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Entry version 95 (17 Jun 2020)
Sequence version 4 (13 Jul 2010)
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Protein

Fibrous sheath-interacting protein 2

Gene

FSIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in spermatogenesis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibrous sheath-interacting protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FSIP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000188738.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21675 FSIP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615796 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5CZC0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spermatogenic failure 34 (SPGF34)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive infertility disorder caused by spermatogenesis defects that result in multiple abnormalities of sperm flagellum, including irregular-caliber, short, coiled, or absent flagella.
Related information in OMIM

Organism-specific databases

MalaCards human disease database

More...
MalaCardsi
FSIP2
MIMi618153 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000188738

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
276234 Non-syndromic male infertility due to sperm motility disorder

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5CZC0 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FSIP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
300669711

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003317501 – 6907Fibrous sheath-interacting protein 2Add BLAST6907

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei430PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5CZC0

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q5CZC0

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q5CZC0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5CZC0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5CZC0

PeptideAtlas

More...
PeptideAtlasi
Q5CZC0

PRoteomics IDEntifications database

More...
PRIDEi
Q5CZC0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62734 [Q5CZC0-1]
62735 [Q5CZC0-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
792

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q5CZC0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5CZC0

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
Q5CZC0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000188738 Expressed in testis and 85 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5CZC0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5CZC0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000188738 Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with AKAP4.

By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q5CZC0, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000344403

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5CZC0 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili5738 – 5766Sequence analysisAdd BLAST29

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ISIK Eukaryota
ENOG4112BP1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00680000100018

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000048_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5CZC0

Database of Orthologous Groups

More...
OrthoDBi
9535at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5CZC0

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038891 FSIP2
IPR031554 FSIP2_C

