Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 89 (11 Dec 2019)
Sequence version 1 (29 Mar 2005)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

MKIAA4112 protein

Gene

Ppfia2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MKIAA4112 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ppfia2Imported
Synonyms:mKIAA4112Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443834 Ppfia2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q5DTM9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini902 – 968SAMInterPro annotationAdd BLAST67
Domaini1031 – 1088SAMInterPro annotationAdd BLAST58
Domaini1112 – 1181SAMInterPro annotationAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni13 – 33DisorderedSequence analysisAdd BLAST21
Regioni443 – 467DisorderedSequence analysisAdd BLAST25
Regioni713 – 742DisorderedSequence analysisAdd BLAST30
Regioni754 – 838DisorderedSequence analysisAdd BLAST85

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili39 – 66Sequence analysisAdd BLAST28
Coiled coili107 – 148Sequence analysisAdd BLAST42
Coiled coili199 – 233Sequence analysisAdd BLAST35
Coiled coili274 – 357Sequence analysisAdd BLAST84
Coiled coili361 – 410Sequence analysisAdd BLAST50
Coiled coili502 – 539Sequence analysisAdd BLAST38
Coiled coili654 – 695Sequence analysisAdd BLAST42
Coiled coili875 – 895Sequence analysisAdd BLAST21
Coiled coili1085 – 1105Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi14 – 33PolarSequence analysisAdd BLAST20
Compositional biasi713 – 731PolarSequence analysisAdd BLAST19
Compositional biasi754 – 774PolyampholyteSequence analysisAdd BLAST21
Compositional biasi788 – 824PolarSequence analysisAdd BLAST37

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0249 Eukaryota
ENOG410XP8Z LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000017513

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09562 SAM_liprin-alpha1_2_3_4_repeat1, 1 hit
cd09565 SAM_liprin-alpha1_2_3_4_repeat2, 1 hit
cd09568 SAM_liprin-alpha1_2_3_4_repeat3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029515 Liprin
IPR037620 Liprin-alpha_SAM_rpt_1
IPR037621 Liprin-alpha_SAM_rpt_2
IPR037622 Liprin-alpha_SAM_rpt_3
IPR030441 PPFIA2
IPR001660 SAM
IPR013761 SAM/pointed_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12587 PTHR12587, 1 hit
PTHR12587:SF6 PTHR12587:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00536 SAM_1, 2 hits
PF07647 SAM_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00454 SAM, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50105 SAM_DOMAIN, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q5DTM9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ETLAMMCEVM PTINEDTPMS QRGSQSSGSD SDSHFEQLMV NMLDERDRLL
60 70 80 90 100
DTLRETQESL SLAQQRLQDV IYDRDSLQRQ LNSALPQDIE SLTGGLTGSK
110 120 130 140 150
GADPPEFAAL TKELNACREQ LLEKEEEISE LKAERNNTRL LLEHLECLVS
160 170 180 190 200
RHERSLRMTV VKRQAQSPSG VSSEVEVLKA LKSLFEHHKA LDEKVRERLR
210 220 230 240 250
VSLERVSALE EELAAANQEI VALREQNVHI QRKMVSSEGS TESEHLEGME
260 270 280 290 300
AGQKVHEKRL SNGSIDSTDD TSQIVELQEL LEKQNYEMAQ MKERLTALSS
310 320 330 340 350
RVGEVEQEAE TARKDLIKTE EMNTKYQRDI REAMAQKEDM EERITTLEKR
360 370 380 390 400
YLSAQRESTS IHDMNDKLEN ELANKEAILR QMEEKNRQLQ ERLELAEQKL
410 420 430 440 450
QQTMRKAETL PEVEAELAQR IAALTKAEER HGNIEERMRH LEGQLEEKNQ
460 470 480 490 500
ELQRARQREK MNEEHNKRLS DTVDRLLTES NERLQLHLKE RMAALEEKNV
510 520 530 540 550
LIQESENFRK NLEESLHDKE RLAEEIEKLR SELDQMKMRT GSLIEPTISR
560 570 580 590 600
THIDTSTELR YSVGSLVDSQ SDYRTTKVIR RPRRGRMGVR RDEPKVKSLG
610 620 630 640 650
DHEWNRTQQI GVLGSHPFES DTEMSDIDDD DRETIFSSMD LLSPSGHSDA
660 670 680 690 700
QTLAMMLQEQ LDAINKEIRL IQEEKESTEL RAEEIENRVA SVSLEGLNLA
710 720 730 740 750
RVHPGTSITA SVTASSLASS SPPSGHSTPK LTPRSPAREM DRMGVMTLPS
760 770 780 790 800
DLRKHRRKIA VVEEDGREDK ATIKCETSPP PTPRAVRMTH TLPSSYHNDA
810 820 830 840 850
RSSLSASLEP DSLGLGSANS SQDSLHKAPK KKGIKSSIGR LFGKKEKARL
860 870 880 890 900
GQLRGFMETE AAAQESLGLG KLGTQAEKDR RLKKKHELLE EARRKGLPFA
910 920 930 940 950
QWDGPTVVAW LELWLGMPAW YVAACRANVK SGAIMSALSD TEIQREIGIS
960 970 980 990 1000
NPLHRLKLRL AIQEMVSLTS PSAPPTSRTP SGNVWVTHEE MENLTAPAKT
1010 1020 1030 1040 1050
KESEEGSWAQ CPVFLQTLAY GDMNHEWIGN EWLPSLGLPQ YRSYFMECLV
1060 1070 1080 1090 1100
DARMLDHLTK KDLRVHLKMV DSFHRTSLQY GIMCLKRLNY DRKELERRRE
1110 1120 1130 1140 1150
ASQHEIKDVL VWSNDRVIRW IQAIGLREYA NNILESGVHG SLIALDENFD
1160 1170 1180 1190 1200
YSSLALLLQI PTQNTQARQI LEREYNNLLA LGTERRLDES DDKNFRRGST
1210 1220 1230 1240 1250
WRRQFPPREV HGISMMPGSS ETLPAGFRLT TTSGQSRKMT TDVASSRLQR
1260
LDNSTVRTYS C
Length:1,261
Mass (Da):143,748
Last modified:March 29, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2DCB75FFDE96E92D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK220491 mRNA Translation: BAD90289.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220491 mRNA Translation: BAD90289.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ5DTM9

Organism-specific databases

MGIiMGI:2443834 Ppfia2

Phylogenomic databases

eggNOGiKOG0249 Eukaryota
ENOG410XP8Z LUCA
HOGENOMiHOG000017513

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ppfia2 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

CDDicd09562 SAM_liprin-alpha1_2_3_4_repeat1, 1 hit
cd09565 SAM_liprin-alpha1_2_3_4_repeat2, 1 hit
cd09568 SAM_liprin-alpha1_2_3_4_repeat3, 1 hit
Gene3Di1.10.150.50, 3 hits
InterProiView protein in InterPro
IPR029515 Liprin
IPR037620 Liprin-alpha_SAM_rpt_1
IPR037621 Liprin-alpha_SAM_rpt_2
IPR037622 Liprin-alpha_SAM_rpt_3
IPR030441 PPFIA2
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR12587 PTHR12587, 1 hit
PTHR12587:SF6 PTHR12587:SF6, 1 hit
PfamiView protein in Pfam
PF00536 SAM_1, 2 hits
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 3 hits
SUPFAMiSSF47769 SSF47769, 3 hits
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5DTM9_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5DTM9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 29, 2005
Last sequence update: March 29, 2005
Last modified: December 11, 2019
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again