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Entry version 94 (11 Dec 2019)
Sequence version 2 (15 Jan 2008)
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Protein

Junctional protein associated with coronary artery disease

Gene

Jcad

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Junctional protein associated with coronary artery disease
Short name:
JCAD1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Jcad1 Publication
Synonyms:Gm328, Kiaa1462
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:2685174 Jcad

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003141861 – 1320Junctional protein associated with coronary artery diseaseAdd BLAST1320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei484PhosphothreonineCombined sources1
Modified residuei486PhosphoserineCombined sources1
Modified residuei851PhosphoserineCombined sources1
Modified residuei1027PhosphoserineBy similarity1
Modified residuei1033PhosphoserineCombined sources1
Modified residuei1245PhosphoserineCombined sources1
Modified residuei1248PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5DTX6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5DTX6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5DTX6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5DTX6

PRoteomics IDEntifications database

More...
PRIDEi
Q5DTX6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5DTX6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5DTX6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000033960 Expressed in 238 organ(s), highest expression level in decidua

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5DTX6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5DTX6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000038613

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5DTX6 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi254 – 416Pro-richAdd BLAST163
Compositional biasi838 – 841Poly-Glu4

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEJ0 Eukaryota
ENOG4110T3P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015348

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082516

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5DTX6

Identification of Orthologs from Complete Genome Data

More...
OMAi
STFHTSE

Database of Orthologous Groups

More...
OrthoDBi
208373at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5DTX6

TreeFam database of animal gene trees

More...
TreeFami
TF335913

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028221 JCAD

The PANTHER Classification System

More...
PANTHERi
PTHR34757 PTHR34757, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15351 JCAD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5DTX6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYSVEDLLIS HGYKPARDAA APCEDKSERC RSTRTGPRAG QGLLNGYKDG
60 70 80 90 100
ATAHTHSRTS LGTGHVSNSE NRISRPRGHR EHQSTSRTPE ARFLNQPSLA
110 120 130 140 150
WSSQPQSGRD DIYWSRGRQE GSGSLCPRDW KELESRGMAQ AYSLPVHVRE
160 170 180 190 200
NLWEVAGRTE HVMKNAIWEE ELRMQDMSLE SWKKPRELGR QASDGDGRKR
210 220 230 240 250
PQEKFEGLYP FVHGEHTSQN RKKSQSLPRA LSPKSLNFTE IPVPLHDGHI
260 270 280 290 300
TGVPKVPPYP PSFPSPSEPM RNLEKASSSG PFPRPKFGKP LKTPCYSSHS
310 320 330 340 350
QPRGEGGFQD HQHRDPRGSY PTRSKDPSHE LGMLDPGLEP PVYVPPPSYR
360 370 380 390 400
SPPQHIPNPY LEDPVPRHVS SNQSQQQVPE KPETSCPLPS GSLAARDLYD
410 420 430 440 450
AMPGSPPQGL PPQPYPIATH GGSIQYIPFD DPRIRHIKLA QPPEFYEEAK
460 470 480 490 500
LDDTSYNPGL LTTQEPAIGK RQYDDAPSVP RGPTPSPVNE QSSAFVHSSP
510 520 530 540 550
RWLQGQLPLG IGPGGFHGQT EHHVMGGLTT NVTDIKAEGH ASSPQPQSEG
560 570 580 590 600
TCKTYTKLRK FETGVQSKKS SKKKSNATIF CLVSIPVKSE SLVLATDTNN
610 620 630 640 650
NDFKLVADKT RGLCQGSALQ EQSLLSMSST DLELQALMGS MAWRRTSPRQ
660 670 680 690 700
GLRESEDGQI DDPRILHLIK PKELQASSPW PGHQYRDQQT QTSFHEDSKS
710 720 730 740 750
SQLLPATKPG EASNVAPTPT CPDTTASEVC LHTALAFSDQ NQKPSVPHLQ
760 770 780 790 800
GQTSLSPSRN SAFSRTSSAI NQASMSKGTS DQLPGANPVP KPEVVKGEST
810 820 830 840 850
TGQCNSTQLF GQFLLKPVSR RPWDLISQLE SFNKELQEEE ESHGGSGSED
860 870 880 890 900
SEAEQPEDCA DSRTKSWALQ GTRTAQQPAG LALENVASPD RRLNDSQSWN
910 920 930 940 950
EEPKPGHSSV HPQSLGPSQE EGSRGVPVQW ADGSLTAEQK SQEDLNGMCE
960 970 980 990 1000
RDFSPRPVSR IAPIDTKAAP LYCLSEPRGS QELTKFGDAV GSVQLGRETP
1010 1020 1030 1040 1050
TQVGNGGDTE VLPCVLLPLA DKYRGHSTPD FRSLELTLGQ EQNAYKLECL
1060 1070 1080 1090 1100
DLENTVEVLP SESLQERAER ILGIEVAVES LLPSARRTEQ SQLPEPDASA
1110 1120 1130 1140 1150
CNPSSSREDS SHSLALPVGP KVATDAFYGR RKCGWTESPL FVGERAPQAS
1160 1170 1180 1190 1200
ICSDVDGFPT SQATSPEPGK KDEEAKAPFK STLFHFMEKS TNVVGPEKRL
1210 1220 1230 1240 1250
RNPSKVVENL QEKLVSPPKK ADSVHLIRMR EVNSLSQMRC LSSKSADSVE
1260 1270 1280 1290 1300
EPDPLKVIKS SAWLSEGLTS LGGKDEAWQA GHLPSVSQNE NGHPEVPRDK
1310 1320
MSDQDLWCAD SYDPSRVERV
Length:1,320
Mass (Da):144,798
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2317F13096AFE1E7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC147227 Genomic DNA No translation available.
AK220394 mRNA Translation: BAD90447.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37719.1

