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Protein

Fc receptor-like B

Gene

Fcrlb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • negative regulation of immune response Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Fc receptor-like B
Alternative name(s):
Fc receptor homolog expressed in B-cells protein 2
Short name:
FREB-2
Fc receptor-like and mucin-like protein 2
Fc receptor-like protein 2
Fc receptor-related protein Y
Short name:
FcRY
Gene namesi
Name:Fcrlb
Synonyms:Fcrl2, Fcrlm2, Fcry, Freb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3576487 Fcrlb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000033299318 – 427Fc receptor-like BAdd BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 85PROSITE-ProRule annotation
Disulfide bondi124 ↔ 168PROSITE-ProRule annotation
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5DRQ8
PRIDEiQ5DRQ8

PTM databases

iPTMnetiQ5DRQ8
PhosphoSitePlusiQ5DRQ8

Expressioni

Tissue specificityi

Expressed at low levels. Expressed in B-lymphocytes. Detected in spleen, lymph node, kidney, lung and brain.2 Publications

Inductioni

Up-regulated upon cell cycle arrest.1 Publication

Gene expression databases

BgeeiENSMUSG00000070524 Expressed in 15 organ(s), highest expression level in spleen

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091895

Structurei

3D structure databases

ProteinModelPortaliQ5DRQ8
SMRiQ5DRQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 101Ig-like C2-type 1Add BLAST79
Domaini103 – 189Ig-like C2-type 2Add BLAST87

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IDZ6 Eukaryota
ENOG410ZPGM LUCA
GeneTreeiENSGT00760000119130
HOGENOMiHOG000036934
HOVERGENiHBG096995
InParanoidiQ5DRQ8
OMAiLESYWCE
OrthoDBiEOG091G0ETN
TreeFamiTF351107

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5DRQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWMLAALLLL VPRSGKAATL EKPVLTLHPP WTTIFKGERV TLRCDGYHPL
60 70 80 90 100
LLELRPISTL WYLGHVLLPS HKKSIEVQAP GVYRCQTRGA PVSDPIHLSV
110 120 130 140 150
SNDWLILQVP YAAVFEGEPL VMRCRGWYDK VVYKLHYYHD GQAVRYFHSS
160 170 180 190 200
TNYTVLQARA SDSGHYQCSG TMRIPVESAP MFSSKVAVTV QELFQTPVLR
210 220 230 240 250
TLSPQEARGR VVLRCETRLH PQKRDTPLQF AFYKYSRPVR RFDWGAEYTV
260 270 280 290 300
PESEVEELES YWCEAATTSR SVRKRSPWLQ LPGRGPVLDL ASTTAPVAQA
310 320 330 340 350
AALGPGDKPL SFRKTPVSRS VQSVTSIPNS TFAGLQFPAG HVATAGPHAC
360 370 380 390 400
APLPASAEQS REALQPKVDL LLREMQLLKG LLSRVVLGLK DPQALHELTE
410 420
TPETPNSHVT VNPATPETTV MEGRVDS
Length:427
Mass (Da):47,502
Last modified:October 3, 2012 - v2
Checksum:i54D9F003FA9A7541
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24V → I in AAZ23789 (PubMed:16263223).Curated1
Sequence conflicti24V → I in AAS82875 (PubMed:15815692).Curated1
Sequence conflicti341H → R in AAZ23789 (PubMed:16263223).Curated1
Sequence conflicti341H → R in AAS82875 (PubMed:15815692).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ119292 mRNA Translation: AAZ23789.1
AY513660 mRNA Translation: AAS82875.1
AC113490 Genomic DNA No translation available.
CCDSiCCDS15475.1
RefSeqiNP_001025155.2, NM_001029984.2
UniGeneiMm.337931

Genome annotation databases

EnsembliENSMUST00000094337; ENSMUSP00000091895; ENSMUSG00000070524
GeneIDi435653
KEGGimmu:435653
UCSCiuc007dmp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ119292 mRNA Translation: AAZ23789.1
AY513660 mRNA Translation: AAS82875.1
AC113490 Genomic DNA No translation available.
CCDSiCCDS15475.1
RefSeqiNP_001025155.2, NM_001029984.2
UniGeneiMm.337931

3D structure databases

ProteinModelPortaliQ5DRQ8
SMRiQ5DRQ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091895

PTM databases

iPTMnetiQ5DRQ8
PhosphoSitePlusiQ5DRQ8

Proteomic databases

PaxDbiQ5DRQ8
PRIDEiQ5DRQ8

Protocols and materials databases

DNASUi435653
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094337; ENSMUSP00000091895; ENSMUSG00000070524
GeneIDi435653
KEGGimmu:435653
UCSCiuc007dmp.1 mouse

Organism-specific databases

CTDi127943
MGIiMGI:3576487 Fcrlb

Phylogenomic databases

eggNOGiENOG410IDZ6 Eukaryota
ENOG410ZPGM LUCA
GeneTreeiENSGT00760000119130
HOGENOMiHOG000036934
HOVERGENiHBG096995
InParanoidiQ5DRQ8
OMAiLESYWCE
OrthoDBiEOG091G0ETN
TreeFamiTF351107

Miscellaneous databases

PROiPR:Q5DRQ8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070524 Expressed in 15 organ(s), highest expression level in spleen

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFCRLB_MOUSE
AccessioniPrimary (citable) accession number: Q5DRQ8
Secondary accession number(s): F8VQL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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