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Entry version 136 (02 Jun 2021)
Sequence version 2 (11 Jul 2006)
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Protein

Sodium-driven chloride bicarbonate exchanger

Gene

Slc4a10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (PubMed:10993873, PubMed:20566632).

Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (PubMed:10993873, PubMed:20566632).

Has also been shown to act as a sodium/biocarbonate cotransporter which is not responsible for net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (By similarity).

Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (PubMed:18165320).

Reduces the excitability of CA1 pyramidal neurons and modulates short-term synaptic plasticity (PubMed:26136660).

Required in retinal cells to maintain normal pH which is necessary for normal vision (PubMed:23056253).

In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity).

By similarity5 Publications

Caution

Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (PubMed:10993873, PubMed:20566632). Has also been shown to act as a sodium/biocarbonate cotransporter which is not responsible for net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Ion transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-425381, Bicarbonate transporters

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.31.2.3, the anion exchanger (ae) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium-driven chloride bicarbonate exchanger1 Publication
Alternative name(s):
Solute carrier family 4 member 10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc4a10Imported
Synonyms:Kiaa4136Imported, Ncbe1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2150150, Slc4a10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 509CytoplasmicSequence analysisAdd BLAST509
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei510 – 530HelicalSequence analysisAdd BLAST21
Topological domaini531 – 538ExtracellularSequence analysis8
Transmembranei539 – 559HelicalSequence analysisAdd BLAST21
Topological domaini560 – 562CytoplasmicSequence analysis3
Transmembranei563 – 583HelicalSequence analysisAdd BLAST21
Topological domaini584 – 596ExtracellularSequence analysisAdd BLAST13
Transmembranei597 – 617HelicalSequence analysisAdd BLAST21
Topological domaini618 – 626CytoplasmicSequence analysis9
Transmembranei627 – 647HelicalSequence analysisAdd BLAST21
Topological domaini648 – 720ExtracellularSequence analysisAdd BLAST73
Transmembranei721 – 741HelicalSequence analysisAdd BLAST21
Topological domaini742 – 762CytoplasmicSequence analysisAdd BLAST21
Transmembranei763 – 783HelicalSequence analysisAdd BLAST21
Topological domaini784 – 809ExtracellularSequence analysisAdd BLAST26
Transmembranei810 – 830HelicalSequence analysisAdd BLAST21
Topological domaini831 – 855CytoplasmicSequence analysisAdd BLAST25
Transmembranei856 – 876HelicalSequence analysisAdd BLAST21
Topological domaini877 – 912ExtracellularSequence analysisAdd BLAST36
Transmembranei913 – 933HelicalSequence analysisAdd BLAST21
Topological domaini934 – 935CytoplasmicSequence analysis2
Transmembranei936 – 956HelicalSequence analysisAdd BLAST21
Topological domaini957 – 998ExtracellularSequence analysisAdd BLAST42
Transmembranei999 – 1019HelicalSequence analysisAdd BLAST21
Topological domaini1020 – 1118CytoplasmicSequence analysisAdd BLAST99

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Homozygotes are born at the expected Mendelian ratio but most pups die around weaning (PubMed:18165320). When fed soft food from the second week of life onward, most pups catch up with the weight of their wild-type littermates and survive (PubMed:18165320). Adults display normal weight and lifespan, are fertile and do not display major behavioral abnormalities (PubMed:18165320). However, brain ventricle size is drastically reduced and mutants show diminished Na+-dependent recovery of pH following acid loading of choroid plexus epithelial cells (PubMed:18165320). Mutants also show reduced excitability of CA3 pyramidal neurson and have increased seizure threshold (PubMed:18165320). Increased excitability of CA1 pyramidal neurons and diminished paired pulse facilitation in the hippocampus (PubMed:26136660). No obvious morphological changes in the retina but mutants display decreased visual acuity and contrast sensitivity in behavioral experiments, smaller scotopic and photopic b-wave amplitudes and longer latencies in electroretinograms, and altered temporal response properties of ganglion cells (PubMed:23056253).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi585E → A: Reduced recovery of intracellular sodium-dependent pH. 1 Publication1
Mutagenesisi891E → A: Reduced recovery of intracellular sodium-dependent pH. 1 Publication1
Mutagenesisi893E → A: Reduced recovery of intracellular sodium-dependent pH. 1 Publication1
Mutagenesisi977H → L: Reduced recovery of intracellular sodium-dependent pH. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002452411 – 1118Sodium-driven chloride bicarbonate exchangerAdd BLAST1118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei89PhosphoserineCombined sources1
Modified residuei94PhosphothreonineCombined sources1
Modified residuei276PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi677N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi687N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi697N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1057PhosphoserineCombined sources1
Modified residuei1085PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5DTL9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5DTL9

