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UniProtKB - Q5DU09 (ZN652_MOUSE)
Protein
Zinc finger protein 652
Gene
Znf652
Organism
Mus musculus (Mouse)
Status
Functioni
Functions as a transcriptional repressor.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 244 – 267 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 271 – 293 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 298 – 321 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 328 – 350 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 356 – 378 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 384 – 406 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 412 – 434 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 440 – 462 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 468 – 491 | C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 652 |
Gene namesi | Name:Znf652 Synonyms:Kiaa0924, Zfp652 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2442221, Zfp652 |
VEuPathDBi | HostDB:ENSMUSG00000075595 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000280429 | 1 – 608 | Zinc finger protein 652Add BLAST | 608 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 57 | PhosphoserineBy similarity | 1 | |
Modified residuei | 100 | PhosphoserineBy similarity | 1 | |
Modified residuei | 103 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 196 | PhosphoserineBy similarity | 1 | |
Modified residuei | 203 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q5DU09 |
jPOSTi | Q5DU09 |
MaxQBi | Q5DU09 |
PaxDbi | Q5DU09 |
PRIDEi | Q5DU09 |
PTM databases
iPTMneti | Q5DU09 |
PhosphoSitePlusi | Q5DU09 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000075595, Expressed in primary visual cortex and 243 other tissues |
ExpressionAtlasi | Q5DU09, baseline and differential |
Genevisiblei | Q5DU09, MM |
Interactioni
Subunit structurei
Interacts with CBFA2T3.
By similarityProtein-protein interaction databases
BioGRIDi | 234503, 30 interactors |
STRINGi | 10090.ENSMUSP00000103345 |
Miscellaneous databases
RNActi | Q5DU09, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 61 – 232 | DisorderedSequence analysisAdd BLAST | 172 | |
Regioni | 497 – 608 | Mediates interaction with CBFA2T3By similarityAdd BLAST | 112 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 67 – 98 | Basic and acidic residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 117 – 145 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 149 – 165 | Acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 169 – 189 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 194 – 209 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 244 – 267 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 271 – 293 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 298 – 321 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 328 – 350 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 356 – 378 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 384 – 406 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 412 – 434 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 440 – 462 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 468 – 491 | C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000157416 |
HOGENOMi | CLU_002678_74_2_1 |
InParanoidi | Q5DU09 |
OMAi | TEEQPFF |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q5DU09 |
TreeFami | TF332655 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5DU09-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSYTASPCPE LVEPCAVHAE GMAQEESHRS QAPPTFYHGA SQELDLSTKV
60 70 80 90 100
YKRESGSPYS VLADTKMSKP HLHETEEQPY FREPRAVSDV HTVKEDRENS
110 120 130 140 150
DDTEEEEEVS YKREQIIVEV NLNNQTLNVS KGEKGVSSQS KETPVLKTSS
