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Protein

Endoribonuclease ZC3H12A

Gene

Zc3h12a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay (PubMed:26000482). Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation (PubMed:19322177, PubMed:21115689, PubMed:23185455, PubMed:26000482). Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (PubMed:23706741, PubMed:26000482, PubMed:19322177, PubMed:21115689, PubMed:23185455). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (PubMed:25282160). Self regulates by destabilizing its own mRNA (PubMed:22037600). Cleaves mRNA harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (PubMed:19322177, PubMed:23185455, PubMed:23706741, PubMed:26000482, PubMed:26134560). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (By similarity). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (By similarity). Plays also a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (By similarity). Affects the overall ubiquitination of cellular proteins (PubMed:21115689). Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis (PubMed:21115689). Induces also deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (By similarity). Prevents stress granules (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock, and energy deprivation (PubMed:21971051). Plays a role in the regulation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state (PubMed:25934862). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (PubMed:18178554, PubMed:19666473, PubMed:22739135). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein (APP)-dependent signaling pathway (By similarity). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial proinflammatory cytokine production (PubMed:21616078).By similarity14 Publications

Cofactori

Mg2+1 PublicationNote: Mg2+ is required for RNase activity (PubMed:19322177).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi226MagnesiumBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri301 – 324C3H1-typeAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Endonuclease, Hydrolase, Nuclease, RNA-binding
Biological processAngiogenesis, Apoptosis, Differentiation, DNA damage, Immunity, Inflammatory response, Neurogenesis, Stress response
LigandMagnesium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Endoribonuclease ZC3H12ACurated (EC:3.1.-.-1 Publication)
Alternative name(s):
Monocyte chemotactic protein-induced protein 11 Publication
Short name:
MCP-induced protein 11 Publication
Short name:
MCPIP-11 Publication
Regnase-11 Publication
Short name:
Reg11 Publication
Zinc finger CCCH domain-containing protein 12AImported
Gene namesi
Name:Zc3h12a1 PublicationImported
Synonyms:Mcpip1 Publication, Mcpip11 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2385891 Zc3h12a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Increased expression of ZC3H12A is associated with ischemic heart disease (PubMed:16574901).1 Publication

