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UniProtKB - Q5D0X4 (TPHB_COMTE)
Protein
1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase
Gene
tphB
Organism
Comamonas testosteroni (Pseudomonas testosteroni)
Status
Functioni
Involved in the degradation of terephthalate (TPA) via the protocatechuate (PCA) 4,5-cleavage pathway. Catalyzes the dehydrogenation of 1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate (DCD) to yield protocatechuate (PCA) (By similarity).
By similarity1 PublicationCatalytic activityi
- (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+ = 3,4-dihydroxybenzoate + CO2 + NADHEC:1.3.1.53
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 159 | Divalent metal cation; shared with dimeric partnerBy similarity | 1 | |
Metal bindingi | 203 | Divalent metal cation; shared with dimeric partnerBy similarity | 1 | |
Metal bindingi | 255 | Divalent metal cation; shared with dimeric partnerBy similarity | 1 |
GO - Molecular functioni
- (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- NAD binding Source: InterPro
GO - Biological processi
- phthalate metabolic process Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Metal-binding, NAD |
Names & Taxonomyi
Protein namesi | Recommended name: 1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase (EC:1.3.1.53)Short name: DCD dehydrogenase Alternative name(s): Terephthalate dihydrodiol dehydrogenase |
Gene namesi | Name:tphB |
Organismi | Comamonas testosteroni (Pseudomonas testosteroni) |
Taxonomic identifieri | 285 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Comamonas |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000418982 | 1 – 315 | 1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenaseAdd BLAST | 315 |
Family & Domainsi
Sequence similaritiesi
Belongs to the PdxA family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR005255, PdxA_fam |
PANTHERi | PTHR30004, PTHR30004, 1 hit |
Pfami | View protein in Pfam PF04166, PdxA, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5D0X4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTIVHRRLAL AIGDPHGIGP EIALKALQQL SATERSLIKV YGPWSALEQA
60 70 80 90 100
AQICQMESLL QDLIHEEAGS LAQPAQWGEI TPQAGLSTVQ SATAAIRACE
110 120 130 140 150
NGEVDAVIAC PHHETAIHRA GIAFSGYPSL LANVLGMNED EVFLMLVGAG
160 170 180 190 200
LRIVHVTLHE SVRSALERLS PQLVVDAVDA AVQTCTLLGV PKPQVAVFGI
210 220 230 240 250
NPHASEGQLF GLEDSQITAP AVETLRKCGL AVDGPMGADM VLAQRKHDLY
260 270 280 290 300
VAMLHDQGHI PIKLLAPNGA SALSIGGRVV LSSVGHGSAM DIAGRGVADS
310
TALLRTIALL GAQPG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY923836 Genomic DNA Translation: AAX18943.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY923836 Genomic DNA Translation: AAX18943.1 |
3D structure databases
SMRi | Q5D0X4 |
ModBasei | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR005255, PdxA_fam |
PANTHERi | PTHR30004, PTHR30004, 1 hit |
Pfami | View protein in Pfam PF04166, PdxA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TPHB_COMTE | |
Accessioni | Q5D0X4Primary (citable) accession number: Q5D0X4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2012 |
Last sequence update: | March 29, 2005 | |
Last modified: | August 12, 2020 | |
This is version 43 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |