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Entry version 79 (16 Oct 2019)
Sequence version 2 (10 Jun 2008)
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Protein

Synaptonemal complex central element protein 1-like

Gene

Syce1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in meiosis. Isoform 1 may be involved in meiosis during spermatogenesis while isoform 2 is probably related to a later stage of meiosis, in the development stage of secondary spermatocytes and spermatids.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processMeiosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptonemal complex central element protein 1-like
Alternative name(s):
Meiosis-related protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Syce1l
Synonyms:Mmrp2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1922247 Syce1l

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003412221 – 247Synaptonemal complex central element protein 1-likeAdd BLAST247

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5D525

PRoteomics IDEntifications database

More...
PRIDEi
Q5D525

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5D525

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is abundantly expressed in testis and weakly in ovary, it is not found in other tissues. Isoform 2 is expressed in testis and poorly in brain, heart, lung and other examined tissues.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Not detected in embryo. Isoform 1 is detected in testis at day 8 after birth while isoform 2 at day 17.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000033409 Expressed in 14 organ(s), highest expression level in testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5D525 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q5D525, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000092796

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5D525

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili71 – 196Sequence analysisAdd BLAST126

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SYCE family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IXYT Eukaryota
ENOG4111C43 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017352

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000059636

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5D525

Identification of Orthologs from Complete Genome Data

More...
OMAi
RILQMHC

Database of Orthologous Groups

More...
OrthoDBi
1275708at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5D525

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026676 SYCE1

The PANTHER Classification System

More...
PANTHERi
PTHR21731 PTHR21731, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15233 SYCE1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5D525-1) [UniParc]FASTAAdd to basket
Also known as: mmrp2

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAELEPLMA EWLGAEKAED TRGQAASLNT MEDLLETVKK LQKEGSLEPQ
60 70 80 90 100
IEDLIHRINE LQQGPAKKRS SEELGEAQAL QEAMHRELDS LNEERVHLEE
110 120 130 140 150
VLRKKQEAVS ILKKHPQERD SDTPHLDAQQ LEERLADLAR QHKDLWEFHV
160 170 180 190 200
LQQRLAQEIS TMEHRKDQLL AERTLLRARL EKVEQRLQEA RETWDSPGNC
210 220 230 240
GLKTELEELE GQSQRSPEAQ NDKGEASQEE QHHLETSEEL PRTGTLC
Length:247
Mass (Da):28,461
Last modified:June 10, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE9B413F5DA4861DA
GO
Isoform 2 (identifier: Q5D525-2) [UniParc]FASTAAdd to basket
Also known as: mmrp1

The sequence of this isoform differs from the canonical sequence as follows:
     125-247: HLDAQQLEER...EELPRTGTLC → QKCTVQFSGF...AVPAQPRSSE

Show »
Length:242
Mass (Da):25,660
Checksum:iA03DBF0FC099487C
GO
Isoform 3 (identifier: Q5D525-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-43: Missing.

Note: No experimental confirmation available.
Show »
Length:226
Mass (Da):26,161
Checksum:i0D397E59FE0DD2DC
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI00479 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4E → G in AAX18325 (PubMed:16328886).Curated1
Sequence conflicti4E → G in AAX18326 (PubMed:16328886).Curated1
Sequence conflicti10A → E in AAX18325 (PubMed:16328886).Curated1
Sequence conflicti10A → E in AAX18326 (PubMed:16328886).Curated1
Sequence conflicti105K → E in AAX18325 (PubMed:16328886).Curated1
Sequence conflicti105K → E in AAX18326 (PubMed:16328886).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03422723 – 43Missing in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_034228125 – 247HLDAQ…TGTLC → QKCTVQFSGFRPKKLGLLLS LQLGCSTTGGEAGGSGKATQ GPLGVPCPAAATGPGDQHDG AQERSASCREDSAASQAGEG GAAAAGGQRDLGQPRELWAE DRAGGIGGAVPAQPRSSE in isoform 2. 2 PublicationsAdd BLAST123

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY899936 mRNA Translation: AAX18326.1
AY899935 mRNA Translation: AAX18325.1
AK015606 mRNA Translation: BAB29903.1
BC100478 mRNA Translation: AAI00479.1 Different initiation.
BC141326 mRNA Translation: AAI41327.1
BC141347 mRNA Translation: AAI41348.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40483.1 [Q5D525-1]
CCDS40484.1 [Q5D525-2]
CCDS85617.1 [Q5D525-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001041610.1, NM_001048145.1 [Q5D525-1]
NP_001273423.1, NM_001286494.1 [Q5D525-3]
NP_083415.1, NM_029139.1 [Q5D525-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000034219; ENSMUSP00000034219; ENSMUSG00000033409 [Q5D525-2]
ENSMUST00000095173; ENSMUSP00000092796; ENSMUSG00000033409 [Q5D525-1]
ENSMUST00000212269; ENSMUSP00000148356; ENSMUSG00000033409 [Q5D525-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
668110

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:668110

UCSC genome browser

More...
UCSCi
uc009nnp.1 mouse [Q5D525-2]
uc009nnq.1 mouse [Q5D525-1]
uc012glc.1 mouse [Q5D525-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY899936 mRNA Translation: AAX18326.1
AY899935 mRNA Translation: AAX18325.1
AK015606 mRNA Translation: BAB29903.1
BC100478 mRNA Translation: AAI00479.1 Different initiation.
BC141326 mRNA Translation: AAI41327.1
BC141347 mRNA Translation: AAI41348.1
CCDSiCCDS40483.1 [Q5D525-1]
CCDS40484.1 [Q5D525-2]
CCDS85617.1 [Q5D525-3]
RefSeqiNP_001041610.1, NM_001048145.1 [Q5D525-1]
NP_001273423.1, NM_001286494.1 [Q5D525-3]
NP_083415.1, NM_029139.1 [Q5D525-2]

3D structure databases

SMRiQ5D525
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ5D525, 1 interactor
STRINGi10090.ENSMUSP00000092796

PTM databases

PhosphoSitePlusiQ5D525

Proteomic databases

PaxDbiQ5D525
PRIDEiQ5D525

Genome annotation databases

EnsembliENSMUST00000034219; ENSMUSP00000034219; ENSMUSG00000033409 [Q5D525-2]
ENSMUST00000095173; ENSMUSP00000092796; ENSMUSG00000033409 [Q5D525-1]
ENSMUST00000212269; ENSMUSP00000148356; ENSMUSG00000033409 [Q5D525-3]
GeneIDi668110
KEGGimmu:668110
UCSCiuc009nnp.1 mouse [Q5D525-2]
uc009nnq.1 mouse [Q5D525-1]
uc012glc.1 mouse [Q5D525-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100130958
MGIiMGI:1922247 Syce1l

Phylogenomic databases

eggNOGiENOG410IXYT Eukaryota
ENOG4111C43 LUCA
GeneTreeiENSGT00390000017352
HOGENOMiHOG000059636
InParanoidiQ5D525
OMAiRILQMHC
OrthoDBi1275708at2759
PhylomeDBiQ5D525

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Syce1l mouse

Protein Ontology

More...
PROi
PR:Q5D525

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000033409 Expressed in 14 organ(s), highest expression level in testis
GenevisibleiQ5D525 MM

Family and domain databases

InterProiView protein in InterPro
IPR026676 SYCE1
PANTHERiPTHR21731 PTHR21731, 1 hit
PfamiView protein in Pfam
PF15233 SYCE1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYC1L_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5D525
Secondary accession number(s): B2RUQ1
, Q497L4, Q5D524, Q9D5A5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: October 16, 2019
This is version 79 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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