The PANTHER Classification System

More...
PANTHERi
PTHR21856 PTHR21856, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15783 FSIP2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5CZC0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELYLGACSK PAKVAVTKTV ASVLAADTQQ CRDGVHKTHF AGVGPAQLLD
60 70 80 90 100
LPLGVKLPVI PGSNAVFYTT NFGEKLFRPS YGFNLTDPYC RLLENQYKSL
110 120 130 140 150
HDPHLKAYYK RKDILKRLKK GGYITSNNKV VCTLRELNKY RQYLTSLKLD
160 170 180 190 200
FERNYIKEQR ILAKQLHNIP ENNQIPQHCD VAQVQNWLLK EGTESIKDQE
210 220 230 240 250
RLMRHRYLDM ISRKLEQLER TAEEQRLFLM DREERRQREH TRRKLTLRRK
260 270 280 290 300
IEEEWKTKEM LLLTRMAEDV KREERIEEQQ HRNREESDRK KQDLLEKKMA
310 320 330 340 350
YHLQKMQDTG FNGEDIGKNT FKYRGQDGTH ASPKNKKKTS EDIMLVYPAG
360 370 380 390 400
DQNTYKETHG HTANAAHQRQ NSSNNFTKKN SASVVYQADV QDNGINQKRD
410 420 430 440 450
GMVSKNSSIF DDRGGINISG QGSIISAQVS PTRNFSRVSQ AFLDPSKEEK
460 470 480 490 500
ETNADWDGRP TKRSSYLCES GPQAHATDPG IFSSPVYTNM QQNLLQNCLQ
510 520 530 540 550
EKVTSEELNI IIQNVMTWVV ATVTSILYPA ITKYEKRLQN NTYPVSDDSI
560 570 580 590 600
LSSDSSSFCS TCSEDFTYRS YTSATTKTFQ AEPCAFVVDT SVRRPTTPIK
610 620 630 640 650
PPPAHVEKTV VGKTCHIKGQ SIISKHKYNK TNLLYSYPKL RSCKSDSHLL
660 670 680 690 700
ASFETGTKKS KDATTETDSL GSSLHCDKTA KAMDEMKNLK NVFVNFKCYL
710 720 730 740 750
KGETEVILES ILREIMSDLT QAIPSLSSVT AEVFVEQCER EKEILLSNAH
760 770 780 790 800
IPSVASEIVE NMLEKLESAV EKKCVEMFSQ DLSVDIKPSL AASDELLTSS
810 820 830 840 850
NGKPLKNSMP HTLDPMCDIA EDMVHAILEK LMTLVSFKQN EFLHLKDTNK
860 870 880 890 900
LSCQQHKTDP ICMFLQRAGK NKSSLESDEA SLIVNEEVQN LISNIFSQSS
910 920 930 940 950
LVAYIEEAIN AILGYIQTEL NNERIIASEE TVVLLQLLED ILFQLHQEPV
960 970 980 990 1000
NESFQKSRQP RISSPSDTKE KYRLTGTRLS NSPRSGRPFP PINVPGMVLY
1010 1020 1030 1040 1050
SDDENEEIDN IVKNVLDSTF KDEKVKSQEQ IPNHWFTKGN TCFECKRNIK
1060 1070 1080 1090 1100
PPTKPGSRSK AAFHDWELKT EPPSTNHEDI LKKKLSSNKD ISTFSQDQKH
1110 1120 1130 1140 1150
QIEKASENIV TSILKEMLKD ISSVPFGHLD SKTGSEASVL VSEKPQGLSH
1160 1170 1180 1190 1200
QEWIDQMFSV SEISTVAQEI TDSVLNILHK ASNYISNTTK SSISSSVHQI
1210 1220 1230 1240 1250
SLHNSDTEHI VKEAPNKYPL KTWFDSEKKM KYLSLFDVDP EKPPWLKSGK
1260 1270 1280 1290 1300
SEPKPVDDIN DKIIRTIFKR LKSFICPKLH MGFKSSLRSQ LSKYTAKIVN
1310 1320 1330 1340 1350