PRoteomics IDEntifications database

More...
PRIDEi
Q5DTL9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
256823 [Q5DTL9-1]
256824 [Q5DTL9-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q5DTL9, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5DTL9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5DTL9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the brain, detected in cerebral cortex, subcortex, cerebellum, hippocampus and medulla (at protein level) (PubMed:20541593, PubMed:18061361, PubMed:21439947, PubMed:24905082). In the cerebrum, expressed at high levels throughout the cortex, at lower levels in striatum and not detectable in the corpus callosum (at protein level) (PubMed:20541593). In the cerebellum, detected at high levels in the molecular layer but at very low levels in the granular layer (at protein level) (PubMed:20541593). In the central nervous system, detected in neurons in the olfactory bulb, cortex and cerebellum (at protein level) (PubMed:18165320). Within the hippocampus, abundantly expressed in CA3 pyramidal cells (at protein level) (PubMed:18165320). Strongly expressed in the retina with high levels in bipolar and amacrine cells (at protein level) (PubMed:23056253). Expressed at high levels in brain and at low levels in the pituitary, testis, kidney and ileum (PubMed:10993873). Also expressed in pancreatic islets (PubMed:10993873). Expressed in the epithelial cells of the choroid plexus (PubMed:14592810, PubMed:15567717). During embryonic development, expressed in neurons of the central nervous system (PubMed:15567717). Also expressed in the peripheral nervous system and in non-neuronal tissues such as the dura and some epithelia including the acid-secreting epithelium of the stomach and the duodenal epithelium (PubMed:15567717). In the embryonic retina, expression is restricted to the neuronal cell layer and the retinal pigment epithelium (PubMed:15567717).9 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In the embryonic central nervous system, detected at 12.5 dpc when expression is observed in all areas of the brain including the cerebellum (PubMed:15567717). In the embryonic cerebral cortex, detected at 14.5 dpc with levels increasing at 18.5 dpc (PubMed:15567717).1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Repressed in the brain by chronic continuous hypoxia (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026904, Expressed in choroid plexus epithelium and 167 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q5DTL9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5DTL9, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
220486, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q5DTL9, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000099796

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5DTL9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5DTL9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 23DisorderedSequence analysisAdd BLAST23
Regioni58 – 97DisorderedSequence analysisAdd BLAST40
Regioni269 – 310DisorderedSequence analysisAdd BLAST42
Regioni457 – 476DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi58 – 75Basic residuesSequence analysisAdd BLAST18
Compositional biasi269 – 298Polar residuesSequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal cytoplasmic domain is likely to have a high level of intrinsic disorder.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1172, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156972

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002289_5_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5DTL9

Identification of Orthologs from Complete Genome Data

More...
OMAi
WRDSNIS

Database of Orthologous Groups

More...
OrthoDBi
265068at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5DTL9

TreeFam database of animal gene trees

More...
TreeFami
TF313630

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013769, Band3_cytoplasmic_dom
IPR011531, HCO3_transpt_C
IPR003020, HCO3_transpt_euk
IPR003024, Na/HCO3_transpt
IPR016152, PTrfase/Anion_transptr

