Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Doublecortin domain-containing protein 2

Gene

Dcdc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein that plays a role in the inhibition of canonical Wnt signaling pathway (By similarity). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Doublecortin domain-containing protein 2
Gene namesi
Name:Dcdc2
Synonyms:Dcdc2a, Kiaa1154
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2652818 Dcdc2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

Animals develop periportal hepatic fibrosis with biliary duct proliferation at age 11 months.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000798051 – 475Doublecortin domain-containing protein 2Add BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei270PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5DU00
PRIDEiQ5DU00

PTM databases

PhosphoSitePlusiQ5DU00

Expressioni

Tissue specificityi

Expressed in hair cells of the inner ear.1 Publication

Gene expression databases

BgeeiENSMUSG00000035910 Expressed in 125 organ(s), highest expression level in metanephric cortical collecting duct
CleanExiMM_DCDC2A
ExpressionAtlasiQ5DU00 baseline and differential

Interactioni

Subunit structurei

Interacts with DVL1, DVL2 and DVL3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ5DU00
STRINGi10090.ENSMUSP00000063650

Structurei

3D structure databases

ProteinModelPortaliQ5DU00
SMRiQ5DU00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 100Doublecortin 1PROSITE-ProRule annotationAdd BLAST84
Domaini139 – 221Doublecortin 2PROSITE-ProRule annotationAdd BLAST83

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3757 Eukaryota
ENOG410ZE6Q LUCA
GeneTreeiENSGT00920000149015
HOGENOMiHOG000082435
HOVERGENiHBG051319
InParanoidiQ5DU00
PhylomeDBiQ5DU00
TreeFamiTF338406

Family and domain databases

CDDicd01617 DCX, 2 hits
Gene3Di3.10.20.230, 2 hits
InterProiView protein in InterPro
IPR033036 DCDC2
IPR003533 Doublecortin_dom
IPR036572 Doublecortin_dom_sf
PANTHERiPTHR23004:SF5 PTHR23004:SF5, 1 hit
PfamiView protein in Pfam
PF03607 DCX, 2 hits
SMARTiView protein in SMART
SM00537 DCX, 2 hits
SUPFAMiSSF89837 SSF89837, 2 hits
PROSITEiView protein in PROSITE
PS50309 DC, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5DU00-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNGPSSRSSH LSQPVVKSVL VYRNGDPFFA GRRVVIHEKK VSSFDVFLKE
60 70 80 90 100
VTGGVQAPFG AVRNIYTPRT GHRIRKLDQI ESGGNYVAGG PEAFKKLNYL
110 120 130 140 150
DIGEIKKRPM EAVNTEVKPV IHSRINVSAR FRKSLHEPCT IFLIANGDLI
160 170 180 190 200
SPASRLLIPK KALNQWDHVL QMVTEKITLR SGAVHRLYTL EGKLVESGAE
210 220 230 240 250
LENGQFYVAV GRDKFKRLPY SELLFDKSAM RRPYGQKASS LPPMVGSRKS
260 270 280 290 300
KGSGNYRQSK STIGSSDNSS PQPLKRKGKK DSNSEKPTKV KQSVKSKTSH
310 320 330 340 350
QAIPDNGEGI FKAGAERSET RGAAEVQEDE DTQVEVPVDQ RPAEIVDEEE
360 370 380 390 400
DGEKTSKDAN QKEDFSAMNG ETEDRGGSKA AGTSEQEEGI PDHGEKKSSP
410 420 430 440 450
SRVNGGTDEE NGEELDQVAE ELQPTEDEKG KAEGDNSGQD EAGLDAQRPP
460 470
RPEVTVTSPQ ENEENEANKA SSAVA
Length:475
Mass (Da):51,953
Last modified:July 19, 2005 - v2
Checksum:iB4195FC005B62F4A
GO
Isoform 2 (identifier: Q5DU00-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-368: EGIFKAGAER...ANQKEDFSAM → WLIKVERDTC...KAQPTYGHSM
     369-475: Missing.