IVLCAIQNEL ELHKENLNLR EIDHTKSLTD KGFFANTDKK LESLVTSIDD
1360 1370 1380 1390 1400
DILASPLLTC IYDMLLSSEN AHQRSISLSS RKPKSATDSV DVQSILPNRQ
1410 1420 1430 1440 1450
DKKSFHKYLA TPCTHHSVNG GNHIKENAKL QVLERIGETL HEMLSKLLGT
1460 1470 1480 1490 1500
HLHSQLSCSQ QSREMTNKNQ KMAAALQSNI QLISKAILDY ILAKLCGVDM
1510 1520 1530 1540 1550
DTSFASCGLK AISESLDIDN PSFASIIEKM AKSTKIISSI VSRRVQEDNK
1560 1570 1580 1590 1600
EETKSKAKPV APVSSKTPST KEMHPNKLKA VASDILNMVF AKLEGFANGH
1610 1620 1630 1640 1650
LEILGAINDG NKKSNKIGWE YESTNISRDT HEASFLSALY MHAKKVSSAI
1660 1670 1680 1690 1700
LKVIQTELNV TSSDLKTSVE NPPPETQILK YVVKLILDAV SSDMFNEMES
1710 1720 1730 1740 1750
EGGGIETYRY RPTYGSLPGG AESDSFLEDD AYTAKKIIDE RSPQREEVKT
1760 1770 1780 1790 1800
RSLKQWALEK TLNKIEVKLK EPHISPIAPI IRNILNEIFQ STLINQLNVL
1810 1820 1830 1840 1850
SLSHSNFNGM PHNVDEPTPQ TSVQFMDKMM DPLLSEADIT IVTDNIVRTV
1860 1870 1880 1890 1900
FHKLYSAAMT ERNVRENRYK TITFSANVSS HEHTYKGKSS VTALDENPCT
1910 1920 1930 1940 1950
FQSRFSVADK ETKVNLAEDI VQAILTNLET FATSKVKSLF YSQVNFTVPV
1960 1970 1980 1990 2000
ALPIQQDHST LSKALSAKDS YSDEQFSCCS VDHTKSGKTN LCQLSLSKLN
2010 2020 2030 2040 2050
TYALQVARRN LQGIKQELDK ERENPFLTHD IGISESIASQ IVNALLDIIS
2060 2070 2080 2090 2100
RKGKCDKNSS DKEIDLDQQK GVIEKLLNET KYRKVLQLQI QDTIEGILCD
2110 2120 2130 2140 2150
IYEKTLFQNN LSFATPTLKC SIADKHSEEN SEMFMEGANK IIPKLSVPKS
2160 2170 2180 2190 2200
DVILISNDIV NIVLHNLSSA ATLVINAKNP TSARLPLTFC DTFPKIDCQQ
2210 2220 2230 2240 2250
PLKGSKTERK TERFSYSRNQ KSAYADDNQI TVVEKEDTQK SATDSCEENA
2260 2270 2280 2290 2300
NFITKTIFKR LESFATERID SLITLAFQSK EKSFVIPELE NCKQNDSIFY
2310 2320 2330 2340 2350
DSSQVESDVN VLKISATETI LSQELTDFTF VGRREKLGST IHLSQARLKT
2360 2370 2380 2390 2400
YADVIASAIL KLIKNDLDLE IQKIYPYQNN ILFQENIIVS EIVDSMLKML
2410 2420 2430 2440 2450
DDKRSVKEIC FNSKENSNFS QLALSNEILL GHKEKERSTK QSLFTKYPLE
2460 2470 2480 2490 2500
QNQMILENKR QIIVLEEIFM RNGESKNKEK GELLIAVEEL LNKLYQRVRE
2510 2520 2530 2540 2550
VTGHLPPLNE TANFISNSKI KTSDTTQKNS FQSHINSVAN DIVESVLGKM
2560 2570 2580 2590 2600
YLVVVTSLYE NNKSRTEVEI SDHNDSLLMK PLRFRETKQA GKISNSPRYA
2610 2620 2630 2640 2650
ISQAYSYVDS QNISVMENTL LPYLPLQVKK DLIQMVLNKI TNFVSLPLKV
2660 2670 2680 2690 2700
SPKDNPKPCF KAHLKTRSKI TTLPKFTKKT HLGLSAAKAK SKTKLGPGEK
2710 2720 2730 2740 2750
