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Entry version 138 (02 Jun 2021)
Sequence version 2 (21 Mar 2006)
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Protein

Uromodulin-like 1

Gene

UMODL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5DID0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uromodulin-like 1
Alternative name(s):
Olfactorin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UMODL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12560, UMODL1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613859, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5DID0

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000177398.18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 1272ExtracellularSequence analysisAdd BLAST1251
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1273 – 1293HelicalSequence analysisAdd BLAST21
Topological domaini1294 – 1318CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
89766

Open Targets

More...
OpenTargetsi
ENSG00000177398

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37200

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5DID0, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UMODL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
90101849

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000022812722 – 1318Uromodulin-like 1Add BLAST1297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi37 ↔ 94Sequence analysis
Disulfide bondi61 ↔ 70Sequence analysis
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi93 ↔ 104Sequence analysis
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi322N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi335N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi417N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi511 ↔ 525By similarity
Disulfide bondi519 ↔ 534By similarity
Disulfide bondi536 ↔ 551By similarity
Glycosylationi585N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi713N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi901 ↔ 914By similarity
Disulfide bondi908 ↔ 923By similarity
Glycosylationi984N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1050N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1157 ↔ 1215By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5DID0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5DID0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5DID0

PeptideAtlas

More...
PeptideAtlasi
Q5DID0

PRoteomics IDEntifications database

More...
PRIDEi
Q5DID0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62743 [Q5DID0-1]
62744 [Q5DID0-2]
62745 [Q5DID0-3]
62746 [Q5DID0-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q5DID0, 10 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5DID0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5DID0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 4 is expressed at low level in kidney, testis and fetal thymus. Isoform 3 is expressed at low level in prostate, testis and fetal thymus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000177398, Expressed in right uterine tube and 95 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5DID0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5DID0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000177398, Tissue enriched (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000386126

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5DID0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5DID0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 106EMIPROSITE-ProRule annotationAdd BLAST74
Domaini114 – 158WAPPROSITE-ProRule annotationAdd BLAST45
Domaini264 – 313EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST50
Domaini314 – 398Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST85
Domaini396 – 510SEA 1PROSITE-ProRule annotationAdd BLAST115
Domaini507 – 552EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST46
Domaini702 – 791Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST90
Domaini788 – 900SEA 2PROSITE-ProRule annotationAdd BLAST113
Domaini897 – 938EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini992 – 1235ZPPROSITE-ProRule annotationAdd BLAST244

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni593 – 655DisorderedSequence analysisAdd BLAST63
Regioni938 – 957DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi619 – 644Polar residuesSequence analysisAdd BLAST26

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVDQ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159975

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005456_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5DID0

Identification of Orthologs from Complete Genome Data

More...
OMAi
KCCPSSR

Database of Orthologous Groups

More...
OrthoDBi
131214at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5DID0

TreeFam database of animal gene trees

More...
TreeFami
TF329882

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
4.10.75.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR036645, Elafin-like_sf
IPR011489, EMI_domain
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR009030, Growth_fac_rcpt_cys_sf
IPR013783, Ig-like_fold
IPR000082, SEA_dom
IPR008197, WAP_dom
IPR001507, ZP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07645, EGF_CA, 3 hits
PF01390, SEA, 1 hit
PF00095, WAP, 1 hit
PF00100, Zona_pellucida, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00023, ZPELLUCIDA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00179, EGF_CA, 3 hits
SM00060, FN3, 2 hits
SM00217, WAP, 1 hit
SM00241, ZP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 1 hit
SSF57184, SSF57184, 1 hit
SSF57256, SSF57256, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 3 hits
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 3 hits
PS51041, EMI, 1 hit
PS50853, FN3, 2 hits
PS50024, SEA, 2 hits
PS51390, WAP, 1 hit
PS51034, ZP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist expressed specifically in testis.

