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UniProtKB - Q5DTW2 (SMBT2_MOUSE)
Protein
Scm-like with four MBT domains protein 2
Gene
Sfmbt2
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptional repressor of HOXB13 gene.
By similarityMiscellaneous
Imprinted gene expressed from the paternal allele in blastocysts and in embryonic tissues early in development. Imprinting is lost in somatic tissues after 7.5 dpc.
GO - Molecular functioni
- chromatin binding Source: GO_Central
- histone binding Source: UniProtKB
- transcription corepressor activity Source: InterPro
GO - Biological processi
- negative regulation of gene expression Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Repressor |
Names & Taxonomyi
Protein namesi | Recommended name: Scm-like with four MBT domains protein 2 |
Gene namesi | Name:Sfmbt2 Synonyms:Kiaa1617 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2447794, Sfmbt2 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytosol
- cytosol Source: MGI
Nucleus
- nuclear body Source: MGI
- nuclear speck Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Other locations
- aggresome Source: MGI
- intracellular membrane-bounded organelle Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071970 | 1 – 938 | Scm-like with four MBT domains protein 2Add BLAST | 938 |
Proteomic databases
MaxQBi | Q5DTW2 |
PaxDbi | Q5DTW2 |
PRIDEi | Q5DTW2 |
ProteomicsDBi | 257201 [Q5DTW2-1] 257202 [Q5DTW2-2] |
PTM databases
iPTMneti | Q5DTW2 |
PhosphoSitePlusi | Q5DTW2 |
Expressioni
Tissue specificityi
Expressed in testis and, at much lower levels, in ovary.1 Publication
Developmental stagei
Overall, expression is high in extraembryonic tissues, and low in somatic tissues. Expression starts between 8-cell and blastocyst stages. At 7.5 dpc, highly expressed in the ectoplacental cone and, at much lower levels, in the embryonic and extraembryonic ectoderm. At 14.5 dpc, highly expressed in placenta and, at much lower levels, in the yolk sac. Expression in other tissues, including brain, heart, liver, kidney, gut and genital ridges, is very low. Expressed preferentially from the paternal allele in blastocysts, in various tissues at 7.5 dpc, as well as in yolk sac and placenta at 11.5 and 14.5 dpc. Biallelically expressed in brain and other somatic tissues at 11.5 and 14.5 dpc.1 Publication
Interactioni
Subunit structurei
Interacts with YY1.
Interacts with methylated histones H3K9me2 and H4K20me2 (By similarity).
By similarityGO - Molecular functioni
- histone binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000040575 |
Miscellaneous databases
RNActi | Q5DTW2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 43 – 143 | MBT 1Add BLAST | 101 | |
Repeati | 151 – 255 | MBT 2Add BLAST | 105 | |
Repeati | 265 – 371 | MBT 3Add BLAST | 107 | |
Repeati | 379 – 475 | MBT 4Add BLAST | 97 | |
Domaini | 868 – 931 | SAMAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 32 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 742 – 836 | DisorderedSequence analysisAdd BLAST | 95 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 8 – 32 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 762 – 778 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 805 – 823 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3766, Eukaryota |
InParanoidi | Q5DTW2 |
Family and domain databases
CDDi | cd09581, SAM_Scm-like-4MBT1_2, 1 hit |
Gene3Di | 1.10.150.50, 1 hit 3.90.1150.190, 1 hit |
InterProi | View protein in InterPro IPR004092, Mbt IPR001660, SAM IPR013761, SAM/pointed_sf IPR037604, Scm-like-4MBT1/2_SAM IPR021987, SLED IPR038348, SLED_sf |
Pfami | View protein in Pfam PF02820, MBT, 4 hits PF00536, SAM_1, 1 hit PF12140, SLED, 1 hit |
