UniProtKB - Q5DU09 (ZN652_MOUSE)

BLAST

>sp|Q5DU09|ZN652_MOUSE Zinc finger protein 652 OS=Mus musculus OX=10090 GN=Znf652 PE=1 SV=2
MSYTASPCPELVEPCAVHAEGMAQEESHRSQAPPTFYHGASQELDLSTKVYKRESGSPYS
VLADTKMSKPHLHETEEQPYFREPRAVSDVHTVKEDRENSDDTEEEEEVSYKREQIIVEV
NLNNQTLNVSKGEKGVSSQSKETPVLKTSSEEDEEETEEEATDNSSDYGENGRQKKKEKQ
VERVRVTQRRTRRAASAAAATTSPAPRTTRGRRKSAELPKRKKRATKEAKAPVQKAKCEE
KETLTCEKCPRVFNTRWYLEKHMNVTHRRMQICDKCGKKFVLESELSLHQQTDCEKNIQC
VSCNKSFKKLWSLHEHIKIVHGYAEKKFACEICEKKFYTMAHVRKHMVAHTKDMPFTCET
CGKSFKRSMSLKVHSLQHSGEKPFRCENCDERFQYKYQLRSHMSIHIGHKQFMCQWCGKD
FNMKQYFDEHMKTHTGEKPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRFS
NMLKAHKEKCFRVTSPVNVPPAVQIPLASAPAAPAPAVANTPTSPAPAVSMSPVGAVLPS
RPVPHPFSHLHIHTHPHHAHHLPIPPVPHLPPPPALFKSEPLNHRSQSEDTFLRHLAEKN
SAAPAQHH

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History
Entry version 99 (07 Nov 2018)
Sequence version 2 (20 Mar 2007)
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Protein

Zinc finger protein 652

Gene

Znf652

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Functions as a transcriptional repressor.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	244 – 267	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	271 – 293	C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	298 – 321	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	328 – 350	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	356 – 378	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	384 – 406	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	412 – 434	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	440 – 462	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	468 – 491	C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 652
Gene namesⁱ	Name:Znf652 Synonyms:Kiaa0924, Zfp652
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:2442221 Zfp652

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000280429	1 – 608	Zinc finger protein 652Add BLAST		608

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	57	PhosphoserineBy similarity	1
Modified residueⁱ	100	PhosphoserineBy similarity	1
Modified residueⁱ	103	PhosphothreonineBy similarity	1
Modified residueⁱ	196	PhosphoserineBy similarity	1
Modified residueⁱ	203	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q5DU09
PRIDEⁱ	Q5DU09

PTM databases

iPTMnetⁱ	Q5DU09
PhosphoSitePlusⁱ	Q5DU09

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000075595 Expressed in 219 organ(s), highest expression level in skeletal muscle tissue
CleanExⁱ	MM_ZFP652
ExpressionAtlasⁱ	Q5DU09 baseline and differential
Genevisibleⁱ	Q5DU09 MM

Interactionⁱ

Subunit structureⁱ

Interacts with CBFA2T3.By similarity

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000089153

STRINGⁱ

10090.ENSMUSP00000089153

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5DU09
SMRⁱ	Q5DU09
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	497 – 608	Mediates interaction with CBFA2T3By similarityAdd BLAST		112

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	104 – 108	Poly-Glu	5
Compositional biasⁱ	194 – 200	Poly-Ala	7
Compositional biasⁱ	496 – 574	Pro-richAdd BLAST	79

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	244 – 267	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	271 – 293	C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	298 – 321	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	328 – 350	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	356 – 378	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	384 – 406	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	412 – 434	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	440 – 462	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	468 – 491	C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000037877
HOGENOMⁱ	HOG000231037
HOVERGENⁱ	HBG064823
InParanoidⁱ	Q5DU09
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G055W
PhylomeDBⁱ	Q5DU09
TreeFamⁱ	TF332655

