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Protein

Teashirt homolog 1

Gene

Tshz1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri246 – 270C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri307 – 331C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri416 – 440C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST25
DNA bindingi891 – 961Homeobox; atypicalAdd BLAST71
Zinc fingeri976 – 998C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1044 – 1067C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Teashirt homolog 1
Alternative name(s):
Serologically defined colon cancer antigen 3 homolog
Gene namesi
Name:Tshz1
Synonyms:Kiaa4206, Sdccag33, Tsh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1346031 Tshz1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Normal Mendelian ratio at birth, but none of the mutant animals survive beyond P0. Newborn mutant mice exhibit a strong defect of the soft palate, vertebral malformations in the cervical and thoracic regions of the axial skeleton and malformations in the middle ear components.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470631 – 1084Teashirt homolog 1Add BLAST1084

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei771PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5DTH5
PaxDbiQ5DTH5
PeptideAtlasiQ5DTH5
PRIDEiQ5DTH5

PTM databases

iPTMnetiQ5DTH5
PhosphoSitePlusiQ5DTH5

Expressioni

Developmental stagei

From E12.5, expressed in the mesenchyme of the developing middle ear, within areas surrounding the condensing malleus and tympanic ring and on both sides of the external acoustic meatus. At 12.5 dpc, borders and surrounds the future cartilages, but excluded from cartilaginous condensations. Not detected in mesenchymal cells in proximal ureters at 14 dpc.2 Publications

Gene expression databases

BgeeiENSMUSG00000046982 Expressed in 314 organ(s), highest expression level in olfactory bulb
CleanExiMM_TSHZ1
GenevisibleiQ5DTH5 MM

Interactioni

Subunit structurei

Interacts (via homeobox domain) with APBB1 (via PID domain 1).1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089388

Structurei

3D structure databases

ProteinModelPortaliQ5DTH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi58 – 195Ser-richAdd BLAST138

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri246 – 270C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri307 – 331C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri416 – 440C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri976 – 998C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1044 – 1067C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IJEQ Eukaryota
ENOG410XQQR LUCA
GeneTreeiENSGT00390000014977
HOGENOMiHOG000231480
HOVERGENiHBG079626
InParanoidiQ5DTH5
KOiK09236
OMAiKSNVSAM
OrthoDBiEOG091G01GX
PhylomeDBiQ5DTH5
TreeFamiTF328447

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR001356 Homeobox_dom
IPR027008 Teashirt_fam
IPR026808 Tshz1
IPR013087 Znf_C2H2_type
PANTHERiPTHR12487 PTHR12487, 1 hit
PTHR12487:SF6 PTHR12487:SF6, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00355 ZnF_C2H2, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q5DTH5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRRKQQAPR RSAAYVPEEE LKAAEIDEEH AEDGGLSLDI QESEFACNEE
60 70 80 90 100
TEIKEAQSYQ NSPVSTATNQ DAGYGSPFSE GSDQLAHFKS SSSREEKEES
110 120 130 140 150
QCPDSVSYPQ DSLAQIKAVY ANLFSESCWS SLALDLKKSN SATSNNDASQ
160 170 180 190 200
KESSTPTPTP PTSTASTACT TATTAITSCS TSTSHSSTTS NSSSSGYDWH
210 220 230 240 250
QAALAKTLQQ TSSYGLLPEP SLFSTVQLYR QNNKLYGSVF TGASKFRCKD
260 270 280 290 300
CSAAYDTLVE LTVHMNETGH YRDDNRDKDS EKTKRWSKPR KRSLMEMEGK
310 320 330 340 350
EDAQKVLKCM YCGHSFESLQ DLSVHMIKTK HYQKVPLKEP VPAITKLVPS
360 370 380 390 400
TKKRALQDLA SPCSPEPTGV ATEVALSESA KDQKTANPYV TPNNRYGYQN
410 420 430 440 450
GASYTWQFEA RKAQILKCME CGSSHDTLQQ LTAHMMVTGH FLKVTTSASK
460 470 480 490 500
KGKQLVLDPV VEEKIQSIPL PPTTHTRLPA SSIKKQPDSP AGSVASEEKK
510 520 530 540 550
EPEKEKEKEK APPAAGDAER KIKEETEDAT EKFEPTALYQ YLREEDLDDS
560 570 580 590 600
PKGGVDILKS LENTVSTAIS KAQNGAPSWG GYPSIHAAYQ LPGTVKPLQS
610 620 630 640 650
AVQSVQIQPS YASSVKSLSS TEHNALLHSP GSLTPPPHKS NVSAMEELVE
660 670 680 690 700
KVTGKVSIKK EERPTEKEKS SPVKAISPVA KENKDLPKTE ETGSKPQKKG
710 720 730 740 750
SDSETGKAKK ESTLDAHTPN GTEPLKAKVT NGCGHLGIIT DHSPEPSFIN
760 770 780 790 800
PLSALQSIMN THLGKVSKPV SPSLDPLAML YKISNSMLDK PVYPTTPAKQ
810 820 830 840 850
ADAIDRYYYE NSDQPIDLTK SKNKPLVSGV ADAVSSPLRE SALMDISDMV
860 870 880 890 900
KNLTGRLTPK SSTPSTVSEK SDADGSSFEE ALDELSPVHK RKGRQSNWNP
910 920 930 940 950
QHLLILQAQF ASSLRETAEG KYIMSDLGPQ ERVHISKFTG LSMTTISHWL
960 970 980 990 1000
ANVKYQLRRT GGTKFLKNLD TGHPVFFCND CASQFRTAST YVSHLETHLG
1010 1020 1030 1040 1050
FSLKDLSKLP LSQIQEQQSV VSKALTNKTL GPLGSSEEDL GSTFQCKLCN
1060 1070 1080
RTFASKHAVK LHLSKTHGKS PEDHLIYVTE LEKQ
Length:1,084
Mass (Da):118,567
Last modified:January 10, 2006 - v2
Checksum:i22EB9A9132E62DC8
GO