The PANTHER Classification System

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PANTHERi
PTHR11453, PTHR11453, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07565, Band_3_cyto, 1 hit
PF00955, HCO3_cotransp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01231, HCO3TRNSPORT
PR01232, NAHCO3TRSPRT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55804, SSF55804, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00834, ae, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 10 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Note: The use of 2 alternative promoters gives rise to isoforms which differ at the N-terminus. In addition, alternative splicing gives rise to further isoform diversity.1 Publication
Isoform 1 (identifier: Q5DTL9-1) [UniParc]FASTAAdd to basket
Also known as: NBCn2-B1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEIKDQGAQM EPLLPTRNDE EAVVDRGGTR SILKTHFEKE DLEGHRTLFI
60 70 80 90 100
GVHVPLGGRK SHRRHRHRGH KHRKRDRERD SGLEDGRESP SFDTPSQRVQ
110 120 130 140 150
FILGTEDDDE EHLPHDLFTE LDEICWREGE DAEWRETARW LKFEEDVEDG
160 170 180 190 200
GERWSKPYVA TLSLHSLFEL RSCILNGTVL LDMHANTIEE IADMVLDQQV
210 220 230 240 250
SSGQLNEDVR HRVHEALMKQ HHHQNQKKLA NRIPIVRSFA DIGKKQSEPN
260 270 280 290 300
SMDKNAGQVV SPQSAPACAE NKNDVSRENS TVDFSKGLGG QQKGHTSPCG
310 320 330 340 350
MKQRLDKGPP HQQEREVDLH FMKKIPPGAE ASNILVGELE FLDRTVVAFV
360 370 380 390 400
RLSPAVLLQG LAEVPIPSRF LFILLGPLGK GQQYHEIGRS IATLMTDEVF
410 420 430 440 450
HDVAYKAKDR NDLVSGIDEF LDQVTVLPPG EWDPSIRIEP PKNVPSQEKR
460 470 480 490 500
KIPAVPNGTA AHGEAEPHGG HSGPELQRTG RIFGGLILDI KRKAPFFWSD
510 520 530 540 550
FRDAFSLQCL ASFLFLYCAC MSPVITFGGL LGEATEGRIS AIESLFGASM
560 570 580 590 600
TGIAYSLFGG QPLTILGSTG PVLVFEKILF KFCKEYGLSY LSLRASIGLW
610 620 630 640 650
TATLCIILVA TDASSLVCYI TRFTEEAFAS LICIIFIYEA LEKLFELSET
660 670 680 690 700
YPINMHNDLE LLTQYSCNCM EPHSPSNDTL KEWRESNLSA SDIIWGNLTV
710 720 730 740 750
SECRSLHGEY VGRACGHGHP YVPDVLFWSV ILFFSTVTMS ATLKQFKTSR
760 770 780 790 800
YFPTKVRSIV SDFAVFLTIL CMVLIDYAIG IPSPKLQVPS VFKPTRDDRG
810 820 830 840 850
WFVTPLGPNP WWTIIAAIIP ALLCTILIFM DQQITAVIIN RKEHKLKKGC
860 870 880 890 900
GYHLDLLMVA VMLGVCSIMG LPWFVAATVL SITHVNSLKL ESECSAPGEQ
910 920 930 940 950
PKFLGIREQR VTGLMIFILM GSSVFMTSIL KFIPMPVLYG VFLYMGASSL
960 970 980 990 1000
KGIQLFDRIK LFWMPAKHQP DFIYLRHVPL RKVHLFTVIQ MSCLGLLWII
1010 1020 1030 1040 1050
KVSRAAIVFP MMVLALVFVR KLMDFLFTKR ELSWLDDLMP ESKKKKLEDA
1060 1070 1080 1090 1100
EKEEEQSMLA MEDEGTVQLP LEGHYRDDPS VINISDEMSK TAMWGNLLVT
1110
ADNSKEKESR FPSKSSPS
Length:1,118
Mass (Da):125,817
Last modified:July 11, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i85E3110C976978A7
GO
Isoform 2 (identifier: Q5DTL9-2) [UniParc]FASTAAdd to basket
Also known as: NBCn2-A1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     287-316: Missing.

Show »
Length:1,088
Mass (Da):122,550
Checksum:iC06FCBC60D21959F
GO
Isoform 3 (identifier: Q5DTL9-3) [UniParc]FASTAAdd to basket
Also known as: NBCn2-C1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     287-316: Missing.
     1116-1118: SPS → NESRKEKKADSGKGVDRETCL

Show »
Length:1,106
Mass (Da):124,611
Checksum:i375E26BEFDEE2D6A
GO
Isoform 4 (identifier: Q5DTL9-4) [UniParc]FASTAAdd to basket
Also known as: NBCn2-D1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1116-1118: SPS → NESRKEKKADSGKGVDRETCL

Show »
Length:1,136
Mass (Da):127,879
Checksum:iC8914182AE27F143
GO
Isoform 5 (identifier: Q5DTL9-5) [UniParc]FASTAAdd to basket
Also known as: NBCn2-E1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MEIKDQGAQMEPLLPT → MQPGSCEHFQSLSQE
     287-316: Missing.

