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Entry version 117 (17 Jun 2020)
Sequence version 2 (15 Jan 2008)
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Protein

Zinc finger FYVE domain-containing protein 26

Gene

Zfyve26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1802 – 1862FYVE-typePROSITE-ProRule annotationAdd BLAST61

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, DNA damage, DNA repair
LigandLipid-binding, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger FYVE domain-containing protein 26
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Zfyve26
Synonyms:Kiaa0321
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1924767 Zfyve26

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003146131 – 2529Zinc finger FYVE domain-containing protein 26Add BLAST2529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei605PhosphoserineBy similarity1
Modified residuei609PhosphoserineBy similarity1
Modified residuei791PhosphoserineBy similarity1
Modified residuei1732PhosphoserineCombined sources1
Modified residuei1754PhosphoserineBy similarity1
Modified residuei1770PhosphoserineCombined sources1
Modified residuei1772PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5DU37

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5DU37

PeptideAtlas

More...
PeptideAtlasi
Q5DU37

PRoteomics IDEntifications database

More...
PRIDEi
Q5DU37

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5DU37

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5DU37

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000066440 Expressed in liver and 267 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5DU37 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5DU37 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AP5Z1, AP5B1, AP5S1 and SPG11.

Interacts with TTC19 and KIF13A (By similarity).

By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q5DU37, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000021547

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5DU37 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5DU37

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili859 – 884Sequence analysisAdd BLAST26
Coiled coili1488 – 1515Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi745 – 773Arg-richAdd BLAST29
Compositional biasi1759 – 1762Poly-Ala4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The FYVE-type zinc finger mediates binding to phosphatidylinositol 3-phosphate and recruitment to the midbody during cytokinesis.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ZFYVE26 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1802 – 1862FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1811 Eukaryota
ENOG410XRV7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00920000149143

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_228199_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5DU37

KEGG Orthology (KO)

More...
KOi
K19027

Identification of Orthologs from Complete Genome Data

More...
OMAi
RAYLTCC

Database of Orthologous Groups

More...
OrthoDBi
1237900at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5DU37