SMARTi | View protein in SMART SM00561, MBT, 4 hits SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS51079, MBT, 4 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5DTW2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MERYLPVSKK RNSSSSLEKI TGSANGNGTL YSEEDTNLEE NDFSWGDYLE
60 70 80 90 100
ETGTRAVPHV SFRHVEISIR SNFQPGMKLE VANKNNPDTY WVATIITTCG
110 120 130 140 150
QLLLLRYCGY GEDRRADFWC DVIIADLHPV GWCTQNNKVL RPPDAIKDKY
160 170 180 190 200
SDWTDFLIRE LTGSRTAPAN LLEGPLRGKG PIDLITVDSL IELQDSQNPF
210 220 230 240 250
QYWIVSVTEN VGGRLRLRYV GLEHTESYDR WLFYLDYRLR PIGWCQENKY
260 270 280 290 300
RMDPPSDLYY LKLPFEWKCA LEKALVLAAE SPLPMEVFKD HADLQSHFFT
310 320 330 340 350
VGMRLETLHI SDPFHIYPAS VTKVFNSKFF QVAIDDLRPE ADKPTMLCHA
360 370 380 390 400
DSLGILPVQW CLKNGVNLAP PKGYSGQDFN WVDYHKQRQA EEAPHFCFKN
410 420 430 440 450
AFSRGFSKNM KLEAVNPVNP GEVCVATVVS VKGRLLWLHL EGLETPMPDI
460 470 480 490 500
IVDMDSMDIF PVGWCEANSY PLTTPYKASS KSKRKTVHFK MEKQLLSPVP
510 520 530 540 550
IEKIPHELCL LPPQMDSPVG AINAKYCCPQ LFVNHRCFSG PFLNKGRISE
560 570 580 590 600
LPQSVGPGMC VLVLKEILTL ITNAAYKPGR VLRELQLVED PEWNSQEEIL
610 620 630 640 650
KAKYGGKTYR AVVKIVRTAD QVMNFCRQVC AKLECCPNLL SPVLISETCP
660 670 680 690 700
ENCSVHTKTR YTYYYGKRRR VIQSSLRVSN IETPPKSTRR RKRRKSVYVQ
710 720 730 740 750
KRRKSAIVVP AGVPAGVPAG VPEDIPAGIP EGIPASIPES IPEGIPESLP
760 770 780 790 800
EAIPESIPKG SAQKTEQEKR ETLDTARKKT GYHGPAYQTD TSAAQVPFAR
810 820 830 840 850
PRRAVTLRRN SEALKRPPVE RARRVRTVPT TASSNNRVKG PLVRIVKPED
860 870 880 890 900
SSQSDEEKLI LESNPLEWSV TDVVRFIKLT DCAPLARIFQ EQDIDGQALL
910 920 930
LLTLPTVQEC MELKLGPAIK LCHQIERVKV AFYAQYAS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ3UH63 | Q3UH63_MOUSE | Scm-like with four MBT domains prot... | Sfmbt2 | 975 | Annotation score: | ||
Q3UH07 | Q3UH07_MOUSE | Scm-like with four MBT domains prot... | Sfmbt2 | 942 | Annotation score: | ||
Q8BG70 | Q8BG70_MOUSE | Scm-like with four MBT domains prot... | Sfmbt2 | 183 | Annotation score: |
Sequence cautioni
The sequence BAD90456 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013858 | 661 | Y → YNKREKGSSLSPASELKDDS ASHATKLQKAKIPQ in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_013859 | 751 | E → ESLPE in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK220408 mRNA Translation: BAD90456.1 Different initiation. AY217748 mRNA Translation: AAO61788.1 |
CCDSi | CCDS57152.1 [Q5DTW2-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK220408 mRNA Translation: BAD90456.1 Different initiation. AY217748 mRNA Translation: AAO61788.1 |
CCDSi | CCDS57152.1 [Q5DTW2-2] |
3D structure databases
SMRi | Q5DTW2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000040575 |
PTM databases
iPTMneti | Q5DTW2 |
PhosphoSitePlusi | Q5DTW2 |
Proteomic databases
MaxQBi | Q5DTW2 |
PaxDbi | Q5DTW2 |
PRIDEi | Q5DTW2 |
ProteomicsDBi | 257201 [Q5DTW2-1] 257202 [Q5DTW2-2] |
Organism-specific databases
MGIi | MGI:2447794, Sfmbt2 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG3766, Eukaryota |
InParanoidi | Q5DTW2 |
Miscellaneous databases
ChiTaRSi | Sfmbt2, mouse |
PROi | PR:Q5DTW2 |
RNActi | Q5DTW2, protein |
SOURCEi | Search... |
Family and domain databases
CDDi | cd09581, SAM_Scm-like-4MBT1_2, 1 hit |
Gene3Di | 1.10.150.50, 1 hit 3.90.1150.190, 1 hit |
InterProi | View protein in InterPro IPR004092, Mbt IPR001660, SAM IPR013761, SAM/pointed_sf IPR037604, Scm-like-4MBT1/2_SAM IPR021987, SLED IPR038348, SLED_sf |
Pfami | View protein in Pfam PF02820, MBT, 4 hits PF00536, SAM_1, 1 hit PF12140, SLED, 1 hit |
SMARTi | View protein in SMART SM00561, MBT, 4 hits SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS51079, MBT, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | SMBT2_MOUSE | |
Accessioni | Q5DTW2Primary (citable) accession number: Q5DTW2 Secondary accession number(s): Q80VG7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | June 7, 2005 | |
Last modified: | February 23, 2022 | |
This is version 94 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot