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Entry version 108 (02 Dec 2020)
Sequence version 2 (24 Jul 2007)
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Protein

Protein NLRC3

Gene

Nlrc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negative regulator of the innate immune response. Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (PubMed:22863753, PubMed:24560620). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination (PubMed:22863753). Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (PubMed:27951586). May also affect NOD1- or NOD2-mediated NF-kappa-B activation (By similarity). Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation (By similarity).By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi144 – 151ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein NLRC3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nlrc3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2444070, Nlrc3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype under basal conditions (PubMed:22863753). Mutant mice show an enhanced response to lipopolysaccharide (LPS)-induced endotoxic shock (PubMed:22863753). Herpes simplex virus 1-infected knockout mice exhibit enhanced innate immunity and reduced morbidity and viral load compared to wild-type animals (PubMed:24560620). Mutant mice are hyper-susceptible to colitis-associated colorectal tumorigenesis (PubMed:27951586).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002961881 – 1064Protein NLRC3Add BLAST1064

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5DU56

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5DU56

PRoteomics IDEntifications database

More...
PRIDEi
Q5DU56

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5DU56

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in bone marrow-derived macrophages.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000049871, Expressed in lymph node and 135 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q5DU56, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5DU56, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Directly interacts (via CARD) with TMEM173/STING; this interaction reduces TMEM173 trafficking to the perinuclear region in response to interferon stimulatory DNA.

Also interacts, but to a lesser extent, with TBK1 (PubMed:24560620).

Interacts with TRAF6; this interaction results in decreased TRAF6 'Lys-63'-linked polyubiquitination, but leaves 'Lys-48'-linked chains unchanged, promoting TRAF6 protein degradation (By similarity).

Interacts with PIK3R1/PIK3R2; this interaction disrupts the association between PIK3R1/PIK3R2 and the p110 catalytic subunit PIK3CA/PIK3CB/PIK3CD and reduces PIK3R1/PIK3R2 activation (PubMed:27951586). Weakly interacts with PYCARD/ASC.

Interacts with CASP1 and CASP5 (By similarity).

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000137628

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5DU56, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini138 – 459NACHTPROSITE-ProRule annotationAdd BLAST322
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati338 – 362LRR 1Add BLAST25
Repeati570 – 593LRR 2Add BLAST24
Repeati632 – 662LRR 3Add BLAST31
Repeati664 – 687LRR 4Add BLAST24
Repeati692 – 715LRR 5Add BLAST24
Repeati720 – 743LRR 6Add BLAST24
Repeati748 – 771LRR 7Add BLAST24
Repeati776 – 799LRR 8Add BLAST24
Repeati804 – 827LRR 9Add BLAST24
Repeati832 – 855LRR 10Add BLAST24
Repeati860 – 883LRR 11Add BLAST24
Repeati888 – 911LRR 12Add BLAST24
Repeati916 – 939LRR 13Add BLAST24
Repeati972 – 995LRR 14Add BLAST24
Repeati1000 – 1022LRR 15Add BLAST23
Repeati1028 – 1051LRR 16Add BLAST24

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The leucine-rich repeat domain may reduce the interaction with TMEM173/STING.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NLRP family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4308, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000159861

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017147_4_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q5DU56

Database of Orthologous Groups

More...
OrthoDBi
259987at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5DU56