Disruption phenotypei

Most mice die within the first 12 weeks (PubMed:21115689). Show severe inflammatory syndromes, including growth retardation, splenomegaly and lymphoadenopathy (PubMed:19322177, PubMed:21115689). show systemic inflammation characterized by T-cell and B-cell activation (PubMed:23706741). Exhibit greatly increased levels of plasma cells and infiltration of plasma cells into the lungs (PubMed:19322177, PubMed:21115689). Show elevated serum immunoglobulin levels and produce anti-nuclear autoantibodies (PubMed:19322177, PubMed:23706741). Mice show increased production of proinflammatory cytokine mRNAs and secreted protein levels, such as IL6, TNF and PTGS2 expression upon lipopolysaccharide (LPS) stimulation in bone marrow macrophages (BBMs) or embryonic fibroblasts, particularly in the early phase of the inflammatory response (PubMed:21115689, PubMed:26000482). Show impaired degradation of IL6 mRNA (PubMed:19322177, PubMed:21115689). Show an increased in both JNK and NF-kappa-B signaling pathway activations upon LPS stimulation (PubMed:21115689). Show an increase in global ubiquitinated protein level in splenocytes (PubMed:21115689). Display a drastic increase in both basal and LPS- or TNF-induced ubiquitination of TRAF2, TRAF3 and TRAF6 in splenocytes (PubMed:21115689). Splenocytes show spontaneously formed aggregation of stress granules (SGs) and were resistant to stress-induced apoptosis (PubMed:21971051). Heterozygous knockout mice display IL-17-dependent enhanced resistance to disseminated Candida albicans infection compared to wild-type mice (PubMed:26320658). Double knockout of ZC3H12A and RC3H1 result in embryonic developmental arrest and death; embryonic fibroblasts from these mice show a higher increase in IL6, TNF and PTGS2 expression upon LPS stimulation, both in early and late phases of the responses, compared to single knockout of either ZC3H12A or RC3H1 (PubMed:26000482). T-cell specific conditional knockout mice die within the first 8 to 17 weeks after birth with the development of severe splenomegaly and the development of a severe autoimmune inflammatory disease (PubMed:23706741). Show massive increase in effector/memory T-cells with elevated production of interferon IFNG, interleukins IL17A and IL4 in response to phorbol 13-acetate 12-myristate (PMA) (PubMed:23706741). Proteolytic cleavage is inhibited in T-cells in response to antigen stimulation (PubMed:23706741). Conditional knockout in myeloid cells show impairment in IL4-induced macrophage M2 polarization (PubMed:25934862).7 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi111R → A: Loss of MALT1-dependent cleavage and degradation in T-cells. 1 Publication1
Mutagenesisi130R → A: Reduces MALT1-dependent cleavage and degradation in T-cells. 1 Publication1
Mutagenesisi136R → A: Reduces MALT1-dependent cleavage and degradation in T-cells. 1 Publication1
Mutagenesisi141D → N: Loss of RNase activity. Loss of mRNAs and miRNAs degradation. Loss of protein deubiquitination and suppression of inhibition on JNK and NF-kappa-B signaling pathway activation. Inhibits induction of angiogenesis and macrophage M2 polarization. Mislocalized in stress granule (SG). Loss of the ability to inhibit SG formation under stress. Does not inhibit binding to IL6 mRNA. Increases ICOS surface expression. 7 Publications1
Mutagenesisi157C → A: Loss of protein deubiquitination and suppression of inhibition on JNK and NF-kappa-B signaling pathway activation. Loss of the ability to inhibit stress granule (SG) formation. No loss of RNase activity. No effect on ICOS surface expression. 3 Publications1
Mutagenesisi158R → A: Reduces MALT1-dependent cleavage and degradation in T-cells. 1 Publication1
Mutagenesisi214R → A: Reduces MALT1-dependent cleavage and degradation in T-cells. 1 Publication1
Mutagenesisi225 – 226DD → AA: Increases ICOS surface expression. 1 Publication2
Mutagenesisi225D → A: Loss of RNase activity, no loss of protein deubiquitination and ability to inhibit stress granule (SG) formation under stress; when associated with A-226. 1 Publication1
Mutagenesisi226D → A: Loss of RNase activity and no loss of protein deubiquitination; when associated with A-226. 1 Publication1
Mutagenesisi278D → A: Loss of inhibition on JNK and NF-kappa-B signaling pathway activation; when associated with A-279. 1 Publication1
Mutagenesisi279D → A: Loss of inhibition on JNK and NF-kappa-B signaling pathway activation; when associated with A-278. 1 Publication1
Mutagenesisi306C → R: Loss of protein deubiquitination and suppression of inhibition on JNK and NF-kappa-B signaling pathway activations. No loss of RNase activity. 2 Publications1
Mutagenesisi435S → A: Reduces its phosphorylation status, does not interact with IKBKB/IKKB and BTRC, inhibits IL6 mRNA instability and IKK-mediated degradation of ZC3H12A; when associated with A-439. 1 Publication1
Mutagenesisi439S → A: Reduces its phosphorylation status, does not interact with IKBKB/IKKB and BTRC, inhibits IL6 mRNA instability and IKK-mediated degradation of ZC3H12A; when associated with A-435. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003415131 – 596Endoribonuclease ZC3H12AAdd BLAST596

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei344PhosphoserineBy similarity1
Modified residuei435Phosphoserine1 Publication1
Modified residuei439Phosphoserine1 Publication1

Post-translational modificationi

Proteolytically cleaved between Arg-111 and Arg-214 by MALT1 in activated T-cells; cleavage at Arg-111 is critical for promoting ZC3H12A degradation in response to T-cell receptor (TCR) stimulation, and hence is necessary for prolonging the stability of a set of mRNAs controlling T-cell activation and Th17 cell differentiation.2 Publications
Phosphorylated by IRAK1; phosphorylation is necessary for subsequent phosphorylation by the I-kappa-B-kinase (IKK) complex. Phosphorylated by I-kappa-B-kinases (IKKs) at Ser-435 and Ser-439 upon lipopolysaccharide (LPS) or IL1B stimulation in macrophages through the MyD88-dependent signaling pathway; these phosphorylations promote rapid ubiquitin proteasome-mediated degradation of ZC3H12A in macrophages and hence allows its target mRNAs, such as IL6, to escape from degradation and accumulate during the inflammatory response (PubMed:22037600).1 Publication
Ubiquitinated; ubiquitination is induced in response to interleukin IL1 receptor stimuli in a IKBKB/IKKB and IRAK1-dependent manner, leading to proteasome-mediated degradation (PubMed:22037600).1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5D1E7
MaxQBiQ5D1E7
PaxDbiQ5D1E7
PRIDEiQ5D1E7

PTM databases

iPTMnetiQ5D1E7
PhosphoSitePlusiQ5D1E7

Expressioni

Tissue specificityi

Highly expressed in macrophages (PubMed:18178554). Expressed in lung, lymph nodes, spleen and thymus (PubMed:22037600). Expressed weakly in heart (PubMed:21616078). Expressed weakly in cardiomyocytes (at protein level) (PubMed:16574901). Expressed in spleen, lung, intestine, brown adipose tissue and thymus (PubMed:18682727). Weakly expressed in the heart (PubMed:16574901). Weakly expressed in cardiomyocytes (PubMed:16574901).5 Publications