TLKDSRSKTA IGLSHIMSAG DAKNLLDTKL PTSELKIYAK DIIINILETI
2760 2770 2780 2790 2800
VKEFGKVKQT KALPSDQIIA AGKIVNTVLQ ELYVTNNCNL AYPMKSSHLR
2810 2820 2830 2840 2850
LSQGNIGTGS LPKQQACFYL ENVSSQLEHI FPREGIFKKL FDKWQTESND
2860 2870 2880 2890 2900
KENEKCKLLM IAENVLTEIS IKAKELEYSL SLLNLPPLEN CESRFYNHFK
2910 2920 2930 2940 2950
GASTRAEDTK AQINMFGREI VEMLLEKLQL CFLSQIPTPD SEETLSNSKE
2960 2970 2980 2990 3000
HITAKSKYGF PNKHSLSSLP IYNTKTKDQI SVGSSNQIVQ EIVETVLNML
3010 3020 3030 3040 3050
ESFVDLQFKH ISKYEFSEIV KMPIENLSSI QQKLLNKKML PKLQPLKMFS
3060 3070 3080 3090 3100
DKSESNTINF KENIQNILLR VHSFHSQLLT YAVNIISDML AVIKNKLDNE
3110 3120 3130 3140 3150
ISQMEPSSIS ILKENIVASE IIGTLMDQCT YFNESLIQNL SRESLFQGAE
3160 3170 3180 3190 3200
NAYTVNQVEL ATNMKMFTSK LKEGSLGINP SQVSKTGFVF CSDEDMKEKY
3210 3220 3230 3240 3250
RVSSDLPTSV RSSVEDTVKN SEPTKRPDSE TMPSCSTRNK VQDHRPRESN
3260 3270 3280 3290 3300
FGSFDQTMKG NSYLPEGSFL QKLLRKASDS TEAALKQVLS FIEMGKGENL
3310 3320 3330 3340 3350
RVFHYENLKP VVEPNQIQTT ISPLKICLAA ENIVNTVLSS CGFPSQPHTN
3360 3370 3380 3390 3400
ENREIMKPFF ISKQSSLSEV SGGQKDNEKS LLRMQDKKIN YIPEEENENL
3410 3420 3430 3440 3450
EASREDSSFL QKLKKKEYPK IETVKEVEAF TFADHEMGSN EVHLIARHVT
3460 3470 3480 3490 3500
TSVVTYLKNF ETTVFSEEKM SVSTWSRKKY ESKQFLRNIY DDSSIYQCCE
3510 3520 3530 3540 3550
HLTESVLYHL TSSISDGTKK GREKEKAWEI QEATFSKIIS IHSQVFESRS
3560 3570 3580 3590 3600
ISIGELALCI SEIIIKILFN NKIIQADIAQ KMVAIPTKYT YCPGIVSGGF
3610 3620 3630 3640 3650
DDLFQDLLVG VIHVLSKEIE VDYHFESNVR NKSFSMHRNN SVPLCNKINR
3660 3670 3680 3690 3700
QASPRDWQFS TQQIGQLFQK NKLSYLACKL NSLVGNLKTS ESKEVVNKVF
3710 3720 3730 3740 3750
NIVSDLFSPD ECLDTGMDSG KIQRTYFYSS NNEQPNSILT NNLQLSSKSV
3760 3770 3780 3790 3800
FLLNVVCEKL IRILLEECTS TAFPDKGSVS EETSAEECQL LKMLQSVEDG
3810 3820 3830 3840 3850
KSDYRKGGMD CECLQVDYMS DLLENVAEID QDLLTSDSML TIISHSLVKS
3860 3870 3880 3890 3900
LMDKLSHSIQ QAPESLPFAN KHLNYRTREI QSSFIKARKS ELIELGQSKS
3910 3920 3930 3940 3950
SLELRSYDSN SLTVSLNNPS VVSSKIQAPF NKHCAVKSSS VSPFERQRTK
3960 3970 3980 3990 4000
EMDKVAIHNK LHQEGIYAGV YSATFLEGII SELFFNLSMS LWGKNKNITV
4010 4020 4030 4040 4050
SWLNEMNTLF VNNVVNEFNN AQVTVLRNAE ERLCFPPVHT ETVSKIVDSV
4060 4070 4080 4090 4100
YYDVLQQYEL KVACGNNPVY DNASIAEQIT NGILLEILDY KLPSCFKEHL
4110 4120 4130 4140 4150
IPHSYYPLKP EIILQKLQSN LTEFTSLPRS SSDYSTMLSH SFLEDVIRRL
4160 4170 4180 4190 4200
LSQLIPPPIT CSSLGKKYLM SSDFNEMSTC IINKVMSAIS KHKIWFTIYD
4210 4220 4230 4240 4250
NQYLYTGKNL QKMVDSVYCN ILQMSDSLVS IQKSIVSRSP IMIDQIASFI
4260 4270 4280 4290 4300
IQEIIENHLQ PFLSGEVLCH PRTPLDPVST IVTQVLSEVI ESHRPQKQSP
4310 4320 4330 4340 4350
LDIHLDSFVR EIVARLLSKI FSPKHNTEIE LKNMTQRIVN SINRHFNKAK
4360 4370 4380 4390 4400
IHILYDDKEQ AFFSFNTDIV DELATSVYRN ALKQHGLDLA VDKESEDSGI
4410 4420 4430 4440 4450
FVENITNLIV AAISDYLLHP LFSGDFSAST YSNSVAENIV QDILSNISKS
4460 4470 4480 4490 4500
TEPSQSVPLY NTLLPYTFLE DMIRVLLSKL FSSASSLVLN RDTQKDISRV
4510 4520 4530 4540 4550
NFNDIASNLV SDIRMKVSQH EIRFSKEEEE TKFIYSEDDI QHLVDSVFAN
4560 4570 4580 4590 4600
VVQTSGSQES AVQNITSSND ILIDRIAGFI IKHICQKHLQ PFVSGKSLSS
4610 4620 4630 4640 4650
SDTYFDDERR QLFYTSVYSS TFLEDVISGV LRKIFHRVVG IVQTKSIRDS
4660 4670 4680 4690 4700
EDELFEKAEE LIHLITGEFS KAQVSIIDNT EERLCLPPVE RDVVKTIVDM
4710 4720 4730 4740 4750
VYSKVLQEYE MEVVPNKDFL NDTKTLAARI TNIILAEIFD FQIHPDLIAN
4760 4770 4780 4790 4800
LPFKSHSKLS ANVLIQRVQY DISKSRFQRQ ASTMYTTMLS HSHLEKIVTQ
4810 4820 4830 4840 4850
LTSQISPLNT SAEQSDTTKS DLSNTVIKLI NEIMSIISKH EICIIKYGNK
4860 4870 4880 4890 4900
KQSMISAKDI QSMVDSIYAD LSHSNIYQSI TKDKKSISDI PVSKIASFII
4910 4920 4930 4940 4950
KEIFNHHIQS FLSEDKTLLL AAVDQTYKLK AIDPKQRELS FIVNSSVFLE
4960 4970 4980 4990 5000
EVISELLCKI LYAFSHNMLV TENPDRVKLK LTRIVTTLVN SIVLEFTTSE
5010 5020 5030 5040 5050
ILVADNFDKN LCFSERYKEM VQKIVNSVYG KVLDQYKSLI QIHRVIQSDT
5060 5070 5080 5090 5100
ICFGRKIYYL LLEEIYDYQV QSLVSGELES SSYSYPQADN IIRNVLNIIT
5110 5120 5130 5140 5150
KDSHALPPYI TVLPHSLLED MVYRLLGHVF PSTHTENELK EKKFPPDDEF
5160 5170 5180 5190 5200
VEAASKLTDE IIKEISEHEI RLSMAEDNAE SMQLEPIENL VDSICNNILK
5210 5220 5230 5240 5250
TSEFQAEVQK DADKKGCSFL SKLAGFIMKE IMYHHLQPFL HGEESSFSDL
5260 5270 5280 5290 5300
SDYDHVSELA KSGKEKTQPS LYSATFLEDI IIDLVHKFCS LLIITEDSKK
5310 5320 5330 5340 5350
NEMAELDIMG LALKLANSLI REFKKSDIKV LPNAEKMFSF PPIDKETVDK
5360 5370 5380 5390 5400
ISNFVYEQFI EKCTSHDIQK GDESNIAIGM IAALTQKAIS AFRIQPLFSG
5410 5420 5430 5440 5450
DWSSTFFSFL NPDNITQRVQ HLPQNTFTQI SRCAKENQLS LPDQSYKDTS
5460 5470 5480 5490 5500
STPDCKNMMS TLEINRGTMN RKKSFKTKDT SVKKGDIQNP VLSSINAIMK