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5DID0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRTSGLALL ALVSAVGPSQ ASGFTEKGLS LLGYQLCSHR VTHTVQKVEA
60 70 80 90 100
VQTSYTSYVS CGGWIPWRRC PKMVYRTQYL VVEVPESRNV TDCCEGYEQL
110 120 130 140 150
GLYCVLPLNQ SGQFTSRPGA CPAEGPEPST SPCSLDIDCP GLEKCCPWSG
160 170 180 190 200
GRYCMAPAPQ APERDPVGSW YNVTILVKMD FKELQQVDPR LLNHMRLLHS
210 220 230 240 250
LVTSALQPMA STVHHLHSAP GNASTTVSRL LLGLPRPLPV ADVSTLLGDI
260 270 280 290 300
AKRVYEVISV QVQDVNECFY EELNACSGRE LCANLEGSYW CVCHQEAPAT
310 320 330 340 350
SPRKLNLEWE DCPPVSDYVV LNVTSDSFQV SWRLNSTQNH TFHVRVYRGM
360 370 380 390 400
ELLRSARTQS QALAVAGLEA GVLYRVKTSY QGCGADVSTT LTIKTNAQVF
410 420 430 440 450
EVTIKIVNHN LTEKLLNRSS VEYQDFSRQL LHEVESSFPP VVSDLYRSGK
460 470 480 490 500
LRMQIVSLQA GSVVVRLKLT VQDPGFPMGI STLAPILQPL LASTVFQIDR
510 520 530 540 550
QGTRVQDWDE CVDSAEHDCS PAAWCINLEG SYTCQCRTTR DATPSRAGRA
560 570 580 590 600
CEGDLVSPMG GGLSAATGVT VPGLGTGTAA LGLENFTLSP SPGYPQGTPA
610 620 630 640 650
AGQAWTPEPS PRRGGSNVVG YDRNNTGKGV EQELQGNSIM EPPSWPSPTE
660 670 680 690 700
DPTGHFLWHA TRSTRETLLN PTWLRNEDSG PSGSVDLPLT STLTALKTPA
710 720 730 740 750
CVPVSIGRIM VSNVTSTGFH LAWEADLAMD STFQLTLTSM WSPAVVLETW
760 770 780 790 800
NTSVTLSGLE PGVLHLVEIM AKACGKEGAR AHLKVRTAAR KLIGKVRIKN
810 820 830 840 850
VRYSESFRNA SSQEYRDFLE LFFRMVRGSL PATMCQHMDA GGVRMEVVSV
860 870 880 890 900
TNGSIVVEFH LLIIADVDVQ EVSAAFLTAF QTVPLLEVIR GDTFIQDYDE
910 920 930 940 950
CERKEDDCVP GTSCRNTLGS FTCSCEGGAP DFPVEYSERP CEGDSPGNET
960 970 980 990 1000
WATSPERPLT TAGTKAAFVQ GTSPTPQGLP QRLNLTGAVR VLCEIEKVVV
1010 1020 1030 1040 1050
AIQKRFLQQE SIPESSLYLS HPSCNVSHSN GTHVLLEAGW SECGTLMQSN
1060 1070 1080 1090 1100
MTNTVVRTTL RNDLSQEGII HHLKILSPIY CAFQNDLLTS SGFTLEWGVY
1110 1120 1130 1140 1150
TIIEDLHGAG NFVTEMQLFI GDSPIPQNYS VSASDDVRIE VGLYRQKSNL
1160 1170 1180 1190 1200
KVVLTECWAT PSSNARDPIT FSFINNSCPV PNTYTNVIEN GNSNKAQFKL
1210 1220 1230 1240 1250
RIFSFINDSI VYLHCKLRVC MESPGATCKI NCNNFRLLQN SETSATHQMS
1260 1270 1280 1290 1300
WGPLIRSEGE PPHAEAGLGA GYVVLIVVAI FVLVAGTATL LIVRYQRMNG
1310
RYNFKIQSNN FSYQVFYE
Length:1,318
Mass (Da):144,294
Last modified:March 21, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6F8ABA3E11C7475D
GO
Isoform 2 (identifier: Q5DID0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     633-633: E → EVPSTAPGLG...TDGPLALPGQ

Show »
Length:1,446
Mass (Da):156,884
Checksum:i92A6CBB29501D164
GO
Isoform 3 (identifier: Q5DID0-3) [UniParc]FASTAAdd to basket
Also known as: UMOLD1S

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Show »
Length:1,246
Mass (Da):136,528
Checksum:i239FB818B187C4A5
GO
Isoform 4 (identifier: Q5DID0-4) [UniParc]FASTAAdd to basket
Also known as: UMOLD1L

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.
     633-633: E → EVPSTAPGLG...TDGPLALPGQ

