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Protein
Submitted name:

MKIAA4137 protein

Gene

Sel1l

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MKIAA4137 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sel1lImported
Synonyms:mKIAA4137Imported, Sel1hImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:1329016 Sel1l

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi165 ↔ 191PROSITE-ProRule annotation
Disulfide bondi179 ↔ 206PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q5DTL8

PRoteomics IDEntifications database

More...
PRIDEi
Q5DTL8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5DTL8 MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q5DTL8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini160 – 208Fibronectin type-IIInterPro annotationAdd BLAST49

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1550 Eukaryota
COG0790 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000239927

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG057766

KEGG Orthology (KO)

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KOi
K14026

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5DTL8

Family and domain databases

Conserved Domains Database

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CDDi
cd00062 FN2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.10, 3 hits
2.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013806 Kringle-like
IPR006597 Sel1-like
IPR011990 TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00040 fn2, 1 hit
PF08238 Sel1, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00059 FN2, 1 hit
SM00671 SEL1, 11 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57440 SSF57440, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q5DTL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GKGRRRNLSR KSGCEAAAQR QRLSWSRRRR RRRRGLSTFE SRMQVRVRLS
60 70 80 90 100
LLLLCAVLLG SAAATSDDKT NQDDSLDSKS SLPTDESVKD HTTTGKVVAG
110 120 130 140 150
QIFVDSEEAE VESLLQDEED SSKTQEEEIS FLESPNPSSK TYEELKRVRK
160 170 180 190 200
PVLTAIEGTA HGEPCHFPFL FLDKEYDECT SDGREDGRLW CATTYDYKTD
210 220 230 240 250
EKWGFCETEE DAAKRRQMQE AEMIYQAGMK ILNGSNRKSQ KREAYRYLQK
260 270 280 290 300
AAGMNHTKAL ERVSYALLFG DYLTQNIQAA KEMFEKLTEE GSPKGQTGLG
310 320 330 340 350
FLYASGLGVN SSQAKALVYY TFGALGGNLI AHMILGYRYW AGIGVLQSCE
360 370 380 390 400
SALTHYRLVA NHVASDISLT GGSVVQRIRL PDEVENPGMN SGMLEEDLIQ
410 420 430 440 450
YYQFLAEKGD VQAQVGLGQL HLHGGRGVEQ NHQRAFDYFN LAANAGNSHA
460 470 480 490 500
MAFLGKMYSE GSDIVPQSNE TALHYFKKAA DMGNPVGQSG LGMAYLYGRG
510 520 530 540 550
VQVNYDLALK YFQKAAEQGW VDGQLQLGSM YYNGIGVKRD YKQALKYFNL
560 570 580 590 600
ASQGGHILAF YNLAQMHASG TGVMRSCHTA VELFKNVCER GRWSERLMTA
610 620 630 640 650
YNSYKDEDYN AAVVQYLLLA EQGYEVAQSN AAFILDQREA TIVGENETYP
660 670 680 690 700
RALLHWNRAA SQGYTVARIK LGDYHFYGFG TDVDYETAFI HYRLASEQQH
710 720 730 740 750
SAQAMFNLGY MHEKGLGIKQ DIHLAKRFYD MAAEASPDAQ VPVFLALCKL
760 770 780 790 800
GVVYFLQYIR EANIRDLFTQ LDMDQLLGPE WDLYLMTIIA LLLGTVIAYR
810 820 830
QRQHQDIPVP RPPGPRPAPP QQEGPPEQQP PQ
Length:832
Mass (Da):93,409
Last modified:March 29, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i590A222B34009F9A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK220502 mRNA Translation: BAD90512.1

NCBI Reference Sequences

More...
RefSeqi
NP_001034178.1, NM_001039089.1
NP_035474.1, NM_011344.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.250605

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
20338

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:20338

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220502 mRNA Translation: BAD90512.1
RefSeqiNP_001034178.1, NM_001039089.1
NP_035474.1, NM_011344.2
UniGeneiMm.250605

3D structure databases

ProteinModelPortaliQ5DTL8
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ5DTL8
PRIDEiQ5DTL8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20338
KEGGimmu:20338

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6400
MGIiMGI:1329016 Sel1l

Phylogenomic databases

eggNOGiKOG1550 Eukaryota
COG0790 LUCA
HOGENOMiHOG000239927
HOVERGENiHBG057766
KOiK14026
PhylomeDBiQ5DTL8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sel1l mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

GenevisibleiQ5DTL8 MM

Family and domain databases

CDDicd00062 FN2, 1 hit
Gene3Di1.25.40.10, 3 hits
2.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013806 Kringle-like
IPR006597 Sel1-like
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF00040 fn2, 1 hit
PF08238 Sel1, 12 hits
SMARTiView protein in SMART
SM00059 FN2, 1 hit
SM00671 SEL1, 11 hits
SUPFAMiSSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5DTL8_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5DTL8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 29, 2005
Last sequence update: March 29, 2005
Last modified: February 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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