Show »
Length:1,087
Mass (Da):122,456
Checksum:iE3DC2CD0E5094770
GO
Isoform 6 (identifier: Q5DTL9-6) [UniParc]FASTAAdd to basket
Also known as: NBCn2-F1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MEIKDQGAQMEPLLPT → MQPGSCEHFQSLSQE

Show »
Length:1,117
Mass (Da):125,724
Checksum:iA40901DEA20D4D72
GO
Isoform 7 (identifier: Q5DTL9-7) [UniParc]FASTAAdd to basket
Also known as: NBCn2-G1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MEIKDQGAQMEPLLPT → MQPGSCEHFQSLSQE
     287-316: Missing.
     1116-1118: SPS → NESRKEKKADSGKGVDRETCL

Show »
Length:1,105
Mass (Da):124,518
Checksum:i67103C9C9F463200
GO
Isoform 8 (identifier: Q5DTL9-8) [UniParc]FASTAAdd to basket
Also known as: NBCn2-H1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MEIKDQGAQMEPLLPT → MQPGSCEHFQSLSQE
     1116-1118: SPS → NESRKEKKADSGKGVDRETCL

Show »
Length:1,135
Mass (Da):127,785
Checksum:i77BEBD047892D39E
GO
Isoform 9 (identifier: Q5DTL9-9) [UniParc]FASTAAdd to basket
Also known as: NBCn2-I1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MEIKDQGAQMEPLLPT → MQPGSCEHFQSLSQE
     287-316: Missing.
     1115-1118: SSPS → RS

Show »
Length:1,085
Mass (Da):122,341
Checksum:iECD155094770FB34
GO
Isoform 10 (identifier: Q5DTL9-10) [UniParc]FASTAAdd to basket
Also known as: NBCn2-J1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MEIKDQGAQMEPLLPT → MQPGSCEHFQSLSQE
     1115-1118: SSPS → RS

Show »
Length:1,115
Mass (Da):125,609
Checksum:i21DF120D4D728F2E
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD90511 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti239F → L in BAB17922 (PubMed:10993873).Curated1
Sequence conflicti256Missing in ADW85802 (PubMed:21439947).Curated1
Sequence conflicti256Missing in AFN27376 (PubMed:23409100).Curated1
Sequence conflicti256Missing in AAH39226 (PubMed:15489334).Curated1
Sequence conflicti345T → A in BAB17922 (PubMed:10993873).Curated1
Sequence conflicti487I → M in BAB17922 (PubMed:10993873).Curated1
Sequence conflicti796 – 797RD → IY in BAB17922 (PubMed:10993873).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0601321 – 16MEIKD…PLLPT → MQPGSCEHFQSLSQE in isoform 5, isoform 6, isoform 7, isoform 8, isoform 9 and isoform 10. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_019654287 – 316Missing in isoform 2, isoform 3, isoform 5, isoform 7 and isoform 9. 5 PublicationsAdd BLAST30
Alternative sequenceiVSP_0601331115 – 1118SSPS → RS in isoform 9 and isoform 10. 1 Publication4
Alternative sequenceiVSP_0601341116 – 1118SPS → NESRKEKKADSGKGVDRETC L in isoform 3, isoform 4, isoform 7 and isoform 8. 2 Publications3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB033759 mRNA Translation: BAB17922.1
HQ825316 mRNA Translation: ADX99207.1
HQ831517 mRNA Translation: ADW85802.1
JF500487 mRNA Translation: AEN71161.1
JF500488 mRNA Translation: AEN71162.1
JF500489 mRNA Translation: AEN71163.1
JF500490 mRNA Translation: AEN71164.1
JX220977 mRNA Translation: AFN27376.1
JX254917 mRNA Translation: AFQ60533.1
AK220501 mRNA Translation: BAD90511.1 Different initiation.
BC039226 mRNA Translation: AAH39226.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS16064.1 [Q5DTL9-2]
CCDS57172.1 [Q5DTL9-1]
CCDS57173.1 [Q5DTL9-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001229307.1, NM_001242378.1 [Q5DTL9-4]
NP_001229309.1, NM_001242380.1 [Q5DTL9-1]
NP_001229310.1, NM_001242381.1
NP_001229312.1, NM_001242383.1
XP_006500511.1, XM_006500448.3
XP_006500512.1, XM_006500449.3
XP_006500513.1, XM_006500450.3
XP_006500514.1, XM_006500451.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000054484; ENSMUSP00000061411; ENSMUSG00000026904 [Q5DTL9-3]
ENSMUST00000102735; ENSMUSP00000099796; ENSMUSG00000026904 [Q5DTL9-2]
ENSMUST00000112480; ENSMUSP00000108099; ENSMUSG00000026904 [Q5DTL9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
94229