5510 5520 5530 5540 5550
SGMINLTSGL ATGVTNKKEV DENKVGICTQ KHSENVSKVT STTTVKSKDT
5560 5570 5580 5590 5600
QEPNLSETFN NNEIEKKRNL IPTDKKGKDD EIYTHFSLII DDTEYEKEVL
5610 5620 5630 5640 5650
GSDSEIGYKK KIDNARESSF KKDDKLFQLS SLKSKRNLGT TTDTLEIRIR
5660 5670 5680 5690 5700
TSSNEGRRDS PTQTCRDEEH HSDYEHVQNV IENIFEDVLE LSSSPEPAYY
5710 5720 5730 5740 5750
SKLSYDQSPP GDNVLNVIQE ISRDSAQSVT TKKVSSSTNK NISAKEKEEE
5760 5770 5780 5790 5800
EREKEKVREE IKSEPSKPDD PQNQRESKPG IFPAKFLEDV ITEMVKQLIF
5810 5820 5830 5840 5850
SSIPETQIQD RCQNVSDKQN QAKLYDTAMK LINSLLKEFS DAQIKVFRPD
5860 5870 5880 5890 5900
KGNQFPGGKV SSVPKVPPRY KEPTTDEAPS SIKIKSADKM PPMHKMMRKP
5910 5920 5930 5940 5950
SSDKIPSIDK TLVNKVVHSS VCNILNDYGS QDSIWKNINS NGENLARRLT
5960 5970 5980 5990 6000
SAVINEIFQR QVNLIFCDEV SVSACLPLES KDVVKKVQKL AQTASKECQT
6010 6020 6030 6040 6050
SSPYTIILPH KFLENVISAL FSKIFSTISS TKTKEPEDNL STELNFLQMK
6060 6070 6080 6090 6100
LVSAVATEIS QDKYMTIQYV ETLQSDDDEI IQLVVQSVYN NLLPQFGSQE
6110 6120 6130 6140 6150
IIQNCVTSGC KILSENIVDL VLREVASNQL QSYFCGELTP HQCVEVENIV
6160 6170 6180 6190 6200
EKILKDVFQT TDVPLPKPSH ADKLSYNIIE EIAVKFLSKL LSIFPKVHKE
6210 6220 6230 6240 6250
RTKSLETDMQ KITSKVLNSV QEFISKSKIK LVPPTKESPT VPVADNATIE
6260 6270 6280 6290 6300
NIVNSIYTSV LKHSGSYTSV FKDLMGKSNV LSDTIGFLMV NAISNSEFQP
6310 6320 6330 6340 6350
QVEEEVSNSE LVLEAVKIME KVIKIIDELK SKEKSSSRKG LTLDAKLLEE
6360 6370 6380 6390 6400
VLALFLAKLI RLPSSSSKDE KNLSKTELNK IASQLSKLVT AEISRSSISL
6410 6420 6430 6440 6450
IASDPEEHCL NPENTERIYQ VVDSVYSNIL QQSGTNKEFY YDIKDTNTAF
6460 6470 6480 6490 6500
PKKVASLIID GVSSFPLDTI NSTISNADLS GELDVNRIVQ KAQEHAFNVI
6510 6520 6530 6540 6550
PELEQEKLDQ NLSEEESPIK IVPHVGKKPV KIDPKIISEH LAVISIKTQP
6560 6570 6580 6590 6600
LEKLKQECLK RTGHSIAELR RASISGRNYS LGSPDLEKRK TERRTSLDKT
6610 6620 6630 6640 6650
GRLDVKPLEA VARNSFQNIR KPDITKVELL KDVQSKNDLI VRLVAHDIDQ
6660 6670 6680 6690 6700
VYLENYIKEE RDSDEDEVVL TQTFAKEEGI KVFEDQVKEV KKPIQSKLSP
6710 6720 6730 6740 6750
KSTLSTSSLK KFLSLSKCCQ TTASANIEST EAISNQVIES KETHVKRAVA
6760 6770 6780 6790 6800
ELDMATPKTM PETASSSWEE KPQCKKEEKN LVTEPTHYFI HRIMSSSSYN
6810 6820 6830 6840 6850
QEDLISSTGE AEDCHSDPSA KILEESSQEQ KPEHGNSVKF ITIFERSKDV
6860 6870 6880 6890 6900
LGSANPSKEV ISETPKPDVS KQGSKMLTKM SSTLSKVFSQ CNTNISRSSS

