Protein NLRC3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: UniProtKB-KW
• phosphatidylinositol 3-kinase regulatory subunit binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.6

    "NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer."
    Karki R., Man S.M., Malireddi R.K., Kesavardhana S., Zhu Q., Burton A.R., Sharma B.R., Qi X., Pelletier S., Vogel P., Rosenstiel P., Kanneganti T.D.
    Nature 540:583-587(2016) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH PIK3R1/PIK3R2, DISRUPTION PHENOTYPE.

GO - Biological processⁱ

• I-kappaB kinase/NF-kappaB signaling Source: UniProtKB <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function."
    Conti B.J., Davis B.K., Zhang J., O'Connor W. Jr., Williams K.L., Ting J.P.-Y.
    J. Biol. Chem. 280:18375-18385(2005) [PubMed] [Europe PMC] [Abstract]
• intracellular signal transduction Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cytokine production involved in inflammatory response Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.5

    "NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING."
    Zhang L., Mo J., Swanson K.V., Wen H., Petrucelli A., Gregory S.M., Zhang Z., Schneider M., Jiang Y., Fitzgerald K.A., Ouyang S., Liu Z.J., Damania B., Shu H.B., Duncan J.A., Ting J.P.
    Immunity 40:329-341(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH TBK1 AND TMEM173, DISRUPTION PHENOTYPE.
• negative regulation of epithelial cell proliferation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.6

    "NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer."
    Karki R., Man S.M., Malireddi R.K., Kesavardhana S., Zhu Q., Burton A.R., Sharma B.R., Qi X., Pelletier S., Vogel P., Rosenstiel P., Kanneganti T.D.
    Nature 540:583-587(2016) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH PIK3R1/PIK3R2, DISRUPTION PHENOTYPE.
• negative regulation of fibroblast proliferation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.6

    "NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer."
    Karki R., Man S.M., Malireddi R.K., Kesavardhana S., Zhu Q., Burton A.R., Sharma B.R., Qi X., Pelletier S., Vogel P., Rosenstiel P., Kanneganti T.D.
    Nature 540:583-587(2016) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH PIK3R1/PIK3R2, DISRUPTION PHENOTYPE.
• negative regulation of I-kappaB kinase/NF-kappaB signaling Source: MGIInferred from mutant phenotypeⁱ
  • Ref.4

    "The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-kappaB."
    Schneider M., Zimmermann A.G., Roberts R.A., Zhang L., Swanson K.V., Wen H., Davis B.K., Allen I.C., Holl E.K., Ye Z., Rahman A.H., Conti B.J., Eitas T.K., Koller B.H., Ting J.P.
    Nat. Immunol. 13:823-831(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
• negative regulation of inflammatory response Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.5

    "NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING."
    Zhang L., Mo J., Swanson K.V., Wen H., Petrucelli A., Gregory S.M., Zhang Z., Schneider M., Jiang Y., Fitzgerald K.A., Ouyang S., Liu Z.J., Damania B., Shu H.B., Duncan J.A., Ting J.P.
    Immunity 40:329-341(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH TBK1 AND TMEM173, DISRUPTION PHENOTYPE.
• negative regulation of innate immune response Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.5

    "NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING."
    Zhang L., Mo J., Swanson K.V., Wen H., Petrucelli A., Gregory S.M., Zhang Z., Schneider M., Jiang Y., Fitzgerald K.A., Ouyang S., Liu Z.J., Damania B., Shu H.B., Duncan J.A., Ting J.P.
    Immunity 40:329-341(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH TBK1 AND TMEM173, DISRUPTION PHENOTYPE.
• negative regulation of interferon-alpha production Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.5

    "NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING."
    Zhang L., Mo J., Swanson K.V., Wen H., Petrucelli A., Gregory S.M., Zhang Z., Schneider M., Jiang Y., Fitzgerald K.A., Ouyang S., Liu Z.J., Damania B., Shu H.B., Duncan J.A., Ting J.P.
    Immunity 40:329-341(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH TBK1 AND TMEM173, DISRUPTION PHENOTYPE.
• negative regulation of interferon-beta production Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.5

