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Protein

Zinc finger protein 652

Gene

Znf652

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a transcriptional repressor.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 267C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri271 – 293C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 321C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri328 – 350C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 491C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 652
Gene namesi
Name:Znf652
Synonyms:Kiaa0924, Zfp652
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2442221 Zfp652

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804291 – 608Zinc finger protein 652Add BLAST608

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei57PhosphoserineBy similarity1
Modified residuei100PhosphoserineBy similarity1
Modified residuei103PhosphothreonineBy similarity1
Modified residuei196PhosphoserineBy similarity1
Modified residuei203PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5DU09
PRIDEiQ5DU09

PTM databases

iPTMnetiQ5DU09
PhosphoSitePlusiQ5DU09

Expressioni

Gene expression databases

BgeeiENSMUSG00000075595 Expressed in 219 organ(s), highest expression level in skeletal muscle tissue
CleanExiMM_ZFP652
ExpressionAtlasiQ5DU09 baseline and differential
GenevisibleiQ5DU09 MM

Interactioni

Subunit structurei

Interacts with CBFA2T3.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089153

Structurei

3D structure databases

ProteinModelPortaliQ5DU09
SMRiQ5DU09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni497 – 608Mediates interaction with CBFA2T3By similarityAdd BLAST112

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi104 – 108Poly-Glu5
Compositional biasi194 – 200Poly-Ala7
Compositional biasi496 – 574Pro-richAdd BLAST79

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 267C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri271 – 293C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 321C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri328 – 350C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 491C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00440000037877
HOGENOMiHOG000231037
HOVERGENiHBG064823
InParanoidiQ5DU09
OrthoDBiEOG091G055W
PhylomeDBiQ5DU09
TreeFamiTF332655

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5DU09-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSYTASPCPE LVEPCAVHAE GMAQEESHRS QAPPTFYHGA SQELDLSTKV
60 70 80 90 100
YKRESGSPYS VLADTKMSKP HLHETEEQPY FREPRAVSDV HTVKEDRENS
110 120 130 140 150
DDTEEEEEVS YKREQIIVEV NLNNQTLNVS KGEKGVSSQS KETPVLKTSS
160 170 180 190 200
EEDEEETEEE ATDNSSDYGE NGRQKKKEKQ VERVRVTQRR TRRAASAAAA
210 220 230 240 250
TTSPAPRTTR GRRKSAELPK RKKRATKEAK APVQKAKCEE KETLTCEKCP
260 270 280 290 300
RVFNTRWYLE KHMNVTHRRM QICDKCGKKF VLESELSLHQ QTDCEKNIQC
310 320 330 340 350
VSCNKSFKKL WSLHEHIKIV HGYAEKKFAC EICEKKFYTM AHVRKHMVAH
360 370 380 390 400
TKDMPFTCET CGKSFKRSMS LKVHSLQHSG EKPFRCENCD ERFQYKYQLR
410 420 430 440 450
SHMSIHIGHK QFMCQWCGKD FNMKQYFDEH MKTHTGEKPF ICEICGKSFT
460 470 480 490 500
SRPNMKRHRR THTGEKPYPC DVCGQRFRFS NMLKAHKEKC FRVTSPVNVP
510 520 530 540 550
PAVQIPLASA PAAPAPAVAN TPTSPAPAVS MSPVGAVLPS RPVPHPFSHL
560 570 580 590 600
HIHTHPHHAH HLPIPPVPHL PPPPALFKSE PLNHRSQSED TFLRHLAEKN

SAAPAQHH
Length:608
Mass (Da):69,441
Last modified:March 20, 2007 - v2
Checksum:i501DA89A7E92289F
GO
Isoform 2 (identifier: Q5DU09-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-350: CVSCNKSFKK...AHVRKHMVAH → VGLTSGGQSF...CCLGLFKTKA
     351-608: Missing.

Note: No experimental confirmation available.
Show »
Length:350
Mass (Da):40,027
Checksum:i315DC9FA56C4BEE9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z443F2Z443_MOUSE
Zinc finger protein 652
Zfp652
451Annotation score:
F2Z3V9F2Z3V9_MOUSE
Zinc finger protein 652
Zfp652
428Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023669300 – 350CVSCN…HMVAH → VGLTSGGQSFQARTWLFRVI WCLPKRIEAEGTDFTNYHFR LCCLGLFKTKA in isoform 2. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_023670351 – 608Missing in isoform 2. 1 PublicationAdd BLAST258

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220361 mRNA Translation: BAD90422.1
AL593858 Genomic DNA Translation: CAM15507.1
BC055752 mRNA Translation: AAH55752.1
CCDSiCCDS36287.1 [Q5DU09-1]
RefSeqiNP_963903.2, NM_201609.2 [Q5DU09-1]
UniGeneiMm.389038
Mm.418731

Genome annotation databases

EnsembliENSMUST00000091565; ENSMUSP00000089153; ENSMUSG00000075595 [Q5DU09-1]
ENSMUST00000107717; ENSMUSP00000103345; ENSMUSG00000075595 [Q5DU09-1]
GeneIDi268469
KEGGimmu:268469
UCSCiuc007laq.1 mouse [Q5DU09-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220361 mRNA Translation: BAD90422.1
AL593858 Genomic DNA Translation: CAM15507.1
BC055752 mRNA Translation: AAH55752.1
CCDSiCCDS36287.1 [Q5DU09-1]
RefSeqiNP_963903.2, NM_201609.2 [Q5DU09-1]
UniGeneiMm.389038
Mm.418731

3D structure databases

ProteinModelPortaliQ5DU09
SMRiQ5DU09
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089153

PTM databases

iPTMnetiQ5DU09
PhosphoSitePlusiQ5DU09

Proteomic databases

PaxDbiQ5DU09
PRIDEiQ5DU09

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091565; ENSMUSP00000089153; ENSMUSG00000075595 [Q5DU09-1]
ENSMUST00000107717; ENSMUSP00000103345; ENSMUSG00000075595 [Q5DU09-1]
GeneIDi268469
KEGGimmu:268469
UCSCiuc007laq.1 mouse [Q5DU09-1]

Organism-specific databases

CTDi268469
MGIiMGI:2442221 Zfp652
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00440000037877
HOGENOMiHOG000231037
HOVERGENiHBG064823
InParanoidiQ5DU09
OrthoDBiEOG091G055W
PhylomeDBiQ5DU09
TreeFamiTF332655

Miscellaneous databases

ChiTaRSiZfp652 mouse
PROiPR:Q5DU09
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000075595 Expressed in 219 organ(s), highest expression level in skeletal muscle tissue
CleanExiMM_ZFP652
ExpressionAtlasiQ5DU09 baseline and differential
GenevisibleiQ5DU09 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN652_MOUSE
AccessioniPrimary (citable) accession number: Q5DU09
Secondary accession number(s): A2A617, Q7TNT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 7, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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