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Entry version 93 (02 Jun 2021)
Sequence version 2 (24 Jul 2007)
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Protein

Retroelement silencing factor 1

Gene

Resf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • histone methyltransferase binding Source: UniProtKB

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Retroelement silencing factor 1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Resf1Imported
Synonyms:Kiaa1551
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1914496, Resf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002952431 – 1521Retroelement silencing factor 1Add BLAST1521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki223Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei910PhosphoserineCombined sources1
Modified residuei996PhosphothreonineBy similarity1
Modified residuei1142PhosphoserineBy similarity1
Cross-linki1411Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1482PhosphoserineBy similarity1
Modified residuei1514PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5DTW7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5DTW7

PRoteomics IDEntifications database

More...
PRIDEi
Q5DTW7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
269158 [Q5DTW7-1]
269159 [Q5DTW7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5DTW7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5DTW7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032712, Expressed in zygote and 303 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5DTW7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5DTW7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SETDB1.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
212044, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q5DTW7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000041180

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5DTW7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5DTW7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni621 – 640DisorderedSequence analysisAdd BLAST20
Regioni1093 – 1147DisorderedSequence analysisAdd BLAST55
Regioni1204 – 1230DisorderedSequence analysisAdd BLAST27
Regioni1312 – 1335DisorderedSequence analysisAdd BLAST24
Regioni1425 – 1444DisorderedSequence analysisAdd BLAST20
Regioni1457 – 1485DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1093 – 1112Polar residuesSequence analysisAdd BLAST20
Compositional biasi1126 – 1143Polar residuesSequence analysisAdd BLAST18
Compositional biasi1466 – 1482Basic and acidic residuesSequence analysisAdd BLAST17

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S9FU, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018491

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002739_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5DTW7