PAHQDEH
Length:6,907
Mass (Da):780,607
Last modified:July 13, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB0E81A627B82ABA2
GO
Isoform 2 (identifier: Q5CZC0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3464-3466: VFS → GRC
     3467-6907: Missing.

Show »
Length:3,466
Mass (Da):391,703
Checksum:iD95CA55780A610BC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y515H0Y515_HUMAN
Fibrous sheath-interacting protein ...
FSIP2
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZL6H7BZL6_HUMAN
Fibrous sheath-interacting protein ...
FSIP2
973Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WUX3A0A087WUX3_HUMAN
Fibrous sheath-interacting protein ...
FSIP2
646Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAY14863 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AK126051 differs from that shown. Reason: Frameshift.Curated
The sequence CAI46017 differs from that shown. Aberrant splicing.Curated
The sequence CAI46017 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti241T → A in CAI56743 (PubMed:17974005).Curated1
Sequence conflicti336K → R in CAI56743 (PubMed:17974005).Curated1
Sequence conflicti430S → P in CAI56743 (PubMed:17974005).Curated1
Sequence conflicti1288R → Q in CAI56743 (PubMed:17974005).Curated1
Sequence conflicti2499R → M in BAC86432 (PubMed:14702039).Curated1
Sequence conflicti2808T → I in BAC86432 (PubMed:14702039).Curated1
Sequence conflicti2895F → L in BAC86432 (PubMed:14702039).Curated1
Sequence conflicti2900K → E in BAC86432 (PubMed:14702039).Curated1
Sequence conflicti5357E → D in BX648733 (PubMed:17974005).Curated1
Sequence conflicti5523N → D in AK126051 (PubMed:14702039).Curated1
Sequence conflicti5564I → V in BX648733 (PubMed:17974005).Curated1
Sequence conflicti5583Y → N in AK126051 (PubMed:14702039).Curated1
Sequence conflicti5649I → T in BX648733 (PubMed:17974005).Curated1
Sequence conflicti5649I → T in AK126051 (PubMed:14702039).Curated1
Sequence conflicti5775R → Q in AK126051 (PubMed:14702039).Curated1
Sequence conflicti5824L → P in CAI46017 (PubMed:17974005).Curated1
Sequence conflicti5960R → H in AK126051 (PubMed:14702039).Curated1
Sequence conflicti5960R → H in BAC86406 (PubMed:14702039).Curated1
Sequence conflicti6165L → Q in AK126051 (PubMed:14702039).Curated1
Sequence conflicti6165L → Q in BAC86406 (PubMed:14702039).Curated1
Sequence conflicti6526G → E in CAI46017 (PubMed:17974005).Curated1
Sequence conflicti6591T → I in BX648733 (PubMed:17974005).Curated1
Sequence conflicti6622P → S in CAI46017 (PubMed:17974005).Curated1
Sequence conflicti6644V → E in BAC86406 (PubMed:14702039).Curated1
Sequence conflicti6730T → I in BX648733 (PubMed:17974005).Curated1
Sequence conflicti6736Q → R in CAI46017 (PubMed:17974005).Curated1
Sequence conflicti6760M → V in BX648733 (PubMed:17974005).Curated1
Sequence conflicti6794M → V in BX648733 (PubMed:17974005).Curated1
Sequence conflicti6883T → A in BX648733 (PubMed:17974005).Curated1
Sequence conflicti6883T → A in CAI46017 (PubMed:17974005).Curated1
Sequence conflicti6883T → A in AK126051 (PubMed:14702039).Curated1
Sequence conflicti6883T → A in BAC86406 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042938306M → V. Corresponds to variant dbSNP:rs9808218Ensembl.1
Natural variantiVAR_075707700L → F1 Publication1
Natural variantiVAR_0757082764P → T1 PublicationCorresponds to variant dbSNP:rs201794247Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0394123464 – 3466VFS → GRC in isoform 2. 1 Publication3
Alternative sequenceiVSP_0394133467 – 6907Missing in isoform 2. 1 PublicationAdd BLAST3441

