
uc008iph.4 mouse [Q5DW34-3]
uc008ipi.4 mouse [Q5DW34-1]
uc012brr.3 mouse [Q5DW34-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB205007 mRNA Translation: BAD90007.1
AL732525 Genomic DNA Translation: CAM22112.1 Different initiation.
AL732525 Genomic DNA Translation: CAM22113.1
AL732525 Genomic DNA Translation: CAM22114.1
BC056938 mRNA Translation: AAH56938.1
BC089302 mRNA Translation: AAH89302.1
CCDSiCCDS15740.1 [Q5DW34-1]
CCDS59634.1 [Q5DW34-2]
CCDS59636.1 [Q5DW34-3]
RefSeqiNP_001012536.2, NM_001012518.3 [Q5DW34-1]
NP_001103156.1, NM_001109686.2 [Q5DW34-2]
NP_001103157.1, NM_001109687.2 [Q5DW34-3]

3D structure databases

SMRiQ5DW34
ModBaseiSearch...

Protein-protein interaction databases

BioGridi218847, 13 interactors
DIPiDIP-49000N
DIP-59572N
IntActiQ5DW34, 10 interactors
MINTiQ5DW34
STRINGi10090.ENSMUSP00000100002

PTM databases

iPTMnetiQ5DW34
PhosphoSitePlusiQ5DW34
SwissPalmiQ5DW34

Proteomic databases

EPDiQ5DW34
jPOSTiQ5DW34
PaxDbiQ5DW34
PeptideAtlasiQ5DW34
PRIDEiQ5DW34

Genome annotation databases

EnsembliENSMUST00000046227; ENSMUSP00000046077; ENSMUSG00000036893 [Q5DW34-3]
ENSMUST00000114432; ENSMUSP00000110075; ENSMUSG00000036893 [Q5DW34-2]
ENSMUST00000147147; ENSMUSP00000119057; ENSMUSG00000036893 [Q5DW34-1]
GeneIDi77683
KEGGimmu:77683
UCSCiuc008iph.4 mouse [Q5DW34-3]
uc008ipi.4 mouse [Q5DW34-1]
uc012brr.3 mouse [Q5DW34-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79813
MGIiMGI:1924933 Ehmt1

Phylogenomic databases

eggNOGiKOG1082 Eukaryota
COG0666 LUCA
COG2940 LUCA
GeneTreeiENSGT00940000156002
HOGENOMiHOG000231216
InParanoidiQ5DW34
KOiK11420
OMAiTNGSCEH
OrthoDBi753093at2759
PhylomeDBiQ5DW34
TreeFamiTF106443

Enzyme and pathway databases

ReactomeiR-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-3214841 PKMTs methylate histone lysines
R-MMU-6804760 Regulation of TP53 Activity through Methylation
R-MMU-8953750 Transcriptional Regulation by E2F6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ehmt1 mouse

Protein Ontology

More...
PROi
PR:Q5DW34

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000036893 Expressed in 242 organ(s), highest expression level in pes
ExpressionAtlasiQ5DW34 baseline and differential
GenevisibleiQ5DW34 MM

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR038035 EHMT1
IPR007728 Pre-SET_dom
IPR001214 SET_dom
PANTHERiPTHR46307:SF2 PTHR46307:SF2, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF05033 Pre-SET, 1 hit
PF00856 SET, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 7 hits
SM00468 PreSET, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS50867 PRE_SET, 1 hit
PS50280 SET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEHMT1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5DW34
Secondary accession number(s): A2AIS3
, A2AIS4, Q5EBR1, Q6PGM0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: October 16, 2019
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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