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 5 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 9 hits
SUPFAMⁱ	SSF57667 SSF57667, 5 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q5DU09-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYTASPCPE LVEPCAVHAE GMAQEESHRS QAPPTFYHGA SQELDLSTKV 
        60         70         80         90        100
YKRESGSPYS VLADTKMSKP HLHETEEQPY FREPRAVSDV HTVKEDRENS 
       110        120        130        140        150
DDTEEEEEVS YKREQIIVEV NLNNQTLNVS KGEKGVSSQS KETPVLKTSS 
       160        170        180        190        200
EEDEEETEEE ATDNSSDYGE NGRQKKKEKQ VERVRVTQRR TRRAASAAAA 
       210        220        230        240        250
TTSPAPRTTR GRRKSAELPK RKKRATKEAK APVQKAKCEE KETLTCEKCP 
       260        270        280        290        300
RVFNTRWYLE KHMNVTHRRM QICDKCGKKF VLESELSLHQ QTDCEKNIQC 
       310        320        330        340        350
VSCNKSFKKL WSLHEHIKIV HGYAEKKFAC EICEKKFYTM AHVRKHMVAH 
       360        370        380        390        400
TKDMPFTCET CGKSFKRSMS LKVHSLQHSG EKPFRCENCD ERFQYKYQLR 
       410        420        430        440        450
SHMSIHIGHK QFMCQWCGKD FNMKQYFDEH MKTHTGEKPF ICEICGKSFT 
       460        470        480        490        500
SRPNMKRHRR THTGEKPYPC DVCGQRFRFS NMLKAHKEKC FRVTSPVNVP 
       510        520        530        540        550
PAVQIPLASA PAAPAPAVAN TPTSPAPAVS MSPVGAVLPS RPVPHPFSHL 
       560        570        580        590        600
HIHTHPHHAH HLPIPPVPHL PPPPALFKSE PLNHRSQSED TFLRHLAEKN 

SAAPAQHH

Length:608

Mass (Da):69,441

Last modified:March 20, 2007 - v2

Checksum:ⁱ501DA89A7E92289F

Isoform 2 (identifier: Q5DU09-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
300-350: CVSCNKSFKK...AHVRKHMVAH → VGLTSGGQSF...CCLGLFKTKA
351-608: Missing.

« Hide

        10         20         30         40         50
MSYTASPCPE LVEPCAVHAE GMAQEESHRS QAPPTFYHGA SQELDLSTKV 
        60         70         80         90        100
YKRESGSPYS VLADTKMSKP HLHETEEQPY FREPRAVSDV HTVKEDRENS 
       110        120        130        140        150
DDTEEEEEVS YKREQIIVEV NLNNQTLNVS KGEKGVSSQS KETPVLKTSS 
       160        170        180        190        200
EEDEEETEEE ATDNSSDYGE NGRQKKKEKQ VERVRVTQRR TRRAASAAAA 
       210        220        230        240        250
TTSPAPRTTR GRRKSAELPK RKKRATKEAK APVQKAKCEE KETLTCEKCP 
       260        270        280        290        300
RVFNTRWYLE KHMNVTHRRM QICDKCGKKF VLESELSLHQ QTDCEKNIQV 
       310        320        330        340        350
GLTSGGQSFQ ARTWLFRVIW CLPKRIEAEG TDFTNYHFRL CCLGLFKTKA

Note: No experimental confirmation available.

Show »

Length:350

Mass (Da):40,027

Checksum:ⁱ315DC9FA56C4BEE9

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F2Z443	F2Z443_MOUSE	Zinc finger protein 652 Zinc finger protein 652	Zfp652	451	Annotation score:
F2Z3V9	F2Z3V9_MOUSE	Zinc finger protein 652 Zinc finger protein 652	Zfp652	428	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_023669	300 – 350	CVSCN…HMVAH → VGLTSGGQSFQARTWLFRVI WCLPKRIEAEGTDFTNYHFR LCCLGLFKTKA in isoform 2. 1 PublicationAdd BLAST		51
Alternative sequenceⁱVSP_023670	351 – 608	Missing in isoform 2. 1 PublicationAdd BLAST		258

