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Protein

Janus kinase and microtubule-interacting protein 3

Gene

Jakmip3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Janus kinase and microtubule-interacting protein 3
Alternative name(s):
Neuroendocrine long coiled-coil protein 2
Gene namesi
Name:Jakmip3
Synonyms:Kiaa4091, Necc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1921254 Jakmip3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003230121 – 844Janus kinase and microtubule-interacting protein 3Add BLAST844

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei384PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5DTN8
PRIDEiQ5DTN8

PTM databases

iPTMnetiQ5DTN8
PhosphoSitePlusiQ5DTN8

Expressioni

Gene expression databases

BgeeiENSMUSG00000056856 Expressed in 90 organ(s), highest expression level in substantia nigra
ExpressionAtlasiQ5DTN8 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi216415, 1 interactor
IntActiQ5DTN8, 1 interactor
STRINGi10090.ENSMUSP00000065675

Structurei

3D structure databases

ProteinModelPortaliQ5DTN8
SMRiQ5DTN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili8 – 259Sequence analysisAdd BLAST252
Coiled coili289 – 421Sequence analysisAdd BLAST133
Coiled coili493 – 621Sequence analysisAdd BLAST129
Coiled coili688 – 833Sequence analysisAdd BLAST146

Sequence similaritiesi

Belongs to the JAKMIP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410II6X Eukaryota
ENOG4110F4A LUCA
GeneTreeiENSGT00390000002812
HOGENOMiHOG000060161
HOVERGENiHBG054249
InParanoidiQ5DTN8
PhylomeDBiQ5DTN8

Family and domain databases

InterProiView protein in InterPro
IPR024836 JAKMIP
IPR031994 JAKMIP_C
PANTHERiPTHR18935 PTHR18935, 1 hit
PfamiView protein in Pfam
PF16034 JAKMIP_CC3, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5DTN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKKGAGSRA KGDKAETLAA LQAANEELRA KLTDIQIELQ QEKSKVSKVE
60 70 80 90 100
REKSQELKQV REHEQRKHAV LVTELKTKLH EEKMKELQAV REALLRQHEA
110 120 130 140 150
ELLRVIKIKD NENQRLQALL NTLRDGAPDK VKTVLLCEAK EEAKKGFEVE
160 170 180 190 200
KVKMQQEISE LKGAKKQVEE ALTMVIQADK IKAAEIRSVY HLHQEEITRI
210 220 230 240 250
KKECEREIRR LMEEIRFKDR AVFVLERELG VQAGHAQRLQ LQKEALDEQL
260 270 280 290 300
SQAKEAERHP GSPRRELPYA SGAGDASDHS GSPEQQLDEK DARRFQLKIA
310 320 330 340 350
ELSAIIRKLE DRNALLSEER NELLKRLREA ESQYKPLLDK NKRLTRKNED
360 370 380 390 400
LSHTLRRIES KLKFVTQENI EMRQRAGIIR RPSSLNDLDQ SQDEREIDFL
410 420 430 440 450
KLQIVEQQNL IDELSKTLET AGYVKSVLER DKLLRYRKQR KKMAKLPKPV
460 470 480 490 500
VVETFFGYDE EASLESDGSS ISYQTDRTDQ TPCTPEDDLE EGMAKEETEL
510 520 530 540 550
RFRQLTMEYQ ALQRAYALLQ EQVGGTLDAE REVKTREQLQ AEIQRAQTRV
560 570 580 590 600
EDLEKALAEQ GQDMKWIEEK QALYRRNQEL VEKIKQMETE EARLKHEVQD
610 620 630 640 650
AKDQNELLEF RILELEERER KSPAINFHHT PFVDGKSPLQ VYCEAEGVTD
660 670 680 690 700
ILVTELMKKL DILGDNANLT NEEQVVVIQA RTVLTLAEKW LQRIEETESA
710 720 730 740 750
LQRKMVDLES EKELFSKQKG YLDEELDYRK QALDQAHKHI LELEAMLYDA
760 770 780 790 800
LQQEAGAKVA ELLSEEEREK LKVAVEQWKR QVMSELRERD AQILRERMEL
810 820 830 840
LQIAQQRIKE LEERIETQKR QIKELEEKFL FLFLFFSLAF ILWS
Length:844
Mass (Da):98,715
Last modified:March 18, 2008 - v2
Checksum:i39541A48498106C4
GO
Isoform 2 (identifier: Q5DTN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     212-285: Missing.
     535-535: T → V
     536-844: Missing.