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.80.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR007111, NACHT_NTPase
IPR041267, NLRP_HD2
IPR041075, NOD2_WH
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13516, LRR_6, 9 hits
PF05729, NACHT, 1 hit
PF17776, NLRC4_HD2, 1 hit
PF17779, NOD2_WH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50837, NACHT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5DU56-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRRYSHDPP GSFRETKVFG FRGEYGCKAL VDLLAGKGSQ LLQVRDKMPD
60 70 80 90 100
SPLGSQSNES RIPKHSEALL SRVGNDPELG SPSHRLASLM LVEGLTDLQL
110 120 130 140 150
KEHDFTQVEA TRGVWHPARV ITLDRLFLPL SRVSIPPRVS LTIGVAGVGK
160 170 180 190 200
TTLVRHFVHC WARGQVGKGF SRVLPLTFRD LNTYEKLSAD RLIQSIFSSI
210 220 230 240 250
GEASLVATAP DRVLLVLDGL DECKTPLEFS NTMACSDPKK EIQVDHLITN
260 270 280 290 300
IIRGNLFPEI SVWITSRPSA AGQIPGGLVD RMTEIRGLTE EEIKVCLEQM
310 320 330 340 350
FPEEQNLLGQ VLSQVQANRA LYLMCTVPAF CRLTGLALGH LYRTRLAVQD
360 370 380 390 400
IELPLPQTLC ELYSWYFRMA LGGEGQDKEK VSPRIKQVTQ GARKMVGTLG
410 420 430 440 450
RLAFHGLVKK KYVFYEQDMK AFGVDLALLQ NTLCSCLLQR EETLASSVAY
460 470 480 490 500
CFIHLSLQEF VAATYYYSAS KRAIFDLFTE SGMSWPRLGF LAHFRCAAQR
510 520 530 540 550
ATQAKDGRLD VFLRFLSGLL SPRVNTLLAG SLLSQGEHQS YRDQVAEVLQ
560 570 580 590 600
GFLHPDAAVC ARAINVLYCL SELRHTELAC SVEEAMRSGT LAGMTSPSHR
610 620 630 640 650
TALAYLLQMS DICSPEADFS LCLSQHVLQS LLPQLLYCQS LRLDNNQFQD
660 670 680 690 700
PVMELLGSVL SGKDCRIRKI SLAENQIGNK GAKALARSLL VNRSLITLDL
710 720 730 740 750
RSNSIGPPGA KALADALKIN RTLTSLSLQS NVIKDDGVMC VAEALVSNQT
760 770 780 790 800
ISMLQLQKNL IGLIGAQQMA DALKQNRSLK ALMFSSNTIG DRGAIALAEA
810 820 830 840 850
LKVNQILENL DLQSNSISDM GVTVLMRALC SNQTLSSLNL RENSISPEGA
860 870 880 890 900
QALTQALCRN NTLKHLDLTA NLLHDRGAQA IAVAVGENHS LTHLHLQWNF
910 920 930 940 950
IQAGAARALG QALQLNRTLT TLDLQENAIG DEGASSVAGA LKVNTTLIAL
960 970 980 990 1000
YLQVASIGSQ GAQALGEALT VNRTLEILDL RGNDVGAAGA KALANALKLN
1010 1020 1030 1040 1050
SSLRRLNLQE NSLGMDGAIF VASALSENHG LHHINLQGNP IGESAARMIS
1060
EAIKTNAPTC TVEI
Length:1,064
Mass (Da):115,993
Last modified:July 24, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00FEB5FEDB6083C0
GO
Isoform 2 (identifier: Q5DU56-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MRRRYSHDPPGSFRETKVFGFRGEYGC → MQAEPFSTLE...YSVGSPAEQV
     643-688: LDNNQFQDPV...NKGAKALARS → WVWGPCRERA...HSWVLSHHSN
     689-1064: Missing.

Show »
Length:726
Mass (Da):80,819
Checksum:i49B0790CAEB64D8C
GO
Isoform 3 (identifier: Q5DU56-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-667: Missing.
     668-670: RKI → MAG

Show »
Length:397
Mass (Da):41,669
Checksum:i19936424DDBB4348
GO
Isoform 4 (identifier: Q5DU56-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-667: Missing.
     668-670: RKI → MAG
     979-979: D → E
     980-1064: Missing.

Show »
Length:312
Mass (Da):32,882
Checksum:iA87126643181743D
GO
Isoform 5 (identifier: Q5DU56-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-636: Missing.
     637-641: YCQSL → MAPLP
     841-875: RENSISPEGAQALTQALCRNNTLKHLDLTANLLHD → MSPQPARKLHQPRGSPGPHSSSLQEQHSEALGPDS
     876-1064: Missing.