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK220361 mRNA Translation: BAD90422.1 AL593858 Genomic DNA Translation: CAM15507.1 BC055752 mRNA Translation: AAH55752.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS36287.1 [Q5DU09-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_963903.2, NM_201609.2 [Q5DU09-1]
UniGeneⁱ	Mm.389038 Mm.418731

Genome annotation databases

Ensemblⁱ	ENSMUST00000091565; ENSMUSP00000089153; ENSMUSG00000075595 [Q5DU09-1] ENSMUST00000107717; ENSMUSP00000103345; ENSMUSG00000075595 [Q5DU09-1]
GeneIDⁱ	268469
KEGGⁱ	mmu:268469
UCSC genome browser More...UCSCⁱ	uc007laq.1 mouse [Q5DU09-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5DU09	Uncharacterized protein		CALJA		498	UniRef90_Q5DU09
zinc finger protein 652 isoform X2		Florida manatee		497
Uncharacterized protein		PANTR		496
UPI000A316CBC		MUSCR		615
UPI000A30C5C1		MUSPA		609
+1

Protein	Similar proteins		Species	Score	Length	Source
Q5DU09	Zinc finger protein 652-A		XENLA		625	UniRef50_Q5DU09
Uncharacterized protein		CALJA		498
zinc finger protein 652 isoform X2		Florida manatee		497
Uncharacterized protein		PANTR		496
Zinc finger protein 652		SARHA		604
+154
Q5DU09-2	Uncharacterized protein (Fragment)		MICCO		330	UniRef50_Q5DU09-2
Uncharacterized protein		TAEGU		339
Zinc finger protein 652		FICAL		338
UPI00039573E0		GEOFO		359
UPI0008DB71C3		SERCA		407
+1

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK220361 mRNA Translation: BAD90422.1 AL593858 Genomic DNA Translation: CAM15507.1 BC055752 mRNA Translation: AAH55752.1
CCDSⁱ	CCDS36287.1 [Q5DU09-1]
RefSeqⁱ	NP_963903.2, NM_201609.2 [Q5DU09-1]
UniGeneⁱ	Mm.389038 Mm.418731

3D structure databases

ProteinModelPortalⁱ	Q5DU09
SMRⁱ	Q5DU09
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000089153

STRINGⁱ

10090.ENSMUSP00000089153

PTM databases

iPTMnetⁱ	Q5DU09
PhosphoSitePlusⁱ	Q5DU09

Proteomic databases

PaxDbⁱ	Q5DU09
PRIDEⁱ	Q5DU09

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000091565; ENSMUSP00000089153; ENSMUSG00000075595 [Q5DU09-1] ENSMUST00000107717; ENSMUSP00000103345; ENSMUSG00000075595 [Q5DU09-1]
GeneIDⁱ	268469
KEGGⁱ	mmu:268469
UCSCⁱ	uc007laq.1 mouse [Q5DU09-1]

Organism-specific databases

CTDⁱ	268469
MGIⁱ	MGI:2442221 Zfp652
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00440000037877
HOGENOMⁱ	HOG000231037
HOVERGENⁱ	HBG064823
InParanoidⁱ	Q5DU09
OrthoDBⁱ	EOG091G055W
PhylomeDBⁱ	Q5DU09
TreeFamⁱ	TF332655

Miscellaneous databases

ChiTaRSⁱ	Zfp652 mouse
Protein Ontology More...PROⁱ	PR:Q5DU09
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000075595 Expressed in 219 organ(s), highest expression level in skeletal muscle tissue
CleanExⁱ	MM_ZFP652
ExpressionAtlasⁱ	Q5DU09 baseline and differential
Genevisibleⁱ	Q5DU09 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 5 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 9 hits
SUPFAMⁱ	SSF57667 SSF57667, 5 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN652_MOUSE
Accessionⁱ	Q5DU09Primary (citable) accession number: Q5DU09 Secondary accession number(s): A2A617, Q7TNT4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
	Last sequence update:	March 20, 2007
	Last modified:	November 7, 2018
	This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5DU09 (ZN652_MOUSE)

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Zinc finger protein 652

Znf652

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