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Protein

Ankyrin repeat domain-containing protein 20B

Gene

ANKRD20A8P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 20B
Alternative name(s):
Ankyrin repeat domain-containing protein 20A pseudogene
Gene namesi
Name:ANKRD20A8P
Synonyms:ANKRD20B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:23666 ANKRD20A8P
neXtProtiNX_Q5CZ79

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000229089

Polymorphism and mutation databases

DMDMi182627628

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003288351 – 823Ankyrin repeat domain-containing protein 20BAdd BLAST823

Proteomic databases

EPDiQ5CZ79
MaxQBiQ5CZ79
PRIDEiQ5CZ79
ProteomicsDBi62729
62730 [Q5CZ79-2]

PTM databases

iPTMnetiQ5CZ79
PhosphoSitePlusiQ5CZ79

Expressioni

Gene expression databases

ExpressionAtlasiQ5CZ79 baseline and differential

Organism-specific databases

HPAiHPA043239
HPA047112
HPA047167
HPA047766
HPA051753

Structurei

3D structure databases

ProteinModelPortaliQ5CZ79
SMRiQ5CZ79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati32 – 65ANK 1Add BLAST34
Repeati66 – 95ANK 2Add BLAST30
Repeati99 – 128ANK 3Add BLAST30
Repeati132 – 161ANK 4Add BLAST30
Repeati165 – 194ANK 5Add BLAST30
Repeati198 – 227ANK 6Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili431 – 480Sequence analysisAdd BLAST50
Coiled coili565 – 724Sequence analysisAdd BLAST160
Coiled coili776 – 805Sequence analysisAdd BLAST30

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00560000076605
HOVERGENiHBG079958
InParanoidiQ5CZ79
PhylomeDBiQ5CZ79

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR039497 CC144C-like_CC_dom
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF14915 CCDC144C, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5CZ79-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLFGFGSRR GQTAEGSIDH VYTGSGYRIR DSELQKIHRA AVKGDAAEVE
60 70 80 90 100
RCLARRSGDL DARDKQHRTA LHLACASGHV QVVTLLVNRK CQIDICDKEN
110 120 130 140 150
RTPLIQAVHC QEEACAVILL KHGANPNLKD IYGNTALHYA VYSESTSLAE
160 170 180 190 200
KLLSHGAHIE ALDKDSNTPL LFAIICKKEK MVEFLLKKKA STHAVDRLRR
210 220 230 240 250
SALMLAVYYD SPGIVSILLK QNIDVFAQDM CGRDAEDYAI SHHLTKIQQQ
260 270 280 290 300
ILEHKQKILK KEKSDVGSSD ESAVSIFHEL RVDSLPASDD KDLSVATKQC
310 320 330 340 350
VPEKVSEPLP GPSHEKGNRI VNGQGEGPPA KHPSLKPTTG VEDPAVKGAV
360 370 380 390 400
QRKNVQTLRA EQALPVASEE EQERHERSEK KQPQVKKGNN TNKSEKIQLS
410 420 430 440 450
ENICDSTSSA AAGRLTQQRK IGKTYPQQFP KKLKEEHDKC TLKQENEEKT
460 470 480 490 500
NVNMLYKKNR EELERKEKQY KKEVEAKQLE PTVQSLEMKS KTARNTPNRD
510 520 530 540 550
FHNHEETKGL MDENCILKAD IAILRQEICT MKNDNLEKEN KYLKDIKIVK
560 570 580 590 600
ETNAALEKYI KLNEEMITET AFRYQQELND LKAENTRLNA ELLKEKESKK
610 620 630 640 650
RLEADIESYQ SRLAAAIGKH SESVKTERNV KLALERTQDV SVQVEMSSAI
660 670 680 690 700
SKVKDENEFL TEQLSETQIK FNALKDKFRK TRDSLRKKSL ALETVQNDLR
710 720 730 740 750
KTQQQTQEMK EMYQNAEAKV NNSTGKWNCV EERICHLQRE NAWLVQQLDD
760 770 780 790 800
VHQKEDHKEI VTNIQRGFIE SGKKDLVLEE KSKKLMNECD HLKESLFQYE
810 820
REKAEGVVSI KEDKYFQTSR KKI
Length:823
Mass (Da):93,909
Last modified:April 8, 2008 - v2
Checksum:i42F58A41BEB97330
GO
Isoform 2 (identifier: Q5CZ79-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-428: Missing.
     429-439: FPKKLKEEHDK → MNFKINVFICR

Note: No experimental confirmation available.
Show »
Length:395
Mass (Da):46,654
Checksum:iC12C659053B3718D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YFB0A0A286YFB0_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD20A8P
141Annotation score:

Sequence cautioni

The sequence CAI56787 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti618G → C in CAI56787 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0328091 – 428Missing in isoform 2. 1 PublicationAdd BLAST428
Alternative sequenceiVSP_032810429 – 439FPKKLKEEHDK → MNFKINVFICR in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073464 Genomic DNA No translation available.
AC097374 Genomic DNA No translation available.
CR936649 mRNA Translation: CAI56787.1 Different initiation.
UniGeneiHs.456852

Genome annotation databases

EnsembliENST00000432432; ENSP00000493420; ENSG00000229089 [Q5CZ79-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073464 Genomic DNA No translation available.
AC097374 Genomic DNA No translation available.
CR936649 mRNA Translation: CAI56787.1 Different initiation.
UniGeneiHs.456852

3D structure databases

ProteinModelPortaliQ5CZ79
SMRiQ5CZ79
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ5CZ79
PhosphoSitePlusiQ5CZ79

Polymorphism and mutation databases

DMDMi182627628

Proteomic databases

EPDiQ5CZ79
MaxQBiQ5CZ79
PRIDEiQ5CZ79
ProteomicsDBi62729
62730 [Q5CZ79-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000432432; ENSP00000493420; ENSG00000229089 [Q5CZ79-1]

Organism-specific databases

GeneCardsiANKRD20A8P
H-InvDBiHIX0002254
HIX0026557
HIX0164337
HGNCiHGNC:23666 ANKRD20A8P
HPAiHPA043239
HPA047112
HPA047167
HPA047766
HPA051753
neXtProtiNX_Q5CZ79
OpenTargetsiENSG00000229089
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00560000076605
HOVERGENiHBG079958
InParanoidiQ5CZ79
PhylomeDBiQ5CZ79

Miscellaneous databases

PROiPR:Q5CZ79

Gene expression databases

ExpressionAtlasiQ5CZ79 baseline and differential

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR039497 CC144C-like_CC_dom
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF14915 CCDC144C, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiAN20B_HUMAN
AccessioniPrimary (citable) accession number: Q5CZ79
Secondary accession number(s): A6NC18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: October 10, 2018
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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