Inductioni

Up-regulated by the transcription factor KLF4 in a interleukin IL4-dependent manner in macrophage (PubMed:25934862). Up-regulated by lipopolysaccharide (LPS) (at protein level) (PubMed:21616078). Up-regulated by chemokine CCL2 during adipocytes differentiation (PubMed:19666473). Up-regulated in activated T lymphocytes (PubMed:23185455). Up-regulated in response to lipopolysaccharide (LPS) in a MyD88-dependent manner in macrophages (PubMed:18178554, PubMed:18682727, PubMed:19322177). Up-regulated by phorbol 13-acetate 12-myristate (PMA) in primary T lymphocytes (PubMed:23185455). Up-regulated by interleukin IL17 in keratinocytes (PubMed:26320658).8 Publications

Gene expression databases

BgeeiENSMUSG00000042677 Expressed in 105 organ(s), highest expression level in jejunum
GenevisibleiQ5D1E7 MM

Interactioni

Subunit structurei

Oligomer (By similarity). Found in a deubiquitination complex with TANK, USP10 and ZC3H12A; this complex inhibits genotoxic stress- or interleukin-1-beta-mediated NF-kappaB activation by promoting IKBKG or TRAF6 deubiquitination. Interacts with IKBKG; this interaction increases in response to DNA damage. Interacts with TANK; this interaction increases in response to DNA damage and serves as a bridge to anchor both TANK and USP10 into a deubiquitinating complex. Interacts with TRAF6; this interaction increases in response to DNA damage and is stimulated by TANK. Interacts with USP10; this interaction increases in response to DNA damage and serves as a bridge to anchor both TANK and USP10 into a deubiquitinating complex. Interacts with ZC3H12D. Interacts with TNRC6A. Interacts with IKBKB/IKKB. Interacts with IKBKB/IKKB (By similarity). Interacts with IKBKB/IKKB (PubMed:22037600). Interacts with BTRC; the interaction occurs when ZC3H12A is phosphorylated in a IKBKB/IKKB-dependent manner (PubMed:22037600). Interacts with IRAK1; this interaction increases the interaction between ZC3H12A and IKBKB/IKKB (PubMed:22037600). Interacts with UPF1; this interaction occurs in a mRNA translationally active- and termination-dependent manner and is essential for ZC3H12A-mediated degradation of target mRNAs (PubMed:26000482). Associates with ribosomes (PubMed:26000482). Interacts with ubiquitin (PubMed:21115689).By similarity3 Publications

Binary interactionsi

Protein-protein interaction databases

IntActiQ5D1E7, 4 interactors
MINTiQ5D1E7
STRINGi10090.ENSMUSP00000037172

Structurei

Secondary structure

1596
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ5D1E7
SMRiQ5D1E7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni42 – 87Ubiquitin association domain1 PublicationAdd BLAST46
Regioni81 – 150Necessary for interaction with TANKBy similarityAdd BLAST70
Regioni112 – 281RNaseBy similarityAdd BLAST170
Regioni214 – 220RNA bindingBy similarity7
Regioni301 – 454Necessary for interaction with ZC3H12DBy similarityAdd BLAST154

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi476 – 533Pro-richSequence analysisAdd BLAST58

Domaini

The C3H1-type zinc finger domain and C-terminal region are necessary for pre-miRNA binding (By similarity). The C-terminal region and proline-rich domain are necessary for oligomerization (By similarity).By similarity

Sequence similaritiesi

Belongs to the ZC3H12 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri301 – 324C3H1-typeAdd BLAST24

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3777 Eukaryota
ENOG410ZNK1 LUCA
GeneTreeiENSGT00750000117218
HOGENOMiHOG000060218
HOVERGENiHBG108758
InParanoidiQ5D1E7
KOiK18668
OMAiYWSEPYQ
OrthoDBiEOG091G03B2
PhylomeDBiQ5D1E7
TreeFamiTF315783

Family and domain databases

InterProiView protein in InterPro
IPR021869 RNase_Zc3h12_NYN
PfamiView protein in Pfam
PF11977 RNase_Zc3h12a, 1 hit

Sequencei

Sequence statusi: Complete.

Q5D1E7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDPCGTKPV QESNPTMSLW SLEDRHSSQG RPQPDQDPVA KEAPTSELQM
60 70 80 90 100
KVDFFRKLGY SSSEIHSVLQ KLGVQADTNT VLGELVKHGS ATERECQALT
110 120 130 140 150
APSPQPPLVP RGGSTPKPST LEPSLPEEDR EGSDLRPVVI DGSNVAMSHG
160 170 180 190 200
NKEVFSCRGI LLAVNWFLER GHTDITVFVP SWRKEQPRPD VPITDQHILR
210 220 230 240 250
ELEKKKILVF TPSRRVGGKR VVCYDDRFIV KLAFESDGVV VSNDTYRDLQ
260 270 280 290 300
GERQEWKRFI EERLLMYSFV NDKFMPPDDP LGRHGPSLDN FLRKKPLPSE
310 320 330 340 350
HRKQPCPYGK KCTYGIKCRF FHPERPSRPQ RSVADELRAN ALLSPPRTPV
360 370 380 390 400
KDKSSQRPSP ASQSSSVSLE AEPGSLDGKK LGARSSPGPH REGSPQTCAP
410 420 430 440 450
AGRSLPVSGG SFGPTEWLAH TQDSLPYTSQ ECLDSGIGSL ESQMSELWGV
460 470 480 490 500
RGGSPGESGP TRGPYAGYHS YGSKVPAAPS FSPFRPAMGA GHFSVPTDYV
510 520 530 540 550
PPPPTYPSRE YWSEPYPLPP PTPVLQEPQR PSPGAGGGPW GRVGDLAKER
560 570 580 590
AGVYTKLCGV FPPHLVEAVM RRFPQLLDPQ QLAAEILSYK SQHLSE
Length:596
Mass (Da):65,598
Last modified:June 10, 2008 - v2
Checksum:i420E116564B70212
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti280P → H in BAE29035 (PubMed:16141072).Curated1
Sequence conflicti315G → E in AAX14018 (PubMed:16574901).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY920404 mRNA Translation: AAX14018.1
AK142501 mRNA Translation: BAE25089.1
AK149698 mRNA Translation: BAE29035.1
AK152196 mRNA Translation: BAE31025.1
AK161150 mRNA Translation: BAE36216.1
AK172357 mRNA Translation: BAE42965.1
AL626775 Genomic DNA No translation available.
BC006817 mRNA Translation: AAH06817.1
BC036563 mRNA Translation: AAH36563.1
CCDSiCCDS18638.1
RefSeqiNP_694799.1, NM_153159.2
UniGeneiMm.402

Genome annotation databases

EnsembliENSMUST00000036188; ENSMUSP00000037172; ENSMUSG00000042677
GeneIDi230738
KEGGimmu:230738
UCSCiuc008urw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY920404 mRNA Translation: AAX14018.1
AK142501 mRNA Translation: BAE25089.1
AK149698 mRNA Translation: BAE29035.1
AK152196 mRNA Translation: BAE31025.1
AK161150 mRNA Translation: BAE36216.1
AK172357 mRNA Translation: BAE42965.1
AL626775 Genomic DNA No translation available.
BC006817 mRNA Translation: AAH06817.1
BC036563 mRNA Translation: AAH36563.1
CCDSiCCDS18638.1
RefSeqiNP_694799.1, NM_153159.2
UniGeneiMm.402

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N5JNMR-A45-89[»]
2N5KNMR-A299-327[»]
2N5LNMR-A544-596[»]
5H9VX-ray2.75A/B/C/D134-339[»]
5H9WX-ray2.60A/B134-339[»]
ProteinModelPortaliQ5D1E7
SMRiQ5D1E7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5D1E7, 4 interactors
MINTiQ5D1E7
STRINGi10090.ENSMUSP00000037172

PTM databases

iPTMnetiQ5D1E7
PhosphoSitePlusiQ5D1E7

Proteomic databases

EPDiQ5D1E7
MaxQBiQ5D1E7
PaxDbiQ5D1E7
PRIDEiQ5D1E7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036188; ENSMUSP00000037172; ENSMUSG00000042677
GeneIDi230738
KEGGimmu:230738
UCSCiuc008urw.2 mouse

Organism-specific databases

CTDi80149
MGIiMGI:2385891 Zc3h12a

Phylogenomic databases

eggNOGiKOG3777 Eukaryota
ENOG410ZNK1 LUCA
GeneTreeiENSGT00750000117218
HOGENOMiHOG000060218
HOVERGENiHBG108758
InParanoidiQ5D1E7
KOiK18668
OMAiYWSEPYQ
OrthoDBiEOG091G03B2
PhylomeDBiQ5D1E7
TreeFamiTF315783

Miscellaneous databases

PROiPR:Q5D1E7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042677 Expressed in 105 organ(s), highest expression level in jejunum
GenevisibleiQ5D1E7 MM

Family and domain databases

InterProiView protein in InterPro
IPR021869 RNase_Zc3h12_NYN
PfamiView protein in Pfam
PF11977 RNase_Zc3h12a, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZC12A_MOUSE
AccessioniPrimary (citable) accession number: Q5D1E7
Secondary accession number(s): Q3U8J3
, Q3UE76, Q8JZW9, Q922T4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: November 7, 2018
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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