Sequence cautioni

The sequence AAF63158 differs from that shown. Reason: Frameshift at positions 502 and 519.Curated
The sequence AAH58264 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD90534 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31A → S in AAF63158 (PubMed:10704881).Curated1
Sequence conflicti140N → S in AAF63158 (PubMed:10704881).Curated1
Sequence conflicti1034G → A in AAF63158 (PubMed:10704881).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220545 mRNA Translation: BAD90534.1 Different initiation.
AF191309 mRNA Translation: AAF63158.1 Frameshift.
BC017636 mRNA Translation: AAH17636.1
BC058264 mRNA Translation: AAH58264.1 Different initiation.
CCDSiCCDS37876.1
RefSeqiNP_001074769.1, NM_001081300.1
UniGeneiMm.102136

Genome annotation databases

EnsembliENSMUST00000060303; ENSMUSP00000089388; ENSMUSG00000046982
GeneIDi110796
KEGGimmu:110796
UCSCiuc008ful.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220545 mRNA Translation: BAD90534.1 Different initiation.
AF191309 mRNA Translation: AAF63158.1 Frameshift.
BC017636 mRNA Translation: AAH17636.1
BC058264 mRNA Translation: AAH58264.1 Different initiation.
CCDSiCCDS37876.1
RefSeqiNP_001074769.1, NM_001081300.1
UniGeneiMm.102136

3D structure databases

ProteinModelPortaliQ5DTH5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089388

PTM databases

iPTMnetiQ5DTH5
PhosphoSitePlusiQ5DTH5

Proteomic databases

MaxQBiQ5DTH5
PaxDbiQ5DTH5
PeptideAtlasiQ5DTH5
PRIDEiQ5DTH5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060303; ENSMUSP00000089388; ENSMUSG00000046982
GeneIDi110796
KEGGimmu:110796
UCSCiuc008ful.1 mouse

Organism-specific databases

CTDi10194
MGIiMGI:1346031 Tshz1
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IJEQ Eukaryota
ENOG410XQQR LUCA
GeneTreeiENSGT00390000014977
HOGENOMiHOG000231480
HOVERGENiHBG079626
InParanoidiQ5DTH5
KOiK09236
OMAiKSNVSAM
OrthoDBiEOG091G01GX
PhylomeDBiQ5DTH5
TreeFamiTF328447

Miscellaneous databases

ChiTaRSiTshz1 mouse
PROiPR:Q5DTH5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046982 Expressed in 314 organ(s), highest expression level in olfactory bulb
CleanExiMM_TSHZ1
GenevisibleiQ5DTH5 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR001356 Homeobox_dom
IPR027008 Teashirt_fam
IPR026808 Tshz1
IPR013087 Znf_C2H2_type
PANTHERiPTHR12487 PTHR12487, 1 hit
PTHR12487:SF6 PTHR12487:SF6, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00355 ZnF_C2H2, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTSH1_MOUSE
AccessioniPrimary (citable) accession number: Q5DTH5
Secondary accession number(s): Q6PE60, Q8VD19, Q9JLD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: November 7, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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