TreeFam database of animal gene trees

More...
TreeFami
TF324517

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028730 ZFYVE26
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR46591 PTHR46591, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01363 FYVE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00064 FYVE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50178 ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5DU37-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSYPFGKEET ATEEELFEFF CECLRRGDWE LAQACVPQLH RGQGEIPQKV
60 70 80 90 100
EDILQALVQC PILLRCGPDI NPQRLAWLWL LVLEKWLAPE KKLLSTAIRR
110 120 130 140 150
KLEFLFLSED LQGDIPETIL KELFETLAQG PAGSIPDRRT PQLSPEAVSV
160 170 180 190 200
LWNLLKQAPR PAQALLELLL EDHHSASLCP SPLQKSLLDL IREALQTLRD
210 220 230 240 250
PASQPPGVAD AVCGALQALC CKAELPESEW RVLCEELLET CRTEDSPLQE
260 270 280 290 300
ERLLGCLLHK AGRNLLSLYG HTYAEKVAER PPKATLSGKD HPDPERAMLA
310 320 330 340 350
LFSTPDPAHA WKMAFFYCLS NNKHFLEQIL VTALTLLKEE DFPSLGYLLD
360 370 380 390 400
REFRPLSHLL VLLGWTHCQS LESAKRLLQT LYRTQDQGHD ELLRDACEGL
410 420 430 440 450
WAHLEVLEWC VQQSSNLIPK RELLCHLHGG DSHSVLYSLH HLTNLPALNE
460 470 480 490 500
EEVLKLLQKE PTKDLQGEHE THDASVPEHL SQCQSLTLYQ GFCAMKYAVY
510 520 530 540 550
ALCVNSHQHS QCQDCRDSAS EDLALVEPGS DSLPSPGASH LFPTYLARCR
560 570 580 590 600
QYLHSIPASL CLEILENIFS LLLITSADLH PEPHLPEDYA EDEDIEGKGP
610 620 630 640 650
LGLRSPSESP QHIAATERRS ERASMGPRNP AHTVPGCPKA EPKDSSPGPH
660 670 680 690 700
KHSFLDLKHF TSGVNGFLAD EFAMGAFLSL LQEQLTEISS HRTPEETKLP
710 720 730 740 750
EDQSCSAARD GLQSRLHRFS KVLSEAQWRY KVVTSNQGSE EQPSRRYRPI
760 770 780 790 800
ATRHSSLRRG RRTRRTRADG RERGSNPSLE GTSSELSTST SEGSLSAVSG
810 820 830 840 850
QVESDSRFQT QPQSSIIPMM FSTPESLLAS CILRGNFAEA HQVVLMFNLK
860 870 880 890 900
SSPIAGELMF VERYQEVIQE LARVEHKIEN QNSDGGNNTI RRTGSGRSTL
910 920 930 940 950
QAIGSAAAAG MVFYSISDVT EKLLSPSEDP IPTLQEDFWI NATPMETTTP
960 970 980 990 1000
LREVLEDLSP PAMAAFDLAC CQCQLWKTCK QLLETAERRL SSSLESRGRR
1010 1020 1030 1040 1050
LDQVVLNPDG MRGFPFVLQQ ISKILSYPLM QTGLAKSETL EERGGGAPRS
1060 1070 1080 1090 1100
SISELLQMCW PSLTEDCVAS HTSLSQQLEQ ALQSLREALA LPESKSTPLS
1110 1120 1130 1140 1150
CLVEQAAQKA PEAEAHPVHI QSQLLQKTLG RQTPAGHRQT DYVGAFFSYC
1160 1170 1180 1190 1200
SSLAAVLLRS LSSDPDHVEV RVGNPFVLLQ QSSSQLVSHL LLERQVPPDR
1210 1220 1230 1240 1250
LAALLAQEHL NLSVPQVIVS CCCEPLTLCL SRQSQQASSL LTHLGMLARE
1260 1270 1280 1290 1300
HASHLLDGLP LSTLGSPRPS ENPSAERKSH SSPKDSLPAF TASALAFLKS
1310 1320 1330 1340 1350
RSKILAMVAC LRTSRGTKVS KPGLSWKELR GRREAPLTAE KVAQECEHLL
1360 1370 1380 1390 1400
EQFPVFEAAL LANWEPLQQA SEPKQSLAAS LCGQANLSTV LLGLHSSLAL
1410 1420 1430 1440 1450
DILTEAFEGA LVARDWPRAL QLIDVYGQDL DDLSIVQDSV LTCAAVCDKE
1460 1470 1480 1490 1500
GWQYLFPVKD ASLRSQLALR FVDKWPLESC LEILAYCVSD MAVQEELKSE
1510 1520 1530 1540 1550
LQRKLMELRV YQKILGLQDP PVWCDWQTLR SCCAEDPSAV MDMMLDSQEY
1560 1570 1580 1590 1600
ELCEEWGRLY PIPREHLVSL HHKHLLHLLE RSEHDKALQL LQRIPDPTMC
1610 1620 1630 1640 1650
LEVTERSLDQ HPSLATSHFL ANYLTSHFYG ELTTDRHREI QALYMGSKVL
1660 1670 1680 1690 1700
LTLPEQHRAS YARLSSSPLL MLEQLLMNMK VDWATTAVQT LHQLLAGQDI
1710 1720 1730 1740 1750
GFTLDEVDSL LSRYAGKALD LPYPLREKRS DSMIHLQEPV HQASDSETLS
1760 1770 1780 1790 1800
RSSSAEFSAA AAPGSALVRS PSPKERAFPQ TQPPVEFVPP ETPPARDQWV
1810 1820 1830 1840 1850
PDETESVCMV CCREHFTMFN RRHHCRRCGR LVCGSCSTKK MVVEGFRENP
1860 1870 1880 1890 1900
TRVCDQCYSY YNKDTPEESP CQSEVPDSAK NESPPYSAVV RVPKATEVEW
1910 1920 1930 1940 1950
ILSLSEEENE LVRSEFYYEQ APSASLCIAI LNLHRDSIAC GHQLIEHCCR
1960 1970 1980 1990 2000
LSRGLTNPEV DAGLLIDIMK QLLFSAKMMF VKAGQSQDLA LCDSYISKVD
2010 2020 2030 2040 2050
VLHLLVAAAY RHVPSLDQIL QPAAVTRLRN QLLEAEYYQL GVEVSTKTGL
2060 2070 2080 2090 2100
DSTGAWHAWG MACLKAGNLT VAREKFTRCL KPPLDLNQLS HGSRLVQDVV
2110 2120 2130 2140 2150
EYLESTVRPL VSLQDDDYFA TLRELEATLR TQSLLLEAIP EGKIMNNTYY
2160 2170 2180 2190 2200
QECLFYLHNY STNLAIISFY MRHNCLREAL LHLLNKESPP EVFIEGIFQP
2210 2220 2230 2240 2250
SYKSGKLHTL ENLLESIDPT LESWGAHLIA ACQHLQKNSY YHILYELQQF
2260 2270 2280 2290 2300
MKDQVRAAMT CIRFFSHKAK SYTELGEKLS WLLKAKDHLK IYLQETSRSS
2310 2320 2330 2340 2350
GRKKATFFRK KMTAADVSRH MNTLQLQMEV TRFLHRCESA GTSQVTTLPL
2360 2370 2380 2390 2400
PTLFGNNHMK MEVACKVMLG GKNVEDGFGI AFRVLQDFQL DAAATYCRAA
2410 2420 2430 2440 2450
RQLVEREKYG EIRQLLKCVS ESGMAAKSDG DTILLNCLEA FKRIPPQELE
2460 2470 2480 2490 2500
GLIQAIHSDD NKVRAYLTCC KLRSAYLIAV KQEHSQAAAL VQQVQQAAKS
2510 2520
SGDSVVQDIC AQWLLTSHSR GAHGSGSRK
Length:2,529
Mass (Da):282,961
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1885B6B0421066FD
GO
Isoform 2 (identifier: Q5DU37-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1201-2529: Missing.