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC007966 Genomic DNA Translation: AAY15001.1
AC008174 Genomic DNA Translation: AAY14863.1 Sequence problems.
BX647691 mRNA Translation: CAI46017.1 Sequence problems.
BX648733 mRNA No translation available.
CR936597 mRNA Translation: CAI56743.1
AK126036 mRNA Translation: BAC86406.1
AK126051 mRNA No translation available.
AK126089 mRNA Translation: BAC86432.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS54426.2 [Q5CZC0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_775922.3, NM_173651.3 [Q5CZC0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000424728; ENSP00000401306; ENSG00000188738 [Q5CZC0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
401024

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:401024

UCSC genome browser

More...
UCSCi
uc061qle.1 human [Q5CZC0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007966 Genomic DNA Translation: AAY15001.1
AC008174 Genomic DNA Translation: AAY14863.1 Sequence problems.
BX647691 mRNA Translation: CAI46017.1 Sequence problems.
BX648733 mRNA No translation available.
CR936597 mRNA Translation: CAI56743.1
AK126036 mRNA Translation: BAC86406.1
AK126051 mRNA No translation available.
AK126089 mRNA Translation: BAC86432.1
CCDSiCCDS54426.2 [Q5CZC0-1]
RefSeqiNP_775922.3, NM_173651.3 [Q5CZC0-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ5CZC0, 2 interactors
STRINGi9606.ENSP00000344403

PTM databases

GlyConnecti792
iPTMnetiQ5CZC0
PhosphoSitePlusiQ5CZC0
UniCarbKBiQ5CZC0

Polymorphism and mutation databases

BioMutaiFSIP2
DMDMi300669711

Proteomic databases

EPDiQ5CZC0
jPOSTiQ5CZC0
MassIVEiQ5CZC0
MaxQBiQ5CZC0
PaxDbiQ5CZC0
PeptideAtlasiQ5CZC0
PRIDEiQ5CZC0
ProteomicsDBi62734 [Q5CZC0-1]
62735 [Q5CZC0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
51870 37 antibodies

Genome annotation databases

EnsembliENST00000424728; ENSP00000401306; ENSG00000188738 [Q5CZC0-1]
GeneIDi401024
KEGGihsa:401024
UCSCiuc061qle.1 human [Q5CZC0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
401024
EuPathDBiHostDB:ENSG00000188738.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FSIP2
HGNCiHGNC:21675 FSIP2
HPAiENSG00000188738 Tissue enriched (testis)
MalaCardsiFSIP2
MIMi615796 gene
618153 phenotype
neXtProtiNX_Q5CZC0
OpenTargetsiENSG00000188738
Orphaneti276234 Non-syndromic male infertility due to sperm motility disorder

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ISIK Eukaryota
ENOG4112BP1 LUCA
GeneTreeiENSGT00680000100018
HOGENOMiCLU_000048_0_0_1
InParanoidiQ5CZC0
OrthoDBi9535at2759
PhylomeDBiQ5CZC0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
401024 2 hits in 787 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FSIP2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
401024
PharosiQ5CZC0 Tdark

Protein Ontology

More...
PROi
PR:Q5CZC0
RNActiQ5CZC0 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000188738 Expressed in testis and 85 other tissues
ExpressionAtlasiQ5CZC0 baseline and differential
GenevisibleiQ5CZC0 HS

Family and domain databases

InterProiView protein in InterPro
IPR038891 FSIP2
IPR031554 FSIP2_C
PANTHERiPTHR21856 PTHR21856, 1 hit
PfamiView protein in Pfam
PF15783 FSIP2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFSIP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5CZC0
Secondary accession number(s): Q53TL3
, Q53TN5, Q5HYH2, Q6ZTZ5, Q6ZU14, Q6ZU21
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 13, 2010
Last modified: June 17, 2020
This is version 95 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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