Note: No experimental confirmation available.
Show »
Length:461
Mass (Da):53,731
Checksum:i51238B1AF62BE310
GO
Isoform 3 (identifier: Q5DTN8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     212-283: Missing.
     535-535: T → V
     536-844: Missing.

Note: No experimental confirmation available.
Show »
Length:463
Mass (Da):53,989
Checksum:iDB5879664979F637
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q7K7E9Q7K7_MOUSE
Janus kinase and microtubule-intera...
Jakmip3
534Annotation score:
A0A1B0GSY2A0A1B0GSY2_MOUSE
Janus kinase and microtubule-intera...
Jakmip3
462Annotation score:
F6TN46F6TN46_MOUSE
Janus kinase and microtubule-intera...
Jakmip3
16Annotation score:

Sequence cautioni

The sequence BAD90506 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti229L → F in BAB31115 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032000212 – 285Missing in isoform 2. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_032001212 – 283Missing in isoform 3. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_032002535T → V in isoform 2 and isoform 3. 1 Publication1
Alternative sequenceiVSP_032003536 – 844Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST309

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220482 mRNA Translation: BAD90506.1 Different initiation.
BC119557 mRNA Translation: AAI19558.1
BC119558 mRNA Translation: AAI19559.1
AK018189 mRNA Translation: BAB31115.2
RefSeqiNP_082984.1, NM_028708.2 [Q5DTN8-1]
UniGeneiMm.334298
Mm.389979

Genome annotation databases

EnsembliENSMUST00000106111; ENSMUSP00000101717; ENSMUSG00000056856 [Q5DTN8-3]
ENSMUST00000213872; ENSMUSP00000151169; ENSMUSG00000111614 [Q5DTN8-3]
GeneIDi74004
KEGGimmu:74004
UCSCiuc029wpf.2 mouse [Q5DTN8-1]
uc033jcq.1 mouse [Q5DTN8-3]
uc033jcr.1 mouse [Q5DTN8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220482 mRNA Translation: BAD90506.1 Different initiation.
BC119557 mRNA Translation: AAI19558.1
BC119558 mRNA Translation: AAI19559.1
AK018189 mRNA Translation: BAB31115.2
RefSeqiNP_082984.1, NM_028708.2 [Q5DTN8-1]
UniGeneiMm.334298
Mm.389979

3D structure databases

ProteinModelPortaliQ5DTN8
SMRiQ5DTN8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216415, 1 interactor
IntActiQ5DTN8, 1 interactor
STRINGi10090.ENSMUSP00000065675

PTM databases

iPTMnetiQ5DTN8
PhosphoSitePlusiQ5DTN8

Proteomic databases

PaxDbiQ5DTN8
PRIDEiQ5DTN8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106111; ENSMUSP00000101717; ENSMUSG00000056856 [Q5DTN8-3]
ENSMUST00000213872; ENSMUSP00000151169; ENSMUSG00000111614 [Q5DTN8-3]
GeneIDi74004
KEGGimmu:74004
UCSCiuc029wpf.2 mouse [Q5DTN8-1]
uc033jcq.1 mouse [Q5DTN8-3]
uc033jcr.1 mouse [Q5DTN8-2]

Organism-specific databases

CTDi282973
MGIiMGI:1921254 Jakmip3
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410II6X Eukaryota
ENOG4110F4A LUCA
GeneTreeiENSGT00390000002812
HOGENOMiHOG000060161
HOVERGENiHBG054249
InParanoidiQ5DTN8
PhylomeDBiQ5DTN8

Miscellaneous databases

PROiPR:Q5DTN8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056856 Expressed in 90 organ(s), highest expression level in substantia nigra
ExpressionAtlasiQ5DTN8 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR024836 JAKMIP
IPR031994 JAKMIP_C
PANTHERiPTHR18935 PTHR18935, 1 hit
PfamiView protein in Pfam
PF16034 JAKMIP_CC3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiJKIP3_MOUSE
AccessioniPrimary (citable) accession number: Q5DTN8
Secondary accession number(s): Q0VDR4, Q0VDR5, Q9CU41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: September 12, 2018
This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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