Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 115 (16 Oct 2019)
Sequence version 2 (20 May 2008)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

PH and SEC7 domain-containing protein 1

Gene

Psd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor for ARF6 (By similarity). Isoform 2 and isoform 3 induce cytoskeletal remodeling, but lead to distinct morphological changes in HeLa cells: isoform 2 induces cell elongation and formation of actin-rich protrusions, whereas isoform 3 promotes the formation of membrane ruffles and loss of stress fibers (PubMed:19494129).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PH and SEC7 domain-containing protein 1
Alternative name(s):
Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6
Short name:
Exchange factor for ARF6
Exchange factor for ARF6 A
Pleckstrin homology and SEC7 domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Psd
Synonyms:Efa6a, Kiaa2011, Psd1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1920978 Psd

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi621E → K: Significantly impaired guanine nucleotide exchange factor activity on ARF6 in PC12 cells. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003341611 – 1024PH and SEC7 domain-containing protein 1Add BLAST1024

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei126PhosphoserineCombined sources1
Modified residuei156PhosphoserineCombined sources1
Modified residuei720PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5DTT2

PeptideAtlas

More...
PeptideAtlasi
Q5DTT2

PRoteomics IDEntifications database

More...
PRIDEi
Q5DTT2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5DTT2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5DTT2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q5DTT2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest expression detected in brain and some expression detected also in uterus, stomach, ovary and intestine, with isoform 2 being expressed at the highest levels. In the brain, isoform 1 is highly expressed in the strata oriens, radiatum, lacunosum-moleculare of the hippocampal CA1-3 regions and the dentate molecular layer of the hippocampal formation, with lower levels detected in the neuronal cell layers and the stratum lucidum (at protein level). Not detected in tongue, thymus, spleen, lung, heart, liver and kidney.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in embryonic, early postnatal and adult brain, with expression up-regulated at postnatal day 4-8 and down-regulated in adults. Isoform 2 expression is up-regulated in adults.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000037126 Expressed in 121 organ(s), highest expression level in CA1 field of hippocampus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5DTT2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5DTT2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ACTN1 (PubMed:17298598).

Interacts (ARF6-bound form) with KCNK1; does not interact with KCNK1 in the absence of ARF6 (PubMed:15540117).

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
216216, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q5DTT2

Protein interaction database and analysis system

More...
IntActi
Q5DTT2, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000093729

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini512 – 706SEC7PROSITE-ProRule annotationAdd BLAST195
Domaini756 – 869PHPROSITE-ProRule annotationAdd BLAST114

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili898 – 924Sequence analysisAdd BLAST27
Coiled coili956 – 983Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi18 – 94Pro-richAdd BLAST77
Compositional biasi432 – 466Pro-richAdd BLAST35
Compositional biasi739 – 744Poly-Ser6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PSD family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0932 Eukaryota
COG5307 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155061

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000069986

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5DTT2

KEGG Orthology (KO)

More...
KOi
K12494

Identification of Orthologs from Complete Genome Data

More...
OMAi
DAPWTER

Database of Orthologous Groups

More...
OrthoDBi
301851at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5DTT2

TreeFam database of animal gene trees

More...
TreeFami
TF319755

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00171 Sec7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1000.11, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011993 PH-like_dom_sf
IPR041681 PH_9
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15410 PH_9, 1 hit
PF01369 Sec7, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00683 SPECTRINPH

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00222 Sec7, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48425 SSF48425, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50190 SEC7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5DTT2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQGAMRFCS EGDCAISPPR CPRRWLPEGP VPQSPPASMY GSTGSLIRRV
60 70 80 90 100
VGPGPRGRDL GRVTAPCTPL RAPPSPHIAP SPWGPSSPTG QPPPGAQSSV
110 120 130 140 150
VIFRFVEKAS VRPLNGLPAS GGLSRSWDLG GISAPRPTPA LGPGCNRKLR
160 170 180 190 200
LEASTSDPLP AGGGSVLPGS RDPSRGPLVP PQIGADGLYS SLPNGLGGTP
210 220 230 240 250
EHLAMHFRGP ADTGFLNQGD TWSSPREVSS HAQRIARAKW EFFYGSLDAP
260 270 280 290 300
SSGAKPPEQV LPSRGVGSKQ GSGVAVGRAA KYSETDLDKV PLRCYRETDI
310 320 330 340 350
DEVLAEREEA DSAIESQPSS EGPHGTAQPP ASRPSPCPGP SSSLGSGNED
360 370 380 390 400
DEAGGEEDVD DEVFEASEGA RPGDHMPHSG LLKSPVPFLL GTSPSADGPD
410 420 430 440 450
SFSCVFEAIL ESHRAKGTSY SSLASLEALA SPGPTQSPFF TFEMPPQPPA
460 470 480 490 500
PRPDPPAPAP LAPLEPDSGT SSAADGPWTQ RREVEESDAG ATLAPRKELP
510 520 530 540 550
SPSHSEDSFG LGAAPLGSEP PLSQLVSDSD SELDSTERLA LGSTDTLSNG
560 570 580 590 600
QKADLEAAQR LAKRLYRLDG FRKADVARHL GKNNDFSKLV AGEYLKFFVF
610 620 630 640 650
TGMTLDQALR VFLKELALMG ETQERERVLA HFSQRYFQCN PEALSSEDGA
660 670 680 690 700
HTLTCALMLL NTDLHGHNIG KRMTCGDFIG NLEGLNDGGD FPRELLKALY
710 720 730 740 750
SSIKNEKLQW AIDEEELRRS LSELADPNPK VIKRVSGGSG SSSSPFLDLT
760 770 780 790 800
PEPGAAVYKH GALVRKVHAD PDCRKTPRGK RGWKSFHGIL KGMILYLQKE
810 820 830 840 850
EYQPGKALSE AELKNAISIH HALATRASDY SKRPHVFYLR TADWRVFLFQ
860 870 880 890 900
APSLEQMQSW ITRINVVAAM FSAPPFPAAV SSQKKFSRPL LPSAATRLSQ
910 920 930 940 950
EEQVRTHEAK LKAMASELRE HRAAHLGKKA RGKEADEQRQ KEAYLEFEKS
960 970 980 990 1000
RYGTYAALLR VKMKAASEEL DTIEAALAQA GSTEDGCPPP HSSPSLRPKP
1010 1020
TSQPRAQRPG SETRAGAGST RPKP
Length:1,024
Mass (Da):109,687
Last modified:May 20, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i207A889E6D16CC99
GO
Isoform 2 (identifier: Q5DTT2-2) [UniParc]FASTAAdd to basket
Also known as: EFA6As

The sequence of this isoform differs from the canonical sequence as follows:
     1-631: Missing.
     632-697: FSQRYFQCNP...GGDFPRELLK → MIGVNSIHSS...RLQSRKKKKA

Note: Produced by alternative promoter usage.
Show »
Length:393
Mass (Da):43,715
Checksum:i57B83FA12E6D4035
GO
Isoform 3 (identifier: Q5DTT2-3) [UniParc]FASTAAdd to basket
Also known as: EFA6A

The sequence of this isoform differs from the canonical sequence as follows:
     518-518: S → SS

Note: Produced by alternative splicing of isoform 1.
Show »
Length:1,025
Mass (Da):109,774
Checksum:i5AF3EAC9C00976A4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YDE5A0A286YDE5_MOUSE
PH and SEC7 domain-containing prote...
Psd
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YCR6A0A286YCR6_MOUSE
PH and SEC7 domain-containing prote...
Psd
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YDD4A0A286YDD4_MOUSE
PH and SEC7 domain-containing prote...
Psd
14Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YDW2A0A286YDW2_MOUSE
PH and SEC7 domain-containing prote...
Psd
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0336371 – 631Missing in isoform 2. 2 PublicationsAdd BLAST631
Alternative sequenceiVSP_041569518S → SS in isoform 3. 2 Publications1
Alternative sequenceiVSP_033638632 – 697FSQRY…RELLK → MIGVNSIHSSAGRLRSRSLC SVRYGRTHRGAETLCYGWPQ RSRSLKPVLYTDLVVSRLQS RKKKKA in isoform 2. 2 PublicationsAdd BLAST66

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC114539 Genomic DNA No translation available.
AK158851 mRNA Translation: BAE34694.1
BC058352 mRNA Translation: AAH58352.1
BC138652 mRNA Translation: AAI38653.1
BC145352 mRNA Translation: AAI45353.1
AK220438 Transcribed RNA Translation: BAD90268.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS29875.1 [Q5DTT2-1]
CCDS84449.1 [Q5DTT2-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001334383.1, NM_001347454.1 [Q5DTT2-3]
NP_082903.2, NM_028627.2 [Q5DTT2-1]
XP_006527449.1, XM_006527386.3 [Q5DTT2-3]
XP_006527451.1, XM_006527388.3 [Q5DTT2-3]
XP_006527452.1, XM_006527389.3 [Q5DTT2-3]
XP_006527454.1, XM_006527391.3 [Q5DTT2-3]
XP_006527456.1, XM_006527393.2 [Q5DTT2-2]
XP_011245678.1, XM_011247376.2 [Q5DTT2-3]
XP_011245679.1, XM_011247377.2 [Q5DTT2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000041391; ENSMUSP00000039728; ENSMUSG00000037126 [Q5DTT2-1]
ENSMUST00000096029; ENSMUSP00000093729; ENSMUSG00000037126 [Q5DTT2-3]
ENSMUST00000224556; ENSMUSP00000153381; ENSMUSG00000037126 [Q5DTT2-2]
ENSMUST00000225323; ENSMUSP00000152942; ENSMUSG00000037126 [Q5DTT2-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
73728

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:73728

UCSC genome browser

More...
UCSCi
uc008htb.1 mouse [Q5DTT2-2]
uc008htd.1 mouse [Q5DTT2-1]
uc012bmt.1 mouse [Q5DTT2-3]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114539 Genomic DNA No translation available.
AK158851 mRNA Translation: BAE34694.1
BC058352 mRNA Translation: AAH58352.1
BC138652 mRNA Translation: AAI38653.1
BC145352 mRNA Translation: AAI45353.1
AK220438 Transcribed RNA Translation: BAD90268.1
CCDSiCCDS29875.1 [Q5DTT2-1]
CCDS84449.1 [Q5DTT2-3]
RefSeqiNP_001334383.1, NM_001347454.1 [Q5DTT2-3]
NP_082903.2, NM_028627.2 [Q5DTT2-1]
XP_006527449.1, XM_006527386.3 [Q5DTT2-3]
XP_006527451.1, XM_006527388.3 [Q5DTT2-3]
XP_006527452.1, XM_006527389.3 [Q5DTT2-3]
XP_006527454.1, XM_006527391.3 [Q5DTT2-3]
XP_006527456.1, XM_006527393.2 [Q5DTT2-2]
XP_011245678.1, XM_011247376.2 [Q5DTT2-3]
XP_011245679.1, XM_011247377.2 [Q5DTT2-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi216216, 1 interactor
CORUMiQ5DTT2
IntActiQ5DTT2, 1 interactor
STRINGi10090.ENSMUSP00000093729

PTM databases

iPTMnetiQ5DTT2
PhosphoSitePlusiQ5DTT2
SwissPalmiQ5DTT2

Proteomic databases

PaxDbiQ5DTT2
PeptideAtlasiQ5DTT2
PRIDEiQ5DTT2

Genome annotation databases

EnsembliENSMUST00000041391; ENSMUSP00000039728; ENSMUSG00000037126 [Q5DTT2-1]
ENSMUST00000096029; ENSMUSP00000093729; ENSMUSG00000037126 [Q5DTT2-3]
ENSMUST00000224556; ENSMUSP00000153381; ENSMUSG00000037126 [Q5DTT2-2]
ENSMUST00000225323; ENSMUSP00000152942; ENSMUSG00000037126 [Q5DTT2-3]
GeneIDi73728
KEGGimmu:73728
UCSCiuc008htb.1 mouse [Q5DTT2-2]
uc008htd.1 mouse [Q5DTT2-1]
uc012bmt.1 mouse [Q5DTT2-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5662
MGIiMGI:1920978 Psd

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG0932 Eukaryota
COG5307 LUCA
GeneTreeiENSGT00940000155061
HOGENOMiHOG000069986
InParanoidiQ5DTT2
KOiK12494
OMAiDAPWTER
OrthoDBi301851at2759
PhylomeDBiQ5DTT2
TreeFamiTF319755

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Psd mouse

Protein Ontology

More...
PROi
PR:Q5DTT2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000037126 Expressed in 121 organ(s), highest expression level in CA1 field of hippocampus
ExpressionAtlasiQ5DTT2 baseline and differential
GenevisibleiQ5DTT2 MM

Family and domain databases

CDDicd00171 Sec7, 1 hit
Gene3Di1.10.1000.11, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR041681 PH_9
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
PfamiView protein in Pfam
PF15410 PH_9, 1 hit
PF01369 Sec7, 1 hit
PRINTSiPR00683 SPECTRINPH
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00222 Sec7, 1 hit
SUPFAMiSSF48425 SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50190 SEC7, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSD1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5DTT2
Secondary accession number(s): B2RS07
, B7ZNN7, Q3TY69, Q6PE10
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 16, 2019
This is version 115 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again