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5DTW7

TreeFam database of animal gene trees

More...
TreeFami
TF336094

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027866, RESF1

The PANTHER Classification System

More...
PANTHERi
PTHR21604, PTHR21604, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15395, DUF4617, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5DTW7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNWNTKQENV PKPPPYSKTQ SSILQHFLMT STTSQSSFNY SPHNQEASQT
60 70 80 90 100
SFNYSLHNQE ACMYSGNSNS VSQPLLSGRN YITPQTQISV SNMPTRTIVA
110 120 130 140 150
SQSSMERVVS TNGKGPQQPN HNLQTVSSGI MQNVWLPSHT EATISHNPDG
160 170 180 190 200
GTNMPYMHPP QNQLVTSDTY SMQLQMAPLH SGKVPMTHQG SQGLNHFIPD
210 220 230 240 250
QLVDWTQYTS NELSYPEYRP PPKQYSYILP ATTSLQVKNN QLPTYTQSLQ
260 270 280 290 300
SKHSVPLSSH QYAAEASKRL SALPYSCRYE NQHVQNAQPV SKHLPMEVPQ
310 320 330 340 350
SSEVHSSEKK KDTYRGFKQQ WQNPNEKVSI GQFSEVKINI KQPYSESVRP
360 370 380 390 400
SGDGVQALVQ NNQEKRKYTY NPNTNQVIDT NATKEKLVRD IKSLVEIKKK
410 420 430 440 450
FSELARKIKI NKSLLMAAGC SKTANTSYTE PIQHSEFSAK EMSAKNGNDC
460 470 480 490 500
SMELLATCLS LWKNQPSKTT EENVPKPLEE KQCNTSRIST TVVGSANPTN
510 520 530 540 550
EVHVKSLCSG VGNSQKMMSS SQTVLPVLIP SCESSGVAVG KGTELQIAVV
560 570 580 590 600
SPLVLSDTNT LPGKDSVPEV LPETLYPVVK EGSVCSLQTQ PTETVALPFD
610 620 630 640 650
VIGAVASNNI SAEIPLPVDK EKQHKPIQGD PDIADSSLGK HSPLGTEVLP
660 670 680 690 700
KPMDSTIVSG PMLQIESICS LAEGDVSYNS QIAEIFNSVQ TEPQKPSPNQ
710 720 730 740 750
VIDSQQEQVY DTTENKDFSL QKDKCVQCTD VPHEVPEQPE PLQPEEPASS
760 770 780 790 800
EYVEANREAT EESCREYTGR KESTAKDVCL PAAIQQDPHP RETDMFSKSD
810 820 830 840 850
HSLPAINEIN DESEPISYLH DQLSELLKEF PYGIETFNRH EVSLDQQKTH
860 870 880 890 900
KIVENQTGGK TSNVSGDSTD QIKITVLNSE QIKELFPEDD QPCDKLAEPE
910 920 930 940 950
NKEIVAEVKS PCDSQIPREE SHDLGMLDPE KDKIHCCALG WLSMVYEGVP
960 970 980 990 1000
QCHCSSTEKK EKDQCLDINS SKQGEQPCNS GITIFEINPV SNNSKTPLTQ
1010 1020 1030 1040 1050
ATEEGHFSAV HGEKTKASKT KDNREGQELA CHFSAKCYKK DKKGNFKIRH
1060 1070 1080 1090 1100
DTSLKMEQKL KNISSKCDIP NPSKCNKIAA PEILHVTTSN SAKNMPFSKQ
1110 1120 1130 1140 1150
ASQESLQKKH TSQDLGPVKA PIELSSNTDP CRSNTSSVQS VSPEKKKLKF
1160 1170 1180 1190 1200
KAGGSRLKYF EKRKTDHVII PDVEIKKKKY EKQEQNKNAG DTLKLCSILT
1210 1220 1230 1240 1250
ESNERASVQE KTVPSPESSD PKGSSSKSTR VITVQEYLQR QKDKQITGNN
1260 1270 1280 1290 1300
ASRNICVETV LCDSGHTKTS KHSAAVSWGK LVEGQSISAE TAKELEHNSS
1310 1320 1330 1340 1350
SHGKDFKIHH SEASRTHSVS NNNKGKFDGK QPDKMFKNKT SMNNESNQMP
1360 1370 1380 1390 1400
LQVKEQRKQY LNRVAFKCTE RESICLTKLD SASKKLSIEK KSGEYTSKTK
1410 1420 1430 1440 1450
DTDKPSMLEF KLCPDVLLKN TSTVDKQDCP GPGPEKEQAP VQVSGIKSTK
1460 1470 1480 1490 1500
EDWLKCIPTR TKMPESSQRD SADSRLSKRS LSADEFEILQ NPVKESNIMF
1510 1520
RTYKKMYLEK RSRSLGSSPV K
Length:1,521
Mass (Da):169,044
Last modified:July 24, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E32F40A89DA62F1
GO
Isoform 2 (identifier: Q5DTW7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1440-1441: Missing.

Show »
Length:1,519
Mass (Da):168,848
Checksum:i220BCC62077F1C4F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WP74A0A087WP74_MOUSE
Retroelement silencing factor 1
Resf1 2810474O19Rik
1,519Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WP47A0A087WP47_MOUSE
Retroelement silencing factor 1
Resf1 2810474O19Rik
1,173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B2KFD0B2KFD0_MOUSE
Retroelement silencing factor 1
Resf1 2810474O19Rik
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WR65A0A087WR65_MOUSE
Retroelement silencing factor 1
Resf1 2810474O19Rik
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T8R9A0A140T8R9_MOUSE
Retroelement silencing factor 1
Resf1 2810474O19Rik
404Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T8W0A0A140T8W0_MOUSE
Retroelement silencing factor 1
Resf1 2810474O19Rik
10Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH89381 differs from that shown. Reason: Frameshift.Curated
The sequence BAB28838 differs from that shown. Reason: Frameshift.Curated
The sequence BAC27639 differs from that shown. Reason: Frameshift.Curated
The sequence BAC27639 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence BAD90453 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14P → S in BAC27639 (PubMed:16141072).Curated1
Sequence conflicti23I → N in BAC27639 (PubMed:16141072).Curated1
Sequence conflicti163Q → R in BAC27639 (PubMed:16141072).Curated1
Sequence conflicti1444S → L in AAH55761 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0268631440 – 1441Missing in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK220403 mRNA Translation: BAD90453.1 Different initiation.
AK013408 mRNA Translation: BAB28838.1 Frameshift.
AK017376 mRNA Translation: BAB30717.1
AK031797 mRNA Translation: BAC27553.2
AK031989 mRNA Translation: BAC27639.1 Sequence problems.
BC055761 mRNA Translation: AAH55761.1
BC089381 mRNA Translation: AAH89381.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS20717.1 [Q5DTW7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001276590.1, NM_001289661.1 [Q5DTW7-1]
NP_001276591.1, NM_001289662.1 [Q5DTW7-1]
NP_080330.1, NM_026054.3 [Q5DTW7-1]
XP_006507144.1, XM_006507081.3 [Q5DTW7-1]
XP_006507146.1, XM_006507083.3 [Q5DTW7-1]
XP_006507147.1, XM_006507084.3 [Q5DTW7-1]
XP_011239924.1, XM_011241622.2 [Q5DTW7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000046689; ENSMUSP00000041180; ENSMUSG00000032712 [Q5DTW7-1]
ENSMUST00000100765; ENSMUSP00000098328; ENSMUSG00000032712 [Q5DTW7-1]
ENSMUST00000189932; ENSMUSP00000140026; ENSMUSG00000032712 [Q5DTW7-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
67246

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:67246

UCSC genome browser

More...
UCSCi
uc009eub.2, mouse [Q5DTW7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220403 mRNA Translation: BAD90453.1 Different initiation.
AK013408 mRNA Translation: BAB28838.1 Frameshift.
AK017376 mRNA Translation: BAB30717.1
AK031797 mRNA Translation: BAC27553.2
AK031989 mRNA Translation: BAC27639.1 Sequence problems.
BC055761 mRNA Translation: AAH55761.1
BC089381 mRNA Translation: AAH89381.1 Frameshift.
CCDSiCCDS20717.1 [Q5DTW7-1]
RefSeqiNP_001276590.1, NM_001289661.1 [Q5DTW7-1]
NP_001276591.1, NM_001289662.1 [Q5DTW7-1]
NP_080330.1, NM_026054.3 [Q5DTW7-1]
XP_006507144.1, XM_006507081.3 [Q5DTW7-1]
XP_006507146.1, XM_006507083.3 [Q5DTW7-1]
XP_006507147.1, XM_006507084.3 [Q5DTW7-1]
XP_011239924.1, XM_011241622.2 [Q5DTW7-1]

3D structure databases

SMRiQ5DTW7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi212044, 1 interactor
IntActiQ5DTW7, 1 interactor
STRINGi10090.ENSMUSP00000041180

PTM databases

iPTMnetiQ5DTW7
PhosphoSitePlusiQ5DTW7

Proteomic databases

jPOSTiQ5DTW7
PaxDbiQ5DTW7
PRIDEiQ5DTW7
ProteomicsDBi269158 [Q5DTW7-1]
269159 [Q5DTW7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
2871, 27 antibodies

The DNASU plasmid repository

More...
DNASUi
67246

Genome annotation databases

EnsembliENSMUST00000046689; ENSMUSP00000041180; ENSMUSG00000032712 [Q5DTW7-1]
ENSMUST00000100765; ENSMUSP00000098328; ENSMUSG00000032712 [Q5DTW7-1]
ENSMUST00000189932; ENSMUSP00000140026; ENSMUSG00000032712 [Q5DTW7-1]
GeneIDi67246
KEGGimmu:67246
UCSCiuc009eub.2, mouse [Q5DTW7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55196
MGIiMGI:1914496, Resf1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiENOG502S9FU, Eukaryota
GeneTreeiENSGT00390000018491
HOGENOMiCLU_002739_0_0_1
InParanoidiQ5DTW7
PhylomeDBiQ5DTW7
TreeFamiTF336094

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
67246, 0 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
2810474O19Rik, mouse

Protein Ontology

More...
PROi
PR:Q5DTW7
RNActiQ5DTW7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032712, Expressed in zygote and 303 other tissues
ExpressionAtlasiQ5DTW7, baseline and differential
GenevisibleiQ5DTW7, MM

Family and domain databases

InterProiView protein in InterPro
IPR027866, RESF1
PANTHERiPTHR21604, PTHR21604, 2 hits
PfamiView protein in Pfam
PF15395, DUF4617, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRESF1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5DTW7
Secondary accession number(s): Q5FWH0
, Q7TNT1, Q8CCW3, Q8CCZ9, Q9CSA5, Q9CU82
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: June 2, 2021
This is version 93 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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