Show »
Length:1,374
Mass (Da):149,118
Checksum:iB8F838BEA34FE48D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y3S4H0Y3S4_HUMAN
Uromodulin-like 1
UMODL1
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y887H0Y887_HUMAN
Uromodulin-like 1
UMODL1
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y856H0Y856_HUMAN
Uromodulin-like 1
UMODL1
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y880H0Y880_HUMAN
Uromodulin-like 1
UMODL1
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y898H0Y898_HUMAN
Uromodulin-like 1
UMODL1
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8E5H0Y8E5_HUMAN
Uromodulin-like 1
UMODL1
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC04211 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025668173V → I1 PublicationCorresponds to variant dbSNP:rs73371577Ensembl.1
Natural variantiVAR_025669274N → D1 PublicationCorresponds to variant dbSNP:rs17114359Ensembl.1
Natural variantiVAR_025670274N → H1 PublicationCorresponds to variant dbSNP:rs17114359Ensembl.1
Natural variantiVAR_025671447R → Q1 PublicationCorresponds to variant dbSNP:rs146310440Ensembl.1
Natural variantiVAR_025672559M → T2 PublicationsCorresponds to variant dbSNP:rs220126Ensembl.1
Natural variantiVAR_025673639I → T2 PublicationsCorresponds to variant dbSNP:rs220129Ensembl.1
Natural variantiVAR_025674698T → P1 PublicationCorresponds to variant dbSNP:rs220130Ensembl.1
Natural variantiVAR_025675850V → I1 PublicationCorresponds to variant dbSNP:rs220146Ensembl.1
Natural variantiVAR_0256761027S → N1 PublicationCorresponds to variant dbSNP:rs150611312Ensembl.1
Natural variantiVAR_0256771068G → S1 PublicationCorresponds to variant dbSNP:rs111996953Ensembl.1
Natural variantiVAR_0256781115E → K1 PublicationCorresponds to variant dbSNP:rs80040922Ensembl.1
Natural variantiVAR_0256791208D → N1 PublicationCorresponds to variant dbSNP:rs220159Ensembl.1
Natural variantiVAR_0256801309N → H3 PublicationsCorresponds to variant dbSNP:rs3819142Ensembl.1
Isoform 2 (identifier: Q5DID0-2)
Natural variantiVAR_082944644D → ECuratedCorresponds to variant dbSNP:rs111772429Ensembl.1
Natural variantiVAR_082945691R → GCuratedCorresponds to variant dbSNP:rs220127Ensembl.1
Natural variantiVAR_082946741T → PCuratedCorresponds to variant dbSNP:rs220128Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0176581 – 72Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_017659633E → EVPSTAPGLGMDQGSPSQVN PSQGSPSQGSLRQESTSQAS PSQRSTSQGSPSQVNPSQRS TSHANSSQGSPSQGSPSQES PSQGSTSQASPSHRNTIGVI GTTSSPKATGSTHSFPPGAT DGPLALPGQ in isoform 2 and isoform 4. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB051810 mRNA Translation: BAD23798.1
AB051811 mRNA Translation: BAD23799.1
AY771619 mRNA Translation: AAX14814.1
AY771620 mRNA Translation: AAX14815.1
AP001620 Genomic DNA No translation available.
AP001621 Genomic DNA No translation available.
AP001622 Genomic DNA No translation available.
AK093654 mRNA Translation: BAC04211.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42935.1 [Q5DID0-2]
CCDS42936.1 [Q5DID0-1]
CCDS56214.1 [Q5DID0-3]
CCDS56215.1 [Q5DID0-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001004416.2, NM_001004416.2 [Q5DID0-1]
NP_001186456.1, NM_001199527.1 [Q5DID0-4]
NP_001186457.2, NM_001199528.2 [Q5DID0-3]
NP_775839.3, NM_173568.3 [Q5DID0-2]
XP_016883995.1, XM_017028506.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000400424; ENSP00000383276; ENSG00000177398 [Q5DID0-3]
ENST00000400427; ENSP00000383279; ENSG00000177398 [Q5DID0-4]
ENST00000408910; ENSP00000386147; ENSG00000177398 [Q5DID0-1]
ENST00000408989; ENSP00000386126; ENSG00000177398 [Q5DID0-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
89766