    "NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING."
    Zhang L., Mo J., Swanson K.V., Wen H., Petrucelli A., Gregory S.M., Zhang Z., Schneider M., Jiang Y., Fitzgerald K.A., Ouyang S., Liu Z.J., Damania B., Shu H.B., Duncan J.A., Ting J.P.
    Immunity 40:329-341(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH TBK1 AND TMEM173, DISRUPTION PHENOTYPE.
• negative regulation of interleukin-12 production Source: CACAOInferred from mutant phenotypeⁱ
  • Ref.4

    "The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-kappaB."
    Schneider M., Zimmermann A.G., Roberts R.A., Zhang L., Swanson K.V., Wen H., Davis B.K., Allen I.C., Holl E.K., Ye Z., Rahman A.H., Conti B.J., Eitas T.K., Koller B.H., Ting J.P.
    Nat. Immunol. 13:823-831(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
• negative regulation of interleukin-1 beta production Source: CACAOInferred from mutant phenotypeⁱ
  • Ref.4

    "The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-kappaB."
    Schneider M., Zimmermann A.G., Roberts R.A., Zhang L., Swanson K.V., Wen H., Davis B.K., Allen I.C., Holl E.K., Ye Z., Rahman A.H., Conti B.J., Eitas T.K., Koller B.H., Ting J.P.
    Nat. Immunol. 13:823-831(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
• negative regulation of interleukin-6 production Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.5

    "NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING."
    Zhang L., Mo J., Swanson K.V., Wen H., Petrucelli A., Gregory S.M., Zhang Z., Schneider M., Jiang Y., Fitzgerald K.A., Ouyang S., Liu Z.J., Damania B., Shu H.B., Duncan J.A., Ting J.P.
    Immunity 40:329-341(2014) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH TBK1 AND TMEM173, DISRUPTION PHENOTYPE.
• negative regulation of NF-kappaB transcription factor activity Source: UniProtKBInferred from sequence or structural similarityⁱ
  • "CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function."
    Conti B.J., Davis B.K., Zhang J., O'Connor W. Jr., Williams K.L., Ting J.P.-Y.
    J. Biol. Chem. 280:18375-18385(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of NIK/NF-kappaB signaling Source: UniProtKB
• negative regulation of NLRP3 inflammasome complex assembly Source: UniProtKB
• negative regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.6

    "NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer."
    Karki R., Man S.M., Malireddi R.K., Kesavardhana S., Zhu Q., Burton A.R., Sharma B.R., Qi X., Pelletier S., Vogel P., Rosenstiel P., Kanneganti T.D.
    Nature 540:583-587(2016) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH PIK3R1/PIK3R2, DISRUPTION PHENOTYPE.
• negative regulation of tumor necrosis factor production Source: CACAOInferred from mutant phenotypeⁱ
  • Ref.4

    "The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-kappaB."
    Schneider M., Zimmermann A.G., Roberts R.A., Zhang L., Swanson K.V., Wen H., Davis B.K., Allen I.C., Holl E.K., Ye Z., Rahman A.H., Conti B.J., Eitas T.K., Koller B.H., Ting J.P.
    Nat. Immunol. 13:823-831(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
• regulation of protein ubiquitination Source: MGIInferred from direct assayⁱ
  • Ref.4

    "The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-kappaB."
    Schneider M., Zimmermann A.G., Roberts R.A., Zhang L., Swanson K.V., Wen H., Davis B.K., Allen I.C., Holl E.K., Ye Z., Rahman A.H., Conti B.J., Eitas T.K., Koller B.H., Ting J.P.
    Nat. Immunol. 13:823-831(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
• response to lipopolysaccharide Source: MGIInferred from mutant phenotypeⁱ
  • Ref.4

    "The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-kappaB."
    Schneider M., Zimmermann A.G., Roberts R.A., Zhang L., Swanson K.V., Wen H., Davis B.K., Allen I.C., Holl E.K., Ye Z., Rahman A.H., Conti B.J., Eitas T.K., Koller B.H., Ting J.P.
    Nat. Immunol. 13:823-831(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
• T cell activation Source: UniProtKBInferred from sequence or structural similarityⁱ
  • "CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function."
    Conti B.J., Davis B.K., Zhang J., O'Connor W. Jr., Williams K.L., Ting J.P.-Y.
    J. Biol. Chem. 280:18375-18385(2005) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• phosphatidylinositol 3-kinase regulatory subunit binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.6

    "NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer."
    Karki R., Man S.M., Malireddi R.K., Kesavardhana S., Zhu Q., Burton A.R., Sharma B.R., Qi X., Pelletier S., Vogel P., Rosenstiel P., Kanneganti T.D.
    Nature 540:583-587(2016) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH PIK3R1/PIK3R2, DISRUPTION PHENOTYPE.

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MRRRYSHDPP GSFRETKVFG FRGEYGCKAL VDLLAGKGSQ LLQVRDKMPD 
        60         70         80         90        100
SPLGSQSNES RIPKHSEALL SRVGNDPELG SPSHRLASLM LVEGLTDLQL 
       110        120        130        140        150
KEHDFTQVEA TRGVWHPARV ITLDRLFLPL SRVSIPPRVS LTIGVAGVGK 
       160        170        180        190        200
TTLVRHFVHC WARGQVGKGF SRVLPLTFRD LNTYEKLSAD RLIQSIFSSI 
       210        220        230        240        250
GEASLVATAP DRVLLVLDGL DECKTPLEFS NTMACSDPKK EIQVDHLITN 
       260        270        280        290        300
IIRGNLFPEI SVWITSRPSA AGQIPGGLVD RMTEIRGLTE EEIKVCLEQM 
       310        320        330        340        350
FPEEQNLLGQ VLSQVQANRA LYLMCTVPAF CRLTGLALGH LYRTRLAVQD 
       360        370        380        390        400
IELPLPQTLC ELYSWYFRMA LGGEGQDKEK VSPRIKQVTQ GARKMVGTLG 
       410        420        430        440        450
RLAFHGLVKK KYVFYEQDMK AFGVDLALLQ NTLCSCLLQR EETLASSVAY 
       460        470        480        490        500
CFIHLSLQEF VAATYYYSAS KRAIFDLFTE SGMSWPRLGF LAHFRCAAQR 
       510        520        530        540        550
ATQAKDGRLD VFLRFLSGLL SPRVNTLLAG SLLSQGEHQS YRDQVAEVLQ 
       560        570        580        590        600
GFLHPDAAVC ARAINVLYCL SELRHTELAC SVEEAMRSGT LAGMTSPSHR 
       610        620        630        640        650
TALAYLLQMS DICSPEADFS LCLSQHVLQS LLPQLLYCQS LRLDNNQFQD 
       660        670        680        690        700
PVMELLGSVL SGKDCRIRKI SLAENQIGNK GAKALARSLL VNRSLITLDL 
       710        720        730        740        750
RSNSIGPPGA KALADALKIN RTLTSLSLQS NVIKDDGVMC VAEALVSNQT 
       760        770        780        790        800
ISMLQLQKNL IGLIGAQQMA DALKQNRSLK ALMFSSNTIG DRGAIALAEA 
       810        820        830        840        850
LKVNQILENL DLQSNSISDM GVTVLMRALC SNQTLSSLNL RENSISPEGA 
       860        870        880        890        900
QALTQALCRN NTLKHLDLTA NLLHDRGAQA IAVAVGENHS LTHLHLQWNF 
       910        920        930        940        950
IQAGAARALG QALQLNRTLT TLDLQENAIG DEGASSVAGA LKVNTTLIAL 
       960        970        980        990       1000
YLQVASIGSQ GAQALGEALT VNRTLEILDL RGNDVGAAGA KALANALKLN 
      1010       1020       1030       1040       1050
SSLRRLNLQE NSLGMDGAIF VASALSENHG LHHINLQGNP IGESAARMIS 
      1060 
EAIKTNAPTC TVEI                                        