Note: No experimental confirmation available.
Show »
Length:368
Mass (Da):41,265
Checksum:i70C563125707206C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GML1R4GML1_MOUSE
Doublecortin domain containing 2a, ...
Dcdc2a mCG_116692
475Annotation score:

Sequence cautioni

The sequence BAD90429 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti398S → A in CAI24561 (PubMed:19468303).Curated1
Sequence conflicti424P → S in CAI24561 (PubMed:19468303).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014672308 – 368EGIFK…DFSAM → WLIKVERDTCLRPQLDGNRN RVTALPPYPWSIHTRHMWDA PGEDRWKKVTNKAQPTYGHS M in isoform 2. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_014673369 – 475Missing in isoform 2. 1 PublicationAdd BLAST107

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220370 mRNA Translation: BAD90429.1 Different initiation.
AL589735 Genomic DNA Translation: CAI24561.1
BC045136 mRNA Translation: AAH45136.1
CCDSiCCDS26386.2 [Q5DU00-1]
CCDS56873.1 [Q5DU00-2]
RefSeqiNP_001182546.1, NM_001195617.1 [Q5DU00-2]
NP_808245.2, NM_177577.3
UniGeneiMm.284719

Genome annotation databases

EnsembliENSMUST00000036932; ENSMUSP00000047641; ENSMUSG00000035910 [Q5DU00-2]
GeneIDi195208
KEGGimmu:195208
UCSCiuc007pwv.1 mouse [Q5DU00-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220370 mRNA Translation: BAD90429.1 Different initiation.
AL589735 Genomic DNA Translation: CAI24561.1
BC045136 mRNA Translation: AAH45136.1
CCDSiCCDS26386.2 [Q5DU00-1]
CCDS56873.1 [Q5DU00-2]
RefSeqiNP_001182546.1, NM_001195617.1 [Q5DU00-2]
NP_808245.2, NM_177577.3
UniGeneiMm.284719

3D structure databases

ProteinModelPortaliQ5DU00
SMRiQ5DU00
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ5DU00
STRINGi10090.ENSMUSP00000063650

PTM databases

PhosphoSitePlusiQ5DU00

Proteomic databases

PaxDbiQ5DU00
PRIDEiQ5DU00

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036932; ENSMUSP00000047641; ENSMUSG00000035910 [Q5DU00-2]
GeneIDi195208
KEGGimmu:195208
UCSCiuc007pwv.1 mouse [Q5DU00-2]

Organism-specific databases

CTDi195208
MGIiMGI:2652818 Dcdc2a
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3757 Eukaryota
ENOG410ZE6Q LUCA
GeneTreeiENSGT00920000149015
HOGENOMiHOG000082435
HOVERGENiHBG051319
InParanoidiQ5DU00
PhylomeDBiQ5DU00
TreeFamiTF338406

Miscellaneous databases

PROiPR:Q5DU00
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035910 Expressed in 125 organ(s), highest expression level in metanephric cortical collecting duct
CleanExiMM_DCDC2A
ExpressionAtlasiQ5DU00 baseline and differential

Family and domain databases

CDDicd01617 DCX, 2 hits
Gene3Di3.10.20.230, 2 hits
InterProiView protein in InterPro
IPR033036 DCDC2
IPR003533 Doublecortin_dom
IPR036572 Doublecortin_dom_sf
PANTHERiPTHR23004:SF5 PTHR23004:SF5, 1 hit
PfamiView protein in Pfam
PF03607 DCX, 2 hits
SMARTiView protein in SMART
SM00537 DCX, 2 hits
SUPFAMiSSF89837 SSF89837, 2 hits
PROSITEiView protein in PROSITE
PS50309 DC, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDCDC2_MOUSE
AccessioniPrimary (citable) accession number: Q5DU00
Secondary accession number(s): Q5SZU0, Q80Y99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 7, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again