Show »
Length:239
Mass (Da):25,538
Checksum:iF63A1D1FCC71C7B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QQ49J3QQ49_MOUSE
Protein NLRC3
Nlrc3
1,102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8VHN0A0A2R8VHN0_MOUSE
Protein NLRC3
Nlrc3
1,199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD90390 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0271391 – 667Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST667
Alternative sequenceiVSP_0271401 – 636Missing in isoform 5. 1 PublicationAdd BLAST636
Alternative sequenceiVSP_0271411 – 27MRRRY…GEYGC → MQAEPFSTLEQPPWQEGDNI GSPGSVLALYSQLLAANTDS TRKQEVWTDRETCLAYSVGS PAEQV in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_027142637 – 641YCQSL → MAPLP in isoform 5. 1 Publication5
Alternative sequenceiVSP_027143643 – 688LDNNQ…ALARS → WVWGPCRERAKEKEPLEWFL ASSHPFPCSLLRLLEFHSWV LSHHSN in isoform 2. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_027144668 – 670RKI → MAG in isoform 3 and isoform 4. 1 Publication3
Alternative sequenceiVSP_027145689 – 1064Missing in isoform 2. 1 PublicationAdd BLAST376
Alternative sequenceiVSP_027146841 – 875RENSI…NLLHD → MSPQPARKLHQPRGSPGPHS SSLQEQHSEALGPDS in isoform 5. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_027147876 – 1064Missing in isoform 5. 1 PublicationAdd BLAST189
Alternative sequenceiVSP_027148979D → E in isoform 4. 1 Publication1
Alternative sequenceiVSP_027149980 – 1064Missing in isoform 4. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK220314 mRNA Translation: BAD90390.1 Different initiation.
AK079766 mRNA Translation: BAC37747.1
AK084199 mRNA Translation: BAC39136.1
AK171971 mRNA Translation: BAE42752.1
BC130223 mRNA Translation: AAI30224.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS70677.1 [Q5DU56-3]

NCBI Reference Sequences

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RefSeqi
NP_780756.1, NM_175547.3 [Q5DU56-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000180200; ENSMUSP00000137325; ENSMUSG00000049871 [Q5DU56-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
268857

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:268857

UCSC genome browser

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UCSCi
uc007xzd.1, mouse [Q5DU56-3]
uc007xze.1, mouse [Q5DU56-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220314 mRNA Translation: BAD90390.1 Different initiation.
AK079766 mRNA Translation: BAC37747.1
AK084199 mRNA Translation: BAC39136.1
AK171971 mRNA Translation: BAE42752.1
BC130223 mRNA Translation: AAI30224.1
CCDSiCCDS70677.1 [Q5DU56-3]
RefSeqiNP_780756.1, NM_175547.3 [Q5DU56-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000137628

PTM databases

PhosphoSitePlusiQ5DU56

Proteomic databases

EPDiQ5DU56
PaxDbiQ5DU56
PRIDEiQ5DU56

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
56241, 46 antibodies

Genome annotation databases

EnsembliENSMUST00000180200; ENSMUSP00000137325; ENSMUSG00000049871 [Q5DU56-3]
GeneIDi268857
KEGGimmu:268857
UCSCiuc007xzd.1, mouse [Q5DU56-3]
uc007xze.1, mouse [Q5DU56-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
197358
MGIiMGI:2444070, Nlrc3

Phylogenomic databases

eggNOGiKOG4308, Eukaryota
GeneTreeiENSGT00940000159861
HOGENOMiCLU_017147_4_1_1
InParanoidiQ5DU56
OrthoDBi259987at2759
PhylomeDBiQ5DU56

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
268857, 0 hits in 17 CRISPR screens

Protein Ontology

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PROi
PR:Q5DU56
RNActiQ5DU56, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000049871, Expressed in lymph node and 135 other tissues
ExpressionAtlasiQ5DU56, baseline and differential
GenevisibleiQ5DU56, MM

Family and domain databases

Gene3Di3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR007111, NACHT_NTPase
IPR041267, NLRP_HD2
IPR041075, NOD2_WH
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF13516, LRR_6, 9 hits
PF05729, NACHT, 1 hit
PF17776, NLRC4_HD2, 1 hit
PF17779, NOD2_WH, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50837, NACHT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNLRC3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5DU56
Secondary accession number(s): A1L3P6
, Q3TAB7, Q8BJF4, Q8BV65
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: December 2, 2020
This is version 108 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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