        10         20         30         40         50
MQAEPFSTLE QPPWQEGDNI GSPGSVLALY SQLLAANTDS TRKQEVWTDR 
        60         70         80         90        100
ETCLAYSVGS PAEQVKALVD LLAGKGSQLL QVRDKMPDSP LGSQSNESRI 
       110        120        130        140        150
PKHSEALLSR VGNDPELGSP SHRLASLMLV EGLTDLQLKE HDFTQVEATR 
       160        170        180        190        200
GVWHPARVIT LDRLFLPLSR VSIPPRVSLT IGVAGVGKTT LVRHFVHCWA 
       210        220        230        240        250
RGQVGKGFSR VLPLTFRDLN TYEKLSADRL IQSIFSSIGE ASLVATAPDR 
       260        270        280        290        300
VLLVLDGLDE CKTPLEFSNT MACSDPKKEI QVDHLITNII RGNLFPEISV 
       310        320        330        340        350
WITSRPSAAG QIPGGLVDRM TEIRGLTEEE IKVCLEQMFP EEQNLLGQVL 
       360        370        380        390        400
SQVQANRALY LMCTVPAFCR LTGLALGHLY RTRLAVQDIE LPLPQTLCEL 
       410        420        430        440        450
YSWYFRMALG GEGQDKEKVS PRIKQVTQGA RKMVGTLGRL AFHGLVKKKY 
       460        470        480        490        500
VFYEQDMKAF GVDLALLQNT LCSCLLQREE TLASSVAYCF IHLSLQEFVA 
       510        520        530        540        550
ATYYYSASKR AIFDLFTESG MSWPRLGFLA HFRCAAQRAT QAKDGRLDVF 
       560        570        580        590        600
LRFLSGLLSP RVNTLLAGSL LSQGEHQSYR DQVAEVLQGF LHPDAAVCAR 
       610        620        630        640        650
AINVLYCLSE LRHTELACSV EEAMRSGTLA GMTSPSHRTA LAYLLQMSDI 
       660        670        680        690        700
CSPEADFSLC LSQHVLQSLL PQLLYCQSLR WVWGPCRERA KEKEPLEWFL 
       710        720 
ASSHPFPCSL LRLLEFHSWV LSHHSN                           

        10         20         30         40         50
MAGSLAENQI GNKGAKALAR SLLVNRSLIT LDLRSNSIGP PGAKALADAL 
        60         70         80         90        100
KINRTLTSLS LQSNVIKDDG VMCVAEALVS NQTISMLQLQ KNLIGLIGAQ 
       110        120        130        140        150
QMADALKQNR SLKALMFSSN TIGDRGAIAL AEALKVNQIL ENLDLQSNSI 
       160        170        180        190        200
SDMGVTVLMR ALCSNQTLSS LNLRENSISP EGAQALTQAL CRNNTLKHLD 
       210        220        230        240        250
LTANLLHDRG AQAIAVAVGE NHSLTHLHLQ WNFIQAGAAR ALGQALQLNR 
       260        270        280        290        300
TLTTLDLQEN AIGDEGASSV AGALKVNTTL IALYLQVASI GSQGAQALGE 
       310        320        330        340        350
ALTVNRTLEI LDLRGNDVGA AGAKALANAL KLNSSLRRLN LQENSLGMDG 
       360        370        380        390 
AIFVASALSE NHGLHHINLQ GNPIGESAAR MISEAIKTNA PTCTVEI    

        10         20         30         40         50
MAGSLAENQI GNKGAKALAR SLLVNRSLIT LDLRSNSIGP PGAKALADAL 
        60         70         80         90        100
KINRTLTSLS LQSNVIKDDG VMCVAEALVS NQTISMLQLQ KNLIGLIGAQ 
       110        120        130        140        150
QMADALKQNR SLKALMFSSN TIGDRGAIAL AEALKVNQIL ENLDLQSNSI 
       160        170        180        190        200
SDMGVTVLMR ALCSNQTLSS LNLRENSISP EGAQALTQAL CRNNTLKHLD 
       210        220        230        240        250
LTANLLHDRG AQAIAVAVGE NHSLTHLHLQ WNFIQAGAAR ALGQALQLNR 
       260        270        280        290        300
TLTTLDLQEN AIGDEGASSV AGALKVNTTL IALYLQVASI GSQGAQALGE 
       310 
ALTVNRTLEI LE                                          

        10         20         30         40         50
MAPLPRLDNN QFQDPVMELL GSVLSGKDCR IRKISLAENQ IGNKGAKALA 
        60         70         80         90        100
RSLLVNRSLI TLDLRSNSIG PPGAKALADA LKINRTLTSL SLQSNVIKDD 
       110        120        130        140        150
GVMCVAEALV SNQTISMLQL QKNLIGLIGA QQMADALKQN RSLKALMFSS 
       160        170        180        190        200
NTIGDRGAIA LAEALKVNQI LENLDLQSNS ISDMGVTVLM RALCSNQTLS 
       210        220        230 
SLNLMSPQPA RKLHQPRGSP GPHSSSLQEQ HSEALGPDS             

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families