Show »
Length:1,200
Mass (Da):133,659
Checksum:i451848DBC25912DF
GO
Isoform 3 (identifier: Q5DU37-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1714: Missing.
     1715-1730: AGKALDLPYPLREKRS → MLVVEQCFVSSLSLSA
     2368-2370: MLG → RRL
     2371-2529: Missing.

Show »
Length:656
Mass (Da):74,354
Checksum:i9C3C4BCD28BD72EE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P6K6A0A1W2P6K6_MOUSE
Zinc finger FYVE domain-containing ...
Zfyve26
487Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P6J0A0A1W2P6J0_MOUSE
Zinc finger FYVE domain-containing ...
Zfyve26
567Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD90401 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti495M → V in BAE21117 (PubMed:16141072).Curated1
Sequence conflicti1180Q → H in AAI41360 (PubMed:15489334).Curated1
Sequence conflicti2489A → V in AAH06654 (PubMed:15489334).Curated1
Sequence conflicti2525S → C in AAH06654 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0303421 – 1714Missing in isoform 3. 1 PublicationAdd BLAST1714
Alternative sequenceiVSP_0303431201 – 2529Missing in isoform 2. 1 PublicationAdd BLAST1329
Alternative sequenceiVSP_0303441715 – 1730AGKAL…REKRS → MLVVEQCFVSSLSLSA in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_0303452368 – 2370MLG → RRL in isoform 3. 1 Publication3
Alternative sequenceiVSP_0303462371 – 2529Missing in isoform 3. 1 PublicationAdd BLAST159

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK029679 mRNA Translation: BAC26561.1
AK041668 mRNA Translation: BAC31027.1
AK132344 mRNA Translation: BAE21117.1
AK169541 mRNA Translation: BAE41219.1
AK220333 mRNA Translation: BAD90401.1 Different initiation.
BC006654 mRNA Translation: AAH06654.1
BC141359 mRNA Translation: AAI41360.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS36481.1 [Q5DU37-1]

NCBI Reference Sequences

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RefSeqi
NP_001008550.1, NM_001008550.1 [Q5DU37-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000021547; ENSMUSP00000021547; ENSMUSG00000066440 [Q5DU37-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
211978

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:211978

UCSC genome browser

More...
UCSCi
uc007oae.1 mouse [Q5DU37-1]
uc007oaf.1 mouse [Q5DU37-3]
uc007oah.1 mouse [Q5DU37-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029679 mRNA Translation: BAC26561.1
AK041668 mRNA Translation: BAC31027.1
AK132344 mRNA Translation: BAE21117.1
AK169541 mRNA Translation: BAE41219.1
AK220333 mRNA Translation: BAD90401.1 Different initiation.
BC006654 mRNA Translation: AAH06654.1
BC141359 mRNA Translation: AAI41360.1
CCDSiCCDS36481.1 [Q5DU37-1]
RefSeqiNP_001008550.1, NM_001008550.1 [Q5DU37-1]

3D structure databases

SMRiQ5DU37
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ5DU37, 2 interactors
STRINGi10090.ENSMUSP00000021547

PTM databases

iPTMnetiQ5DU37
PhosphoSitePlusiQ5DU37

Proteomic databases

EPDiQ5DU37
PaxDbiQ5DU37
PeptideAtlasiQ5DU37
PRIDEiQ5DU37

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
24903 69 antibodies

Genome annotation databases

EnsembliENSMUST00000021547; ENSMUSP00000021547; ENSMUSG00000066440 [Q5DU37-1]
GeneIDi211978
KEGGimmu:211978
UCSCiuc007oae.1 mouse [Q5DU37-1]
uc007oaf.1 mouse [Q5DU37-3]
uc007oah.1 mouse [Q5DU37-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23503
MGIiMGI:1924767 Zfyve26

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG1811 Eukaryota
ENOG410XRV7 LUCA
GeneTreeiENSGT00920000149143
HOGENOMiCLU_228199_0_0_1
InParanoidiQ5DU37
KOiK19027
OMAiRAYLTCC
OrthoDBi1237900at2759
PhylomeDBiQ5DU37
TreeFamiTF324517

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
211978 1 hit in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Zfyve26 mouse

Protein Ontology

More...
PROi
PR:Q5DU37
RNActiQ5DU37 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000066440 Expressed in liver and 267 other tissues
ExpressionAtlasiQ5DU37 baseline and differential
GenevisibleiQ5DU37 MM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR028730 ZFYVE26
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR46591 PTHR46591, 1 hit
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50178 ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZFY26_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5DU37
Secondary accession number(s): B9EJ71
, Q3TEM9, Q3V1N3, Q8BY74, Q8CDR8, Q923B4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 17, 2020
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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