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:94229

UCSC genome browser

More...
UCSCi
uc008jve.3, mouse [Q5DTL9-2]
uc008jvf.3, mouse [Q5DTL9-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033759 mRNA Translation: BAB17922.1
HQ825316 mRNA Translation: ADX99207.1
HQ831517 mRNA Translation: ADW85802.1
JF500487 mRNA Translation: AEN71161.1
JF500488 mRNA Translation: AEN71162.1
JF500489 mRNA Translation: AEN71163.1
JF500490 mRNA Translation: AEN71164.1
JX220977 mRNA Translation: AFN27376.1
JX254917 mRNA Translation: AFQ60533.1
AK220501 mRNA Translation: BAD90511.1 Different initiation.
BC039226 mRNA Translation: AAH39226.1
CCDSiCCDS16064.1 [Q5DTL9-2]
CCDS57172.1 [Q5DTL9-1]
CCDS57173.1 [Q5DTL9-3]
RefSeqiNP_001229307.1, NM_001242378.1 [Q5DTL9-4]
NP_001229309.1, NM_001242380.1 [Q5DTL9-1]
NP_001229310.1, NM_001242381.1
NP_001229312.1, NM_001242383.1
XP_006500511.1, XM_006500448.3
XP_006500512.1, XM_006500449.3
XP_006500513.1, XM_006500450.3
XP_006500514.1, XM_006500451.3

3D structure databases

SMRiQ5DTL9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi220486, 2 interactors
IntActiQ5DTL9, 1 interactor
STRINGi10090.ENSMUSP00000099796

Protein family/group databases

TCDBi2.A.31.2.3, the anion exchanger (ae) family

PTM databases

GlyGeniQ5DTL9, 3 sites
iPTMnetiQ5DTL9
PhosphoSitePlusiQ5DTL9

Proteomic databases

jPOSTiQ5DTL9
PaxDbiQ5DTL9
PRIDEiQ5DTL9
ProteomicsDBi256823 [Q5DTL9-1]
256824 [Q5DTL9-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
48063, 27 antibodies

The DNASU plasmid repository

More...
DNASUi
94229

Genome annotation databases

EnsembliENSMUST00000054484; ENSMUSP00000061411; ENSMUSG00000026904 [Q5DTL9-3]
ENSMUST00000102735; ENSMUSP00000099796; ENSMUSG00000026904 [Q5DTL9-2]
ENSMUST00000112480; ENSMUSP00000108099; ENSMUSG00000026904 [Q5DTL9-1]
GeneIDi94229
KEGGimmu:94229
UCSCiuc008jve.3, mouse [Q5DTL9-2]
uc008jvf.3, mouse [Q5DTL9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57282
MGIiMGI:2150150, Slc4a10

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG1172, Eukaryota
GeneTreeiENSGT00940000156972
HOGENOMiCLU_002289_5_2_1
InParanoidiQ5DTL9
OMAiWRDSNIS
OrthoDBi265068at2759
PhylomeDBiQ5DTL9
TreeFamiTF313630

Enzyme and pathway databases

ReactomeiR-MMU-425381, Bicarbonate transporters

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
94229, 2 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Slc4a10, mouse

Protein Ontology

More...
PROi
PR:Q5DTL9
RNActiQ5DTL9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026904, Expressed in choroid plexus epithelium and 167 other tissues
ExpressionAtlasiQ5DTL9, baseline and differential
GenevisibleiQ5DTL9, MM

Family and domain databases

InterProiView protein in InterPro
IPR013769, Band3_cytoplasmic_dom
IPR011531, HCO3_transpt_C
IPR003020, HCO3_transpt_euk
IPR003024, Na/HCO3_transpt
IPR016152, PTrfase/Anion_transptr
PANTHERiPTHR11453, PTHR11453, 1 hit
PfamiView protein in Pfam
PF07565, Band_3_cyto, 1 hit
PF00955, HCO3_cotransp, 1 hit
PRINTSiPR01231, HCO3TRNSPORT
PR01232, NAHCO3TRSPRT
SUPFAMiSSF55804, SSF55804, 1 hit
TIGRFAMsiTIGR00834, ae, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS4A10_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5DTL9
Secondary accession number(s): E9NX85
, F1DFN1, G3F8Y7, G3F8Y8, G3F8Y9, G3F8Z0, I6VS12, J7K287, Q8CFS3, Q9EST0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: June 2, 2021
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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