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:89766

UCSC genome browser

More...
UCSCi
uc002zad.2, human [Q5DID0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051810 mRNA Translation: BAD23798.1
AB051811 mRNA Translation: BAD23799.1
AY771619 mRNA Translation: AAX14814.1
AY771620 mRNA Translation: AAX14815.1
AP001620 Genomic DNA No translation available.
AP001621 Genomic DNA No translation available.
AP001622 Genomic DNA No translation available.
AK093654 mRNA Translation: BAC04211.1 Different initiation.
CCDSiCCDS42935.1 [Q5DID0-2]
CCDS42936.1 [Q5DID0-1]
CCDS56214.1 [Q5DID0-3]
CCDS56215.1 [Q5DID0-4]
RefSeqiNP_001004416.2, NM_001004416.2 [Q5DID0-1]
NP_001186456.1, NM_001199527.1 [Q5DID0-4]
NP_001186457.2, NM_001199528.2 [Q5DID0-3]
NP_775839.3, NM_173568.3 [Q5DID0-2]
XP_016883995.1, XM_017028506.1

3D structure databases

SMRiQ5DID0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000386126

PTM databases

GlyGeniQ5DID0, 10 sites
iPTMnetiQ5DID0
PhosphoSitePlusiQ5DID0

Genetic variation databases

BioMutaiUMODL1
DMDMi90101849

Proteomic databases

jPOSTiQ5DID0
MassIVEiQ5DID0
PaxDbiQ5DID0
PeptideAtlasiQ5DID0
PRIDEiQ5DID0
ProteomicsDBi62743 [Q5DID0-1]
62744 [Q5DID0-2]
62745 [Q5DID0-3]
62746 [Q5DID0-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
42290, 42 antibodies

The DNASU plasmid repository

More...
DNASUi
89766

Genome annotation databases

EnsembliENST00000400424; ENSP00000383276; ENSG00000177398 [Q5DID0-3]
ENST00000400427; ENSP00000383279; ENSG00000177398 [Q5DID0-4]
ENST00000408910; ENSP00000386147; ENSG00000177398 [Q5DID0-1]
ENST00000408989; ENSP00000386126; ENSG00000177398 [Q5DID0-2]
GeneIDi89766
KEGGihsa:89766
UCSCiuc002zad.2, human [Q5DID0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
89766
DisGeNETi89766

GeneCards: human genes, protein and diseases

More...
GeneCardsi
UMODL1
HGNCiHGNC:12560, UMODL1
HPAiENSG00000177398, Tissue enriched (lymphoid)
MIMi613859, gene
neXtProtiNX_Q5DID0
OpenTargetsiENSG00000177398
PharmGKBiPA37200
VEuPathDBiHostDB:ENSG00000177398.18

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QVDQ, Eukaryota
GeneTreeiENSGT00940000159975
HOGENOMiCLU_005456_0_0_1
InParanoidiQ5DID0
OMAiKCCPSSR
OrthoDBi131214at2759
PhylomeDBiQ5DID0
TreeFamiTF329882

Enzyme and pathway databases

PathwayCommonsiQ5DID0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
89766, 4 hits in 979 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
UMODL1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
89766
PharosiQ5DID0, Tdark

Protein Ontology

More...
PROi
PR:Q5DID0
RNActiQ5DID0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000177398, Expressed in right uterine tube and 95 other tissues
ExpressionAtlasiQ5DID0, baseline and differential
GenevisibleiQ5DID0, HS

Family and domain databases

CDDicd00063, FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
4.10.75.10, 1 hit
InterProiView protein in InterPro
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR036645, Elafin-like_sf
IPR011489, EMI_domain
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR009030, Growth_fac_rcpt_cys_sf
IPR013783, Ig-like_fold
IPR000082, SEA_dom
IPR008197, WAP_dom
IPR001507, ZP_dom
PfamiView protein in Pfam
PF07645, EGF_CA, 3 hits
PF01390, SEA, 1 hit
PF00095, WAP, 1 hit
PF00100, Zona_pellucida, 1 hit
PRINTSiPR00023, ZPELLUCIDA
SMARTiView protein in SMART
SM00179, EGF_CA, 3 hits
SM00060, FN3, 2 hits
SM00217, WAP, 1 hit
SM00241, ZP, 1 hit
SUPFAMiSSF49265, SSF49265, 1 hit
SSF57184, SSF57184, 1 hit
SSF57256, SSF57256, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 3 hits
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 3 hits
PS51041, EMI, 1 hit
PS50853, FN3, 2 hits
PS50024, SEA, 2 hits
PS51390, WAP, 1 hit
PS51034, ZP_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUROL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5DID0
Secondary accession number(s): C9JCE6
, Q5DIC9, Q6LA40, Q6LA41, Q8N216
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: June 2, 2021
This is version 138 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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