NCBI Reference Sequences

More...
RefSeqi
NP_001075432.1, NM_001081963.1
XP_006525966.1, XM_006525903.2
XP_006525967.1, XM_006525904.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000037029; ENSMUSP00000038613; ENSMUSG00000033960
ENSMUST00000234153; ENSMUSP00000157313; ENSMUSG00000033960

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
240185

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:240185

UCSC genome browser

More...
UCSCi
uc008dyl.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC147227 Genomic DNA No translation available.
AK220394 mRNA Translation: BAD90447.1
CCDSiCCDS37719.1
RefSeqiNP_001075432.1, NM_001081963.1
XP_006525966.1, XM_006525903.2
XP_006525967.1, XM_006525904.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038613

PTM databases

iPTMnetiQ5DTX6
PhosphoSitePlusiQ5DTX6

Proteomic databases

EPDiQ5DTX6
jPOSTiQ5DTX6
MaxQBiQ5DTX6
PaxDbiQ5DTX6
PRIDEiQ5DTX6

Genome annotation databases

EnsembliENSMUST00000037029; ENSMUSP00000038613; ENSMUSG00000033960
ENSMUST00000234153; ENSMUSP00000157313; ENSMUSG00000033960
GeneIDi240185
KEGGimmu:240185
UCSCiuc008dyl.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57608
MGIiMGI:2685174 Jcad

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG410IEJ0 Eukaryota
ENOG4110T3P LUCA
GeneTreeiENSGT00390000015348
HOGENOMiHOG000082516
InParanoidiQ5DTX6
OMAiSTFHTSE
OrthoDBi208373at2759
PhylomeDBiQ5DTX6
TreeFamiTF335913

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q5DTX6
RNActiQ5DTX6 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000033960 Expressed in 238 organ(s), highest expression level in decidua
ExpressionAtlasiQ5DTX6 baseline and differential
GenevisibleiQ5DTX6 MM

Family and domain databases

InterProiView protein in InterPro
IPR028221 JCAD
PANTHERiPTHR34757 PTHR34757, 1 hit
PfamiView protein in Pfam
PF15351 JCAD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJCAD_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5DTX6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: December 11, 2019
This is version 94 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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