160 170 180 190 200
EEDEEETEEE ATDNSSDYGE NGRQKKKEKQ VERVRVTQRR TRRAASAAAA
210 220 230 240 250
TTSPAPRTTR GRRKSAELPK RKKRATKEAK APVQKAKCEE KETLTCEKCP
260 270 280 290 300
RVFNTRWYLE KHMNVTHRRM QICDKCGKKF VLESELSLHQ QTDCEKNIQC
310 320 330 340 350
VSCNKSFKKL WSLHEHIKIV HGYAEKKFAC EICEKKFYTM AHVRKHMVAH
360 370 380 390 400
TKDMPFTCET CGKSFKRSMS LKVHSLQHSG EKPFRCENCD ERFQYKYQLR
410 420 430 440 450
SHMSIHIGHK QFMCQWCGKD FNMKQYFDEH MKTHTGEKPF ICEICGKSFT
460 470 480 490 500
SRPNMKRHRR THTGEKPYPC DVCGQRFRFS NMLKAHKEKC FRVTSPVNVP
510 520 530 540 550
PAVQIPLASA PAAPAPAVAN TPTSPAPAVS MSPVGAVLPS RPVPHPFSHL
560 570 580 590 600
HIHTHPHHAH HLPIPPVPHL PPPPALFKSE PLNHRSQSED TFLRHLAEKN
SAAPAQHH
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF2Z3V9 | F2Z3V9_MOUSE | Zinc finger protein 652 | Zfp652 | 428 | Annotation score: | ||
F2Z443 | F2Z443_MOUSE | Zinc finger protein 652 | Zfp652 | 451 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023669 | 300 – 350 | CVSCN…HMVAH → VGLTSGGQSFQARTWLFRVI WCLPKRIEAEGTDFTNYHFR LCCLGLFKTKA in isoform 2. 1 PublicationAdd BLAST | 51 | |
Alternative sequenceiVSP_023670 | 351 – 608 | Missing in isoform 2. 1 PublicationAdd BLAST | 258 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK220361 mRNA Translation: BAD90422.1 AL593858 Genomic DNA Translation: CAM15507.1 BC055752 mRNA Translation: AAH55752.1 |
CCDSi | CCDS36287.1 [Q5DU09-1] |
RefSeqi | NP_963903.2, NM_201609.2 [Q5DU09-1] |
Genome annotation databases
Ensembli | ENSMUST00000091565; ENSMUSP00000089153; ENSMUSG00000075595 [Q5DU09-1] ENSMUST00000107717; ENSMUSP00000103345; ENSMUSG00000075595 [Q5DU09-1] |
GeneIDi | 268469 |
KEGGi | mmu:268469 |
UCSCi | uc007laq.1, mouse [Q5DU09-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK220361 mRNA Translation: BAD90422.1 AL593858 Genomic DNA Translation: CAM15507.1 BC055752 mRNA Translation: AAH55752.1 |
CCDSi | CCDS36287.1 [Q5DU09-1] |
RefSeqi | NP_963903.2, NM_201609.2 [Q5DU09-1] |
3D structure databases
SMRi | Q5DU09 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 234503, 30 interactors |
STRINGi | 10090.ENSMUSP00000103345 |
PTM databases
iPTMneti | Q5DU09 |
PhosphoSitePlusi | Q5DU09 |
Proteomic databases
EPDi | Q5DU09 |
jPOSTi | Q5DU09 |
MaxQBi | Q5DU09 |
PaxDbi | Q5DU09 |
PRIDEi | Q5DU09 |
Protocols and materials databases
Antibodypediai | 30374, 70 antibodies from 21 providers |
DNASUi | 268469 |
Genome annotation databases
Ensembli | ENSMUST00000091565; ENSMUSP00000089153; ENSMUSG00000075595 [Q5DU09-1] ENSMUST00000107717; ENSMUSP00000103345; ENSMUSG00000075595 [Q5DU09-1] |
GeneIDi | 268469 |
KEGGi | mmu:268469 |
UCSCi | uc007laq.1, mouse [Q5DU09-1] |
Organism-specific databases
CTDi | 268469 |
MGIi | MGI:2442221, Zfp652 |
VEuPathDBi | HostDB:ENSMUSG00000075595 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000157416 |
HOGENOMi | CLU_002678_74_2_1 |
InParanoidi | Q5DU09 |
OMAi | TEEQPFF |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q5DU09 |
TreeFami | TF332655 |
Miscellaneous databases
BioGRID-ORCSi | 268469, 6 hits in 64 CRISPR screens |
ChiTaRSi | Zfp652, mouse |
PROi | PR:Q5DU09 |
RNActi | Q5DU09, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000075595, Expressed in primary visual cortex and 243 other tissues |
ExpressionAtlasi | Q5DU09, baseline and differential |
Genevisiblei | Q5DU09, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN652_MOUSE | |
Accessioni | Q5DU09Primary (citable) accession number: Q5DU09 Secondary accession number(s): A2A617, Q7TNT4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | March 20, 2007 | |
Last modified: | February 23, 2022 | |
This is version 114 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families