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UniProtKB - Q5DU58 (Q5DU58_MOUSE)

Entry version 80 (10 Feb 2021)
Sequence version 1 (29 Mar 2005)
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Protein
Submitted name:

MFLJ00285 protein

Gene

Pkd1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MFLJ00285 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pkd1Imported
Synonyms:mFLJ00285Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:97603, Pkd1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5DU58, MM

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini72 – 151PKDInterPro annotationAdd BLAST80
Domaini149 – 237PKDInterPro annotationAdd BLAST89
Domaini258 – 315PKDInterPro annotationAdd BLAST58
Domaini340 – 405PKDInterPro annotationAdd BLAST66
Domaini431 – 491PKDInterPro annotationAdd BLAST61
Domaini509 – 573PKDInterPro annotationAdd BLAST65
Domaini595 – 650PKDInterPro annotationAdd BLAST56
Domaini744 – 830PKDInterPro annotationAdd BLAST87

Keywords - Domaini

TransmembraneARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		1276906at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013783, Ig-like_fold
IPR022409, PKD/Chitinase_dom
IPR000601, PKD_dom
IPR035986, PKD_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00801, PKD, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00089, PKD, 9 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49299, SSF49299, 8 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50093, PKD, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q5DU58-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
YTRVLPSSSS RTLLQLWLTA SNHVSNITVN YNVTVERMNK MHGLWVSAVP 
        60         70         80         90        100
TVLPPNATLA LTGGVLVDSA VEVAFLWNFG DGEQVLRQFK PPYDESFQVP 
       110        120        130        140        150
DPTVAQVLVE HNTTHIYTTP GEYNLTVLVS NTYENLTQQV TVSVRTVLPN 
       160        170        180        190        200
VAIGMSSNVL VAGQPITFSP YPLPSTDGVL YTWDFGDGSP VLIQSQPVLN 
       210        220        230        240        250
HTYSMTGTYR ITLEVNNTVS SVTAHADIRV FQELHGLTVY LSPSVEQGAP 
       260        270        280        290        300
MVVSASVESG DNITWTFDMG DGTVFTGPEA TVQHVYLRAQ NFTVTVEAAN 
       310        320        330        340        350
PAGHLSQSLH VQVFVLEVLR IEPSTCIPTQ PSAQLMAHVT GDPVHYLFDW 
       360        370        380        390        400
TFGDGSSNVT VHGHPSVTHN FTRSGIFPLA LVLSSHVNKA HYFTSICVEP 
       410        420        430        440        450
EIRNITLQPE RQFVKLGDEA RLVAYSWPPF PYRYTWDFGT EDTTHTQTGG 
       460        470        480        490        500
SEVKFIYREP GSYLVIVTVS NNISSTNDSA FVEVQEPVLV TGIRINGSHV 
       510        520        530        540        550
LELQQPYLLS AMGSGSPATY LWELGDGSQS EGPEVTHIYS STGDFTVRVS 
       560        570        580        590        600
GWNEVSRSEA QLNITVKQRV RGLTINASRT VVPLNGSVSF STLLEVGSDV 
       610        620        630        640        650
HYSWVLCDRC TPIPGGPTIS YTFRSVGTFN IIVTAENEVG SAQDSIFIYV 
       660        670        680        690        700
LQFIEGLQVA GGDNGCCFPT NYTLQLQAAV RDGTNISYSW TAQQEGSLIT 
       710        720        730        740        750
LFGSGKCFSL TALKASTYYV HLRATNMLGS AAANRTIDFV EPVESLILSA 
       760        770        780        790        800
SPNPAAVNMS LTLCAELAGG SGVVYTWYLE EGLSWKTSMP STTHTFATPG 
       810        820        830 
LHLVRVTAEN QLGSVNATVE VAIQVPVGGL SIRTSEQQ
Length:838
Mass (Da):91,025
Last modified:March 29, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i568BCA90C613D5AA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei838Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK220312 mRNA Translation: BAD90231.1

NCBI Reference Sequences

More...RefSeqi		NP_038658.2, NM_013630.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		18763

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:18763

UCSC genome browser

More...UCSCi		uc012amm.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220312 mRNA Translation: BAD90231.1
RefSeqiNP_038658.2, NM_013630.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

GeneIDi18763
KEGGimmu:18763
UCSCiuc012amm.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5310
MGIiMGI:97603, Pkd1

Phylogenomic databases

OrthoDBi1276906at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		18763, 0 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Pkd1, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

GenevisibleiQ5DU58, MM

Family and domain databases

Gene3Di2.60.40.10, 8 hits
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR022409, PKD/Chitinase_dom
IPR000601, PKD_dom
IPR035986, PKD_dom_sf
PfamiView protein in Pfam
PF00801, PKD, 9 hits
SMARTiView protein in SMART
SM00089, PKD, 9 hits
SUPFAMiSSF49299, SSF49299, 8 hits
PROSITEiView protein in PROSITE
PS50093, PKD, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5DU58_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5DU58
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 29, 2005
Last sequence update: March 29, 2005
Last modified: February 10, 2021
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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