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Entry version 118 (29 Sep 2021)
Sequence version 1 (29 Mar 2005)
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Protein
Submitted name:

MKIAA4216 protein

Gene

Ube3a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei874Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathwayPROSITE-ProRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MKIAA4216 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ube3aImported
Synonyms:mKIAA4216Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:105098, Ube3a

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5DTH1

PeptideAtlas

More...
PeptideAtlasi
Q5DTH1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5DTH1, MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini578 – 906HECTInterPro annotationAdd BLAST329

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 59DisorderedSequence analysisAdd BLAST59
Regioni207 – 259DisorderedSequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi44 – 59Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi207 – 232Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi243 – 257Polar residuesSequence analysisAdd BLAST15

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
WSIVHAM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5DTH1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00078, HECTc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
6.10.130.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032353, AZUL
IPR042556, AZUL_sf
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR017134, UBE3A

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16558, AZUL, 1 hit
PF00632, HECT, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037201, Ubiquitin-protein_ligase_E6-AP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00119, HECTc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56204, SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50237, HECT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q5DTH1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
DPAVAPAKGN EAVAGGGGGR GRQGPVRRPQ LRGPQPTRGG EDRSPGESQS
60 70 80 90 100
EDIEASRMKR AAAKHLIERY YHQLTEGCGN EACTNEFCAS CPTFLRMDNN
110 120 130 140 150
AAAIKALELY KINAKLCDPH PSKKGASSAY LENSKGASNN SEIKMNKKEG
160 170 180 190 200
KDFKDVIYLT EEKVYEIYEF CRESEDYSPL IRVIGRIFSS AEALVLSFRK
210 220 230 240 250
VKQHTKEELK SLQEKDEDKD EDEKEKAACS AAAMEEDSEA SSSRMGDSSQ
260 270 280 290 300
GDNNVQKLGP DDVTVDIDAI RRVYSSLLAN EKLETAFLNA LVYLSPNVEC
310 320 330 340 350
DLTYHNVYTR DPNYLNLFII VMENSNLHSP EYLEMALPLF CKAMCKLPLE
360 370 380 390 400
AQGKLIRLWS KYSADQIRRM METFQQLITY KVISNEFNSR NLVNDDDAIV
410 420 430 440 450
AASKCLKMVY YANVVGGDVD TNHNEEDDEE PIPESSELTL QELLGDERRN
460 470 480 490 500
KKGPRVDPLE TELGVKTLDC RKPLISFEEF INEPLNDVLE MDKDYTFFKV
510 520 530 540 550
ETENKFSFMT CPFILNAVTK NLGLYYDNRI RMYSERRITV LYSLVQGQQL
560 570 580 590 600
NPYLRLKVRR DHIIDDALVR LEMIAMENPA DLKKQLYVEF EGEQGVDEGG
610 620 630 640 650
VSKEFFQLVV EEIFNPDIGM FTYDEATKLF WFNPSSFETE GQFTLIGIVL
660 670 680 690 700
GLAIYNNCIL DVHFPMVVYR KLMGKKGTFR DLGDSHPVLY QSLKDLLEYE
710 720 730 740 750
GSVEDDMMIT FQISQTDLFG NPMMYDLKEN GDKIPITNEN RKEFVNLYSD
760 770 780 790 800
YILNKSVEKQ FKAFRRGFHM VTNESPLKYL FRPEEIELLI CGSRNLDFQA
810 820 830 840 850
LEETTEYDGG YTRESVVIRE FWEIVHSFTD EQKRLFLQFT TGTDRAPVGG
860 870 880 890 900
LGKLKMIIAK NGPDTERLPT SHTCFNVLLL PEYSSKEKLK ERLLKAITYA

KGFGML
Length:906
Mass (Da):103,343
Last modified:March 29, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF588CBBAA5F3C8DE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK220549 mRNA Translation: BAD90321.1

NCBI Reference Sequences

More...
RefSeqi
NP_001029134.1, NM_001033962.1
NP_035798.2, NM_011668.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22215

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:22215

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220549 mRNA Translation: BAD90321.1
RefSeqiNP_001029134.1, NM_001033962.1
NP_035798.2, NM_011668.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

MaxQBiQ5DTH1
PeptideAtlasiQ5DTH1

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
22215

Genome annotation databases

GeneIDi22215
KEGGimmu:22215

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7337
MGIiMGI:105098, Ube3a

Phylogenomic databases

OMAiWSIVHAM
PhylomeDBiQ5DTH1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
22215, 3 hits in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ube3a, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

GenevisibleiQ5DTH1, MM

Family and domain databases

CDDicd00078, HECTc, 1 hit
Gene3Di6.10.130.10, 1 hit
InterProiView protein in InterPro
IPR032353, AZUL
IPR042556, AZUL_sf
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR017134, UBE3A
PfamiView protein in Pfam
PF16558, AZUL, 1 hit
PF00632, HECT, 1 hit
PIRSFiPIRSF037201, Ubiquitin-protein_ligase_E6-AP, 1 hit
SMARTiView protein in SMART
SM00119, HECTc, 1 hit
SUPFAMiSSF56204, SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237, HECT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5DTH1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5DTH1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 29, 2005
Last sequence update: March 29, 2005
Last modified: September 29, 2021
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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