UniProtKB - Q5DNL9 (Q5DNL9_9HIV1)
Protein
Submitted name:
Reverse transcriptase
Gene
pol
Organism
Human immunodeficiency virus 1
Status
Functioni
GO - Molecular functioni
- aspartic-type endopeptidase activity Source: UniProtKB-KW
- nucleic acid binding Source: InterPro
- RNA-directed DNA polymerase activity Source: UniProtKB-KW
- RNA-DNA hybrid ribonuclease activity Source: InterPro
GO - Biological processi
- DNA integration Source: UniProtKB-KW
- DNA recombination Source: UniProtKB-KW
Keywordsi
Molecular function | Aspartyl proteaseARBA annotation, EndonucleaseARBA annotation, Hydrolase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed DNA polymeraseImportedARBA annotation, Transferase |
Biological process | DNA integrationARBA annotation, DNA recombinationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Reverse transcriptaseImported |
Gene namesi | Name:polImported |
Organismi | Human immunodeficiency virus 1Imported |
Taxonomic identifieri | 11676 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Pararnavirae › Artverviricota › Revtraviricetes › Ortervirales › Retroviridae › Orthoretrovirinae › Lentivirus |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 234 | Reverse transcriptaseInterPro annotationAdd BLAST | 191 | |
Domaini | 434 – 557 | RNase HInterPro annotationAdd BLAST | 124 |
Family and domain databases
Gene3Di | 3.30.420.10, 1 hit 3.30.70.270, 3 hits |
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR043128, Rev_trsase/Diguanyl_cyclase IPR012337, RNaseH-like_sf IPR002156, RNaseH_domain IPR036397, RNaseH_sf IPR000477, RT_dom IPR010659, RVT_connect IPR010661, RVT_thumb |
Pfami | View protein in Pfam PF00075, RNase_H, 1 hit PF00078, RVT_1, 1 hit PF06815, RVT_connect, 1 hit PF06817, RVT_thumb, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS50879, RNASE_H, 1 hit PS50878, RT_POL, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q5DNL9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
PISPIETVPV QLKPGMDGPK VKQWPLTEEK IKALVEICTE MEKEGKISKI
60 70 80 90 100
GPENPYNTPV FAIKKKDSTK WRKLVDFREL NKKTQDFWEV QLGIPHPAGL
110 120 130 140 150
KKKKSVTVLD VGDAYFSVPL DPDFRKYTAF TIPSINNETP GIRYQYNVLP
160 170 180 190 200
QGWKGSPAIF QSSMTKILEP FRKQNPEIVI YQYMDDLYVG SDLEIGQHRT
210 220 230 240 250
KIEELRQHLL RWGLTTPDKK HQKEPPFLWM GYELHPDKWA VQPIVLPEKD
260 270 280 290 300
SWTVNDIQKL VGKLNWASQI YAGIKVRELC KLLRGTKALT EVIPLTEEAE
310 320 330 340 350
LELAENREIL KEPVHGVYYD PSKDLIAEIQ KQGQGQWTYQ IYQEPFKNLK
360 370 380 390 400
TGKYARMRGA HTNDVKQLTE AVQKIAMESI VIWGKTPKFR LPIQKETWET
410 420 430 440 450
WWAEYWQATW IPEWEFVNTP PLVKLWYQLE KEPIVGAETF YVDGAANRET
460 470 480 490 500
KLGKAGYVTD KGRQKVVSLT DTTNQKTELQ AIHLALQDSG SEVNIVTDSQ
510 520 530 540 550
YALGIIQAQP DKSESELVNQ IIEQLINKEK VYLAWVPAHK GIGGNEQVDK
560
LVSTGIRKVL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 560 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY560468 Genomic DNA Translation: AAT66854.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY560468 Genomic DNA Translation: AAT66854.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family and domain databases
Gene3Di | 3.30.420.10, 1 hit 3.30.70.270, 3 hits |
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR043128, Rev_trsase/Diguanyl_cyclase IPR012337, RNaseH-like_sf IPR002156, RNaseH_domain IPR036397, RNaseH_sf IPR000477, RT_dom IPR010659, RVT_connect IPR010661, RVT_thumb |
Pfami | View protein in Pfam PF00075, RNase_H, 1 hit PF00078, RVT_1, 1 hit PF06815, RVT_connect, 1 hit PF06817, RVT_thumb, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS50879, RNASE_H, 1 hit PS50878, RT_POL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5DNL9_9HIV1 | |
Accessioni | Q5DNL9Primary (citable) accession number: Q5DNL9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 29, 2005 |
Last sequence update: | March 29, 2005 | |
Last modified: | December 2, 2020 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |